Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	SIGMAR1 💬	[2] Amyotrophic lateral sclerosis, Pathways of neurodegeneration - multiple diseases	Dextromethorphan 💬	Dextromethorphan	[11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
2	CD52 💬	-	Alemtuzumab 💬	Alemtuzumab	[22] 13, 15, 19, 20, 36, 43, 44, 46, 49, 51, 60, 62, 63, 65, 85, 96, 164, 234, 283, 284, 285, 326 💬
3	TNFSF13B 💬	[4] Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Intestinal immune network for IgA production, Rheumatoid arthritis	Belimumab 💬	Belimumab	[13] 11, 13, 43, 44, 46, 49, 51, 53, 63, 66, 222, 296, 300 💬
4	TNFSF13B 💬	[4] Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Intestinal immune network for IgA production, Rheumatoid arthritis	Atacicept 💬	Atacicept	[4] 13, 46, 49, 66 💬
5	CYSLTR1 💬	[2] Calcium signaling pathway, Neuroactive ligand-receptor interaction	Ibudilast 💬	Ibudilast	[2] 2, 13 💬
6	CYSLTR1 💬	[2] Calcium signaling pathway, Neuroactive ligand-receptor interaction	Montelukast 💬	Montelukast	[8] 6, 13, 46, 61, 63, 85, 98, 228 💬
7	CA5B 💬	[2] Nitrogen metabolism, Metabolic pathways	Acetazolamide 💬	Acetazolamide	[8] 13, 86, 90, 115, 154, 155, 225, 230 💬
8	CHRM1 💬	[8] Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Cholinergic synapse, Regulation of actin cytoskeleton, Alzheimer disease, Pathways of neurodegeneration - multiple diseases	Oxybutynin 💬	Oxybutynin	[3] 6, 13, 53 💬
9	CHRM2 💬	[6] Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Cholinergic synapse, Regulation of actin cytoskeleton	Oxybutynin 💬	Oxybutynin	[3] 6, 13, 53 💬
10	CHRM3 💬	[11] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Cholinergic synapse, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Alzheimer disease, Pathways of neurodegeneration - multiple diseases	Oxybutynin 💬	Oxybutynin	[3] 6, 13, 53 💬
11	CHRM3 💬	[11] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Cholinergic synapse, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Alzheimer disease, Pathways of neurodegeneration - multiple diseases	Darifenacin 💬	Darifenacin	[2] 6, 13 💬
12	CHRM3 💬	[11] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Cholinergic synapse, Taste transduction, Regulation of actin cytoskeleton, Insulin secretion, Salivary secretion, Gastric acid secretion, Pancreatic secretion, Alzheimer disease, Pathways of neurodegeneration - multiple diseases	Solifenacin 💬	Solifenacin	[3] 6, 13, 53 💬
13	CHRM4 💬	[3] Neuroactive ligand-receptor interaction, Cholinergic synapse, Regulation of actin cytoskeleton	Oxybutynin 💬	Oxybutynin	[3] 6, 13, 53 💬
14	CHRM5 💬	[6] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Cholinergic synapse, Regulation of actin cytoskeleton, Alzheimer disease, Pathways of neurodegeneration - multiple diseases	Oxybutynin 💬	Oxybutynin	[3] 6, 13, 53 💬
15	CHRNA1 💬	[2] Virion - Lyssavirus, Neuroactive ligand-receptor interaction	Nicotine 💬	Nicotine	[3] 6, 13, 84 💬
16	CHRNA2 💬	[1] Neuroactive ligand-receptor interaction	Nicotine 💬	Nicotine	[3] 6, 13, 84 💬
17	CHRNA3 💬	[3] Neuroactive ligand-receptor interaction, Cholinergic synapse, Chemical carcinogenesis - receptor activation	Nicotine 💬	Nicotine	[3] 6, 13, 84 💬
18	CHRNA4 💬	[4] Neuroactive ligand-receptor interaction, Cholinergic synapse, Nicotine addiction, Chemical carcinogenesis - receptor activation	Nicotine 💬	Nicotine	[3] 6, 13, 84 💬
19	CHRNA5 💬	[1] Neuroactive ligand-receptor interaction	Nicotine 💬	Nicotine	[3] 6, 13, 84 💬
20	CHRNA7 💬	[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Cholinergic synapse, Alzheimer disease, Pathways of neurodegeneration - multiple diseases, Nicotine addiction, Chemical carcinogenesis - receptor activation	Nicotine 💬	Nicotine	[3] 6, 13, 84 💬
21	CHRNB1 💬	[1] Neuroactive ligand-receptor interaction	Nicotine 💬	Nicotine	[3] 6, 13, 84 💬
22	CHRNB2 💬	[4] Neuroactive ligand-receptor interaction, Cholinergic synapse, Nicotine addiction, Chemical carcinogenesis - receptor activation	Nicotine 💬	Nicotine	[3] 6, 13, 84 💬
23	CHRNB3 💬	[1] Neuroactive ligand-receptor interaction	Nicotine 💬	Nicotine	[3] 6, 13, 84 💬
24	CHRNB4 💬	[3] Neuroactive ligand-receptor interaction, Cholinergic synapse, Chemical carcinogenesis - receptor activation	Nicotine 💬	Nicotine	[3] 6, 13, 84 💬
25	CHRND 💬	[1] Neuroactive ligand-receptor interaction	Nicotine 💬	Nicotine	[3] 6, 13, 84 💬
26	CHRNE 💬	[1] Neuroactive ligand-receptor interaction	Nicotine 💬	Nicotine	[3] 6, 13, 84 💬
27	CHRNG 💬	[1] Neuroactive ligand-receptor interaction	Nicotine 💬	Nicotine	[3] 6, 13, 84 💬
28	CLCN2 💬	[1] Mineral absorption	Lubiprostone 💬	Lubiprostone	[4] 6, 13, 290, 299 💬
29	CNR1 💬	[4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Thermogenesis, Retrograde endocannabinoid signaling	Dronabinol 💬	Dronabinol	[8] 2, 8, 13, 36, 46, 96, 271, 298 💬
30	CNR1 💬	[4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Thermogenesis, Retrograde endocannabinoid signaling	Nabilone 💬	Nabilone	[3] 6, 13, 127 💬
31	CNR1 💬	[4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Thermogenesis, Retrograde endocannabinoid signaling	Cannabidiol 💬	Cannabidiol	[20] 2, 6, 8, 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
32	CNR2 💬	[1] Neuroactive ligand-receptor interaction	Dronabinol 💬	Dronabinol	[8] 2, 8, 13, 36, 46, 96, 271, 298 💬
33	CNR2 💬	[1] Neuroactive ligand-receptor interaction	Nabilone 💬	Nabilone	[3] 6, 13, 127 💬
34	CNR2 💬	[1] Neuroactive ligand-receptor interaction	Cannabidiol 💬	Cannabidiol	[20] 2, 6, 8, 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
35	ADORA1 💬	[7] cGMP-PKG signaling pathway, cAMP signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction	Adenosine 💬	Adenosine	[3] 13, 58, 65 💬
36	ADORA2A 💬	[7] Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Parkinson disease, Alcoholism	Adenosine 💬	Adenosine	[3] 13, 58, 65 💬
37	ADORA2B 💬	[5] Rap1 signaling pathway, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Alcoholism	Adenosine 💬	Adenosine	[3] 13, 58, 65 💬
38	ADORA3 💬	[3] cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction	Adenosine 💬	Adenosine	[3] 13, 58, 65 💬
39	CSF3R 💬	[5] Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Hematopoietic cell lineage, Pathways in cancer	Filgrastim 💬	Filgrastim	[35] 2, 6, 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
40	CSF3R 💬	[5] Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Hematopoietic cell lineage, Pathways in cancer	Lenograstim 💬	Lenograstim	[7] 2, 13, 16, 18, 19, 57, 65 💬
41	ADRA1D 💬	[6] Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Salivary secretion	Tamsulosin 💬	Tamsulosin	[1] 13 💬
42	ADRA1B 💬	[6] Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Salivary secretion	Tamsulosin 💬	Tamsulosin	[1] 13 💬
43	ADRA1A 💬	[7] Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Salivary secretion	Silodosin 💬	Silodosin	[2] 6, 13 💬
44	ADRA1A 💬	[7] Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Salivary secretion	Alfuzosin 💬	Alfuzosin	[1] 13 💬
45	ADRA1A 💬	[7] Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Salivary secretion	Tamsulosin 💬	Tamsulosin	[1] 13 💬
46	ADRA2A 💬	[2] cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction	Guanabenz 💬	Guanabenz	[2] 2, 13 💬
47	ADRA2A 💬	[2] cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction	Brimonidine 💬	Brimonidine	[2] 13, 90 💬
48	ADRA2A 💬	[2] cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction	Tizanidine 💬	Tizanidine	[1] 13 💬
49	ADRA2B 💬	[2] cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction	Guanabenz 💬	Guanabenz	[2] 2, 13 💬
50	ADRA2B 💬	[2] cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction	Brimonidine 💬	Brimonidine	[2] 13, 90 💬
51	ADRA2B 💬	[2] cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction	Tizanidine 💬	Tizanidine	[1] 13 💬
52	ADRA2C 💬	[2] cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction	Guanabenz 💬	Guanabenz	[2] 2, 13 💬
53	ADRA2C 💬	[2] cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction	Brimonidine 💬	Brimonidine	[2] 13, 90 💬
54	ADRA2C 💬	[2] cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction	Tizanidine 💬	Tizanidine	[1] 13 💬
55	ADRB2 💬	[9] Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Adrenergic signaling in cardiomyocytes, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation	Albuterol 💬	Salbutamol	[12] 3, 11, 12, 13, 49, 85, 86, 89, 111, 113, 256, 299 💬
56	ADRB2 💬	[9] Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Adrenergic signaling in cardiomyocytes, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation	Clenbuterol 💬	Clenbuterol	[5] 1, 2, 6, 13, 256 💬
57	ADRB2 💬	[9] Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Adrenergic signaling in cardiomyocytes, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation	Isoxsuprine 💬	Isoxsuprine	[1] 13 💬
58	ADRB3 💬	[8] Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction, Thermogenesis, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Chemical carcinogenesis - receptor activation	Mirabegron 💬	Mirabegron	[4] 6, 13, 53, 226 💬
59	CYP17A1 💬	[6] Steroid hormone biosynthesis, Metabolic pathways, Ovarian steroidogenesis, Prolactin signaling pathway, Cortisol synthesis and secretion, Cushing syndrome	Ketoconazole 💬	Ketoconazole	[3] 8, 13, 75 💬
60	DDC 💬	[9] Tyrosine metabolism, Phenylalanine metabolism, Tryptophan metabolism, Metabolic pathways, Serotonergic synapse, Dopaminergic synapse, Cocaine addiction, Amphetamine addiction, Alcoholism	Carbidopa 💬	Carbidopa	[7] 6, 13, 17, 90, 140, 164, 201 💬
61	DHFR 💬	[5] One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors, Antifolate resistance	Methotrexate 💬	Methotrexate	[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬
62	DHODH 💬	[3] Pyrimidine metabolism, Metabolic pathways, Biosynthesis of cofactors	Teriflunomide 💬	Teriflunomide	[3] 13, 25, 26 💬
63	NQO1 💬	[7] Ubiquinone and other terpenoid-quinone biosynthesis, Metabolic pathways, Biosynthesis of cofactors, Pathways in cancer, Chemical carcinogenesis - reactive oxygen species, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis	Warfarin 💬	Warfarin	[11] 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91 💬
64	DNMT1 💬	[3] Cysteine and methionine metabolism, Metabolic pathways, MicroRNAs in cancer	Decitabine 💬	Decitabine	[3] 13, 60, 63 💬
65	DNMT3A 💬	[3] Cysteine and methionine metabolism, Metabolic pathways, MicroRNAs in cancer	Decitabine 💬	Decitabine	[3] 13, 60, 63 💬
66	DNMT3B 💬	[3] Cysteine and methionine metabolism, Metabolic pathways, MicroRNAs in cancer	Decitabine 💬	Decitabine	[3] 13, 60, 63 💬
67	DRD2 💬	[8] Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism	Domperidone 💬	Domperidone	[5] 6, 13, 17, 51, 230 💬
68	DRD2 💬	[8] Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism	Domperidone maleate 💬	Domperidone	[5] 6, 13, 17, 51, 230 💬
69	DRD2 💬	[8] Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism	Quetiapine 💬	Quetiapine	[2] 6, 13 💬
70	ABAT 💬	[7] Alanine, aspartate and glutamate metabolism, Valine, leucine and isoleucine degradation, beta-Alanine metabolism, Propanoate metabolism, Butanoate metabolism, Metabolic pathways, GABAergic synapse	Valproic acid 💬	Valproic acid	[14] 2, 3, 5, 6, 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬
71	S1PR1 💬	[3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction	Fingolimod 💬	Fingolimod	[3] 13, 14, 156 💬
72	S1PR1 💬	[3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction	Ozanimod 💬	Ozanimod	[3] 13, 96, 97 💬
73	S1PR1 💬	[3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction	Ponesimod 💬	Ponesimod	[1] 13 💬
74	S1PR1 💬	[3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction	Siponimod 💬	Siponimod	[2] 13, 50 💬
75	S1PR3 💬	[2] Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction	Ozanimod 💬	Ozanimod	[3] 13, 96, 97 💬
76	ELANE 💬	[3] Neutrophil extracellular trap formation, Transcriptional misregulation in cancer, Systemic lupus erythematosus	Sivelestat 💬	Sivelestat	[3] 13, 85, 96 💬
77	DHFR2 💬	[5] One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors, Antifolate resistance	Methotrexate 💬	Methotrexate	[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬
78	ESR1 💬	[9] Endocrine resistance, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Endocrine and other factor-regulated calcium reabsorption, Pathways in cancer, Proteoglycans in cancer, Chemical carcinogenesis - receptor activation, Breast cancer	Estradiol 💬	Estradiol	[7] 13, 46, 49, 65, 76, 226, 299 💬
79	ESR1 💬	[9] Endocrine resistance, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Endocrine and other factor-regulated calcium reabsorption, Pathways in cancer, Proteoglycans in cancer, Chemical carcinogenesis - receptor activation, Breast cancer	Estriol 💬	Estriol	[2] 13, 227 💬
80	ESR1 💬	[9] Endocrine resistance, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Endocrine and other factor-regulated calcium reabsorption, Pathways in cancer, Proteoglycans in cancer, Chemical carcinogenesis - receptor activation, Breast cancer	Ethinyl estradiol 💬	Ethinylestradiol	[4] 13, 46, 49, 299 💬
81	ESR1 💬	[9] Endocrine resistance, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Endocrine and other factor-regulated calcium reabsorption, Pathways in cancer, Proteoglycans in cancer, Chemical carcinogenesis - receptor activation, Breast cancer	Estriol tripropionate 💬	Estriol	[2] 13, 227 💬
82	ESR2 💬	[7] Endocrine resistance, Estrogen signaling pathway, Prolactin signaling pathway, GnRH secretion, Pathways in cancer, Chemical carcinogenesis - receptor activation, Breast cancer	Estradiol 💬	Estradiol	[7] 13, 46, 49, 65, 76, 226, 299 💬
83	ESR2 💬	[7] Endocrine resistance, Estrogen signaling pathway, Prolactin signaling pathway, GnRH secretion, Pathways in cancer, Chemical carcinogenesis - receptor activation, Breast cancer	Estriol 💬	Estriol	[2] 13, 227 💬
84	ESR2 💬	[7] Endocrine resistance, Estrogen signaling pathway, Prolactin signaling pathway, GnRH secretion, Pathways in cancer, Chemical carcinogenesis - receptor activation, Breast cancer	Estriol tripropionate 💬	Estriol	[2] 13, 227 💬
85	FDPS 💬	[4] Terpenoid backbone biosynthesis, Metabolic pathways, Influenza A, Human T-cell leukemia virus 1 infection	Zoledronic acid 💬	Zoledronic acid	[13] 5, 6, 13, 17, 46, 65, 93, 95, 96, 270, 274, 299, 333 💬
86	FDPS 💬	[4] Terpenoid backbone biosynthesis, Metabolic pathways, Influenza A, Human T-cell leukemia virus 1 infection	Zoledronic acid 💬	Zoledronic acid	[13] 5, 6, 13, 17, 46, 65, 93, 95, 96, 270, 274, 299, 333 💬
87	FGFR2 💬	[13] EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, Endocytosis, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton, Pathways in cancer, Prostate cancer, Gastric cancer, Central carbon metabolism in cancer	Palifermin 💬	Palifermin	[5] 13, 36, 38, 39, 65 💬
88	NCSTN 💬	[2] Notch signaling pathway, Alzheimer disease	Tarenflurbil 💬	Tarenflurbil	[1] 13 💬
89	CA14 💬	[2] Nitrogen metabolism, Metabolic pathways	Acetazolamide 💬	Acetazolamide	[8] 13, 86, 90, 115, 154, 155, 225, 230 💬
90	MTOR 💬	[51] EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, HIF-1 signaling pathway, Phospholipase D signaling pathway, Autophagy - other, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Cellular senescence, Apelin signaling pathway, Neutrophil extracellular trap formation, JAK-STAT signaling pathway, Th17 cell differentiation, Thermogenesis, Insulin signaling pathway, Thyroid hormone signaling pathway, Adipocytokine signaling pathway, Type II diabetes mellitus, Insulin resistance, Growth hormone synthesis, secretion and action, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Shigellosis, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Chemical carcinogenesis - receptor activation, Colorectal cancer, Pancreatic cancer, Glioma, Prostate cancer, Acute myeloid leukemia, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Diabetic cardiomyopathy	Sirolimus 💬	Sirolimus	[40] 2, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬
91	MTOR 💬	[51] EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, HIF-1 signaling pathway, Phospholipase D signaling pathway, Autophagy - other, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Cellular senescence, Apelin signaling pathway, Neutrophil extracellular trap formation, JAK-STAT signaling pathway, Th17 cell differentiation, Thermogenesis, Insulin signaling pathway, Thyroid hormone signaling pathway, Adipocytokine signaling pathway, Type II diabetes mellitus, Insulin resistance, Growth hormone synthesis, secretion and action, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Shigellosis, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Chemical carcinogenesis - receptor activation, Colorectal cancer, Pancreatic cancer, Glioma, Prostate cancer, Acute myeloid leukemia, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Diabetic cardiomyopathy	Temsirolimus 💬	Temsirolimus	[1] 13 💬
92	GABBR1 💬	[7] cAMP signaling pathway, Neuroactive ligand-receptor interaction, GABAergic synapse, Taste transduction, Estrogen signaling pathway, GnRH secretion, Morphine addiction	Baclofen 💬	Baclofen	[8] 2, 10, 13, 18, 65, 70, 149, 206 💬
93	GABBR1 💬	[7] cAMP signaling pathway, Neuroactive ligand-receptor interaction, GABAergic synapse, Taste transduction, Estrogen signaling pathway, GnRH secretion, Morphine addiction	Arbaclofen placarbil 💬	Arbaclofen Placarbil	[1] 13 💬
94	GABBR1 💬	[7] cAMP signaling pathway, Neuroactive ligand-receptor interaction, GABAergic synapse, Taste transduction, Estrogen signaling pathway, GnRH secretion, Morphine addiction	Arbaclofen 💬	Arbaclofen	[2] 13, 206 💬
95	GABRA1 💬	[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction	Midazolam 💬	Midazolam	[12] 2, 3, 6, 13, 21, 46, 70, 96, 97, 272, 298, 299 💬
96	GABRA1 💬	[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction	Flumazenil 💬	Flumazenil	[5] 6, 13, 17, 18, 206 💬
97	GABRA1 💬	[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction	Eszopiclone 💬	Eszopiclone	[3] 6, 13, 46 💬
98	GABRA2 💬	[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction	Midazolam 💬	Midazolam	[12] 2, 3, 6, 13, 21, 46, 70, 96, 97, 272, 298, 299 💬
99	GABRA2 💬	[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction	Flumazenil 💬	Flumazenil	[5] 6, 13, 17, 18, 206 💬
100	GABRA2 💬	[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction	Eszopiclone 💬	Eszopiclone	[3] 6, 13, 46 💬
101	GABRA3 💬	[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction	Midazolam 💬	Midazolam	[12] 2, 3, 6, 13, 21, 46, 70, 96, 97, 272, 298, 299 💬
102	GABRA3 💬	[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction	Flumazenil 💬	Flumazenil	[5] 6, 13, 17, 18, 206 💬
103	GABRA3 💬	[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction	Eszopiclone 💬	Eszopiclone	[3] 6, 13, 46 💬
104	GABRA4 💬	[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction	Midazolam 💬	Midazolam	[12] 2, 3, 6, 13, 21, 46, 70, 96, 97, 272, 298, 299 💬
105	GABRA4 💬	[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction	Flumazenil 💬	Flumazenil	[5] 6, 13, 17, 18, 206 💬
106	GABRA4 💬	[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction	Eszopiclone 💬	Eszopiclone	[3] 6, 13, 46 💬
107	GABRA5 💬	[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction	Midazolam 💬	Midazolam	[12] 2, 3, 6, 13, 21, 46, 70, 96, 97, 272, 298, 299 💬
108	GABRA5 💬	[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction	Flumazenil 💬	Flumazenil	[5] 6, 13, 17, 18, 206 💬
109	GABRA5 💬	[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction	Eszopiclone 💬	Eszopiclone	[3] 6, 13, 46 💬
110	GABRA6 💬	[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction	Midazolam 💬	Midazolam	[12] 2, 3, 6, 13, 21, 46, 70, 96, 97, 272, 298, 299 💬
111	GABRA6 💬	[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction	Flumazenil 💬	Flumazenil	[5] 6, 13, 17, 18, 206 💬
112	GABRA6 💬	[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction	Eszopiclone 💬	Eszopiclone	[3] 6, 13, 46 💬
113	GABRB1 💬	[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, Serotonergic synapse, GABAergic synapse, Morphine addiction, Nicotine addiction	Midazolam 💬	Midazolam	[12] 2, 3, 6, 13, 21, 46, 70, 96, 97, 272, 298, 299 💬
114	GABRB1 💬	[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, Serotonergic synapse, GABAergic synapse, Morphine addiction, Nicotine addiction	Flumazenil 💬	Flumazenil	[5] 6, 13, 17, 18, 206 💬
115	GABRB1 💬	[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, Serotonergic synapse, GABAergic synapse, Morphine addiction, Nicotine addiction	Eszopiclone 💬	Eszopiclone	[3] 6, 13, 46 💬
116	GABRB2 💬	[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, Serotonergic synapse, GABAergic synapse, Morphine addiction, Nicotine addiction	Midazolam 💬	Midazolam	[12] 2, 3, 6, 13, 21, 46, 70, 96, 97, 272, 298, 299 💬
117	GABRB2 💬	[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, Serotonergic synapse, GABAergic synapse, Morphine addiction, Nicotine addiction	Flumazenil 💬	Flumazenil	[5] 6, 13, 17, 18, 206 💬
118	GABRB2 💬	[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, Serotonergic synapse, GABAergic synapse, Morphine addiction, Nicotine addiction	Eszopiclone 💬	Eszopiclone	[3] 6, 13, 46 💬
119	GABRB3 💬	[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, Serotonergic synapse, GABAergic synapse, Morphine addiction, Nicotine addiction	Midazolam 💬	Midazolam	[12] 2, 3, 6, 13, 21, 46, 70, 96, 97, 272, 298, 299 💬
120	GABRB3 💬	[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, Serotonergic synapse, GABAergic synapse, Morphine addiction, Nicotine addiction	Flumazenil 💬	Flumazenil	[5] 6, 13, 17, 18, 206 💬
121	GABRB3 💬	[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, Serotonergic synapse, GABAergic synapse, Morphine addiction, Nicotine addiction	Eszopiclone 💬	Eszopiclone	[3] 6, 13, 46 💬
122	GABRD 💬	[5] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction	Midazolam 💬	Midazolam	[12] 2, 3, 6, 13, 21, 46, 70, 96, 97, 272, 298, 299 💬
123	GABRD 💬	[5] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction	Flumazenil 💬	Flumazenil	[5] 6, 13, 17, 18, 206 💬
124	GABRD 💬	[5] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction	Eszopiclone 💬	Eszopiclone	[3] 6, 13, 46 💬
125	GABRE 💬	[5] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction	Midazolam 💬	Midazolam	[12] 2, 3, 6, 13, 21, 46, 70, 96, 97, 272, 298, 299 💬
126	GABRE 💬	[5] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction	Flumazenil 💬	Flumazenil	[5] 6, 13, 17, 18, 206 💬
127	GABRE 💬	[5] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction	Eszopiclone 💬	Eszopiclone	[3] 6, 13, 46 💬
128	GABRG1 💬	[5] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction	Midazolam 💬	Midazolam	[12] 2, 3, 6, 13, 21, 46, 70, 96, 97, 272, 298, 299 💬
129	GABRG1 💬	[5] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction	Flumazenil 💬	Flumazenil	[5] 6, 13, 17, 18, 206 💬
130	GABRG1 💬	[5] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction	Eszopiclone 💬	Eszopiclone	[3] 6, 13, 46 💬
131	GABRG2 💬	[5] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction	Midazolam 💬	Midazolam	[12] 2, 3, 6, 13, 21, 46, 70, 96, 97, 272, 298, 299 💬
132	GABRG2 💬	[5] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction	Flumazenil 💬	Flumazenil	[5] 6, 13, 17, 18, 206 💬
133	GABRG2 💬	[5] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction	Eszopiclone 💬	Eszopiclone	[3] 6, 13, 46 💬
134	GABRG3 💬	[5] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction	Midazolam 💬	Midazolam	[12] 2, 3, 6, 13, 21, 46, 70, 96, 97, 272, 298, 299 💬
135	GABRG3 💬	[5] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction	Flumazenil 💬	Flumazenil	[5] 6, 13, 17, 18, 206 💬
136	GABRG3 💬	[5] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction	Eszopiclone 💬	Eszopiclone	[3] 6, 13, 46 💬
137	GABRP 💬	[5] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction	Midazolam 💬	Midazolam	[12] 2, 3, 6, 13, 21, 46, 70, 96, 97, 272, 298, 299 💬
138	GABRP 💬	[5] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction	Flumazenil 💬	Flumazenil	[5] 6, 13, 17, 18, 206 💬
139	GABRP 💬	[5] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction	Eszopiclone 💬	Eszopiclone	[3] 6, 13, 46 💬
140	GAD1 💬	[7] Alanine, aspartate and glutamate metabolism, beta-Alanine metabolism, Taurine and hypotaurine metabolism, Butanoate metabolism, Metabolic pathways, GABAergic synapse, Type I diabetes mellitus	Valproic acid 💬	Valproic acid	[14] 2, 3, 5, 6, 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬
141	GAD2 💬	[7] Alanine, aspartate and glutamate metabolism, beta-Alanine metabolism, Taurine and hypotaurine metabolism, Butanoate metabolism, Metabolic pathways, GABAergic synapse, Type I diabetes mellitus	Valproic acid 💬	Valproic acid	[14] 2, 3, 5, 6, 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬
142	ABL1 💬	[11] ErbB signaling pathway, Ras signaling pathway, Cell cycle, Axon guidance, Neurotrophin signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, MicroRNAs in cancer, Chemical carcinogenesis - reactive oxygen species, Chronic myeloid leukemia, Viral myocarditis	Imatinib 💬	Imatinib	[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
143	GHRHR 💬	[2] Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action	Somatorelin 💬	Somatorelin	[2] 13, 78 💬
144	GLP1R 💬	[3] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Insulin secretion	Dulaglutide 💬	Dulaglutide	[2] 13, 299 💬
145	GRIA1 💬	[14] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Retrograde endocannabinoid signaling, Glutamatergic synapse, Dopaminergic synapse, Long-term depression, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Nicotine addiction	Riluzole 💬	Riluzole	[9] 2, 3, 5, 8, 13, 17, 18, 203, 206 💬
146	GRIA2 💬	[15] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Retrograde endocannabinoid signaling, Glutamatergic synapse, Dopaminergic synapse, Long-term depression, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction	Riluzole 💬	Riluzole	[9] 2, 3, 5, 8, 13, 17, 18, 203, 206 💬
147	GRIA3 💬	[13] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Retrograde endocannabinoid signaling, Glutamatergic synapse, Dopaminergic synapse, Long-term depression, Huntington disease, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Nicotine addiction, Transcriptional misregulation in cancer	Riluzole 💬	Riluzole	[9] 2, 3, 5, 8, 13, 17, 18, 203, 206 💬
148	GRIA4 💬	[10] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Retrograde endocannabinoid signaling, Glutamatergic synapse, Dopaminergic synapse, Huntington disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Nicotine addiction	Riluzole 💬	Riluzole	[9] 2, 3, 5, 8, 13, 17, 18, 203, 206 💬
149	GRIK1 💬	[2] Neuroactive ligand-receptor interaction, Glutamatergic synapse	Riluzole 💬	Riluzole	[9] 2, 3, 5, 8, 13, 17, 18, 203, 206 💬
150	GRIK2 💬	[2] Neuroactive ligand-receptor interaction, Glutamatergic synapse	Riluzole 💬	Riluzole	[9] 2, 3, 5, 8, 13, 17, 18, 203, 206 💬
151	GRIK3 💬	[2] Neuroactive ligand-receptor interaction, Glutamatergic synapse	Riluzole 💬	Riluzole	[9] 2, 3, 5, 8, 13, 17, 18, 203, 206 💬
152	GRIK4 💬	[2] Neuroactive ligand-receptor interaction, Glutamatergic synapse	Riluzole 💬	Riluzole	[9] 2, 3, 5, 8, 13, 17, 18, 203, 206 💬
153	GRIK5 💬	[2] Neuroactive ligand-receptor interaction, Glutamatergic synapse	Riluzole 💬	Riluzole	[9] 2, 3, 5, 8, 13, 17, 18, 203, 206 💬
154	GRIN1 💬	[18] Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism	Riluzole 💬	Riluzole	[9] 2, 3, 5, 8, 13, 17, 18, 203, 206 💬
155	GRIN1 💬	[18] Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism	Dextromethorphan 💬	Dextromethorphan	[11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
156	GRIN1 💬	[18] Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism	Amantadine 💬	Amantadine	[4] 6, 8, 13, 127 💬
157	GRIN1 💬	[18] Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism	Ketamine 💬	Ketamine	[8] 2, 4, 6, 13, 70, 113, 156, 215 💬
158	GRIN1 💬	[18] Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism	Memantine 💬	Memantine	[8] 2, 6, 8, 13, 49, 127, 205, 206 💬
159	GRIN2A 💬	[19] Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism, Systemic lupus erythematosus	Riluzole 💬	Riluzole	[9] 2, 3, 5, 8, 13, 17, 18, 203, 206 💬
160	GRIN2A 💬	[19] Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism, Systemic lupus erythematosus	Dextromethorphan 💬	Dextromethorphan	[11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
161	GRIN2A 💬	[19] Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism, Systemic lupus erythematosus	Amantadine 💬	Amantadine	[4] 6, 8, 13, 127 💬
162	GRIN2A 💬	[19] Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism, Systemic lupus erythematosus	Ketamine 💬	Ketamine	[8] 2, 4, 6, 13, 70, 113, 156, 215 💬
163	GRIN2A 💬	[19] Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism, Systemic lupus erythematosus	Memantine 💬	Memantine	[8] 2, 6, 8, 13, 49, 127, 205, 206 💬
164	GRIN2B 💬	[19] Ras signaling pathway, Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism, Systemic lupus erythematosus	Riluzole 💬	Riluzole	[9] 2, 3, 5, 8, 13, 17, 18, 203, 206 💬
165	GRIN2B 💬	[19] Ras signaling pathway, Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism, Systemic lupus erythematosus	Dextromethorphan 💬	Dextromethorphan	[11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
166	GRIN2B 💬	[19] Ras signaling pathway, Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism, Systemic lupus erythematosus	Amantadine 💬	Amantadine	[4] 6, 8, 13, 127 💬
167	GRIN2B 💬	[19] Ras signaling pathway, Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism, Systemic lupus erythematosus	Ketamine 💬	Ketamine	[8] 2, 4, 6, 13, 70, 113, 156, 215 💬
168	GRIN2B 💬	[19] Ras signaling pathway, Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism, Systemic lupus erythematosus	Memantine 💬	Memantine	[8] 2, 6, 8, 13, 49, 127, 205, 206 💬
169	GRIN2C 💬	[15] Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism	Riluzole 💬	Riluzole	[9] 2, 3, 5, 8, 13, 17, 18, 203, 206 💬
170	GRIN2C 💬	[15] Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism	Dextromethorphan 💬	Dextromethorphan	[11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
171	GRIN2C 💬	[15] Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism	Amantadine 💬	Amantadine	[4] 6, 8, 13, 127 💬
172	GRIN2C 💬	[15] Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism	Ketamine 💬	Ketamine	[8] 2, 4, 6, 13, 70, 113, 156, 215 💬
173	GRIN2C 💬	[15] Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism	Memantine 💬	Memantine	[8] 2, 6, 8, 13, 49, 127, 205, 206 💬
174	GRIN2D 💬	[15] Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism	Riluzole 💬	Riluzole	[9] 2, 3, 5, 8, 13, 17, 18, 203, 206 💬
175	GRIN2D 💬	[15] Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism	Dextromethorphan 💬	Dextromethorphan	[11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
176	GRIN2D 💬	[15] Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism	Amantadine 💬	Amantadine	[4] 6, 8, 13, 127 💬
177	GRIN2D 💬	[15] Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism	Ketamine 💬	Ketamine	[8] 2, 4, 6, 13, 70, 113, 156, 215 💬
178	GRIN2D 💬	[15] Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism	Memantine 💬	Memantine	[8] 2, 6, 8, 13, 49, 127, 205, 206 💬
179	NR3C1 💬	[1] Neuroactive ligand-receptor interaction	Dexamethasone 💬	Dexamethasone	[22] 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 81, 84, 96, 97, 162, 222, 235, 257, 283, 296, 299 💬
180	NR3C1 💬	[1] Neuroactive ligand-receptor interaction	Methylprednisolone 💬	Methylprednisolone	[46] 2, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 95, 96, 97, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬
181	NR3C1 💬	[1] Neuroactive ligand-receptor interaction	Prednisolone 💬	Prednisolone	[42] 3, 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬
182	NR3C1 💬	[1] Neuroactive ligand-receptor interaction	Prednisone 💬	Prednisone	[45] 2, 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 95, 96, 97, 113, 162, 164, 205, 222, 224, 228, 283, 284, 288, 299, 300, 307, 331 💬
183	NR3C1 💬	[1] Neuroactive ligand-receptor interaction	Methylprednisolone hemisuccinate 💬	Methylprednisolone hemisuccinate	[7] 13, 49, 50, 51, 53, 97, 211 💬
184	HCRTR1 💬	[1] Neuroactive ligand-receptor interaction	Suvorexant 💬	Suvorexant	[3] 5, 6, 13 💬
185	HCRTR2 💬	[1] Neuroactive ligand-receptor interaction	Suvorexant 💬	Suvorexant	[3] 5, 6, 13 💬
186	HMGCR 💬	[4] Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion	Simvastatin 💬	Simvastatin	[21] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬
187	HMGCR 💬	[4] Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion	Atorvastatin 💬	Atorvastatin	[19] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299 💬
188	HMGCR 💬	[4] Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion	Pravastatin 💬	Pravastatin	[9] 13, 46, 49, 67, 79, 96, 164, 265, 333 💬
189	HPRT1 💬	[4] Purine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism	Tioguanine 💬	Tioguanine	[2] 13, 37 💬
190	HRH1 💬	[3] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels	Diphenhydramine 💬	Diphenhydramine	[8] 11, 13, 49, 51, 70, 86, 222, 256 💬
191	HRH1 💬	[3] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels	Loratadine 💬	Loratadine	[4] 13, 46, 89, 98 💬
192	HRH1 💬	[3] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels	Clemastine 💬	Clemastine	[1] 13 💬
193	HRH1 💬	[3] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels	Desloratadine 💬	Desloratadine	[1] 13 💬
194	HRH1 💬	[3] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels	Cetirizine 💬	Cetirizine	[4] 13, 28, 35, 300 💬
195	HRH1 💬	[3] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels	Dexchlorpheniramine 💬	Dexchlorpheniramine	[2] 13, 49 💬
196	HRH1 💬	[3] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels	Fexofenadine 💬	Fexofenadine	[2] 13, 46 💬
197	HRH2 💬	[3] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gastric acid secretion	Ranitidine 💬	Ranitidine	[2] 13, 65 💬
198	HTR2A 💬	[5] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels	Cisapride 💬	Cisapride	[1] 13 💬
199	HTR2A 💬	[5] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels	Cisapride 💬	Cisapride	[1] 13 💬
200	HTR2A 💬	[5] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels	Quetiapine 💬	Quetiapine	[2] 6, 13 💬
201	HTR3A 💬	[2] Serotonergic synapse, Taste transduction	Cisapride 💬	Cisapride	[1] 13 💬
202	HTR3A 💬	[2] Serotonergic synapse, Taste transduction	Cisapride 💬	Cisapride	[1] 13 💬
203	HTR4 💬	[4] Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse	Cisapride 💬	Cisapride	[1] 13 💬
204	HTR4 💬	[4] Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse	Cisapride 💬	Cisapride	[1] 13 💬
205	HTR4 💬	[4] Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse	Prucalopride 💬	Prucalopride	[3] 13, 51, 96 💬
206	IFNAR1 💬	[18] Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, Necroptosis, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, Hepatitis C, Hepatitis B, Measles, Influenza A, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Coronavirus disease - COVID-19, Pathways in cancer	Interferon beta-1b 💬	Interferon beta-1b	[1] 13 💬
207	IFNAR1 💬	[18] Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, Necroptosis, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, Hepatitis C, Hepatitis B, Measles, Influenza A, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Coronavirus disease - COVID-19, Pathways in cancer	Interferon alfa 💬	Interferon alfa	[6] 13, 25, 26, 28, 56, 96 💬
208	IFNAR1 💬	[18] Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, Necroptosis, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, Hepatitis C, Hepatitis B, Measles, Influenza A, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Coronavirus disease - COVID-19, Pathways in cancer	Interferon beta-1a 💬	Interferon beta-1a	[4] 13, 26, 96, 97 💬
209	IFNAR1 💬	[18] Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, Necroptosis, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, Hepatitis C, Hepatitis B, Measles, Influenza A, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Coronavirus disease - COVID-19, Pathways in cancer	Peginterferon beta-1a 💬	Peginterferon beta-1a	[1] 13 💬
210	IFNAR2 💬	[17] Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, Necroptosis, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, Hepatitis C, Measles, Influenza A, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Coronavirus disease - COVID-19, Pathways in cancer	Interferon beta-1b 💬	Interferon beta-1b	[1] 13 💬
211	IFNAR2 💬	[17] Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, Necroptosis, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, Hepatitis C, Measles, Influenza A, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Coronavirus disease - COVID-19, Pathways in cancer	Interferon alfa 💬	Interferon alfa	[6] 13, 25, 26, 28, 56, 96 💬
212	IFNAR2 💬	[17] Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, Necroptosis, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, Hepatitis C, Measles, Influenza A, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Coronavirus disease - COVID-19, Pathways in cancer	Interferon beta-1a 💬	Interferon beta-1a	[4] 13, 26, 96, 97 💬
213	IFNAR2 💬	[17] Cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, Necroptosis, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, Hepatitis C, Measles, Influenza A, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Coronavirus disease - COVID-19, Pathways in cancer	Peginterferon beta-1a 💬	Peginterferon beta-1a	[1] 13 💬
214	IL1A 💬	[21] MAPK signaling pathway, Cytokine-cytokine receptor interaction, Necroptosis, Cellular senescence, Osteoclast differentiation, Hematopoietic cell lineage, Non-alcoholic fatty liver disease, AGE-RAGE signaling pathway in diabetic complications, Type I diabetes mellitus, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pertussis, Leishmaniasis, Tuberculosis, Measles, Influenza A, Inflammatory bowel disease, Rheumatoid arthritis, Graft-versus-host disease, Fluid shear stress and atherosclerosis	Pirfenidone 💬	Pirfenidone	[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
215	IL1B 💬	[44] Antifolate resistance, MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Necroptosis, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, C-type lectin receptor signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Th17 cell differentiation, TNF signaling pathway, Inflammatory mediator regulation of TRP channels, Non-alcoholic fatty liver disease, AGE-RAGE signaling pathway in diabetic complications, Alcoholic liver disease, Type I diabetes mellitus, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Legionellosis, Yersinia infection, Leishmaniasis, Chagas disease, African trypanosomiasis, Malaria, Amoebiasis, Tuberculosis, Measles, Human cytomegalovirus infection, Influenza A, Herpes simplex virus 1 infection, Coronavirus disease - COVID-19, Inflammatory bowel disease, Rheumatoid arthritis, Graft-versus-host disease, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis	Pirfenidone 💬	Pirfenidone	[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
216	IL1R1 💬	[13] MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Osteoclast differentiation, Hematopoietic cell lineage, Th17 cell differentiation, Inflammatory mediator regulation of TRP channels, Pathogenic Escherichia coli infection, Shigellosis, Amoebiasis, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Fluid shear stress and atherosclerosis	Anakinra 💬	Anakinra	[18] 2, 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
217	IL2RA 💬	[11] Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Endocytosis, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Hematopoietic cell lineage, Th1 and Th2 cell differentiation, Th17 cell differentiation, Measles, Human T-cell leukemia virus 1 infection, Pathways in cancer	Daclizumab 💬	Daclizumab	[8] 13, 56, 60, 65, 97, 107, 283, 284 💬
218	IL6 💬	[51] EGFR tyrosine kinase inhibitor resistance, Antifolate resistance, Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, HIF-1 signaling pathway, FoxO signaling pathway, PI3K-Akt signaling pathway, Cellular senescence, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, C-type lectin receptor signaling pathway, JAK-STAT signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Th17 cell differentiation, TNF signaling pathway, Intestinal immune network for IgA production, Insulin resistance, Non-alcoholic fatty liver disease, AGE-RAGE signaling pathway in diabetic complications, Alcoholic liver disease, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Salmonella infection, Pertussis, Legionellosis, Yersinia infection, Chagas disease, African trypanosomiasis, Malaria, Amoebiasis, Tuberculosis, Hepatitis B, Measles, Human cytomegalovirus infection, Influenza A, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Coronavirus disease - COVID-19, Pathways in cancer, Transcriptional misregulation in cancer, Inflammatory bowel disease, Rheumatoid arthritis, Graft-versus-host disease, Hypertrophic cardiomyopathy, Lipid and atherosclerosis	Pirfenidone 💬	Pirfenidone	[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
219	IL6R 💬	[12] EGFR tyrosine kinase inhibitor resistance, Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, HIF-1 signaling pathway, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Hematopoietic cell lineage, Th17 cell differentiation, Non-alcoholic fatty liver disease, Human cytomegalovirus infection, Coronavirus disease - COVID-19, Pathways in cancer	Tocilizumab 💬	Tocilizumab	[21] 2, 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬
220	IL6R 💬	[12] EGFR tyrosine kinase inhibitor resistance, Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, HIF-1 signaling pathway, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Hematopoietic cell lineage, Th17 cell differentiation, Non-alcoholic fatty liver disease, Human cytomegalovirus infection, Coronavirus disease - COVID-19, Pathways in cancer	Satralizumab 💬	Satralizumab	[3] 11, 13, 86 💬
221	IL10 💬	[22] Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, FoxO signaling pathway, C-type lectin receptor signaling pathway, JAK-STAT signaling pathway, T cell receptor signaling pathway, Intestinal immune network for IgA production, Pertussis, Yersinia infection, Leishmaniasis, Chagas disease, African trypanosomiasis, Malaria, Toxoplasmosis, Amoebiasis, Staphylococcus aureus infection, Tuberculosis, Asthma, Autoimmune thyroid disease, Inflammatory bowel disease, Systemic lupus erythematosus, Allograft rejection	Pirfenidone 💬	Pirfenidone	[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
222	IL17A 💬	[6] Cytokine-cytokine receptor interaction, IL-17 signaling pathway, Th17 cell differentiation, Alcoholic liver disease, Inflammatory bowel disease, Rheumatoid arthritis	Secukinumab 💬	Secukinumab	[8] 13, 37, 41, 46, 107, 160, 269, 271 💬
223	IMPDH1 💬	[4] Purine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism	Mycophenolate mofetil 💬	Mycophenolate mofetil	[34] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬
224	IMPDH1 💬	[4] Purine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism	Mycophenolic acid 💬	Mycophenolic acid	[36] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 💬
225	IMPDH2 💬	[4] Purine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism	Mycophenolate mofetil 💬	Mycophenolate mofetil	[34] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬
226	IMPDH2 💬	[4] Purine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism	Mycophenolic acid 💬	Mycophenolic acid	[36] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 💬
227	ITGA4 💬	[14] PI3K-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, Cell adhesion molecules, Hematopoietic cell lineage, Leukocyte transendothelial migration, Intestinal immune network for IgA production, Regulation of actin cytoskeleton, Yersinia infection, Leishmaniasis, Human papillomavirus infection, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy	Firategrast 💬	Firategrast	[1] 13 💬
228	ITGA4 💬	[14] PI3K-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, Cell adhesion molecules, Hematopoietic cell lineage, Leukocyte transendothelial migration, Intestinal immune network for IgA production, Regulation of actin cytoskeleton, Yersinia infection, Leishmaniasis, Human papillomavirus infection, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy	Natalizumab 💬	Natalizumab	[6] 13, 15, 25, 46, 63, 96 💬
229	AR 💬	[4] Oocyte meiosis, Pathways in cancer, Chemical carcinogenesis - receptor activation, Prostate cancer	Testosterone 💬	Testosterone	[8] 1, 2, 3, 13, 60, 76, 78, 113 💬
230	AR 💬	[4] Oocyte meiosis, Pathways in cancer, Chemical carcinogenesis - receptor activation, Prostate cancer	Testosterone undecanoate 💬	Testosterone undecanoate	[2] 13, 60 💬
231	ITGAL 💬	[12] Rap1 signaling pathway, Cell adhesion molecules, Neutrophil extracellular trap formation, Natural killer cell mediated cytotoxicity, Leukocyte transendothelial migration, Regulation of actin cytoskeleton, Malaria, Staphylococcus aureus infection, Human T-cell leukemia virus 1 infection, Epstein-Barr virus infection, Rheumatoid arthritis, Viral myocarditis	Efalizumab 💬	Efalizumab	[9] 11, 13, 37, 46, 49, 53, 61, 95, 96 💬
232	KCNA4 💬	[2] Cortisol synthesis and secretion, Cushing syndrome	Dalfampridine 💬	Dalfampridine	[5] 3, 4, 6, 13, 14 💬
233	KCNC3 💬	[1] Spinocerebellar ataxia	Dalfampridine 💬	Dalfampridine	[5] 3, 4, 6, 13, 14 💬
234	KCND2 💬	[1] Serotonergic synapse	Dalfampridine 💬	Dalfampridine	[5] 3, 4, 6, 13, 14 💬
235	KCND3 💬	[1] Spinocerebellar ataxia	Dalfampridine 💬	Dalfampridine	[5] 3, 4, 6, 13, 14 💬
236	KCNJ11 💬	[3] Insulin secretion, GnRH secretion, Type II diabetes mellitus	Diazoxide 💬	Diazoxide	[2] 13, 193 💬
237	CA13 💬	[2] Nitrogen metabolism, Metabolic pathways	Acetazolamide 💬	Acetazolamide	[8] 13, 86, 90, 115, 154, 155, 225, 230 💬
238	KIT 💬	[11] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer	Imatinib 💬	Imatinib	[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
239	KIT 💬	[11] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer, Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer	Masitinib 💬	Masitinib	[6] 2, 5, 6, 13, 46, 96 💬
240	LTB 💬	[3] Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Rheumatoid arthritis	Baminercept 💬	Baminercept	[4] 13, 46, 53, 97 💬
241	MC2R 💬	[5] cAMP signaling pathway, Neuroactive ligand-receptor interaction, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, Cushing syndrome	Corticotropin 💬	Corticotropin	[12] 2, 13, 14, 46, 49, 50, 66, 75, 81, 84, 145, 222 💬
242	ACHE 💬	[2] Glycerophospholipid metabolism, Cholinergic synapse	Rivastigmine 💬	Rivastigmine	[3] 5, 6, 13 💬
243	ACHE 💬	[2] Glycerophospholipid metabolism, Cholinergic synapse	Donepezil 💬	Donepezil	[9] 5, 6, 13, 46, 78, 124, 127, 156, 206 💬
244	MTNR1A 💬	[2] Neuroactive ligand-receptor interaction, Circadian entrainment	Melatonin 💬	Melatonin	[12] 6, 8, 13, 37, 46, 49, 72, 78, 90, 97, 145, 202 💬
245	MTNR1B 💬	[2] Neuroactive ligand-receptor interaction, Circadian entrainment	Melatonin 💬	Melatonin	[12] 6, 8, 13, 37, 46, 49, 72, 78, 90, 97, 145, 202 💬
246	ATP4A 💬	[4] Oxidative phosphorylation, Metabolic pathways, Collecting duct acid secretion, Gastric acid secretion	Pantoprazole 💬	Pantoprazole	[2] 13, 65 💬
247	ATP4A 💬	[4] Oxidative phosphorylation, Metabolic pathways, Collecting duct acid secretion, Gastric acid secretion	Esomeprazole 💬	Esomeprazole	[8] 13, 46, 86, 98, 107, 113, 298, 299 💬
248	ATP4B 💬	[4] Oxidative phosphorylation, Metabolic pathways, Collecting duct acid secretion, Gastric acid secretion	Pantoprazole 💬	Pantoprazole	[2] 13, 65 💬
249	ATP4B 💬	[4] Oxidative phosphorylation, Metabolic pathways, Collecting duct acid secretion, Gastric acid secretion	Esomeprazole 💬	Esomeprazole	[8] 13, 46, 86, 98, 107, 113, 298, 299 💬
250	OPRD1 💬	[3] cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction	Naltrexone 💬	Naltrexone	[13] 6, 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226 💬
251	OPRD1 💬	[3] cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction	Oxycodone 💬	Oxycodone	[5] 6, 13, 70, 226, 298 💬
252	OPRD1 💬	[3] cGMP-PKG signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction	Loperamide 💬	Loperamide	[2] 13, 97 💬
253	OPRK1 💬	[1] Neuroactive ligand-receptor interaction	Naltrexone 💬	Naltrexone	[13] 6, 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226 💬
254	OPRK1 💬	[1] Neuroactive ligand-receptor interaction	Oxycodone 💬	Oxycodone	[5] 6, 13, 70, 226, 298 💬
255	OPRK1 💬	[1] Neuroactive ligand-receptor interaction	Loperamide 💬	Loperamide	[2] 13, 97 💬
256	OPRM1 💬	[3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction	Naltrexone 💬	Naltrexone	[13] 6, 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226 💬
257	OPRM1 💬	[3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction	Oxycodone 💬	Oxycodone	[5] 6, 13, 70, 226, 298 💬
258	OPRM1 💬	[3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction	Loperamide 💬	Loperamide	[2] 13, 97 💬
259	APH1A 💬	[2] Notch signaling pathway, Alzheimer disease	Tarenflurbil 💬	Tarenflurbil	[1] 13 💬
260	PDCD1 💬	[3] Cell adhesion molecules, T cell receptor signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer	Nivolumab 💬	Nivolumab	[12] 13, 26, 41, 46, 49, 50, 51, 53, 85, 96, 97, 159 💬
261	PDE3A 💬	[6] Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway, cAMP signaling pathway, Renin secretion, Morphine addiction	Ibudilast 💬	Ibudilast	[2] 2, 13 💬
262	PDE3B 💬	[11] Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway, cAMP signaling pathway, Apelin signaling pathway, Insulin signaling pathway, Progesterone-mediated oocyte maturation, Glucagon signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction	Ibudilast 💬	Ibudilast	[2] 2, 13 💬
263	PDE4A 💬	[5] Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction	Ibudilast 💬	Ibudilast	[2] 2, 13 💬
264	PDE4A 💬	[5] Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction	Rolipram 💬	Rolipram	[2] 8, 13 💬
265	PDE4B 💬	[5] Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction	Ibudilast 💬	Ibudilast	[2] 2, 13 💬
266	PDE4B 💬	[5] Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction	Rolipram 💬	Rolipram	[2] 8, 13 💬
267	PDE4C 💬	[5] Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction	Ibudilast 💬	Ibudilast	[2] 2, 13 💬
268	PDE4C 💬	[5] Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction	Rolipram 💬	Rolipram	[2] 8, 13 💬
269	PDE4D 💬	[5] Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction	Ibudilast 💬	Ibudilast	[2] 2, 13 💬
270	PDE4D 💬	[5] Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction	Rolipram 💬	Rolipram	[2] 8, 13 💬
271	PDGFRA 💬	[20] EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, Phospholipase D signaling pathway, Endocytosis, PI3K-Akt signaling pathway, Focal adhesion, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, Human cytomegalovirus infection, Pathways in cancer, MicroRNAs in cancer, Glioma, Prostate cancer, Melanoma, Central carbon metabolism in cancer, Choline metabolism in cancer	Imatinib 💬	Imatinib	[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
272	PGR 💬	[5] Oocyte meiosis, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Chemical carcinogenesis - receptor activation, Breast cancer	Norethindrone 💬	Norethisterone	[4] 13, 46, 49, 299 💬
273	PGR 💬	[5] Oocyte meiosis, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Chemical carcinogenesis - receptor activation, Breast cancer	Levonorgestrel 💬	Levonorgestrel	[1] 13 💬
274	PGR 💬	[5] Oocyte meiosis, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Chemical carcinogenesis - receptor activation, Breast cancer	Medroxyprogesterone acetate 💬	Medroxyprogesterone acetate	[8] 13, 35, 46, 49, 50, 51, 60, 107 💬
275	PGR 💬	[5] Oocyte meiosis, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Chemical carcinogenesis - receptor activation, Breast cancer	Dydrogesterone 💬	Dydrogesterone	[1] 13 💬
276	PGR 💬	[5] Oocyte meiosis, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Chemical carcinogenesis - receptor activation, Breast cancer	Nomegestrol 💬	Nomegestrol	[1] 13 💬
277	PGR 💬	[5] Oocyte meiosis, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Chemical carcinogenesis - receptor activation, Breast cancer	Nomegestrol acetate 💬	Nomegestrol acetate	[1] 13 💬
278	S1PR5 💬	[2] Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction	Ozanimod 💬	Ozanimod	[3] 13, 96, 97 💬
279	S1PR5 💬	[2] Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction	Siponimod 💬	Siponimod	[2] 13, 50 💬
280	PPARG 💬	[11] PPAR signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Osteoclast differentiation, Thermogenesis, Non-alcoholic fatty liver disease, Huntington disease, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Lipid and atherosclerosis	Pioglitazone 💬	Pioglitazone	[17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
281	PPP3CA 💬	[33] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Oocyte meiosis, Cellular senescence, Wnt signaling pathway, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Tuberculosis, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis	Tacrolimus 💬	Tacrolimus	[34] 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
282	PPP3CA 💬	[33] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Oocyte meiosis, Cellular senescence, Wnt signaling pathway, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Tuberculosis, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis	Tacrolimus 💬	Tacrolimus	[34] 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
283	PPP3CB 💬	[33] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Oocyte meiosis, Cellular senescence, Wnt signaling pathway, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Tuberculosis, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis	Tacrolimus 💬	Tacrolimus	[34] 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
284	PPP3CB 💬	[33] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Oocyte meiosis, Cellular senescence, Wnt signaling pathway, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Tuberculosis, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis	Tacrolimus 💬	Tacrolimus	[34] 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
285	PPP3CC 💬	[33] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Oocyte meiosis, Cellular senescence, Wnt signaling pathway, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Tuberculosis, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis	Tacrolimus 💬	Tacrolimus	[34] 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
286	PPP3CC 💬	[33] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Oocyte meiosis, Cellular senescence, Wnt signaling pathway, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Tuberculosis, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis	Tacrolimus 💬	Tacrolimus	[34] 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
287	PPP3R1 💬	[32] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Oocyte meiosis, Cellular senescence, Wnt signaling pathway, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Long-term potentiation, Glutamatergic synapse, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Tuberculosis, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis	Tacrolimus 💬	Tacrolimus	[34] 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
288	PPP3R1 💬	[32] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Oocyte meiosis, Cellular senescence, Wnt signaling pathway, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Long-term potentiation, Glutamatergic synapse, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Tuberculosis, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis	Tacrolimus 💬	Tacrolimus	[34] 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
289	PPP3R2 💬	[32] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Oocyte meiosis, Cellular senescence, Wnt signaling pathway, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Long-term potentiation, Glutamatergic synapse, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Tuberculosis, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis	Tacrolimus 💬	Tacrolimus	[34] 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
290	PPP3R2 💬	[32] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Oocyte meiosis, Cellular senescence, Wnt signaling pathway, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Long-term potentiation, Glutamatergic synapse, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Tuberculosis, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis	Tacrolimus 💬	Tacrolimus	[34] 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
291	CHRNA9 💬	[2] Neuroactive ligand-receptor interaction, Chemical carcinogenesis - receptor activation	Nicotine 💬	Nicotine	[3] 6, 13, 84 💬
292	PRKAA1 💬	[20] FoxO signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Apelin signaling pathway, Tight junction, Circadian rhythm, Thermogenesis, Insulin signaling pathway, Adipocytokine signaling pathway, Oxytocin signaling pathway, Glucagon signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease, Alcoholic liver disease, Hypertrophic cardiomyopathy, Fluid shear stress and atherosclerosis	Metformin 💬	Metformin	[25] 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
293	PRKAA2 💬	[20] FoxO signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Apelin signaling pathway, Tight junction, Circadian rhythm, Thermogenesis, Insulin signaling pathway, Adipocytokine signaling pathway, Oxytocin signaling pathway, Glucagon signaling pathway, Insulin resistance, Non-alcoholic fatty liver disease, Alcoholic liver disease, Hypertrophic cardiomyopathy, Fluid shear stress and atherosclerosis	Metformin 💬	Metformin	[25] 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
294	CACNA2D3 💬	[7] MAPK signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Oxytocin signaling pathway, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy	Gabapentin 💬	Gabapentin	[5] 6, 13, 19, 70, 298 💬
295	CACNA2D3 💬	[7] MAPK signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Oxytocin signaling pathway, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy	Pregabalin 💬	Pregabalin	[5] 13, 36, 46, 70, 298 💬
296	PSENEN 💬	[2] Notch signaling pathway, Alzheimer disease	Tarenflurbil 💬	Tarenflurbil	[1] 13 💬
297	GABRQ 💬	[5] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction	Midazolam 💬	Midazolam	[12] 2, 3, 6, 13, 21, 46, 70, 96, 97, 272, 298, 299 💬
298	GABRQ 💬	[5] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction	Flumazenil 💬	Flumazenil	[5] 6, 13, 17, 18, 206 💬
299	GABRQ 💬	[5] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction	Eszopiclone 💬	Eszopiclone	[3] 6, 13, 46 💬
300	PSEN1 💬	[6] Wnt signaling pathway, Notch signaling pathway, Neurotrophin signaling pathway, Alzheimer disease, Pathways of neurodegeneration - multiple diseases, Human papillomavirus infection	Tarenflurbil 💬	Tarenflurbil	[1] 13 💬
301	PSMB5 💬	[8] Proteasome, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases	Bortezomib 💬	Bortezomib	[17] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 222, 228, 256, 283, 288, 331 💬
302	PSMB5 💬	[8] Proteasome, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases	Ixazomib 💬	Ixazomib	[5] 13, 16, 28, 51, 61 💬
303	RGMA 💬	[2] TGF-beta signaling pathway, Axon guidance	Elezanumab 💬	Elezanumab	[1] 13 💬
304	CHRNA10 💬	[1] Neuroactive ligand-receptor interaction	Nicotine 💬	Nicotine	[3] 6, 13, 84 💬
305	PTGDR 💬	[1] Neuroactive ligand-receptor interaction	Ramatroban 💬	Ramatroban	[1] 13 💬
306	PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Platelet activation	Ibudilast 💬	Ibudilast	[2] 2, 13 💬
307	PTGS1 💬	[5] Arachidonic acid metabolism, Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes	Aspirin 💬	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬
308	PTGS1 💬	[5] Arachidonic acid metabolism, Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes	Naproxen 💬	Naproxen	[4] 13, 46, 107, 271 💬
309	PTGS1 💬	[5] Arachidonic acid metabolism, Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes	Ibuprofen 💬	Ibuprofen	[7] 13, 46, 65, 107, 113, 271, 299 💬
310	PTGS1 💬	[5] Arachidonic acid metabolism, Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes	Acetaminophen 💬	Acetaminophen	[15] 3, 6, 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬
311	PTGS1 💬	[5] Arachidonic acid metabolism, Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes	Flurbiprofen 💬	Flurbiprofen	[3] 13, 21, 46 💬
312	PTGS1 💬	[5] Arachidonic acid metabolism, Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes	Diclofenac 💬	Diclofenac	[5] 13, 34, 46, 78, 271 💬
313	PTGS2 💬	[22] Arachidonic acid metabolism, Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, C-type lectin receptor signaling pathway, IL-17 signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Alzheimer disease, Pathways of neurodegeneration - multiple diseases, Leishmaniasis, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Chemical carcinogenesis - DNA adducts, MicroRNAs in cancer, Small cell lung cancer	Aspirin 💬	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬
314	PTGS2 💬	[22] Arachidonic acid metabolism, Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, C-type lectin receptor signaling pathway, IL-17 signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Alzheimer disease, Pathways of neurodegeneration - multiple diseases, Leishmaniasis, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Chemical carcinogenesis - DNA adducts, MicroRNAs in cancer, Small cell lung cancer	Naproxen 💬	Naproxen	[4] 13, 46, 107, 271 💬
315	PTGS2 💬	[22] Arachidonic acid metabolism, Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, C-type lectin receptor signaling pathway, IL-17 signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Alzheimer disease, Pathways of neurodegeneration - multiple diseases, Leishmaniasis, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Chemical carcinogenesis - DNA adducts, MicroRNAs in cancer, Small cell lung cancer	Ibuprofen 💬	Ibuprofen	[7] 13, 46, 65, 107, 113, 271, 299 💬
316	PTGS2 💬	[22] Arachidonic acid metabolism, Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, C-type lectin receptor signaling pathway, IL-17 signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Alzheimer disease, Pathways of neurodegeneration - multiple diseases, Leishmaniasis, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Chemical carcinogenesis - DNA adducts, MicroRNAs in cancer, Small cell lung cancer	Acetaminophen 💬	Acetaminophen	[15] 3, 6, 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬
317	PTGS2 💬	[22] Arachidonic acid metabolism, Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, C-type lectin receptor signaling pathway, IL-17 signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Alzheimer disease, Pathways of neurodegeneration - multiple diseases, Leishmaniasis, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Chemical carcinogenesis - DNA adducts, MicroRNAs in cancer, Small cell lung cancer	Flurbiprofen 💬	Flurbiprofen	[3] 13, 21, 46 💬
318	PTGS2 💬	[22] Arachidonic acid metabolism, Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, C-type lectin receptor signaling pathway, IL-17 signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Alzheimer disease, Pathways of neurodegeneration - multiple diseases, Leishmaniasis, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Chemical carcinogenesis - DNA adducts, MicroRNAs in cancer, Small cell lung cancer	Diclofenac 💬	Diclofenac	[5] 13, 34, 46, 78, 271 💬
319	RARA 💬	[5] Th17 cell differentiation, Estrogen signaling pathway, Pathways in cancer, Transcriptional misregulation in cancer, Acute myeloid leukemia	Vitamin A 💬	Vitamin A	[3] 13, 53, 90 💬
320	RARB 💬	[4] Pathways in cancer, Small cell lung cancer, Non-small cell lung cancer, Gastric cancer	Vitamin A 💬	Vitamin A	[3] 13, 53, 90 💬
321	RRM1 💬	[6] Purine metabolism, Pyrimidine metabolism, Glutathione metabolism, Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism	Cladribine 💬	Cladribine	[3] 11, 13, 94 💬
322	RRM1 💬	[6] Purine metabolism, Pyrimidine metabolism, Glutathione metabolism, Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism	Fludarabine 💬	Fludarabine	[20] 11, 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 286, 326 💬
323	RRM2 💬	[7] Purine metabolism, Pyrimidine metabolism, Glutathione metabolism, Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism, p53 signaling pathway	Hydroxyurea 💬	Hydroxyurea	[8] 3, 13, 19, 20, 65, 85, 86, 284 💬
324	RXRA 💬	[17] PPAR signaling pathway, PI3K-Akt signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Adipocytokine signaling pathway, Parathyroid hormone synthesis, secretion and action, Non-alcoholic fatty liver disease, Bile secretion, Hepatitis C, Pathways in cancer, Transcriptional misregulation in cancer, Chemical carcinogenesis - receptor activation, Thyroid cancer, Small cell lung cancer, Non-small cell lung cancer, Gastric cancer, Lipid and atherosclerosis	Bexarotene 💬	Bexarotene	[2] 13, 75 💬
325	RXRB 💬	[13] PPAR signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Adipocytokine signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Transcriptional misregulation in cancer, Chemical carcinogenesis - receptor activation, Thyroid cancer, Small cell lung cancer, Non-small cell lung cancer, Gastric cancer, Lipid and atherosclerosis	Bexarotene 💬	Bexarotene	[2] 13, 75 💬
326	RXRG 💬	[13] PPAR signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Adipocytokine signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Transcriptional misregulation in cancer, Chemical carcinogenesis - receptor activation, Thyroid cancer, Small cell lung cancer, Non-small cell lung cancer, Gastric cancer, Lipid and atherosclerosis	Bexarotene 💬	Bexarotene	[2] 13, 75 💬
327	SCN1A 💬	[1] Dopaminergic synapse	Carbamazepine 💬	Carbamazepine	[3] 6, 13, 231 💬
328	SCN1A 💬	[1] Dopaminergic synapse	Lamotrigine 💬	Lamotrigine	[5] 13, 34, 38, 114, 144 💬
329	SCN1A 💬	[1] Dopaminergic synapse	Lidocaine 💬	Lidocaine	[13] 6, 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬
330	SCN1A 💬	[1] Dopaminergic synapse	Phenytoin 💬	Phenytoin	[1] 13 💬
331	SCN1A 💬	[1] Dopaminergic synapse	Oxcarbazepine 💬	Oxcarbazepine	[1] 13 💬
332	SCN1A 💬	[1] Dopaminergic synapse	Lidocaine hydrochloride monohydrate 💬	Lidocaine	[13] 6, 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬
333	SCN1A 💬	[1] Dopaminergic synapse	Quinidine 💬	Quinidine	[3] 2, 8, 13 💬
334	SCN2A 💬	[1] Taste transduction	Carbamazepine 💬	Carbamazepine	[3] 6, 13, 231 💬
335	SCN2A 💬	[1] Taste transduction	Lamotrigine 💬	Lamotrigine	[5] 13, 34, 38, 114, 144 💬
336	SCN2A 💬	[1] Taste transduction	Lidocaine 💬	Lidocaine	[13] 6, 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬
337	SCN2A 💬	[1] Taste transduction	Phenytoin 💬	Phenytoin	[1] 13 💬
338	SCN2A 💬	[1] Taste transduction	Oxcarbazepine 💬	Oxcarbazepine	[1] 13 💬
339	SCN2A 💬	[1] Taste transduction	Lidocaine hydrochloride monohydrate 💬	Lidocaine	[13] 6, 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬
340	SCN2A 💬	[1] Taste transduction	Quinidine 💬	Quinidine	[3] 2, 8, 13 💬
341	SCN3A 💬	[1] Taste transduction	Carbamazepine 💬	Carbamazepine	[3] 6, 13, 231 💬
342	SCN3A 💬	[1] Taste transduction	Lamotrigine 💬	Lamotrigine	[5] 13, 34, 38, 114, 144 💬
343	SCN3A 💬	[1] Taste transduction	Lidocaine 💬	Lidocaine	[13] 6, 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬
344	SCN3A 💬	[1] Taste transduction	Phenytoin 💬	Phenytoin	[1] 13 💬
345	SCN3A 💬	[1] Taste transduction	Oxcarbazepine 💬	Oxcarbazepine	[1] 13 💬
346	SCN3A 💬	[1] Taste transduction	Lidocaine hydrochloride monohydrate 💬	Lidocaine	[13] 6, 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬
347	SCN3A 💬	[1] Taste transduction	Quinidine 💬	Quinidine	[3] 2, 8, 13 💬
348	SCN5A 💬	[1] Adrenergic signaling in cardiomyocytes	Carbamazepine 💬	Carbamazepine	[3] 6, 13, 231 💬
349	SCN5A 💬	[1] Adrenergic signaling in cardiomyocytes	Lamotrigine 💬	Lamotrigine	[5] 13, 34, 38, 114, 144 💬
350	SCN5A 💬	[1] Adrenergic signaling in cardiomyocytes	Lidocaine 💬	Lidocaine	[13] 6, 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬
351	SCN5A 💬	[1] Adrenergic signaling in cardiomyocytes	Phenytoin 💬	Phenytoin	[1] 13 💬
352	SCN5A 💬	[1] Adrenergic signaling in cardiomyocytes	Oxcarbazepine 💬	Oxcarbazepine	[1] 13 💬
353	SCN5A 💬	[1] Adrenergic signaling in cardiomyocytes	Lidocaine hydrochloride monohydrate 💬	Lidocaine	[13] 6, 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬
354	SCN5A 💬	[1] Adrenergic signaling in cardiomyocytes	Quinidine 💬	Quinidine	[3] 2, 8, 13 💬
355	SCN9A 💬	[1] Taste transduction	Carbamazepine 💬	Carbamazepine	[3] 6, 13, 231 💬
356	SCN9A 💬	[1] Taste transduction	Lamotrigine 💬	Lamotrigine	[5] 13, 34, 38, 114, 144 💬
357	SCN9A 💬	[1] Taste transduction	Lidocaine 💬	Lidocaine	[13] 6, 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬
358	SCN9A 💬	[1] Taste transduction	Phenytoin 💬	Phenytoin	[1] 13 💬
359	SCN9A 💬	[1] Taste transduction	Oxcarbazepine 💬	Oxcarbazepine	[1] 13 💬
360	SCN9A 💬	[1] Taste transduction	Lidocaine hydrochloride monohydrate 💬	Lidocaine	[13] 6, 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬
361	SCN9A 💬	[1] Taste transduction	Quinidine 💬	Quinidine	[3] 2, 8, 13 💬
362	SCNN1A 💬	[2] Taste transduction, Aldosterone-regulated sodium reabsorption	Amiloride 💬	Amiloride	[4] 13, 67, 225, 299 💬
363	SCNN1B 💬	[2] Taste transduction, Aldosterone-regulated sodium reabsorption	Amiloride 💬	Amiloride	[4] 13, 67, 225, 299 💬
364	SCNN1G 💬	[2] Taste transduction, Aldosterone-regulated sodium reabsorption	Amiloride 💬	Amiloride	[4] 13, 67, 225, 299 💬
365	CCL2 💬	[17] Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, NOD-like receptor signaling pathway, IL-17 signaling pathway, TNF signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Yersinia infection, Chagas disease, Malaria, Human cytomegalovirus infection, Influenza A, Herpes simplex virus 1 infection, Coronavirus disease - COVID-19, Rheumatoid arthritis, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis	Pirfenidone 💬	Pirfenidone	[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
366	SLC6A1 💬	[2] Synaptic vesicle cycle, GABAergic synapse	Gabapentin 💬	Gabapentin	[5] 6, 13, 19, 70, 298 💬
367	SLC6A2 💬	[1] Synaptic vesicle cycle	Methylphenidate 💬	Methylphenidate	[7] 6, 13, 34, 84, 113, 179, 206 💬
368	SLC6A2 💬	[1] Synaptic vesicle cycle	Atomoxetine 💬	Atomoxetine	[4] 6, 8, 13, 17 💬
369	SLC6A2 💬	[1] Synaptic vesicle cycle	Duloxetine 💬	Duloxetine	[2] 6, 13 💬
370	SLC6A2 💬	[1] Synaptic vesicle cycle	Lisdexamfetamine 💬	Lisdexamfetamine	[1] 13 💬
371	SLC6A2 💬	[1] Synaptic vesicle cycle	Venlafaxine 💬	Venlafaxine	[3] 6, 13, 46 💬
372	SLC6A3 💬	[7] Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism	Armodafinil 💬	Armodafinil	[3] 6, 13, 84 💬
373	SLC6A3 💬	[7] Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism	Methylphenidate 💬	Methylphenidate	[7] 6, 13, 34, 84, 113, 179, 206 💬
374	SLC6A3 💬	[7] Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism	Lisdexamfetamine 💬	Lisdexamfetamine	[1] 13 💬
375	SLC6A4 💬	[2] Synaptic vesicle cycle, Serotonergic synapse	Fluoxetine 💬	Fluoxetine	[6] 13, 17, 78, 86, 179, 206 💬
376	SLC6A4 💬	[2] Synaptic vesicle cycle, Serotonergic synapse	Paroxetine 💬	Paroxetine	[4] 6, 13, 46, 85 💬
377	SLC6A4 💬	[2] Synaptic vesicle cycle, Serotonergic synapse	Citalopram 💬	Citalopram	[7] 6, 8, 13, 18, 46, 98, 127 💬
378	SLC6A4 💬	[2] Synaptic vesicle cycle, Serotonergic synapse	Duloxetine 💬	Duloxetine	[2] 6, 13 💬
379	SLC6A4 💬	[2] Synaptic vesicle cycle, Serotonergic synapse	Escitalopram 💬	Escitalopram	[4] 2, 6, 13, 46 💬
380	SLC6A4 💬	[2] Synaptic vesicle cycle, Serotonergic synapse	Venlafaxine 💬	Venlafaxine	[3] 6, 13, 46 💬
381	SLC12A3 💬	-	Hydrochlorothiazide 💬	Hydrochlorothiazide	[4] 13, 67, 225, 235 💬
382	SLC12A3 💬	-	Indapamide 💬	Indapamide	[1] 13 💬
383	SNAP25 💬	[2] Synaptic vesicle cycle, Insulin secretion	Botulinum toxin type A 💬	Botulinum toxin type A	[14] 2, 5, 6, 7, 13, 15, 17, 36, 47, 51, 70, 113, 149, 226 💬
384	SNAP25 💬	[2] Synaptic vesicle cycle, Insulin secretion	Rimabotulinumtoxin B 💬	Botulinum toxin type B	[4] 2, 6, 13, 51 💬
385	ABCC8 💬	[3] ABC transporters, Insulin secretion, Type II diabetes mellitus	Diazoxide 💬	Diazoxide	[2] 13, 193 💬
386	TBXA2R 💬	[3] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Platelet activation	Ramatroban 💬	Ramatroban	[1] 13 💬
387	BTK 💬	[7] NF-kappa B signaling pathway, Osteoclast differentiation, Platelet activation, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Epstein-Barr virus infection, Primary immunodeficiency	Zanubrutinib 💬	Zanubrutinib	[5] 13, 63, 222, 300, 331 💬
388	BTK 💬	[7] NF-kappa B signaling pathway, Osteoclast differentiation, Platelet activation, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Epstein-Barr virus infection, Primary immunodeficiency	Fenebrutinib 💬	Fenebrutinib	[1] 13 💬
389	BTK 💬	[7] NF-kappa B signaling pathway, Osteoclast differentiation, Platelet activation, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Epstein-Barr virus infection, Primary immunodeficiency	Orelabrutinib 💬	Orelabrutinib	[4] 13, 49, 61, 63 💬
390	BTK 💬	[7] NF-kappa B signaling pathway, Osteoclast differentiation, Platelet activation, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Epstein-Barr virus infection, Primary immunodeficiency	Remibrutinib 💬	Remibrutinib	[2] 13, 53 💬
391	BTK 💬	[7] NF-kappa B signaling pathway, Osteoclast differentiation, Platelet activation, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Epstein-Barr virus infection, Primary immunodeficiency	Evobrutinib 💬	Evobrutinib	[3] 13, 46, 49 💬
392	THRA 💬	[2] Neuroactive ligand-receptor interaction, Thyroid hormone signaling pathway	Liothyronine 💬	Liothyronine	[4] 13, 78, 210, 212 💬
393	THRB 💬	[2] Neuroactive ligand-receptor interaction, Thyroid hormone signaling pathway	Liothyronine 💬	Liothyronine	[4] 13, 78, 210, 212 💬
394	TNF 💬	[67] Antifolate resistance, MAPK signaling pathway, Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, NF-kappa B signaling pathway, Sphingolipid signaling pathway, mTOR signaling pathway, Apoptosis, Necroptosis, TGF-beta signaling pathway, Osteoclast differentiation, Antigen processing and presentation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, C-type lectin receptor signaling pathway, Hematopoietic cell lineage, Natural killer cell mediated cytotoxicity, IL-17 signaling pathway, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, TNF signaling pathway, Adipocytokine signaling pathway, Type II diabetes mellitus, Insulin resistance, Non-alcoholic fatty liver disease, AGE-RAGE signaling pathway in diabetic complications, Alcoholic liver disease, Type I diabetes mellitus, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Legionellosis, Yersinia infection, Leishmaniasis, Chagas disease, African trypanosomiasis, Malaria, Toxoplasmosis, Amoebiasis, Tuberculosis, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Herpes simplex virus 1 infection, Epstein-Barr virus infection, Human immunodeficiency virus 1 infection, Coronavirus disease - COVID-19, Proteoglycans in cancer, Asthma, Inflammatory bowel disease, Systemic lupus erythematosus, Rheumatoid arthritis, Allograft rejection, Graft-versus-host disease, Hypertrophic cardiomyopathy, Dilated cardiomyopathy, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis	Pirfenidone 💬	Pirfenidone	[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
395	TOP2A 💬	[1] Platinum drug resistance	Etoposide 💬	Etoposide	[11] 11, 13, 14, 26, 28, 34, 60, 65, 85, 164, 331 💬
396	TOP2A 💬	[1] Platinum drug resistance	Dexrazoxane 💬	Dexrazoxane	[1] 13 💬
397	TOP2A 💬	[1] Platinum drug resistance	Pixantrone 💬	Pixantrone	[2] 11, 13 💬
398	TOP2A 💬	[1] Platinum drug resistance	Mitoxantrone 💬	Mitoxantrone	[1] 13 💬
399	TOP2B 💬	[1] Platinum drug resistance	Etoposide 💬	Etoposide	[11] 11, 13, 14, 26, 28, 34, 60, 65, 85, 164, 331 💬
400	TOP2B 💬	[1] Platinum drug resistance	Dexrazoxane 💬	Dexrazoxane	[1] 13 💬
401	TOP2B 💬	[1] Platinum drug resistance	Pixantrone 💬	Pixantrone	[2] 11, 13 💬
402	TOP2B 💬	[1] Platinum drug resistance	Mitoxantrone 💬	Mitoxantrone	[1] 13 💬
403	C5 💬	[11] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Neutrophil extracellular trap formation, Regulation of actin cytoskeleton, Alcoholic liver disease, Prion disease, Pertussis, Staphylococcus aureus infection, Herpes simplex virus 1 infection, Coronavirus disease - COVID-19, Systemic lupus erythematosus	Eculizumab 💬	Eculizumab	[7] 11, 13, 14, 61, 62, 109, 222 💬
404	C5 💬	[11] Neuroactive ligand-receptor interaction, Complement and coagulation cascades, Neutrophil extracellular trap formation, Regulation of actin cytoskeleton, Alcoholic liver disease, Prion disease, Pertussis, Staphylococcus aureus infection, Herpes simplex virus 1 infection, Coronavirus disease - COVID-19, Systemic lupus erythematosus	Ravulizumab 💬	Ravulizumab	[7] 2, 11, 13, 50, 62, 66, 109 💬
405	VDR 💬	[5] Parathyroid hormone synthesis, secretion and action, Endocrine and other factor-regulated calcium reabsorption, Mineral absorption, Tuberculosis, Chemical carcinogenesis - receptor activation	Cholecalciferol 💬	Cholecalciferol	[24] 6, 13, 19, 20, 28, 34, 46, 49, 51, 53, 56, 60, 65, 84, 85, 96, 97, 98, 162, 202, 228, 271, 298, 299 💬
406	VEGFA 💬	[24] EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, HIF-1 signaling pathway, PI3K-Akt signaling pathway, VEGF signaling pathway, Focal adhesion, Relaxin signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Chemical carcinogenesis - receptor activation, Chemical carcinogenesis - reactive oxygen species, Renal cell carcinoma, Pancreatic cancer, Bladder cancer, Rheumatoid arthritis, Fluid shear stress and atherosclerosis	Bevacizumab 💬	Bevacizumab	[6] 13, 34, 85, 87, 227, 280 💬
407	XDH 💬	[6] Purine metabolism, Caffeine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism, Peroxisome	Febuxostat 💬	Febuxostat	[3] 2, 6, 13 💬
408	CA1 💬	[2] Nitrogen metabolism, Metabolic pathways	Acetazolamide 💬	Acetazolamide	[8] 13, 86, 90, 115, 154, 155, 225, 230 💬
409	CA2 💬	[7] Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation, Collecting duct acid secretion, Gastric acid secretion, Pancreatic secretion, Bile secretion	Acetazolamide 💬	Acetazolamide	[8] 13, 86, 90, 115, 154, 155, 225, 230 💬
410	CA3 💬	[2] Nitrogen metabolism, Metabolic pathways	Acetazolamide 💬	Acetazolamide	[8] 13, 86, 90, 115, 154, 155, 225, 230 💬
411	CA4 💬	[3] Nitrogen metabolism, Metabolic pathways, Proximal tubule bicarbonate reclamation	Acetazolamide 💬	Acetazolamide	[8] 13, 86, 90, 115, 154, 155, 225, 230 💬
412	CA5A 💬	[2] Nitrogen metabolism, Metabolic pathways	Acetazolamide 💬	Acetazolamide	[8] 13, 86, 90, 115, 154, 155, 225, 230 💬
413	CA6 💬	[2] Nitrogen metabolism, Metabolic pathways	Acetazolamide 💬	Acetazolamide	[8] 13, 86, 90, 115, 154, 155, 225, 230 💬
414	CA7 💬	[2] Nitrogen metabolism, Metabolic pathways	Acetazolamide 💬	Acetazolamide	[8] 13, 86, 90, 115, 154, 155, 225, 230 💬
415	CA8 💬	[2] Nitrogen metabolism, Metabolic pathways	Acetazolamide 💬	Acetazolamide	[8] 13, 86, 90, 115, 154, 155, 225, 230 💬
416	CA9 💬	[2] Nitrogen metabolism, Metabolic pathways	Acetazolamide 💬	Acetazolamide	[8] 13, 86, 90, 115, 154, 155, 225, 230 💬
417	CA12 💬	[2] Nitrogen metabolism, Metabolic pathways	Acetazolamide 💬	Acetazolamide	[8] 13, 86, 90, 115, 154, 155, 225, 230 💬
418	CACNA1C 💬	[34] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Circadian entrainment, Long-term potentiation, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Dopaminergic synapse, Taste transduction, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Type II diabetes mellitus, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy	Amlodipine 💬	Amlodipine	[4] 13, 51, 67, 298 💬
419	CACNA1D 💬	[35] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cellular senescence, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Tight junction, Circadian entrainment, Retrograde endocannabinoid signaling, Glutamatergic synapse, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Dopaminergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Type II diabetes mellitus, Cushing syndrome, Growth hormone synthesis, secretion and action, Carbohydrate digestion and absorption, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy	Amlodipine 💬	Amlodipine	[4] 13, 51, 67, 298 💬
420	CACNA1F 💬	[27] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Retrograde endocannabinoid signaling, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy	Amlodipine 💬	Amlodipine	[4] 13, 51, 67, 298 💬
421	CACNA1S 💬	[27] MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Vascular smooth muscle contraction, Retrograde endocannabinoid signaling, Cholinergic synapse, Serotonergic synapse, GABAergic synapse, Insulin secretion, GnRH signaling pathway, Oxytocin signaling pathway, Renin secretion, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Cushing syndrome, Growth hormone synthesis, secretion and action, Alzheimer disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Chemical carcinogenesis - receptor activation, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy	Amlodipine 💬	Amlodipine	[4] 13, 51, 67, 298 💬
422	CACNA2D1 💬	[7] MAPK signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Oxytocin signaling pathway, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy	Gabapentin 💬	Gabapentin	[5] 6, 13, 19, 70, 298 💬
423	CACNA2D1 💬	[7] MAPK signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Oxytocin signaling pathway, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy	Pregabalin 💬	Pregabalin	[5] 13, 36, 46, 70, 298 💬
424	IL1R2 💬	[7] Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Amoebiasis, Human T-cell leukemia virus 1 infection, Transcriptional misregulation in cancer, Prostate cancer, Fluid shear stress and atherosclerosis	Anakinra 💬	Anakinra	[18] 2, 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
425	VKORC1 💬	[3] Ubiquinone and other terpenoid-quinone biosynthesis, Metabolic pathways, Biosynthesis of cofactors	Warfarin 💬	Warfarin	[11] 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91 💬
426	ALDH5A1 💬	[3] Alanine, aspartate and glutamate metabolism, Butanoate metabolism, Metabolic pathways	Valproic acid 💬	Valproic acid	[14] 2, 3, 5, 6, 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬
427	TAS1R2 💬	[2] Taste transduction, Carbohydrate digestion and absorption	Aspartame 💬	Aspartame	[4] 6, 13, 67, 86 💬
428	TAS1R3 💬	[2] Taste transduction, Carbohydrate digestion and absorption	Aspartame 💬	Aspartame	[4] 6, 13, 67, 86 💬
429	LINGO1 💬	-	Opicinumab 💬	Opicinumab	[1] 13 💬
430	PDE5A 💬	[3] Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway	Vardenafil 💬	Vardenafil	[3] 13, 86, 299 💬
431	S1PR4 💬	[3] FoxO signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction	Ozanimod 💬	Ozanimod	[3] 13, 96, 97 💬
432	TNFSF13 💬	[3] Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, Rheumatoid arthritis	Atacicept 💬	Atacicept	[4] 13, 46, 49, 66 💬
433	CACNA1I 💬	[7] MAPK signaling pathway, Calcium signaling pathway, Circadian entrainment, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Cushing syndrome	Valproic acid 💬	Valproic acid	[14] 2, 3, 5, 6, 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬
434	CACNA1H 💬	[7] MAPK signaling pathway, Calcium signaling pathway, Circadian entrainment, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Cushing syndrome	Valproic acid 💬	Valproic acid	[14] 2, 3, 5, 6, 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬
435	CACNA1G 💬	[8] MAPK signaling pathway, Calcium signaling pathway, Circadian entrainment, Aldosterone synthesis and secretion, Cortisol synthesis and secretion, GnRH secretion, Type II diabetes mellitus, Cushing syndrome	Valproic acid 💬	Valproic acid	[14] 2, 3, 5, 6, 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬
436	CHRNA6 💬	[3] Neuroactive ligand-receptor interaction, Cholinergic synapse, Nicotine addiction	Nicotine 💬	Nicotine	[3] 6, 13, 84 💬
437	CACNA2D2 💬	[7] MAPK signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Oxytocin signaling pathway, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy	Gabapentin 💬	Gabapentin	[5] 6, 13, 19, 70, 298 💬
438	CACNA2D2 💬	[7] MAPK signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Oxytocin signaling pathway, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy	Pregabalin 💬	Pregabalin	[5] 13, 36, 46, 70, 298 💬
439	S1PR2 💬	[2] Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction	Ozanimod 💬	Ozanimod	[3] 13, 96, 97 💬
440	CD19 💬	[5] PI3K-Akt signaling pathway, Hematopoietic cell lineage, B cell receptor signaling pathway, Epstein-Barr virus infection, Primary immunodeficiency	Inebilizumab 💬	Inebilizumab	[4] 11, 13, 51, 300 💬
441	MS4A1 💬	[1] Hematopoietic cell lineage	Rituximab 💬	Rituximab	[48] 11, 13, 14, 19, 26, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331 💬
442	MS4A1 💬	[1] Hematopoietic cell lineage	Ocrelizumab 💬	Ocrelizumab	[3] 13, 46, 49 💬
443	MS4A1 💬	[1] Hematopoietic cell lineage	Ofatumumab 💬	Ofatumumab	[3] 13, 35, 46 💬
444	MS4A1 💬	[1] Hematopoietic cell lineage	Ublituximab 💬	Ublituximab	[1] 13 💬
445	CACNA2D4 💬	[7] MAPK signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Oxytocin signaling pathway, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy	Gabapentin 💬	Gabapentin	[5] 6, 13, 19, 70, 298 💬
446	CACNA2D4 💬	[7] MAPK signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Oxytocin signaling pathway, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy	Pregabalin 💬	Pregabalin	[5] 13, 36, 46, 70, 298 💬
447	CD80 💬	[11] Virion - Adenovirus, Cell adhesion molecules, Toll-like receptor signaling pathway, Intestinal immune network for IgA production, Type I diabetes mellitus, Autoimmune thyroid disease, Systemic lupus erythematosus, Rheumatoid arthritis, Allograft rejection, Graft-versus-host disease, Viral myocarditis	Abatacept 💬	Abatacept	[26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬
448	CD86 💬	[13] Virion - Adenovirus, Cell adhesion molecules, Toll-like receptor signaling pathway, Intestinal immune network for IgA production, Type I diabetes mellitus, Kaposi sarcoma-associated herpesvirus infection, Transcriptional misregulation in cancer, Autoimmune thyroid disease, Systemic lupus erythematosus, Rheumatoid arthritis, Allograft rejection, Graft-versus-host disease, Viral myocarditis	Abatacept 💬	Abatacept	[26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬
449	CD38 💬	[7] Nicotinate and nicotinamide metabolism, Metabolic pathways, Calcium signaling pathway, Hematopoietic cell lineage, Oxytocin signaling pathway, Salivary secretion, Pancreatic secretion	Daratumumab 💬	Daratumumab	[5] 13, 28, 48, 49, 63 💬
450	GABBR2 💬	[7] cAMP signaling pathway, Neuroactive ligand-receptor interaction, GABAergic synapse, Taste transduction, Estrogen signaling pathway, GnRH secretion, Morphine addiction	Baclofen 💬	Baclofen	[8] 2, 10, 13, 18, 65, 70, 149, 206 💬
451	GABBR2 💬	[7] cAMP signaling pathway, Neuroactive ligand-receptor interaction, GABAergic synapse, Taste transduction, Estrogen signaling pathway, GnRH secretion, Morphine addiction	Arbaclofen placarbil 💬	Arbaclofen Placarbil	[1] 13 💬
452	GABBR2 💬	[7] cAMP signaling pathway, Neuroactive ligand-receptor interaction, GABAergic synapse, Taste transduction, Estrogen signaling pathway, GnRH secretion, Morphine addiction	Arbaclofen 💬	Arbaclofen	[2] 13, 206 💬
453	KEAP1 💬	[6] Ubiquitin mediated proteolysis, Parkinson disease, Pathways in cancer, Chemical carcinogenesis - reactive oxygen species, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis	Dimethyl fumarate 💬	Dimethyl fumarate	[5] 13, 49, 51, 86, 296 💬
454	SV2A 💬	[1] ECM-receptor interaction	Levetiracetam 💬	Levetiracetam	[5] 2, 4, 6, 13, 307 💬