166. Pseudoxanthoma elasticum
[
9 clinical trials,
17 drugs（DrugBank:
5 drugs),
5 target genes / 25 target pathways ]
Searched query = "Pseudoxanthoma elasticum"
The queries were searched in Public_title, Scientific_title, and Condition of the data. Export date: 11/20/2019, 11/21/2019. Trials are sorted by Date_enrolment from most recent to oldest in the table.
| No. | TrialID | Date_ enrollement | Last_Refreshed_ on | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | EUCTR2016-004021-16-ES | 31/10/2018 | 7 January 2019 | Response to oral lansoprazole in patients with Pseudoxanthoma Elasticum | Response to oral lansoprazole in inorganic pyrophosphate levels in patients with Grönblad-Stranberg disease (Pseudoxanthoma Elasticum) - FIM-PXE-2016-01 | Grönblad-Stranberg disease (Pseudoxanthoma Elasticum) MedDRA version: 19.1 Level: PT Classification code 10037150 Term: Pseudoxanthoma elasticum System Organ Class: 10010331 - Congenital, familial and genetic disorders ;Therapeutic area: Body processes [G] - Metabolic Phenomena [G03] | Trade Name: Lansoprazole Pharmaceutical Form: Capsule INN or Proposed INN: Lansolprazole CAS Number: 103577-45-3 Other descriptive name: LANSOPRAZOLE Concentration unit: mg milligram(s) Concentration type: equal Concentration number: 30- Pharmaceutical form of the placebo: Capsule Route of administration of the placebo: Oral use | Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud (FIMABIS) | Authorised | Female: yes Male: yes | 20 | Phase 2 | Spain | |||
| 2 | EUCTR2018-001492-20-FI | 20/06/2018 | 20 August 2018 | Pyrophosphate therapy in PXE disease | Pseudoxanthoma elasticum – supplementation therapy of pyrophosphate deficiency | Pseudoxanthoma elasticum;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] | Trade Name: SODIUM ACID PYROPHOSPHATE Product Code: CAS No.: 7758-16-9 | Tampere university hospital | Authorised | Female: yes Male: yes | 100 | Phase 2;Phase 3 | Finland | |||
| 3 | NCT02537054 | September 2015 | 20 May 2019 | Intravitreal Aflibercept for Therapy of Patients With Pseudoxanthoma Elasticum (PXE) | Intravitreal Aflibercept (Eylea) for Therapy of Choroidal Neovascularization (CNV) and Fibrovascular Proliferation (FVP) in Patients With Pseudoxanthoma Elasticum (PXE) | Pseudoxanthoma Elasticum | Drug: Aflibercept | University Hospital, Bonn | Not recruiting | 18 Years | 65 Years | All | 15 | Phase 2 | Germany | |
| 4 | EUCTR2014-005263-33-DE | 29/04/2015 | 10 September 2018 | Intravitreal Aflibercept (Eylea®) for therapy of choroidal neovascularization and fibrovascular proliferation in patients with Pseudoxanthoma elasticum | Intravitreal Aflibercept (Eylea®) for therapy of choroidal neovascularization and fibrovascular proliferation in patients with Pseudoxanthoma elasticum - EyNeP | Choroidal neovascularizations and fibrovascular proliferations in patients with Pseudoxanthoma elasticum MedDRA version: 20.0 Level: PT Classification code 10037150 Term: Pseudoxanthoma elasticum System Organ Class: 10010331 - Congenital, familial and genetic disorders ;Therapeutic area: Diseases [C] - Eye Diseases [C11] | Trade Name: Eylea Pharmaceutical Form: Solution for injection | Medizinische Fakultät der Universität Bonn | Not Recruiting | Female: yes Male: yes | 15 | Phase 2 | Germany | |||
| 5 | EUCTR2013-001421-55-FR | 13/06/2013 | 11 December 2017 | An open-label Extended Clinical Protocol of ranibizumab to evaluate Safety and Efficacy in rare VEGF driven ocular diseases. - ECLIPSE | An open-label Extended Clinical Protocol of ranibizumab to evaluate Safety and Efficacy in rare VEGF driven ocular diseases. - ECLIPSE | Choroidal neovascularization not related to wet Age-related macular degeneration (wAMD), pathologic myopia (PM)or Pseudoxanthoma elasticum (PXE), as well as in Macular Edema (ME) not related to Retinal Vein Occlusion (RVO) or Diabetic macular edema (DME) and other ocular neovascularization and/or complication such as Rubeosis Iridis and Neovacular Glaucoma and Proliferative Diabetic Retinopathy requiring Vitrectomy MedDRA version: 18.0 Level: HLGT Classification code 10047060 Term: Retina, choroid and vitreous haemorrhages and vascular disorders System Organ Class: 10015919 - Eye disorders ;Therapeutic area: Diseases [C] - Eye Diseases [C11] | Trade Name: Lucentis Product Name: Lucentis Product Code: RFB002A Pharmaceutical Form: Solution for injection INN or Proposed INN: RANIBIZUMAB CAS Number: 347396-82-1 Current Sponsor code: RFB002 Concentration unit: µl microlitre(s) Concentration type: equal Concentration number: 50- | Novartis Pharma S.A.S | Not Recruiting | Female: yes Male: yes | 500 | Phase 3 | France | |||
| No. | TrialID | Date_ enrollement | Last_Refreshed_ on | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 6 | NCT01525875 | August 2012 | 1 February 2016 | Magnesium Supplements In The Treatment Of Pseudoxanthoma Elasticum (PXE) | Magnesium Supplements In The Treatment Of Pseudoxanthoma Elasticum (PXE) | Pseudoxanthoma Elasticum | Drug: Magnesium Oxide;Drug: Placebo | Mark Lebwohl | Not recruiting | 18 Years | N/A | Both | 44 | Phase 2 | United States | |
| 7 | NCT00510965 | August 2007 | 19 February 2015 | Ranibizumab to Treat Choroidal Neovascularization (CNV) in Patients With Pseudoxanthoma Elasticum (PXE) | Ranibizumab in Choroidal Neovascularization (CNV) Due to Pseudoxanthoma Elasticum (PXE, Groenblad-Strandberg-Syndrome) | Choroidal Neovascularization | Drug: Intravitreal injection ranibizumab | University Hospital, Bonn | Novartis | Not recruiting | 18 Years | 65 Years | Both | 10 | Phase 2 | Germany |
| 8 | EUCTR2006-006231-49-DE | 24/07/2007 | 19 March 2012 | Ranibizumab in choroidal neovascularization (CNV) due to Pseudoxanthoma elasticum (PXE, Groenblad-Strandberg Syndrome) - PXE-CNV 06 | Ranibizumab in choroidal neovascularization (CNV) due to Pseudoxanthoma elasticum (PXE, Groenblad-Strandberg Syndrome) - PXE-CNV 06 | Pseudoxanthoma elasticum (PXE) is an inherited systemic disease characterized by changes in the elastic tissue. Pseudoxanthoma elasticum mainly affects the skin, eyes, heart, and GI system. The cutaneous and ocular findings of PXE are referred to as Grönblad-Strandberg syndrome. Pseudoxanthoma elasticum may be autosomal dominant or autosomal recessive. In Pseudoxanthoma elasticum, choroidal nevoscualrization (CNV) is a frequently occuring complication in late stage disease MedDRA version: 8.1 Level: LLT Classification code 10037150 Term: Pseudoxanthoma elasticum | Trade Name: Lucentis Product Name: Lucentis Product Code: RFB002 Pharmaceutical Form: Solution for injection INN or Proposed INN: ranibizumab Current Sponsor code: CRFB002ADE03 Other descriptive name: RFB002, rhuFab V2 Concentration unit: mg/ml milligram(s)/millilitre Concentration type: equal Concentration number: 10- | Department of Ophthalmology, Bonn University | Authorised | Female: yes Male: yes | Germany | |||||
| 9 | NCT00470977 | May 2007 | 19 February 2015 | Treatment of Exudative and Vasogenic Chorioretinal Diseases Including Variants of AMD and Other CNV Related Maculopathy | Treatment of Exudative and Vasogenic Chorioretinal Diseases Including Variants of AMD and Other CNV Related Maculopathy With Intravitreal Injection of Lucentis (Ranibizumab Injection) | Coats' Disease;Idiopathic Retinal Telangiectasia;Retinal Angiomatous Proliferation;Polypoidal Choroidal Vasculopathy;Pseudoxanthoma Elasticum;Pathological Myopia;Multi-focal Choroiditis;Rubeosis Iridis;Von Hippel Lindau Disease;BEST VITELLIFORM MACULAR DYSTROPHY, MULTIFOCAL (Disorder) | Drug: ranibizumab injection (0.5 mg) | Manhattan Eye, Ear & Throat Hospital | Genentech, Inc. | Not recruiting | 18 Years | N/A | Both | 18 | Phase 1/Phase 2 | United States |