70. Spinal stenosis
[
69 clinical trials,
104 drugs（DrugBank:
42 drugs),
56 target genes / 80 target pathways ]
Searched query = "Spinal stenosis", "Extensive spinal canal stenosis"
The queries were searched in Public_title, Scientific_title, and Condition of the data. Export date: 11/21/2019, 11/20/2019. Trials are sorted by Date_enrolment from most recent to oldest in the table.
| No. | TrialID | Date_ enrollement | Last_Refreshed_ on | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT04066296 | September 2019 | 2 September 2019 | Outcomes for Lumbar Decompressions With Use of Liposomal Bupivicaine | A Double Blinded Randomized Control Trial in Outcomes for Lumbar Decompressions With Use of Liposomal Bupivicaine | Lumbar Spinal Stenosis | Drug: Liposomal bupivacaine | University of Colorado, Denver | Not recruiting | 18 Years | N/A | All | 100 | Phase 2 | ||
| 2 | NCT03879447 | June 24, 2019 | 11 November 2019 | Effectiveness and Safety of Korean Medicine for Low Back Pain or Sciatica Due to Lumbar Stenosis/Spondylolisthesis | Observational Study on the Effectiveness and Safety of Integrative Korean Medicine Treatment for Patients With Low Back Pain or Sciatica Due to Lumbar Stenosis or Spondylolisthesis | Lumbar Spinal Stenosis;Lumbar Spondylolisthesis;Low Back Pain;Sciatica;Neurogenic Claudication | Drug: Herbal medicine;Procedure: Chuna manual medicine;Procedure: Bee venom pharmacopuncture;Procedure: Pharmacopuncture;Procedure: Acupuncture;Procedure: Electroacupuncture;Procedure: Cupping;Procedure: Other intervention(s) | Jaseng Medical Foundation | Recruiting | 19 Years | 75 Years | All | 240 | Phase 2 | Korea, Republic of | |
| 3 | NCT04007094 | February 12, 2019 | 15 July 2019 | Single-Armed Use of ViviGen Cellular Bone Matrix in Patients Undergoing Posterolateral Lumbar Surgery | A Prospective, Single Arm Study of Patients Undergoing Posterolateral Lumbar Fusion (Without Interbody) Supplemented With ViviGen Cellular Bone Matrix | Degenerative Disc Disease;Spinal Stenosis;Spondylosis;Spondylolisthesis | Drug: ViviGen Cellular Bone Matrix | Ohio State University | DePuy Synthes | Recruiting | 18 Years | N/A | All | 50 | Phase 4 | United States |
| 4 | NCT03745040 | January 26, 2019 | 18 March 2019 | Liposomal Bupivacaine in One-level Instrumented Posterior Spinal Fusion | Does Liposomal Bupivacaine Improve Postoperative Pain Control After One Level Posterior Spinal Fusion With Instrumentation | Lumbar Spinal Stenosis;Lumbar Disc Herniation;Lumbar Disc Disease;Lumbar Spondylolisthesis | Drug: Liposomal bupivacaine | Allina Health System | Twin Cities Spine Center | Recruiting | 18 Years | N/A | All | 60 | Phase 4 | United States |
| 5 | NCT03883022 | September 3, 2018 | 1 April 2019 | Vancomycin Powder Combined With Autogenous Bone Graft as a Prevention for Post-operative Infection for Spine Surgery | Vancomycin Powder Combined With Autogenous Bone Graft as a Prevention for Post-operative Infection for Spine Surgery | Spinal Fusion;Spinal Stenosis;Spondylolisthesis | Drug: with U-VANCO (vancomycin hydrochloride);Drug: without U-VANCO (vancomycin hydrochloride) | Taipei Veterans General Hospital, Taiwan | Recruiting | 20 Years | N/A | All | 400 | N/A | Taiwan | |
| No. | TrialID | Date_ enrollement | Last_Refreshed_ on | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 6 | NCT03647501 | August 22, 2018 | 30 September 2019 | Lumbar Fusion With Nexxt Spine 3D-Printed Titanium Interbody Cages | Lumbar Fusion With 3D-Printed Porous Titanium Interbody Cages - A Single-Blinded Randomized Controlled Trial Evaluating Nexxt Matrixx(TM) Versus PEEK Cages | Lumbar Degenerative Disc Disease;Lumbar Spinal Stenosis;Lumbar Spondylolisthesis;Lumbar Spinal Deformity;Lumbar Spondylosis | Device: Interbody cage (titanium);Device: Interbody cage (PEEK) | Ohio State University | Nexxt Spine, LLC | Recruiting | 18 Years | N/A | All | 70 | N/A | United States |
| 7 | ChiCTR1800016968 | 2018-07-15 | 9 July 2018 | A prospective study on the effect of different antiosteoporosis drugs on patients after lumbar fusion surgery | A prospective study on the effect of different antiosteoporosis drugs on patients after lumbar fusion surgery | Osteoporosis with lumbar spinal stenosis | C:Lumbar Fusion Surgery+Basic anti-osteoporosis drugs;A:Lumbar Fusion Surgery+MenatetrenoneSoft Capsules;B:Lumbar Fusion Surgery+Teriparatide acetate; | Qilu Hospital of Shandong University | Recruiting | 20 | 80 | Both | C:40;A:40;B:40; | Other | China | |
| 8 | NCT03553186 | July 11, 2018 | 15 July 2019 | Tranexamic Acid in Adult Spinal Deformity Surgery | Topical Tranexamic Acid as a Adjunct to Intravenous Tranexamic Acid in Adult Spinal Deformity Surgery | Spinal Deformity;Degenerative Lumbar Spinal Stenosis;Blood Loss, Surgical | Drug: Tranexamic Acid 100 MG/ML;Drug: Placebo | Hospital for Special Surgery, New York | Recruiting | 18 Years | 80 Years | All | 100 | Phase 3 | United States | |
| 9 | NCT03584074 | July 1, 2018 | 16 July 2018 | Clinical Trial of Pregabalin and COX2 in Spinal Stenosis | Comparative Study for Decrease of Pain Intensity and Pain Sensitivity Between Pregabalin + COX-2 Inhibitor and COX-2 Inhibitor in Patients With Lumbar Spinal Stenosis: Randomized Controlled Trial | Spinal Stenosis Lumbar | Drug: Celebrex 200Mg Capsule;Drug: Pregabalin 75mg | Seoul National University Bundang Hospital | Not recruiting | 40 Years | N/A | All | 60 | Phase 4 | ||
| 10 | JPRN-JapicCTI-183866 | 02/2/2018 | 16 July 2019 | Placebo-controlled, double-blind, exploratory study of NS-304 in lumbar spinal stenosis (LSS) patients with intermittent claudication (Early Phase II study) | Placebo-controlled, double-blind, exploratory study of NS-304 in lumbar spinal stenosis (LSS) patients with intermittent claudication (Early Phase II study) | LSS | Intervention name : NS-304 INN of the intervention : Selexipag Dosage And administration of the intervention : Oral administration Control intervention name : NS-304 Placebo INN of the control intervention : - Dosage And administration of the control intervention : Oral administration | Nippon Shinyaku Co., Ltd. | Not Recruiting | 40 | 79 | BOTH | 120 | Phase 2 | Japan | |
| No. | TrialID | Date_ enrollement | Last_Refreshed_ on | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 11 | JPRN-UMIN000030881 | 2018/01/18 | 2 April 2019 | Dietary supplementation in patients following lumbar spine surgery: a randomized controlled trial | lumbar spinal stenosis | Intervention group Twice-daily ingestion of amino acids supplementation for 3 weeks after spinal surgery (100kcal, protein 10g) Postoperative rehabilitation for 3 weeks Control group Twice-daily ingestion of placebo (non amino acids) supplementation for 3 weeks after spinal surgery (100kcal, protein 0g ) Postoperative rehabilitation for 3 weeks | Wakayama Medical University | Recruiting | 50years-old | 90years-old | Male and Female | 80 | Not selected | Japan | ||
| 12 | NCT03245671 | December 2017 | 16 December 2017 | Particulate vs. Nonparticulate Epidural Steroid Injections for Lumbar Foraminal Stenosis | Particulate vs. Nonparticulate Epidural Steroid Injections for the Treatment of Symptomatic Unilateral Lumbar Foraminal Stenosis: a Prospective Double-blinded Randomized Study | Lumbar Spinal Stenosis | Drug: Kenalog Injectable Product;Drug: Decadron Phosphate, Injectable;Procedure: Epidural Steroid Injection | Hospital for Special Surgery, New York | Not recruiting | 18 Years | 90 Years | All | 0 | Phase 4 | United States | |
| 13 | ChiCTR-INR-17012403 | 2017-09-01 | 21 August 2017 | Application of erythropoietin in enriched bone marrow stem cells technique to promote bone regeneration | Application of erythropoietin in enriched bone marrow stem cells technique to promote bone regeneration | bone defect, bone non-union and lumber spinal stenosis | treatment group:administer erythropoietin (150U/kg) three to five times via subcutaneous or intravenous injection before operation;controlled group:administer normal saline three times via subcutaneous or intravenous injection before operation; | Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine | Not Recruiting | 18 | 65 | Both | treatment group:44;controlled group:44; | New Treatment Measure Clinical Study | China | |
| 14 | NCT02975011 | March 4, 2017 | 19 November 2018 | Effectiveness and Safety of Korean Medicine for Lumbar Stenosis Patients With Sciatica | Observational Study on the Effectiveness and Safety of Integrative Korean Medicine Treatment for Patients With Sciatica Due to Lumbar Stenosis: Multicenter, Prospective, Single Group Observational Study | Lumbar Spinal Stenosis | Drug: Herbal medicine;Procedure: Chuna manipulation;Procedure: Bee venom pharmacopuncture;Procedure: Pharmacopuncture;Procedure: Acupuncture;Procedure: Electroacupuncture;Procedure: Cupping;Other: Other intervention(s) | Jaseng Medical Foundation | Not recruiting | 19 Years | 75 Years | All | 38 | Phase 2 | Korea, Republic of | |
| 15 | NCT03011866 | February 2017 | 16 December 2017 | Tranexamic Acid in Reducing Gross Hemorrhage and Transfusions of Spine Surgeries | Intravenous Versus Topical Use of Tranexamic Acid in Reducing Gross Hemorrhage and Transfusions of Spine Surgeries (TARGETS) : A Prospective, Randomized, Double Blind, Head-to-head Comparison Study | Spinal Stenosis;Intervertebral Disc Displacement | Drug: Wound topically irrigated with 500mg TXA;Drug: 1mg/kg/hr TXA intravenous infusion till the last suture | Peking Union Medical College Hospital | Not recruiting | 50 Years | N/A | All | 176 | N/A | ||
| No. | TrialID | Date_ enrollement | Last_Refreshed_ on | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 16 | EUCTR2016-002887-14-FI | 31/10/2016 | 7 November 2016 | Dose-response of ketamine in patient controlled analgesia in orthopaedic surgery patients | Dose response study of Patient Controlled Analgesia (PCA) of S-ketamine in orthopaedic spine surgery patients - DoseRespKeta | Patients who are scheduled for elective posterolateral lumbar spine fusion with bilateral transpedicular screw instrumentation MedDRA version: 19.0 Level: LLT Classification code 10041595 Term: Spinal stenosis lumbar System Organ Class: 100000004859 ;Therapeutic area: Body processes [G] - Bones and nerves physological processes [G11] | Trade Name: Ketanest-S Pharmaceutical Form: Injection INN or Proposed INN: KETAMINE CAS Number: 6740-88-1 Concentration unit: mg/ml milligram(s)/millilitre Concentration type: equal Concentration number: 5- Trade Name: Oxycodone Orion Pharmaceutical Form: Injection INN or Proposed INN: OXYCODONE CAS Number: 76-42-6 Concentration unit: mg/ml milligram(s)/millilitre Concentration type: equal Concentration number: 10- | University of Turku | Authorised | Female: yes Male: yes | Phase 1;Phase 4 | Finland | ||||
| 17 | NCT02939482 | October 1, 2016 | 15 July 2019 | A Study Comparison of Clinical Outcome After Different Rate of Infusion in Caudal Epidural Steroid Injection | A Prospective Study Comparison of Clinical Outcome After Different Rate Infusion in Caudal Epidural Steroid Injection | Spinal Stenosis;Lumbosacral Spondylosis;Radiculopathy | Drug: Triamcinolone Acetonide and normal saline solution | Navamindradhiraj University | Not recruiting | 20 Years | N/A | All | 112 | N/A | Thailand | |
| 18 | NCT02932020 | October 2016 | 11 June 2018 | AlloGen-LI Treatment of Spinal Stenosis | Pilot Study Investigating the Utility of Epidural AlloGen-LI Injection for Treatment of Spinal Stenosis Symptoms | Low Back Pain | Drug: AlloGen-LI;Drug: depomedrol;Device: MRI;Drug: 0.5% marcaine | University of Southern California | Vivex Biomedical, Inc. | Not recruiting | 18 Years | N/A | All | 0 | N/A | United States |
| 19 | NCT02902380 | September 27, 2016 | 12 March 2018 | The Effect of Dexmedetomidine on Neuroendocrine Stress Hormone Release and Heart Rate Variability in Patients Undergoing Major Spinal Surgery | Spinal Stenosis | Drug: dexmedetomidine group;Drug: control group | Yonsei University | Not recruiting | 20 Years | 70 Years | All | 52 | N/A | Korea, Republic of | ||
| 20 | EUCTR2015-002694-37-FI | 01/09/2016 | 11 January 2016 | Dexmedetomidine is a drug that is used mainly for sedation in the intensive care unit. Purpose of this study is to determine does Dexmedetomidine infusion provide pain management in the postoperative period and prevent chronic pain. Patients are randomized to receive either placebo or dexmedetomidine infusion. DEXPAIN-study has been approved by Kuopio university hospitals ethics committee. | Dexmedetomidine infusion in pain management during low back surgery Dexmedetomidine is an alpha-2-adrenergic agonist that is used mainly for sedation in the intensive care unit. Alpha-2-adrenoceptors agonists have several beneficial actions in a surgical patient. They decrease symphatetic tone, reduce anesthetic and opioid requirements and cause sedation and analgesia. Pain after low back surgery is intense and can become chronic. We need a new drug to manage pain during postoperative period and to prevent chronic pain. DEXPAIN-study has been approved by Kuopio university hospitals ethics committee. Study is single centered, randomized and placebo-controlled study. A total of 60 patients scheduled for low back surgery will be enrolled in this study. Patients eligibility will be assessed by pre-determined inclusion-exclusion-criteria. Purpose of this study is to determine does Dexmedetomidine infusion provide pain management in the postoperative period and prevent chronic pain. Patients are randomized to receive either placebo or dexmedetomidine infusion. Patients in the dexmedetomidine group receive dexmedetomidine loading dose 1ug/kg for 10 minutes and continuous infusion 1.4 ug/kg/h during surgery and post-anesthesia care unit. Total infusion time will be four hours. Anesthesia is standardized and post-operative pain is treated with patient controlled analgesia made of oxycodone. Questionnaires will be used to assess pain control. Study is scheduled to start as soon as we obtain permission from Finnish Medicines Agency and receive sufficient funding. | Low back pain, Discus prolapse, Spinal stenosis;Therapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03] | Trade Name: Dexmedetomidine Product Name: Dexdor Pharmaceutical Form: Concentrate and solvent for solution for infusion INN or Proposed INN: DEXMEDETOMIDINE CAS Number: 113775-47-6 Pharmaceutical form of the placebo: Concentrate and solvent for solution for infusion Route of administration of the placebo: Intravenous use | Kuopio University hospital | Authorised | Female: no Male: yes | Finland | |||||
| No. | TrialID | Date_ enrollement | Last_Refreshed_ on | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 21 | NCT02838615 | July 2016 | 16 December 2017 | Comparison of Transforaminal vs. Parasagittal Interlaminar Epidural Injection | Comparison of Lumbar Epidural Steroid Injection: Transforaminal vs. Parasagittal Interlaminar Approach | Spinal Stenosis | Procedure: epidural steroid (dexamethasone) injection | Keimyung University Dongsan Medical Center | Not recruiting | N/A | N/A | All | 56 | N/A | ||
| 22 | NCT02826889 | May 24, 2016 | 16 December 2017 | Assessing the Diagnostic Accuracy of Corrected Flow Time (FTc) and Pleth Variability Index (PVI) as Predictors of Fluid Responsiveness in Patients in the Prone Position Using the Jackson Table | Elective Posterior Lumbar Spinal Fusion for Spinal Stenosis;Spondylolisthesis;Spinal Fractures;Scoliosis or Tumors | Device: Pleth Variability Index (PVI);Device: Philips Intelivue MP70 monitor | Yonsei University | Not recruiting | 19 Years | 75 Years | All | 58 | N/A | Korea, Republic of | ||
| 23 | NCT02700451 | March 2016 | 4 November 2019 | Post-op Acetaminophen vs NSAID Use on Lumbar Spinal Fusion Outcomes | A Randomized Controlled Trial of Post-operative Acetaminophen Versus Nonsteroidal Anti-Inflammatory Drug (NSAID) Use on Lumbar Spinal Fusion Outcomes | Lumbar Osteoarthritis;Spondylosis;Lumbar Disc Disease;Spinal Stenosis | Drug: Ketorolac;Drug: Acetaminophen;Drug: Placebo | Hospital for Special Surgery, New York | Recruiting | 18 Years | 75 Years | All | 300 | N/A | United States | |
| 24 | NCT02725723 | March 2016 | 11 April 2016 | Thermographic Images as an Objective Method for Assessing the Efficacy of Steroidal Epidural Injections | Thermographic Images as an Objective Method for Assessing the Efficacy of Steroidal Epidural Injections | Spinal Stenosis | Device: Therm-AppTM TH, thermographic camera;Drug: epidural injection | Tel-Aviv Sourasky Medical Center | Not recruiting | 18 Years | 80 Years | Both | 40 | Phase 2/Phase 3 | ||
| 25 | NCT02625194 | January 1, 2016 | 22 July 2019 | The Utility of Oxygen Insufflation During Flexible Fiberoptic Bronchoscope-guided Intubation | The Utility of Oxygen Insufflation During Flexible Fiberoptic Bronchoscope-guided Intubation | Lumbar Spinal Stenosis | Drug: Oxygen | Yonsei University | Not recruiting | 20 Years | 60 Years | All | 36 | N/A | Korea, Republic of | |
| No. | TrialID | Date_ enrollement | Last_Refreshed_ on | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 26 | NCT02444351 | June 26, 2015 | 21 January 2019 | Botulinum Toxin Type A Injection Into the Gastrocnemius Muscle for Treatment of Nocturnal Calf Cramps in Patients With Lumbar Spinal Stenosis | Spinal Stenosis With Nocturnal Calf Cramps | Drug: botulinum toxin type A (Nabota®) injection into the gastrocnemius muscle;Other: no intervention | Yonsei University | Not recruiting | 20 Years | 80 Years | All | 50 | N/A | Korea, Republic of | ||
| 27 | EUCTR2014-003252-31-FI | 15/05/2015 | 10 July 2015 | Dose-response of dexmedetomidine in patient controlled analgesia in orthopaedic surgery patients | Dose response study of Patient Controlled Analgesia (PCA) of Dexmedetomidine in orthopaedic spine surgery patients - DoserespDex_2.0 | Patients, who are scheduled for elective posterolateral lumbar spine fusion with bilateral transpedicular screw instrumentation MedDRA version: 17.1 Level: LLT Classification code 10041595 Term: Spinal stenosis lumbar System Organ Class: 100000004859 ;Therapeutic area: Body processes [G] - Bones and nerves physological processes [G11] | Trade Name: Dexdor Pharmaceutical Form: Infusion INN or Proposed INN: deksmedetomidiini CAS Number: 145108-58-3 Other descriptive name: DEXMEDETOMIDINE HYDROCHLORIDE Trade Name: Oxanest Pharmaceutical Form: Injection INN or Proposed INN: oksikodoni CAS Number: 124-90-3 Other descriptive name: OXYCODONE HYDROCHLORIDE | University of Turku | Authorised | Female: yes Male: yes | Finland | |||||
| 28 | NCT02459392 | May 2015 | 15 July 2019 | EuroPainClinics® Study II (Prospective Trial) | EuroPainClinics® Study II (Prospective Randomized Double Blinded Trial) | Lumbar Spinal Stenosis | Other: Epiduroscopy;Drug: Hyaluronic Acid;Drug: DepoMedrol | Europainclinics z.ú. | Recruiting | 18 Years | N/A | All | 300 | N/A | Czechia;Czech Republic | |
| 29 | NCT02416804 | January 2015 | 16 December 2017 | Postoperative Analgesia With Buprenorphine for Postoperative Pain Control and Quality of Life After Spinal Surgery | Postoperative Analgesia With Buprenorphine Transdermal System (BTDS) Versus Tramadol for Postoperative Pain Control and Quality of Life After Spinal Surgery | Spinal Stenosis;Pain, Postoperative | Drug: Buprenorphine;Drug: Tramadol | Seoul National University Hospital | Not recruiting | 20 Years | N/A | All | 69 | Phase 4 | Korea, Republic of | |
| 30 | NCT02093520 | May 2014 | 16 December 2017 | The MiDAS ENCORE Study | MILD® Percutaneous Image-Guided Lumbar Decompression Versus Epidural Steroid Injections in Patients With Lumbar Spinal Stenosis Exhibiting Neurogenic Claudication | Spinal Stenosis, Lumbar Region, With Neurogenic Claudication | Procedure: MILD Procedure;Drug: Epidural Steroid Injection | Vertos Medical, Inc. | Not recruiting | 65 Years | N/A | All | 302 | N/A | United States | |
| No. | TrialID | Date_ enrollement | Last_Refreshed_ on | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 31 | JPRN-UMIN000012918 | 2014/04/01 | 2 April 2019 | Long-term efficacy and safety of Limaprost for the treatment of Lumbar Spinal Stenosis | Lumbar Spinal Stenosis | Limaprost alfadex(15 micro g/day), 1yrs. | Kansai LSS Forum | Not Recruiting | 50years-old | 80years-old | Male and Female | 300 | Not selected | Japan | ||
| 32 | NCT02070484 | February 2014 | 16 December 2017 | Human Amniotic Tissue-derived Allograft, NuCel, in Posteriolateral Lumbar Fusions for Degenerative Disc Disease | Efficacy of a Human Amniotic Tissue-derived Allograft, NuCel, in Patients Undergoing Posteriolateral Lumbar Fusions for Degenerative Disc Disease | Lumbar Degenerative Disc Disease;Spinal Stenosis;Spondylolisthesis;Spondylosis;Intervertebral Disk Displacement;Intervertebral Disk Degeneration;Spinal Diseases;Bone Diseases;Musculoskeletal Diseases;Spondylolysis | Biological: NuCel;Biological: Demineralized Bone Matrix | OhioHealth | NuTech Medical, Inc | Not recruiting | 18 Years | 75 Years | All | 6 | N/A | United States |
| 33 | NCT02103543 | January 2014 | 16 December 2017 | Comparison of the Order of Treatment in Lumbar Spinal Stenosis | A Randomized Trial in Patients With Lumbar Spinal Stenosis, Comparing the Order of Treatment With Epidural Corticosteroid Injections and Physical Therapy | Lumbar Spinal Stenosis | Other: physical therapy;Procedure: lumbar interlaminar epidural steroid injection;Drug: epidural steroid injection | Emory University | Not recruiting | 18 Years | 65 Years | All | 0 | N/A | United States | |
| 34 | NCT02023372 | December 2013 | 27 May 2019 | Efficacy Study of NuCel® in Patients Undergoing Fusion of the Lumbar Spine | NuTech NuCel®: A Prospective, Efficacy Study of NuCel® in Patients Undergoing Fusion for One, Two or Three Level Degenerative Disease of the Lumbar Spine. | Intervertebral Disc Disease;Intervertebral Disc Degeneration;Spondylosis;Spondylolisthesis;Spinal Stenosis | Biological: NuCel with Autograft | NuTech Medical, Inc | Carolina Neurosurgery & Spine Associates;Atrium Health;Organogenesis | Recruiting | 21 Years | N/A | All | 57 | N/A | United States |
| 35 | NCT01943435 | November 20, 2013 | 11 June 2018 | Study Comparing 3 Different Treatments for Arthritis of the Lower Back (Lumbar Spinal Stenosis) | A Comparison of Non-Surgical Treatment Methods for Patients With Lumbar Spinal Stenosis | Lumbar Spinal Stenosis | Drug: NSAIDs; adjunctive analgesics; adjunctive anti-depressants;Procedure: Lumbar epidural injection;Other: Joint Mobilizations (spine, sacroiliac, hip);Other: Individualized exercises: clinical setting;Other: Group Exercise: community setting | Michael Schneider, DC, PhD | Patient-Centered Outcomes Research Institute | Not recruiting | 60 Years | N/A | All | 259 | N/A | United States |
| No. | TrialID | Date_ enrollement | Last_Refreshed_ on | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 36 | NCT01934868 | November 2013 | 12 March 2018 | Prolotherapy Versus Epidural Steroid Injections (ESI) for Lumbar Pain Radiating to the Leg | A Comparison of the Long Term Outcomes of Prolotherapy Versus Interlaminar Epidural Steroid Injections (ESI) for Lumbar Pain Radiating to the Leg | Sciatica;Spinal Stenosis of Lumbar Region;Degeneration of Lumbar or Lumbosacral Intervertebral Disc | Drug: prolotherapy solution of 20% dextrose;Drug: Epidural Steroid Injection | Hadassah Medical Organization | Reuth Medical Center | Recruiting | 18 Years | 90 Years | All | 160 | Early Phase 1 | Israel |
| 37 | NCT01995461 | May 2013 | 19 October 2017 | Bilateral Transforaminal Epidural Steroid Injections for Degenerative Lumbar Spinal Stenosis | Effectiveness of Bilateral Transforaminal Epidural Steroid Injections in Degenerative Lumbar Spinal Stenosis Patients With Neurogenic Claudication: A Prospective Outcome Study | Spinal Stenosis, Lumbar Region, With Neurogenic Claudication | Drug: bilateral transforaminal epidural steroid injections | Marshfield Clinic Research Foundation | Not recruiting | 40 Years | 90 Years | All | 26 | N/A | United States | |
| 38 | NCT01888536 | February 2013 | 28 December 2015 | A Study to Evaluate Efficacy of ?Opast Tablet?for Neurologic Claudication in Patients With Lumbar Spinal Stenosis | A Randomized, Double-Blind, Comparative, Multi-Center, Phase ? Clinical Trial to Evaluate Efficacy of ?Opast Tablet?for Neurologic Claudication in Patients With Lumbar Spinal Stenosis | Neurologic Claudication in Patients With Lumbar Spinal Stenosis | Drug: Limaprost;Drug: Pregabalin;Drug: Placebo(for Pregabalin);Drug: Placebo(for Limaprost) | Yungjin Pharm. Co., Ltd. | Not recruiting | 20 Years | 75 Years | Both | 182 | Phase 4 | Korea, Republic of | |
| 39 | ChiCTR-TRC-13003639 | 2012-09-13 | 18 April 2017 | The application of Analgesia Nociception Index guided Remifentanil administration during general anesthesia for Spinal Surgery | The application of Analgesia Nociception Index guided Remifentanil administration during general anesthesia for Spinal Surgery | Lumbar spinal stenosis and/or lumbar intervertebral disc herniation | ANI group:ANI guide the administration of remifentanil;control group:remifentanil was adapted by Anaesthesiologist corresponding to clinical experiences ; | Peking University Third Hospital | Not Recruiting | 18 | 70 | Both | ANI group:30;control group:30; | Other | China | |
| 40 | NCT02063035 | August 2012 | 16 December 2017 | Effectiveness Study of the Drug Tranexamic Acid to Reduce Post-surgery Blood Loss in Spinal Surgery | Topical Application of Tranexamic Acid to Reduce Postoperative Blood Loss in Posterior Approach Spinal Surgery | Lumbar Spinal Stenosis;Thoracic Spinal Stenosis | Drug: Tranexamic Acid;Drug: Placebo | Massachusetts General Hospital | Not recruiting | 18 Years | 85 Years | All | 29 | Phase 4 | United States | |
| No. | TrialID | Date_ enrollement | Last_Refreshed_ on | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 41 | NCT02090244 | August 2012 | 29 April 2019 | Does PTH 1-34 (Teriparatide) Enhance Spinal Fusion in Humans? | Förbättrar PTH Postero-lateral fusionsläkning Vid Ryggkirurgi? | Spinal Stenosis | Drug: Teriparatide | University Hospital, Linkoeping | Medical Research Council of Southeast Sweden | Not recruiting | N/A | N/A | All | 34 | Phase 4 | Sweden |
| 42 | EUCTR2011-006152-36-DK | 10/05/2012 | 23 July 2018 | Does postoperative treatment with parathyroidea hormone Forteo® improve the disability in elderly patients undergoing spinal stabilization fusion surgery compared with patients treated with placebo. If that is the case, is there a correlation between improvement of disability and solid osseous healing? | Postoperative treatment with parathyroidea hormone Forteo® in patients undergoing posterolateral spinal fusion surgery. A prospektive and a randomized double-blinded, placebo-controlled study - PTH-U-DESE-STUDY | Spinal stenosis MedDRA version: 14.1 Level: LLT Classification code 10041597 Term: Spinal stenosis of lumbar region System Organ Class: 10028395 - Musculoskeletal and connective tissue disorders ;Therapeutic area: Diseases [C] - Musculoskeletal Diseases [C05] | Trade Name: Forteo Product Name: Forsteo Product Code: 0002-8971 Pharmaceutical Form: Solution for injection in pre-filled pen INN or Proposed INN: teriparatide [rDNA origin] contains recombinant human parathyroid hormone (1-34) CAS Number: 52232-67-4 Other descriptive name: rhPTH (1-34) Concentration unit: mg milligram(s) Concentration type: equal Concentration number: 20- Pharmaceutical form of the placebo: Injection Route of administration of the placebo: Subcutaneous use | Middelfart Rygsektor | Not Recruiting | Female: yes Male: yes | 100 | Phase 2 | Denmark | |||
| 43 | NCT02271191 | May 2012 | 19 February 2015 | Effect of Nicardipine on Renal Function in Deliberate Hypotension | Effect of Nicardipine on Renal Function in Deliberate Hypotension | Spinal Stenosis | Drug: Nicardipine | Yonsei University | Not recruiting | 20 Years | N/A | Both | 64 | Phase 4 | ||
| 44 | EUCTR2012-000747-26-FI | 27/04/2012 | 28 February 2019 | Ketamine to reduce postoperative pain in back surgery | Administration of S-Ketamine during spinal surgery to reduce postoperative pain | adult patients undergoing spinal surgery MedDRA version: 14.1 Level: LLT Classification code 10041595 Term: Spinal stenosis lumbar System Organ Class: 10028395 - Musculoskeletal and connective tissue disorders ;Therapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03] | Trade Name: Ketanest-S Product Name: Ketanest-S Pharmaceutical Form: Injection CAS Number: 33643-46-8 Other descriptive name: ESKETAMINE HYDROCHLORIDE Pharmaceutical form of the placebo: Injection Route of administration of the placebo: Intravenous use | Helsinki Universiy Central Hospital | Not Recruiting | Female: yes Male: yes | 192 | Phase 4 | Finland | |||
| 45 | JPRN-UMIN000007419 | 2012/04/01 | 2 April 2019 | A Prospective, Randomized, Multicenter Trial of Pregabalin and Celecoxib for Lumbar Spinal Stenosis | Lumbar Spinal Stenosis | Celecoxib Pregabalin | Department of Orthopedic Surgery Kobe University Graduate School of Medicine | Not Recruiting | 50years-old | 90years-old | Male and Female | 80 | Not selected | Japan | ||
| No. | TrialID | Date_ enrollement | Last_Refreshed_ on | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 46 | NCT01618435 | March 2012 | 19 September 2016 | The Clinical Effect of i-FACTOR® Versus Allograft in Non-instrumented Posterolateral Spondylodesis Operation in the Elderly With Spinal Stenosis Due to Degenerative Spondylolisthesis | The Clinical Effect of i-FACTOR® Versus Allograft in Non-instrumented Posterolateral Spondylodesis Operation | Spinal Stenosis | Biological: i-FACTOR | Sygehus Lillebaelt | CeraPedics, Inc | Not recruiting | 60 Years | N/A | Both | 108 | Phase 3 | Denmark |
| 47 | NCT01522846 | January 2012 | 19 February 2015 | Heparin Solution and INTEM/HEPTEM Analysis | Influence by Heparinized Flush Solution of the Radial Artery Catheter: INTEM and HEPTEM Analysis. | Brain Tumor;Spinal Stenosis;Cerebral Artery Anuerysm | Drug: Heparin | Seoul National University Bundang Hospital | Not recruiting | 20 Years | N/A | Both | 25 | N/A | Korea, Republic of | |
| 48 | NCT02257723 | January 2012 | 19 November 2018 | The Effect of Integrated CAM Treatment in Hospitalized Patients | The Effect of Integrated CAM Treatment in Patients Hospitalized at a Korean Medicine Hospital | Low Back Pain;Neck Pain;Knee Pain;Shoulder Pain;Intervertebral Disc Herniation;Spinal Stenosis | Drug: Herbal medicine;Procedure: Acupuncture;Procedure: Pharmacopuncture;Procedure: Bee venom pharmacopuncture;Procedure: Chuna manipulation | Jaseng Hospital of Korean Medicine | Not recruiting | N/A | N/A | All | 2946 | Phase 4 | Korea, Republic of | |
| 49 | JPRN-UMIN000006588 | 2011/11/01 | 2 April 2019 | Effect of antiplatelet agent on muscle cramps after surgery of lumbar spinal stenosis in patients with lumbar spinal canal stenosis and peripheral artery disease | Lumbar spinal canal stenosis | Continuous administration of cilostazol | Juntendo University Department of Orthopaedic Surgery | Recruiting | Not applicable | Not applicable | Male and Female | 30 | Not applicable | Japan | ||
| 50 | NCT01456377 | July 2011 | 19 February 2015 | The Effectiveness of Oral Corticosteroids in the Treatment of Lumbar Stenosis | A Prospective Controlled Study Randomized Double Blind Study, Evaluate the Effectiveness of Oral Corticosteroids in the Treatment of Stenosis of Lumbar Canal In Symptomatic Patients | Spinal Stenosis of Lumbar Region | Drug: predinose oral;Drug: placebo group | Federal University of São Paulo | Recruiting | 50 Years | 75 Years | Both | 60 | N/A | Brazil | |
| No. | TrialID | Date_ enrollement | Last_Refreshed_ on | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 51 | NCT01238536 | April 2011 | 16 December 2017 | Lumbar Epidural Steroid Injections for Spinal Stenosis Multicenter Randomized, Controlled Trial (LESS Trial) | Multicenter Randomized Controlled Trial of Epidural Steroid Injections for Spinal Stenosis in Persons 50 and Older | Spinal Stenosis;Low Back Pain | Procedure: Epidural steroid with local anesthetic injection;Procedure: Epidural local anesthetic injection;Drug: Epidural steroid injection;Drug: Epidural local anesthetic injection | University of Washington | Kaiser Permanente;University of California, San Francisco;Henry Ford Hospital;Harvard Pilgrim Health Care;Harvard Vanguard Medical Associates;University of Colorado, Denver;Mayo Clinic;Stanford University;Massachusetts General Hospital;Virginia Spine Research Institute;Oregon Health and Science University;Dallas VA Medical Center | Not recruiting | 50 Years | N/A | All | 400 | Phase 4 | United States |
| 52 | NCT01315145 | March 2011 | 19 October 2017 | MiDAS III (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study | MiDAS III (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study | Lumbar Spinal Stenosis | Procedure: Percutaneous Lumbar Decompression;Drug: Epidural Steroid Injection | Vertos Medical, Inc. | Not recruiting | 50 Years | N/A | All | 138 | N/A | United States | |
| 53 | JPRN-UMIN000004825 | 2011/01/01 | 2 April 2019 | A randomized comparative study of Celecoxib and Limaprost alfadex on the patients with lumber spinal stenosis for the effectiveness for symptoms and QOL | Lumbar spinal stenosis | 15ug/day Limaprost arfadex for 8 weeks 200mg/day Celecoxib for 8 weeks | University of Tsukuba, Course of life-style related disorders donated by JA Ibaraki Public Welfare Federation | Mito Kyodo Hospital | Not Recruiting | 40years-old | 85years-old | Male and Female | 134 | Phase 3 | Japan | |
| 54 | NCT01275547 | January 2011 | 19 February 2015 | The Analgesic Effect of Combined Treatment With Intranasal S-ketamine and Intranasal Midazolam | The Analgesic Effect of Combined Treatment With Intranasal S-Ketamine and Intranasal Midazolam Compared With Morphine Patient Controlled Analgesia in Spinal Surgery Patients | Analgesia, Patient-controlled;Spinal Stenosis | Drug: s-ketamine & midazolam;Drug: Morphine PCA | University Hospital, Basel, Switzerland | Not recruiting | 18 Years | N/A | Both | 22 | Phase 2/Phase 3 | Switzerland | |
| 55 | JPRN-UMIN000005382 | 2010/12/01 | 2 April 2019 | Intraoperative perineural infiltration of ropivacaine for acute postlaminectomy pain | lumbar spinal stenosis | General anesthesia and NSAIDs. As a contorol,saline 10ml infiltrate per one interspinal segment. Generalanesthesia and NSAIDs. 0.2%ropivacaine 10ml infiltrate per one interspinal segment. General anesthesia and NSAIDs. From catheter in injury part,administration of 0.2%ropivacaine 6ml/h. Duration of administration:2 days after the operation. | Higashi Ohmiya general hospital | Not Recruiting | 20years-old | 75years-old | Male and Female | 60 | Not selected | Japan | ||
| No. | TrialID | Date_ enrollement | Last_Refreshed_ on | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 56 | JPRN-UMIN000005959 | 2010/11/01 | 2 April 2019 | Prospective clinical study of the therapeutic effects of prostaglandin in patients with combined lumbar spinal stenosis and arteriosclerosis obliterans showing intermittent claudication | Patients with combined lumbar spinal stenosis and arteriosclerosis obliterans | Prostaglandin for injection (alprostadil) group: 60 mcg of prostaglandin for injection is intravenously administered once a week or more. This therapy is repeated 10 times or more. Ripple injection (alprostadil Injection) group: 10 mcg of ripple injection is administered intravenously once a week or more. This treatment is repeated 10 times or more. Conventional treatment group | Tokai University Hospital Department of Orthopaedic Surgery | Not Recruiting | 20years-old | Not applicable | Male and Female | 300 | Not selected | Japan | ||
| 57 | NCT03532945 | October 28, 2010 | 11 June 2018 | A Follow-up Study to Evaluate the Efficacy and Safety of Novomax in Posterior Lumbar Interbody Fusion | A Long-term Follow-up Study to Evaluate the Efficacy and Safety for the Patients With Bioactive Glass-ceramic Intervertebral Spacer (Novomax) in Posterior Lumbar Interbody Fusion: Comparison With a Titanium Cage | Degenerative Lumbar Spinal Stenosis | Device: Bioactive Glass-Ceramic Spacer;Device: Titanium cage | BioAlpha Inc. | Not recruiting | 30 Years | 80 Years | All | 62 | N/A | ||
| 58 | NCT01377623 | September 2010 | 16 December 2017 | Pilot Study on the Effect of Dexmedetomidine on Inflammatory Responses in Patients Undergoing Lumbar Spinal Fusion | Pilot Study on the Effect of Dexmedetomidine on Inflammatory Responses in Patients Undergoing Lumbar Spinal Fusion | Spinal Stenosis;Inflammation | Drug: Dexmedetomidine group;Drug: Placebo group | New York University School of Medicine | Hospira, now a wholly owned subsidiary of Pfizer | Not recruiting | 18 Years | N/A | All | 66 | N/A | United States |
| 59 | NCT01097486 | June 2010 | 26 August 2019 | Safety and Preliminary Efficacy Study of NeoFuse in Subjects Undergoing Multi-Level Anterior Cervical Discectomy | Phase 2 Study Evaluating Safety and Preliminary Efficacy of NeoFuse When Combined With MasterGraft Matrix in Subjects Undergoing Multi-Level Anterior Cervical Discectomy and Fusion With Anterior Cervical Plate Fixation | Cervical Degenerative Disc Disease;Degenerative Spondylolisthesis;Spinal Stenosis | Biological: NeoFuse;Procedure: Allograft | Mesoblast, Ltd. | Not recruiting | 18 Years | 70 Years | All | 24 | Phase 2 | United States | |
| 60 | NCT01127100 | May 2010 | 8 August 2016 | Gabapentin Versus Transdermal Fentanyl Matrix for Chronic Neuropathic Pain | Gabapentin Versus Transdermal Fentanyl Matrix (TDF) for Chronic Neuropathic Pain (of Radicular Origin): A Multicenter Randomized, Parallel Group, Rater Blinded, Non-inferiority Trial | Neuropathic Pain;Spinal Stenosis | Drug: transdermal fentanyl matrix, gabapentin | Seoul National University Hospital | Seoul National University Bundang Hospital;Asan Medical Center;Inje University;Chonnam National University Hospital;Chung-Ang University Hosptial, Chung-Ang University College of Medicine;Dankook University | Not recruiting | 20 Years | 80 Years | Both | 108 | Phase 4 | Korea, Republic of |
| No. | TrialID | Date_ enrollement | Last_Refreshed_ on | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 61 | NCT01052324 | March 2010 | 19 February 2015 | The Effect Site Concentration of Remifentanil for Conscious Sedation During Awake Nasotracheal Fiberoptic Intubation | The Effect Site Concentration of Remifentanil for Conscious Sedation During Awake Nasotracheal Fiberoptic Intubation | Cervical Disc Herniation;Cervical Spinal Stenosis;Cervical Spine Damage | Drug: Remifentanil | Yonsei University | Not recruiting | 20 Years | 65 Years | Both | 19 | Phase 4 | Korea, Republic of | |
| 62 | NCT00996073 | September 2009 | 26 August 2019 | Safety and Preliminary Efficacy Study of NeoFuse in Subjects Requiring Lumbar Interbody Fusion | A Prospective, Multicenter, Randomized, Open-Label, Controlled Study Evaluating Safety and Preliminary Efficacy of NeoFuse When Combined With MasterGraft Matrix in Subjects Undergoing Lumbar Interbody Fusion With Instrumentation | Degenerative Disc Disease;Degenerative Spondylolisthesis;Spinal Stenosis | Biological: Lumbar Interbody Fusion with Autograft;Biological: Lumbar Interbody Fusion with NeoFuse | Mesoblast, Ltd. | Not recruiting | 18 Years | 70 Years | All | 24 | Phase 2 | United States | |
| 63 | NCT00995371 | August 2009 | 19 October 2017 | Study of Epidural Steroid Injection (ESI) Versus Minimally Invasive Lumbar Decompression (Mild®) in Patients With Symptomatic Lumbar Central Canal Stenosis | Comparative Study of Epidural Steroid Injection Versus Mild® (Minimally Invasive Lumbar Decompression) Procedure in Patients Diagnosed With Symptomatic Moderate to Severe Lumbar Central Canal Stenosis | Lumbar Spinal Stenosis | Device: MILD® (Minimally Invasive Lumbar Decompression);Drug: Epidural Steroid Injection | Coastal Orthopedics & Sports Medicine | Vertos Medical, Inc. | Not recruiting | 18 Years | N/A | All | 38 | Phase 4 | United States |
| 64 | NCT00808665 | June 2009 | 11 June 2018 | Intraoperative Infusion of Precedex to Reduce Length of Stay After Lumbar Spine Fusion | Does Continuous Perioperative Dexmedetomidine Infusion Reduce Time to Discharge in Patients Undergoing Major Lumbar Fusion? A Double-Blind, Placebo-Controlled Study | Spinal Fusion Acquired;Spinal Stenosis;Lesions of Lumbosacral Intervertebral Disc;Spinal Diseases | Drug: Dexmedetomidine;Drug: 0.9% Saline | Vanderbilt University Medical Center | Not recruiting | 18 Years | 85 Years | All | 68 | Phase 4 | United States | |
| 65 | NCT00908375 | May 2009 | 19 October 2017 | Efficacy of Pregabalin in Patients With Radicular Pain | Efficacy of Pregabalin in Patients With Radicular Pain | Neuropathy; Radicular, Lumbar, Lumbosacral;Failed Back Surgery Syndrome;Spinal Stenosis;Herniated Disc | Drug: Pregabalin;Drug: Sugar Pill | Northwestern University | Not recruiting | 18 Years | 64 Years | All | 39 | Phase 4 | United States | |
| No. | TrialID | Date_ enrollement | Last_Refreshed_ on | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 66 | NCT00638443 | March 2008 | 19 October 2017 | Lumbar Stenosis Outcomes Research (LUSTOR) | Lumbar Stenosis Outcomes Research (LUSTOR)- A Randomized, Double-blind, Cross-over Trial of Pregabalin vs. Diphenhydramine in Patients With Lumbar Spinal Stenosis and Neuropathic Low Back Pain | Lumbar Spinal Stenosis | Drug: Pregabalin;Drug: Diphenhydramine | University of Rochester | Pfizer | Not recruiting | 50 Years | N/A | All | 29 | Phase 4 | United States |
| 67 | NCT00652093 | March 2008 | 19 October 2017 | Lumbar Stenosis Outcomes Research II | Lumbar Stenosis Outcomes Research II: Opana IR Versus Placebo and Active Control (Darvocet) for the Treatment of Walking Impairment in Lumbar Spinal Stenosis: A Double-Blind Randomized, Cross-Over Trial | Lumbar Spinal Stenosis | Drug: opana then darvocet then placebo;Drug: opana then placebo then darvocet;Drug: placebo then opana then darvocet;Drug: Placebo then darvocet then opana;Drug: Darvocet then opana then placebo;Drug: Darvocet then placebo then opana | University of Rochester | Endo Pharmaceuticals | Not recruiting | 50 Years | N/A | All | 24 | Phase 4 | United States |
| 68 | NCT00370799 | January 2007 | 19 February 2015 | Effectiveness of Caudal Epidural Injections in Treatment of Chronic Low Back and Lower Extremity Pain | A Randomized, Prospective, Double-Blind Controlled Evaluation of the Effectiveness of Caudal Epidural Injections in Lumbar Disc Herniations, Spinal Stenosis, Discogenic Pain, and Post-Lumbar Laminectomy Syndrome | Low Back Pain | Drug: Caudal epidural injection;Drug: Caudal Epidural Injection with generic Celestone;Drug: Caudal Epidural Injection with Celestone;Drug: Caudal Epidural Injection with DepoMedrol | Pain Management Center of Paducah | Not recruiting | 18 Years | N/A | Both | 240 | Phase 0 | United States | |
| 69 | NCT00320619 | September 2000 | 8 August 2016 | Epsilon-Aminocaproaic Acid to Reduce the Need for Blood Transfusions During and Following Spine Surgery | Aminocaproic Acid and Bleeding in Spinal Surgery | Scoliosis;Kyphosis;Lordosis;Spondylitis;Spinal Stenosis | Drug: Epsilon-Aminocaproic Acid (EACA);Drug: Placebo | National Heart, Lung, and Blood Institute (NHLBI) | Not recruiting | 18 Years | N/A | Both | 182 | N/A | United States |