DR info

Clinical trials : 3,340 / Drugs : 2,163 - (DrugBank : 383) / Drug target genes : 241 - Drug target pathways : 238

Multiple sclerosis/Neuromyelitis optica and other diseases between which drug repositioning might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Drug repositionability

ID	Diseases (Sorted by drug repositionability)
13	Multiple sclerosis/Neuromyelitis optica
6	Parkinson disease
2	Amyotrophic lateral sclerosis
96	Crohn disease
46	Malignant rheumatoid arthritis
97	Ulcerative colitis
156	Rett syndrome
84	Sarcoidosis
8	Huntington disease
86	Pulmonary arterial hypertension
5	Progressive supranuclear palsy
70	Spinal stenosis
49	Systemic lupus erythematosus
3	Spinal muscular atrophy
206	Fragile X syndrome
21	Mitochondrial disease
51	Scleroderma
193	Prader-Willi syndrome
36	Epidermolysis bullosa
65	Primary immunodeficiency
18	Spinocerebellar degeneration
226	Interstitial cystitis with Hunners ulcer
17	Multiple system atrophy
85	Idiopathic interstitial pneumonia
34	Neurofibromatosis
298	Hereditary pancreatitis
140	Dorabe syndrome
144	Lennox-Gastaut syndrome
299	Cystic fibrosis
296	Biliary atresia
90	Retinitis pigmentosa
107	Juvenile idiopathic arthritis
11	Myasthenia gravis
98	Eosinophilic gastrointestinal disease
113	Muscular dystrophy
158	Tuberous sclerosis
50	Dermatomyositis
53	Sjogren syndrome
155	Acquired aphasia with convulsive disorder
78	Hypopituitarism
222	Primary nephrotic syndrome
231	Alpha-1-antitrypsin deficiency
63	Idiopathic thrombocytopenic purpura
60	Aplastic anemia
145	West syndrome
58	Hypertrophic cardiomyopathy
41	Giant cell arteritis
22	Moyamoya disease
19	Lysosomal storage disease
66	IgA nephropathy
26	HTLV-1-associated myelopathy
205	Fragile X syndrome related disease
127	Frontotemporal lobar degeneration
164	Oculocutaneous albinism
225	Congenital nephrogenic diabetes insipidus
28	Systemic amyloidosis
75	Cushing disease
271	Ankylosing spondylitis
285	Fanconi anemia
162	Pemphigoid
283	Acquired pure red cell aplasia
114	Non-dystrophic myotonia syndrome
230	Alveolar hypoventilation syndrome
256	Muscle glycogenosis
272	Fibrodysplasia ossificans progressiva
284	Diamond-Blackfan anemia
152	PCDH19 related syndrome
56	Behcet disease
228	Bronchiolitis obliterans
300	IgG4-related disease
201	Angelman syndrome
331	Idiopathic multicentric castleman disease
45	Eosinophilic granulomatosis with Polyangiitis
203	22q11.2 deletion syndrome
95	Autoimmune hepatitis
35	Pemphigus
61	Autoimmune hemolytic anemia
38	Stevens-Johnson syndrome
115	Hereditary periodic paralysis
154	Epilepsy with continuous spikes and waves during slow sleep
265	Lipodystrophy
62	Paroxysmal nocturnal hemoglobinuria
43	Microscopic polyangiitis
4	Primary lateral sclerosis
55	Relapsing polychondritis
14	Chronic inflammatory demyelinating polyneuropathy
42	Polyarteritis nodosa
89	Lymphangioleiomyomatosis
215	Tetralogy of Fallot
10	Charcot-Marie-Tooth disease
40	Takayasu arteritis
149	Hemiconvulsion hemiplegia epilepsy syndrome
37	Generalised pustular psoriasis
224	Purpura nephritis
44	Wegener granulomatosis
20	Adrenoleukodystrophy
39	Toxic epidermal necrolysis
233	Wolfram syndrome
227	Osler disease
81	Congenital adrenal hyperplasia
160	Congenital ichthyosis
286	Hereditary sideroblastic anemia
212	Tricuspid atresia
93	Primary biliary cholangitis
254	Porphyria
64	Thrombotic thrombocytopenic purpura
236	Pseudohypoparathyroidism
67	Polycystic kidney disease
280	Huge arteriovenous malformation with cervicofacial or limb lesion
102	Rubinstein-Taybi syndrome
25	Progressive multifocal leukoencephalopathy
269	Pyogenic arthritis
94	Primary sclerosing cholangitis
88	Chronic thromboembolic pulmonary hypertension
151	Rasmussen encephalitis
83	Addison disease
47	Buerger disease
15	Inclusion body myositis
288	Autoimmune acquired coagulation factor deficiency
179	Williams syndrome
234	Peroxisomal disease (except Adrenoleukodystrophy)
326	Osteopetrosis
12	Congenital myasthenic syndrome
302	Leber hereditary optic neuropathy
294	Congenital diaphragmatic hernia
211	Hypoplastic left heart syndrome
1	Spinal and bulbar muscular atrophy
274	Osteogenesis Imperfecta
270	Chronic recurrent multifocal osteomyelitis
76	Pituitary gonadotropin secretion hyperthyroidism
168	Ehlers-Danlos syndrome
169	Menkes disease
170	Occipital horn syndrome
87	Pulmonary veno-occlusive disease
106	Cryopyrin-associated periodic syndrome
246	Methylmalonic acidemia
167	Marfan syndrome
210	Single Ventricle
157	Sturge-Weber syndrome
278	Huge lymphatic malformation with cervicofacial lesion
16	Crow-Fukase syndrome
118	Myelomeningocele
187	Kabuki syndrome
171	Wilson disease
323	Aromatic L-amino acid decarboxylase deficiency
124	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
251	Urea cycle disorder
202	Smith-Magenis syndrome
71	Idiopathic osteonecrosis of the femoral head
77	Growth hormone secreting pituitary adenoma
337	Homocystinuria
195	Noonan syndrome
282	Congenital dyserythropoietic anemia
307	Canavan disease
139	Congenital cerebral hypomyelination
120	Hereditary dystonia
266	Familial mediterranean fever
159	Xeroderma pigmentosum
166	Pseudoxanthoma elasticum
301	Macular dystrophy
57	Idiopathic dilated cardiomyopathy
74	Prolactin secreting pituitary adenoma
218	Alport syndrome
310	Congenital anomalies syndrome
229	Autoimmune pulmonary alveolar proteinosis
172	Hypophosphatasia
80	Resistance to thyroid hormone
79	Homozygous familial hypercholesterolemia
309	Progressive myoclonus epilepsy
333	Hutchinson-Gilford syndrome
91	Budd-Chiari syndrome
238	Vitamin D-resistant rickets
235	Hypoparathyroidism
137	Focal cortical dysplasia
192	Cockayne syndrome
277	Lymphangiomatosis
281	Klippel-Trenaunay-Weber syndrome
111	Congenital myopathy
108	TNF receptor-associated periodic syndrome
267	Hyper-IgD syndrome
99	Chronic intestinal pseudo-obstruction
317	Trifunctional protein deficiency
54	Adult still disease
191	Werner syndrome
52	Mixed connective tissue disease
290	Chronic nonspecific multiple ulcers of the small intestine
220	Rapidly progressive glomerulonephritis
30	Distal myopathy