43. Microscopic polyangiitis Disease details / Clinical trials / Drug dev / DR info


Clinical trials : 88 Drugs : 81 - (DrugBank : 21) / Drug target genes : 15 - Drug target pathways : 90

Drugs and their primary sponsors and trial info
5009111000001105   
   Cambridge University Hospitals NHS Foundation Trust
      2008   Phase 2   EUCTR2006-001663-33-SE   Austria;Czech Republic;France;Germany;Italy;Spain;Sweden;United Kingdom;
Alemtuzumab   
   Cambridge University Hospitals NHS Foundation Trust
      2011   Phase 4   NCT01405807   United Kingdom;
Avacopan   
   CHEMOCENTRYX, INC.
      2017   Phase 3   EUCTR2016-001121-14-IT   Australia;Austria;Belgium;Canada;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
   ChemoCentryx, Inc.
      2017   Phase 3   EUCTR2016-001121-14-SE   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-001121-14-NO   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-001121-14-NL   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-001121-14-HU   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-001121-14-GB   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-001121-14-ES   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-001121-14-DK   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-001121-14-CZ   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-001121-14-BE   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-001121-14-AT   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      -   Phase 3   EUCTR2016-001121-14-IE   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      -   Phase 3   EUCTR2016-001121-14-FR   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      -   Phase 3   EUCTR2016-001121-14-DE   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
Azathioprine   
   Assistance Publique - Hôpitaux de Paris
      2008   Phase 3   NCT00748644   France;
      2003   Phase 3   NCT00307645   France;United Kingdom;
   Cambridge University Hospitals NHS Foundation Trust
      2015   Phase 3   EUCTR2012-001102-14-CZ   Australia;Austria;Canada;Czech Republic;Denmark;Germany;Ireland;Italy;Mexico;Netherlands;New Zealand;Poland;Spain;Sweden;Switzerland;United Kingdom;
      2014   Phase 3   EUCTR2012-001102-14-IT   Australia;Austria;Canada;Czech Republic;Denmark;Germany;Ireland;Italy;Mexico;Netherlands;New Zealand;Poland;Spain;Sweden;Switzerland;United Kingdom;
      2013   Phase 3   NCT01697267   Australia;Canada;Czech Republic;Czechia;Ireland;Italy;Japan;New Zealand;Sweden;United Kingdom;United States;
      2013   -   EUCTR2012-001102-14-ES   Australia;Austria;Canada;Czech Republic;Denmark;Germany;Ireland;Italy;Mexico;Netherlands;New Zealand;Poland;Spain;Sweden;Switzerland;United Kingdom;
      -   Phase 3   EUCTR2012-001102-14-GB   Australia;Austria;Canada;Czech Republic;Denmark;Germany;Ireland;Italy;Mexico;Netherlands;New Zealand;Poland;Spain;Sweden;Switzerland;United Kingdom;
   Hospices Civils de Lyon
      1996   Phase 4   NCT00400075   Switzerland;
   Human Genome Sciences Inc., a GSK Company
      2013   Phase 3   NCT01663623   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Czechia;Finland;France;Germany;Hungary;India;Ireland;Italy;Mexico;Norway;Peru;Poland;Romania;Russian Federation;Spain;Sweden;Switzerland;United Kingdom;United States;
   National Institute of Allergy and Infectious Diseases (NIAID)
      2005   Phase 2/Phase 3   NCT00104299   Netherlands;United States;
   Tokyo women'
   University College Cork , Ireland
      2014   Phase 3   EUCTR2012-001102-14-IE   Australia;Austria;Canada;Czech Republic;Denmark;Germany;Ireland;Italy;Japan;Mexico;Netherlands;New Zealand;Poland;Spain;Sweden;Switzerland;United Kingdom;
   University Hospital Birmingham NHS Foundation Trust
      2003   Phase 2   NCT00753103   United Kingdom;
   University of Miyazaki Hospital
      2014   Phase 3   JPRN-UMIN000012409   Japan,North America,South America,Australia,Europe;
   s medical universityInstitute of rheumatology
Belimumab   
   Human Genome Sciences Inc., a GSK Company
      2013   Phase 3   NCT01663623   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;Czechia;Finland;France;Germany;Hungary;India;Ireland;Italy;Mexico;Norway;Peru;Poland;Romania;Russian Federation;Spain;Sweden;Switzerland;United Kingdom;United States;
Benlysta 400 mg powder for concentrate for solution for infusion   
   Human Genome Sciences Inc. (a wholly owned subsidiary of GlaxoSmithKline PLC)
      2013   Phase 2   EUCTR2011-004569-33-DE   Australia;Austria;Belgium;Canada;Czech Republic;Finland;France;Germany;Hungary;India;Ireland;Italy;Mexico;Peru;Poland;Romania;Russian Federation;Spain;Sweden;Switzerland;United Kingdom;United States;
   Human Genome Sciences, Inc. (a wholly owned subsidiary of GlaxoSmithKline PLC)
      2013   Phase 3   EUCTR2011-004569-33-SE   Australia;Austria;Belgium;Canada;Czech Republic;Finland;France;Germany;Hungary;India;Ireland;Italy;Mexico;Peru;Poland;Romania;Russian Federation;Spain;Sweden;Switzerland;United Kingdom;United States;
      2013   Phase 3   EUCTR2011-004569-33-HU   Australia;Austria;Belgium;Canada;Czech Republic;Finland;France;Germany;Hungary;India;Ireland;Italy;Mexico;Peru;Poland;Romania;Russian Federation;Spain;Sweden;Switzerland;United Kingdom;United States;
      2013   Phase 3   EUCTR2011-004569-33-ES   Australia;Austria;Belgium;Canada;Czech Republic;Finland;France;Germany;Hungary;India;Ireland;Italy;Mexico;Peru;Poland;Romania;Russian Federation;Spain;Sweden;Switzerland;United Kingdom;United States;
      2013   Phase 2   EUCTR2011-004569-33-PL   Australia;Austria;Belgium;Canada;Czech Republic;Finland;France;Germany;Hungary;India;Ireland;Italy;Mexico;Peru;Poland;Romania;Russian Federation;Spain;Sweden;Switzerland;United Kingdom;United States;
      2013   Phase 2   EUCTR2011-004569-33-IE   Australia;Austria;Belgium;Canada;Czech Republic;Finland;France;Germany;Hungary;India;Ireland;Italy;Mexico;Peru;Poland;Romania;Russian Federation;Spain;Sweden;Switzerland;United Kingdom;United States;
      2013   Phase 2   EUCTR2011-004569-33-CZ   Australia;Austria;Belgium;Canada;Czech Republic;Finland;France;Germany;Hungary;India;Ireland;Italy;Mexico;Peru;Poland;Romania;Russian Federation;Spain;Sweden;Switzerland;United Kingdom;United States;
      2013   Phase 2   EUCTR2011-004569-33-BE   Australia;Austria;Belgium;Canada;Czech Republic;Finland;France;Germany;Hungary;India;Ireland;Italy;Mexico;Peru;Poland;Romania;Russian Federation;Spain;Sweden;Switzerland;United Kingdom;United States;
      2012   Phase 3   EUCTR2011-004569-33-GB   Australia;Austria;Belgium;Canada;Czech Republic;Finland;France;Germany;Hungary;India;Ireland;Italy;Mexico;Peru;Poland;Romania;Russian Federation;Spain;Sweden;Switzerland;United Kingdom;United States;
Benlysta 400mg polvere per concentrato per soluzione per infusione   
   HUMAN GENOME SCIENCES INC
      2013   -   EUCTR2011-004569-33-IT   Australia;Belgium;Canada;Czech Republic;European Union;Germany;Hungary;India;Ireland;Italy;Mexico;Peru;Poland;Russian Federation;Spain;Sweden;Switzerland;United Kingdom;United States;
Blisibimod   
   Anthera Pharmaceuticals
      2014   Phase 2   NCT01598857   -
CCX168   
   CHEMOCENTRYX, INC.
      2017   Phase 3   EUCTR2016-001121-14-IT   Australia;Austria;Belgium;Canada;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
   ChemoCentryx, Inc.
      2017   Phase 3   EUCTR2016-001121-14-SE   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-001121-14-NO   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-001121-14-NL   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-001121-14-HU   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-001121-14-GB   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-001121-14-ES   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-001121-14-DK   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-001121-14-CZ   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-001121-14-BE   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-001121-14-AT   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      -   Phase 3   EUCTR2016-001121-14-IE   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      -   Phase 3   EUCTR2016-001121-14-FR   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      -   Phase 3   EUCTR2016-001121-14-DE   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
CELLCEPT   
   Vasculitis and Lupus Clinic
      2008   -   EUCTR2006-001663-33-IT   Austria;France;Germany;Italy;Spain;Sweden;United Kingdom;
CellCept (mycophenolate mofetil)   
   Mayo Clinic
      2002   Phase 1   NCT00405860   United States;
Cellcept   
   Cambridge University Hospitals NHS Foundation Trust
      2008   Phase 2   EUCTR2006-001663-33-SE   Austria;Czech Republic;France;Germany;Italy;Spain;Sweden;United Kingdom;
Chimeric monoclonal antibody, IgG4 subtype   
   InflaRx GmbH
      2019   Phase 2   EUCTR2018-000768-27-SE   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Italy;Netherlands;Russian Federation;Spain;Sweden;Switzerland;United Kingdom;
      2019   Phase 2   EUCTR2018-000768-27-NL   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Italy;Netherlands;Russian Federation;Spain;Sweden;United Kingdom;
      2019   Phase 2   EUCTR2018-000768-27-IT   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Ireland;Italy;Netherlands;Russian Federation;Spain;Sweden;United Kingdom;
      2019   Phase 2   EUCTR2018-000768-27-GB   Belgium;Czech Republic;Denmark;France;Germany;Ireland;Italy;Netherlands;Russian Federation;Spain;Sweden;Switzerland;United Kingdom;
      2019   Phase 2   EUCTR2018-000768-27-ES   Belgium;Czech Republic;Denmark;France;Germany;Ireland;Italy;Netherlands;Russian Federation;Spain;Sweden;United Kingdom;
      2019   Phase 2   EUCTR2018-000768-27-DK   Belgium;Czech Republic;Denmark;France;Germany;Ireland;Italy;Netherlands;Russian Federation;Spain;Sweden;Switzerland;United Kingdom;
      2019   Phase 2   EUCTR2018-000768-27-DE   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Italy;Netherlands;Russian Federation;Spain;Sweden;United Kingdom;
      2019   Phase 2   EUCTR2018-000768-27-CZ   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Italy;Netherlands;Russian Federation;Spain;Sweden;United Kingdom;
      2019   Phase 2   EUCTR2018-000768-27-BE   Belgium;Czech Republic;Denmark;France;Germany;Ireland;Italy;Netherlands;Russian Federation;Spain;Sweden;United Kingdom;
Corticosteroid and azathioprine   
   Assistance Publique - Hôpitaux de Paris
      2008   Phase 3   NCT00647166   France;
Cyclophosphamide   
   Assistance Publique - Hôpitaux de Paris
      2003   Phase 3   NCT00307645   France;United Kingdom;
   Cambridge University Hospitals NHS Foundation Trust
      1998   Phase 2/Phase 3   NCT00430105   -
   Hospices Civils de Lyon
      1996   Phase 4   NCT00400075   Switzerland;
   National Institute of Allergy and Infectious Diseases (NIAID)
      2005   Phase 2/Phase 3   NCT00104299   Netherlands;United States;
   Saitama Medical Center, Saitama Medical UniversityDepartment of Rheumatology and Clinical Immunology
      2013   -   JPRN-UMIN000011244   Japan;
   University Hospital Birmingham NHS Foundation Trust
      2003   Phase 2   NCT00753103   United Kingdom;
   University Medical Centre Groningen
      2004   Phase 3   NCT00103792   Netherlands;
   University of Parma
      2008   Phase 2   NCT00751517   Italy;
   Vasculitis and Lupus Clinic
      2008   -   EUCTR2006-001663-33-IT   Austria;France;Germany;Italy;Spain;Sweden;United Kingdom;
Cyclophosphamide, Azathioprine,prednisone,methylprednisolone   
   Assistance Publique - Hôpitaux de Paris
      2005   Phase 4   NCT00307671   France;
DELTACORTENE   
   AZIENDA OSPEDALIERA SPEDALI CIVILI DI BRESCIA
      2010   Phase 4   EUCTR2009-013220-24-IT   Czech Republic;Denmark;Italy;Poland;Spain;Sweden;United Kingdom;
ENDOXAN BAXTER   
   Vasculitis and Lupus Clinic
      2008   -   EUCTR2006-001663-33-IT   Austria;France;Germany;Italy;Spain;Sweden;United Kingdom;
Freeze-Dried Sulfonated Human Normal Immunoglobulin (GGS)   
   TEIJIN PHARMA LIMITED
      2014   Phase 3   JPRN-JapicCTI-132394   Japan;
GALEN® tablet   
   InflaRx GmbH
      2019   Phase 2   EUCTR2018-000768-27-NL   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Italy;Netherlands;Russian Federation;Spain;Sweden;United Kingdom;
      2019   Phase 2   EUCTR2018-000768-27-IT   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Ireland;Italy;Netherlands;Russian Federation;Spain;Sweden;United Kingdom;
      2019   Phase 2   EUCTR2018-000768-27-ES   Belgium;Czech Republic;Denmark;France;Germany;Ireland;Italy;Netherlands;Russian Federation;Spain;Sweden;United Kingdom;
      2019   Phase 2   EUCTR2018-000768-27-BE   Belgium;Czech Republic;Denmark;France;Germany;Ireland;Italy;Netherlands;Russian Federation;Spain;Sweden;United Kingdom;
Glucocorticoid (GC)   
   InflaRx GmbH
      2019   Phase 2   NCT03895801   Belgium;Czechia;Denmark;France;Germany;Italy;Netherlands;Russian Federation;Spain;Sweden;Switzerland;United Kingdom;
Glucocorticoids   
   Chiba University
      2014   Phase 4   NCT02198248   Japan;
   Massachusetts General Hospital
      2014   Phase 4   NCT02169219   United States;
Glucocorticoids (GC)   
   InflaRx GmbH
      2019   Phase 2   EUCTR2018-000768-27-SE   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Italy;Netherlands;Russian Federation;Spain;Sweden;Switzerland;United Kingdom;
      2019   Phase 2   EUCTR2018-000768-27-NL   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Italy;Netherlands;Russian Federation;Spain;Sweden;United Kingdom;
      2019   Phase 2   EUCTR2018-000768-27-IT   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Ireland;Italy;Netherlands;Russian Federation;Spain;Sweden;United Kingdom;
      2019   Phase 2   EUCTR2018-000768-27-ES   Belgium;Czech Republic;Denmark;France;Germany;Ireland;Italy;Netherlands;Russian Federation;Spain;Sweden;United Kingdom;
      2019   Phase 2   EUCTR2018-000768-27-DK   Belgium;Czech Republic;Denmark;France;Germany;Ireland;Italy;Netherlands;Russian Federation;Spain;Sweden;Switzerland;United Kingdom;
      2019   Phase 2   EUCTR2018-000768-27-DE   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Italy;Netherlands;Russian Federation;Spain;Sweden;United Kingdom;
      2019   Phase 2   EUCTR2018-000768-27-CZ   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Italy;Netherlands;Russian Federation;Spain;Sweden;United Kingdom;
      2019   Phase 2   EUCTR2018-000768-27-BE   Belgium;Czech Republic;Denmark;France;Germany;Ireland;Italy;Netherlands;Russian Federation;Spain;Sweden;United Kingdom;
Glucocorticoids - Reduced Dose   
   University of Pennsylvania
      2010   Phase 3   NCT03919825   -
Glucocorticoids - Standard Dose   
   University of Pennsylvania
      2010   Phase 3   NCT03919825   -
Glucocorticoids [Reduced Dose]   
   University of Pennsylvania
      2010   Phase 3   NCT00987389   Australia;Belgium;Canada;Czech Republic;Czechia;Denmark;France;Greece;Italy;Japan;Mexico;New Zealand;Norway;Sweden;United Kingdom;United States;
Glucocorticoids [Standard Dose]   
   University of Pennsylvania
      2010   Phase 3   NCT00987389   Australia;Belgium;Canada;Czech Republic;Czechia;Denmark;France;Greece;Italy;Japan;Mexico;New Zealand;Norway;Sweden;United Kingdom;United States;
Hydroxychloroquine   
   Guy's and St Thomas' NHS Foundation Trust
      2020   Phase 4   NCT04316494   United Kingdom;
IFX-1   
   InflaRx GmbH
      2019   Phase 2   NCT03895801   Belgium;Czechia;Denmark;France;Germany;Italy;Netherlands;Russian Federation;Spain;Sweden;Switzerland;United Kingdom;
      2019   Phase 2   EUCTR2018-000768-27-SE   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Italy;Netherlands;Russian Federation;Spain;Sweden;Switzerland;United Kingdom;
      2019   Phase 2   EUCTR2018-000768-27-NL   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Italy;Netherlands;Russian Federation;Spain;Sweden;United Kingdom;
      2019   Phase 2   EUCTR2018-000768-27-IT   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Ireland;Italy;Netherlands;Russian Federation;Spain;Sweden;United Kingdom;
      2019   Phase 2   EUCTR2018-000768-27-GB   Belgium;Czech Republic;Denmark;France;Germany;Ireland;Italy;Netherlands;Russian Federation;Spain;Sweden;Switzerland;United Kingdom;
      2019   Phase 2   EUCTR2018-000768-27-ES   Belgium;Czech Republic;Denmark;France;Germany;Ireland;Italy;Netherlands;Russian Federation;Spain;Sweden;United Kingdom;
      2019   Phase 2   EUCTR2018-000768-27-DK   Belgium;Czech Republic;Denmark;France;Germany;Ireland;Italy;Netherlands;Russian Federation;Spain;Sweden;Switzerland;United Kingdom;
      2019   Phase 2   EUCTR2018-000768-27-DE   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Italy;Netherlands;Russian Federation;Spain;Sweden;United Kingdom;
      2019   Phase 2   EUCTR2018-000768-27-CZ   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Italy;Netherlands;Russian Federation;Spain;Sweden;United Kingdom;
      2019   Phase 2   EUCTR2018-000768-27-BE   Belgium;Czech Republic;Denmark;France;Germany;Ireland;Italy;Netherlands;Russian Federation;Spain;Sweden;United Kingdom;
      2018   Phase 2   NCT03712345   Canada;United States;
Infliximab   
   Assistance Publique - Hôpitaux de Paris
      2004   -   NCT00307593   France;
   University Hospital Birmingham NHS Foundation Trust
      2003   Phase 2   NCT00753103   United Kingdom;
Intravenous immunoglobulins (human immunoglobulins G)   
   Assistance Publique - Hôpitaux de Paris
      2001   Phase 3   NCT00307658   France;
Intravenous methyl prednisolone   
   Cambridge University Hospitals NHS Foundation Trust
      1995   Phase 2/Phase 3   NCT01408836   United Kingdom;
MabThera   
   Cambridge University Hospitals NHS Foundation Trust
      2014   Phase 3   EUCTR2012-001102-14-IT   Australia;Austria;Canada;Czech Republic;Denmark;Germany;Ireland;Italy;Mexico;Netherlands;New Zealand;Poland;Spain;Sweden;Switzerland;United Kingdom;
      2013   -   EUCTR2012-001102-14-ES   Australia;Austria;Canada;Czech Republic;Denmark;Germany;Ireland;Italy;Mexico;Netherlands;New Zealand;Poland;Spain;Sweden;Switzerland;United Kingdom;
      -   Phase 3   EUCTR2012-001102-14-GB   Australia;Austria;Canada;Czech Republic;Denmark;Germany;Ireland;Italy;Mexico;Netherlands;New Zealand;Poland;Spain;Sweden;Switzerland;United Kingdom;
   University College Cork , Ireland
      2014   Phase 3   EUCTR2012-001102-14-IE   Australia;Austria;Canada;Czech Republic;Denmark;Germany;Ireland;Italy;Japan;Mexico;Netherlands;New Zealand;Poland;Spain;Sweden;Switzerland;United Kingdom;
MabThera®   
   Cambridge University Hospitals NHS Foundation Trust
      2015   Phase 3   EUCTR2012-001102-14-CZ   Australia;Austria;Canada;Czech Republic;Denmark;Germany;Ireland;Italy;Mexico;Netherlands;New Zealand;Poland;Spain;Sweden;Switzerland;United Kingdom;
   F. HOFFMANN - LA ROCHE LTD.
      2013   -   EUCTR2012-002062-13-IT   Italy;Turkey;United Kingdom;United States;
   F. Hoffmann-La Roche Ltd.
      2013   Phase 2   EUCTR2012-002062-13-GB   Canada;France;Germany;Italy;Serbia;Turkey;United Kingdom;United States;
      2013   Phase 2   EUCTR2012-002062-13-DE   Canada;France;Germany;Italy;Serbia;Turkey;United Kingdom;United States;
Methotrexate   
   Cambridge University Hospitals NHS Foundation Trust
      2015   Phase 3   EUCTR2012-001102-14-CZ   Australia;Austria;Canada;Czech Republic;Denmark;Germany;Ireland;Italy;Mexico;Netherlands;New Zealand;Poland;Spain;Sweden;Switzerland;United Kingdom;
      2014   Phase 3   EUCTR2012-001102-14-IT   Australia;Austria;Canada;Czech Republic;Denmark;Germany;Ireland;Italy;Mexico;Netherlands;New Zealand;Poland;Spain;Sweden;Switzerland;United Kingdom;
      -   Phase 3   EUCTR2012-001102-14-GB   Australia;Austria;Canada;Czech Republic;Denmark;Germany;Ireland;Italy;Mexico;Netherlands;New Zealand;Poland;Spain;Sweden;Switzerland;United Kingdom;
   University College Cork , Ireland
      2014   Phase 3   EUCTR2012-001102-14-IE   Australia;Austria;Canada;Czech Republic;Denmark;Germany;Ireland;Italy;Japan;Mexico;Netherlands;New Zealand;Poland;Spain;Sweden;Switzerland;United Kingdom;
   University of Parma
      2008   Phase 2   NCT00751517   Italy;
Methylprednisolone   
   Hoffmann-La Roche
      2015   Phase 4   NCT02115997   India;
   University Hospital Birmingham NHS Foundation Trust
      2003   Phase 2   NCT00753103   United Kingdom;
Methylprednisolone (or other glucocorticoid)   
   National Institute of Allergy and Infectious Diseases (NIAID)
      2005   Phase 2/Phase 3   NCT00104299   Netherlands;United States;
Mycophenolate   
   University College Cork , Ireland
      2014   Phase 3   EUCTR2012-001102-14-IE   Australia;Austria;Canada;Czech Republic;Denmark;Germany;Ireland;Italy;Japan;Mexico;Netherlands;New Zealand;Poland;Spain;Sweden;Switzerland;United Kingdom;
Mycophenolate mofetil   
   Assistance Publique - Hôpitaux de Paris
      2003   Phase 3   NCT00307645   France;United Kingdom;
   Cambridge University Hospitals NHS Foundation Trust
      2008   Phase 2   EUCTR2006-001663-33-SE   Austria;Czech Republic;France;Germany;Italy;Spain;Sweden;United Kingdom;
   University Hospital Birmingham NHS Foundation Trust
      2003   Phase 2   NCT00753103   United Kingdom;
   University Medical Centre Groningen
      2004   Phase 3   NCT00103792   Netherlands;
Mycophenolate mofetil,methotrexate   
   Assistance Publique - Hôpitaux de Paris
      2005   Phase 4   NCT00307671   France;
Mycophenolic acid   
   University College Cork , Ireland
      2014   Phase 3   EUCTR2012-001102-14-IE   Australia;Austria;Canada;Czech Republic;Denmark;Germany;Ireland;Italy;Japan;Mexico;Netherlands;New Zealand;Poland;Spain;Sweden;Switzerland;United Kingdom;
   Vasculitis and Lupus Clinic
      2008   -   EUCTR2006-001663-33-IT   Austria;France;Germany;Italy;Spain;Sweden;United Kingdom;
Naltrexone Hydrochloride   
   University of Pennsylvania
      2019   Phase 2   NCT03482479   United States;
Pednisone   
   ChemoCentryx, Inc.
      2017   Phase 3   EUCTR2016-001121-14-NO   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-001121-14-NL   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-001121-14-HU   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-001121-14-GB   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-001121-14-ES   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-001121-14-CZ   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-001121-14-BE   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      -   Phase 3   EUCTR2016-001121-14-IE   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      -   Phase 3   EUCTR2016-001121-14-FR   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
Placebo (physiological saline)   
   TEIJIN PHARMA LIMITED
      2014   Phase 3   JPRN-JapicCTI-132394   Japan;
Plaquenil - Hydroxychloroquine 200mg Film coated tablets   
   Guy's and St. Thomas' NHS Foundation Trust
      2020   Phase 4   EUCTR2018-001268-40-GB   United Kingdom;
Plasma Exchange   
   University of Pennsylvania
      2010   Phase 3   NCT00987389   Australia;Belgium;Canada;Czech Republic;Czechia;Denmark;France;Greece;Italy;Japan;Mexico;New Zealand;Norway;Sweden;United Kingdom;United States;
Plasma exchange   
   Cambridge University Hospitals NHS Foundation Trust
      1995   Phase 2/Phase 3   NCT01408836   United Kingdom;
   University Hospital Birmingham NHS Foundation Trust
      2003   Phase 2   NCT00753103   United Kingdom;
PredniSONE Tablets, USP   
   InflaRx GmbH
      2019   Phase 2   EUCTR2018-000768-27-SE   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Italy;Netherlands;Russian Federation;Spain;Sweden;Switzerland;United Kingdom;
      2019   Phase 2   EUCTR2018-000768-27-NL   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Italy;Netherlands;Russian Federation;Spain;Sweden;United Kingdom;
      2019   Phase 2   EUCTR2018-000768-27-IT   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Ireland;Italy;Netherlands;Russian Federation;Spain;Sweden;United Kingdom;
      2019   Phase 2   EUCTR2018-000768-27-GB   Belgium;Czech Republic;Denmark;France;Germany;Ireland;Italy;Netherlands;Russian Federation;Spain;Sweden;Switzerland;United Kingdom;
      2019   Phase 2   EUCTR2018-000768-27-ES   Belgium;Czech Republic;Denmark;France;Germany;Ireland;Italy;Netherlands;Russian Federation;Spain;Sweden;United Kingdom;
      2019   Phase 2   EUCTR2018-000768-27-DK   Belgium;Czech Republic;Denmark;France;Germany;Ireland;Italy;Netherlands;Russian Federation;Spain;Sweden;Switzerland;United Kingdom;
      2019   Phase 2   EUCTR2018-000768-27-DE   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Italy;Netherlands;Russian Federation;Spain;Sweden;United Kingdom;
      2019   Phase 2   EUCTR2018-000768-27-CZ   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Italy;Netherlands;Russian Federation;Spain;Sweden;United Kingdom;
      2019   Phase 2   EUCTR2018-000768-27-BE   Belgium;Czech Republic;Denmark;France;Germany;Ireland;Italy;Netherlands;Russian Federation;Spain;Sweden;United Kingdom;
Prednisolone   
   University Hospital Birmingham NHS Foundation Trust
      2003   Phase 2   NCT00753103   United Kingdom;
Prednison acis®   
   ChemoCentryx, Inc.
      2017   Phase 3   EUCTR2016-001121-14-SE   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-001121-14-NO   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-001121-14-NL   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-001121-14-HU   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-001121-14-GB   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-001121-14-ES   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-001121-14-DK   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-001121-14-CZ   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-001121-14-BE   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      2017   Phase 3   EUCTR2016-001121-14-AT   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      -   Phase 3   EUCTR2016-001121-14-IE   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      -   Phase 3   EUCTR2016-001121-14-FR   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
      -   Phase 3   EUCTR2016-001121-14-DE   Australia;Austria;Belgium;Canada;Czech Republic;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
Prednison acis¿   
   CHEMOCENTRYX, INC.
      2017   Phase 3   EUCTR2016-001121-14-IT   Australia;Austria;Belgium;Canada;Czech Republic;Czechia;Denmark;France;Germany;Hungary;Ireland;Italy;Netherlands;New Zealand;Norway;Spain;Sweden;Switzerland;United Kingdom;United States;
Prednisone   
   AZIENDA OSPEDALIERA SPEDALI CIVILI DI BRESCIA
      2010   Phase 4   EUCTR2009-013220-24-IT   Czech Republic;Denmark;Italy;Poland;Spain;Sweden;United Kingdom;
   Hoffmann-La Roche
      2015   Phase 4   NCT02115997   India;
   National Institute of Allergy and Infectious Diseases (NIAID)
      2005   Phase 2/Phase 3   NCT00104299   Netherlands;United States;
Prednisone (and methylprednisolone)   
   Assistance Publique - Hôpitaux de Paris
      2003   Phase 3   NCT00307645   France;United Kingdom;
Prednisone, methylprednisolone,cyclophosphamides   
   Assistance Publique - Hôpitaux de Paris
      2005   Phase 4   NCT00307671   France;
RO0452294/V01   
   F. Hoffmann-La Roche Ltd.
      2013   Phase 2   EUCTR2012-002062-13-GB   Canada;France;Germany;Italy;Serbia;Turkey;United Kingdom;United States;
      2013   Phase 2   EUCTR2012-002062-13-DE   Canada;France;Germany;Italy;Serbia;Turkey;United Kingdom;United States;
RO0452294/V02   
   F. Hoffmann-La Roche Ltd.
      2013   Phase 2   EUCTR2012-002062-13-GB   Canada;France;Germany;Italy;Serbia;Turkey;United Kingdom;United States;
      2013   Phase 2   EUCTR2012-002062-13-DE   Canada;France;Germany;Italy;Serbia;Turkey;United Kingdom;United States;
Remission induction therapy   
   Masayoshi Harigai
      2018   Phase 2   JPRN-JMA-IIA00325   Japan;
Rituximab   
   Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust
      2006   Phase 3   EUCTR2005-003610-15-CZ   Czech Republic;Sweden;United Kingdom;
   Assistance Publique - Hôpitaux de Paris
      2020   Phase 3   NCT03920722   France;
      2008   Phase 3   NCT00748644   France;
      2004   -   NCT00307593   France;
   CHU de Saint-Etienne
      2015   Phase 4   EUCTR2015-001807-29-FR   France;
   Cambridge University Hospitals NHS Foundation Trust
      2014   Phase 3   EUCTR2012-001102-14-IT   Australia;Austria;Canada;Czech Republic;Denmark;Germany;Ireland;Italy;Mexico;Netherlands;New Zealand;Poland;Spain;Sweden;Switzerland;United Kingdom;
      2013   Phase 3   NCT01697267   Australia;Canada;Czech Republic;Czechia;Ireland;Italy;Japan;New Zealand;Sweden;United Kingdom;United States;
      2013   -   EUCTR2012-001102-14-ES   Australia;Austria;Canada;Czech Republic;Denmark;Germany;Ireland;Italy;Mexico;Netherlands;New Zealand;Poland;Spain;Sweden;Switzerland;United Kingdom;
      -   Phase 3   EUCTR2012-001102-14-GB   Australia;Austria;Canada;Czech Republic;Denmark;Germany;Ireland;Italy;Mexico;Netherlands;New Zealand;Poland;Spain;Sweden;Switzerland;United Kingdom;
   Chiba University
      2014   Phase 4   NCT02198248   Japan;
   Genentech, Inc.
      2012   -   NCT01613599   United States;
   Hoffmann-La Roche
      2015   Phase 4   NCT02115997   India;
      2013   Phase 2   NCT01750697   Canada;France;Germany;Italy;Serbia;Turkey;United Kingdom;United States;
   Massachusetts General Hospital
      2014   Phase 4   NCT02169219   United States;
   National Institute of Allergy and Infectious Diseases (NIAID)
      2005   Phase 2/Phase 3   NCT00104299   Netherlands;United States;
   University College Cork , Ireland
      2014   Phase 3   EUCTR2012-001102-14-IE   Australia;Austria;Canada;Czech Republic;Denmark;Germany;Ireland;Italy;Japan;Mexico;Netherlands;New Zealand;Poland;Spain;Sweden;Switzerland;United Kingdom;
   University of Miyazaki Hospital
      2014   Phase 3   JPRN-UMIN000012409   Japan,North America,South America,Australia,Europe;
Rituximab (Arm A)   
   Assistance Publique - Hôpitaux de Paris
      2012   Phase 3   NCT01731561   France;
Rituximab (Arm B)   
   Assistance Publique - Hôpitaux de Paris
      2012   Phase 3   NCT01731561   France;
Ro106-1443   
   Cambridge University Hospitals NHS Foundation Trust
      2008   Phase 2   EUCTR2006-001663-33-SE   Austria;Czech Republic;France;Germany;Italy;Spain;Sweden;United Kingdom;
Sendoxan   
   Cambridge University Hospitals NHS Foundation Trust
      2008   Phase 2   EUCTR2006-001663-33-SE   Austria;Czech Republic;France;Germany;Italy;Spain;Sweden;United Kingdom;
Tocilizumab   
    Clinical Immunology Saitama Medical Center, Saitama Medical Universitity
   Department of Rheumatology &
   Saitama Medical Center, Saitama Medical UniversityDepartment of Rheumatology and Clinical Immunology
      2013   -   JPRN-UMIN000011244   Japan;
      2013   -   JPRN-UMIN000011242   Japan;
Vilobelimab   
   InflaRx GmbH
      2019   Phase 2   EUCTR2018-000768-27-SE   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Italy;Netherlands;Russian Federation;Spain;Sweden;Switzerland;United Kingdom;
      2019   Phase 2   EUCTR2018-000768-27-NL   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Italy;Netherlands;Russian Federation;Spain;Sweden;United Kingdom;
      2019   Phase 2   EUCTR2018-000768-27-DE   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Italy;Netherlands;Russian Federation;Spain;Sweden;United Kingdom;
      2019   Phase 2   EUCTR2018-000768-27-CZ   Belgium;Czech Republic;Czechia;Denmark;France;Germany;Italy;Netherlands;Russian Federation;Spain;Sweden;United Kingdom;
Vitamin D   
   Christian Pagnoux
      2020   -   NCT04280601   Canada;