211. Hypoplastic left heart syndrome Disease details / Clinical trials / Drug dev / DR info
Clinical trials : 22 / Drugs : 29 - (DrugBank : 9) / Drug target genes : 5 - Drug target pathways : 14
Drugs and their primary sponsors and trial info
Allo-hMSCs
Longeveron Inc.
2015 Phase 1 NCT02398604 United States;
Ambrisentan
Kevin Hill
2015 Phase 2 NCT02080637 United States;
Autologous (self) mononuclear cells derived from umbilical cord blood
Timothy J Nelson, MD, PhD
2019 Phase 2 NCT03779711 United States;
Autologous Human Placental Cord Blood Mononuclear Cells
Murdoch Childrens Research Institute
2018 Phase 1 NCT03431480 Australia;
Autologous Umbilical Cord Blood
Michael Cotten
2011 Phase 1 NCT01445041 United States;
Autologous cell-based delivery
Timothy J Nelson, MD, PhD
2013 Phase 1 NCT01883076 United States;
Bosentan
Rigshospitalet, Denmark
2011 Phase 2 NCT01292551 Denmark;Sweden;
C-kit+ cells
University of Miami
2019 Phase 1 NCT03406884 United States;
Curosurf
University of Michigan
2020 Phase 1 NCT04181255 United States;
Erythropoetin
Baylor College of Medicine
2006 Phase 1/Phase 2 NCT00513240 United States;
Lomecel-B medicinal signaling cells
Ann & Robert H Lurie Children's Hospital of Chicago
2021 Phase 2 NCT04925024 United States;
Longeveron Mesenchymal Stem Cells
Longeveron Inc.
2018 Phase 1/Phase 2 NCT03525418 United States;
METHYLPREDNISOLONE SODIUM SUCCINATE
Pertti Suominen
2009 - EUCTR2008-007413-76-FI Finland;
MPC
Boston Children's Hospital
2017 Phase 1/Phase 2 NCT03079401 United States;
Maternal Hyperoxygenation
The Hospital for Sick Children
2018 Phase 1/Phase 2 NCT03136835 Canada;
Maternal hyperoxygenation
Beijing Anzhen Hospital
2016 - NCT03147014 China;
Metyyliprednisoloninatriumsuksinaatti
Pertti Suominen
2009 - EUCTR2008-007413-76-FI Finland;
Nitrogen
Institutional Review Board of Kagoshima University
2015 - JPRN-UMIN000017311 Japan;
Normal saline
Baylor College of Medicine
2006 Phase 1/Phase 2 NCT00513240 United States;
Oxandrolone
HealthCore-NERI
2019 Phase 1/Phase 2 NCT04090697 Canada;United States;
Rexlemestrocel-L
Boston Children's Hospital
2017 Phase 1/Phase 2 NCT03079401 United States;
Sham
University of Michigan
2020 Phase 1 NCT04181255 United States;
Sildenafil
Children's Hospital of Philadelphia
2007 Phase 2 NCT00507819 United States;
Stage II Surgical repair
Timothy J Nelson, MD, PhD
2019 Phase 2 NCT03779711 United States;
Tracleer
Lars Søndergaard
2010 - EUCTR2010-022389-28-DK Denmark;
Vitamin C
University of Michigan
2009 - NCT00974025 United States;
Longeveron Inc.
2015 Phase 1 NCT02398604 United States;
Ambrisentan
Kevin Hill
2015 Phase 2 NCT02080637 United States;
Autologous (self) mononuclear cells derived from umbilical cord blood
Timothy J Nelson, MD, PhD
2019 Phase 2 NCT03779711 United States;
Autologous Human Placental Cord Blood Mononuclear Cells
Murdoch Childrens Research Institute
2018 Phase 1 NCT03431480 Australia;
Autologous Umbilical Cord Blood
Michael Cotten
2011 Phase 1 NCT01445041 United States;
Autologous cell-based delivery
Timothy J Nelson, MD, PhD
2013 Phase 1 NCT01883076 United States;
Bosentan
Rigshospitalet, Denmark
2011 Phase 2 NCT01292551 Denmark;Sweden;
C-kit+ cells
University of Miami
2019 Phase 1 NCT03406884 United States;
Curosurf
University of Michigan
2020 Phase 1 NCT04181255 United States;
Erythropoetin
Baylor College of Medicine
2006 Phase 1/Phase 2 NCT00513240 United States;
Lomecel-B medicinal signaling cells
Ann & Robert H Lurie Children's Hospital of Chicago
2021 Phase 2 NCT04925024 United States;
Longeveron Mesenchymal Stem Cells
Longeveron Inc.
2018 Phase 1/Phase 2 NCT03525418 United States;
METHYLPREDNISOLONE SODIUM SUCCINATE
Pertti Suominen
2009 - EUCTR2008-007413-76-FI Finland;
MPC
Boston Children's Hospital
2017 Phase 1/Phase 2 NCT03079401 United States;
Maternal Hyperoxygenation
The Hospital for Sick Children
2018 Phase 1/Phase 2 NCT03136835 Canada;
Maternal hyperoxygenation
Beijing Anzhen Hospital
2016 - NCT03147014 China;
Metyyliprednisoloninatriumsuksinaatti
Pertti Suominen
2009 - EUCTR2008-007413-76-FI Finland;
Nitrogen
Institutional Review Board of Kagoshima University
2015 - JPRN-UMIN000017311 Japan;
Normal saline
Baylor College of Medicine
2006 Phase 1/Phase 2 NCT00513240 United States;
Oxandrolone
HealthCore-NERI
2019 Phase 1/Phase 2 NCT04090697 Canada;United States;
Rexlemestrocel-L
Boston Children's Hospital
2017 Phase 1/Phase 2 NCT03079401 United States;
Sham
University of Michigan
2020 Phase 1 NCT04181255 United States;
Sildenafil
Children's Hospital of Philadelphia
2007 Phase 2 NCT00507819 United States;
Stage II Surgical repair
Timothy J Nelson, MD, PhD
2019 Phase 2 NCT03779711 United States;
Tracleer
Lars Søndergaard
2010 - EUCTR2010-022389-28-DK Denmark;
Vitamin C
University of Michigan
2009 - NCT00974025 United States;