KEGG DRUG

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No.	Drug (Description in trials)	DrugBank	KEGG DRUG	KEGG GENES	KEGG PATHWAY	Disease ID
1	Elexacaftor / Ivacaftor / Tezacaftor	[3] Elexacaftor, Ivacaftor, Tezacaftor	[3] Ivacaftor , Tezacaftor , Elexacaftor 💬	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299 💬
2	Elexacaftor 100 MG / Ivacaftor 75 MG / Tezacaftor 50 MG, 2 tablets each morning + Ivacaftor 150 mg one tablet each evening	[3] Elexacaftor, Ivacaftor, Tezacaftor	[3] Ivacaftor , Tezacaftor , Elexacaftor 💬	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299 💬
3	Elexacaftor-tezacaftor-ivacaftor exposure	[3] Elexacaftor, Ivacaftor, Tezacaftor	[3] Ivacaftor , Tezacaftor , Elexacaftor 💬	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299 💬
4	Elexacaftor/tezacaftor/ivacaftor	[3] Elexacaftor, Ivacaftor, Tezacaftor	[3] Ivacaftor , Tezacaftor , Elexacaftor 💬	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299 💬
5	Ivacaftor or elexacaftor/tezacaftor/ivacaftor	[3] Elexacaftor, Ivacaftor, Tezacaftor	[3] Ivacaftor , Tezacaftor , Elexacaftor 💬	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299 💬
6	TEZACAFTOR	[1] Tezacaftor	[1] Tezacaftor 💬	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299 💬
7	Tezacaftor (TEZ)	[1] Tezacaftor	[1] Tezacaftor 💬	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299 💬
8	Tezacaftor/Ivacaftor	[2] Ivacaftor, Tezacaftor	[2] Ivacaftor , Tezacaftor 💬	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299 💬
9	Tezacaftor/Ivacaftor + Ivacaftor	[2] Ivacaftor, Tezacaftor	[2] Ivacaftor , Tezacaftor 💬	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299 💬
10	Tezacaftor/Ivacaftor 100mg/150mg	[2] Ivacaftor, Tezacaftor	[2] Ivacaftor , Tezacaftor 💬	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299 💬
11	Tezacaftor/Ivacaftor/100mg/150mg	[2] Ivacaftor, Tezacaftor	[2] Ivacaftor , Tezacaftor 💬	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299 💬
12	Treatment with cystic fibrosis transmembrane regulator (CFTR) modualtors Ivacaftor, Lumacaftor-Ivacaftor, Tezacaftor-Ivacaftor, Elexacaftor-Tezacaftor-Ivacaftor	[4] Elexacaftor, Ivacaftor, Lumacaftor, Tezacaftor	[4] Ivacaftor , Lumacaftor , Tezacaftor , Elexacaftor 💬	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299 💬
13	VX-121/tezacaftor/deutivacaftor	[2] Deutivacaftor, Tezacaftor	[2] Tezacaftor , Deutivacaftor 💬	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299 💬
14	VX-659/Tezacaftor/Ivacaftor	[3] Ivacaftor, Tezacaftor, VX-659	[2] Ivacaftor , Tezacaftor 💬	[1] CFTR 💬	[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬	[1] 299 💬