316. Carnitine cycle disorder
[
3 clinical trials,
10 drugs（DrugBank:
4 drugs),
2 target genes / 8 target pathways ]
Searched query = "Carnitine cycle disorder", "Carnitine palmitoyltransferase I deficiency", "CPT1 deficiency", "Carnitine palmitoyltransferase II deficiency", "CPT2 deficiency", "Carnitine acylcarnitine translocase deficiency", "CACT deficiency", "Carnitine transporter deficiency", "OCTN 2 deficiency"
The queries were searched in Public_title, Scientific_title, and Condition of the data. Export date: 11/20/2019, 11/21/2019. Trials are sorted by Date_enrolment from most recent to oldest in the table.
| No. | TrialID | Date_ enrollement | Last_Refreshed_ on | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT02517307 | February 2016 | 29 July 2019 | Fatty Acid Oxidation Defects and Insulin Sensitivity | Role of Fatty Acid Oxidation Defects in Insulin Sensitivity | Very Long-chain Acyl-CoA Dehydrogenase Deficiency;Trifunctional Protein Deficiency;Long-chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency;Medium-chain Acyl-CoA Dehydrogenase Deficiency;Normal Volunteers;Carnitine Palmitoyltransferase II Deficiency, Myopathic | Drug: Intralipid/Heparin;Drug: Glycerol/Saline;Drug: Hyperinsulinemic euglycemic clamp | Oregon Health and Science University | Recruiting | 18 Years | N/A | All | 50 | N/A | United States | |
| 2 | NCT02226419 | August 2013 | 25 May 2015 | Fat and Sugar Metabolism During Exercise, With and Without L-carnitine in Patients With Carnitine Transporter Deficiency | Fat and Carbohydrate Metabolism During Exercise, With and Without L-carnitine Supplementation in Patients With Carnitine Transporter Deficiency | Carnitine Transporter, Plasma-membrane, Deficiency of | Dietary Supplement: Break in L-carnitine treatment | Karen Lindhardt Madsen | Rigshospitalet, Denmark | Not recruiting | 18 Years | N/A | Both | 14 | N/A | |
| 3 | NCT00336167 | June 2006 | 19 February 2015 | Bezafibrate Trial in CPT2 Deficiency | Clinical Trial on the Effect of Bezafibrate in the Muscular Form of Carnitine Palmitoyltransferase 2 Deficiency | Carnitine Palmitoyl Transferase 2 Deficiency | Drug: bezafibrate (drug) | Assistance Publique - Hôpitaux de Paris | Association Française contre les Myopathies (AFM), Paris;Institut National de la Santé Et de la Recherche Médicale, France | Recruiting | 18 Years | N/A | Both | 12 | Phase 3 | France |