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No. Drug (Description in trials) DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
15009111000001105----[1] 43 💬
2ALEMTUZUMAB[1] Alemtuzumab[1] Alemtuzumab 💬[1] CD52 💬-[17] 13, 15, 19, 20, 36, 43, 44, 46, 51, 60, 63, 65, 85, 96, 164, 283, 284 💬
3Avacopan[1] Avacopan[1] Avacopan 💬[1] C5AR1 💬[6] Alcoholic liver disease, Complement and coagulation cascades, Coronavirus disease - COVID-19, Neuroactive ligand-receptor interaction, Neutrophil extracellular trap formation, Staphylococcus aureus infection 💬[3] 43, 44, 222 💬
4Azathioprine[1] Azathioprine[1] Azathioprine 💬--[21] 6, 11, 13, 19, 35, 42, 43, 44, 45, 46, 49, 63, 65, 66, 85, 93, 94, 95, 96, 97, 162 💬
5BELIMUMAB[1] Belimumab[1] Belimumab 💬[1] TNFSF13B 💬[4] Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, NF-kappa B signaling pathway, Rheumatoid arthritis 💬[13] 11, 13, 43, 44, 46, 49, 51, 53, 63, 66, 222, 296, 300 💬
6Belimumab 10 mg/kg[1] Belimumab[1] Belimumab 💬[1] TNFSF13B 💬[4] Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, NF-kappa B signaling pathway, Rheumatoid arthritis 💬[3] 43, 46, 49 💬
7Benlysta[1] Belimumab[1] Belimumab 💬[1] TNFSF13B 💬[4] Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, NF-kappa B signaling pathway, Rheumatoid arthritis 💬[5] 43, 49, 53, 66, 222 💬
8Benlysta 400 mg powder for concentrate for solution for infusion[1] Belimumab[1] Belimumab 💬[1] TNFSF13B 💬[4] Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, NF-kappa B signaling pathway, Rheumatoid arthritis 💬[2] 43, 49 💬
9Benlysta 400mg polvere per concentrato per soluzione per infusione[1] Belimumab[1] Belimumab 💬[1] TNFSF13B 💬[4] Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, NF-kappa B signaling pathway, Rheumatoid arthritis 💬[1] 43 💬
10Blisibimod[1] Blisibimod[1] Blisibimod 💬--[5] 43, 44, 49, 63, 66 💬
11CCX168----[5] 43, 44, 66, 109, 222 💬
12CELLCEPT[1] Mycophenolate mofetil[1] Mycophenolate mofetil 💬[2] IMPDH1,
IMPDH2 💬		[4] Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism, Purine metabolism 💬[5] 11, 13, 42, 43, 49 💬
13CellCept (Mycophenolate Mofetil)[2] Mycophenolate mofetil,
Mycophenolic acid		[2] Mycophenolate mofetil ,
Mycophenolic acid 💬		[2] IMPDH1,
IMPDH2 💬		[4] Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism, Purine metabolism 💬[2] 42, 43 💬
14Chimeric monoclonal antibody, IgG4 subtype----[2] 43, 44 💬
15Corticosteroid----[9] 13, 42, 43, 44, 45, 66, 96, 97, 222 💬
16Corticosteroid and azathioprine[1] Azathioprine[1] Azathioprine 💬--[4] 42, 43, 44, 45 💬
17Cyclophosphamide[1] Cyclophosphamide[2] Cyclophosphamide ,
Cyclophosphamide 💬		--[44] 11, 13, 14, 16, 19, 20, 26, 28, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 56, 60, 62, 65, 66, 84, 85, 93, 96, 162, 164, 172, 205, 222, 224, 256, 274, 283, 284, 285, 288, 326, 331 💬
18Cyclophosphamide, Azathioprine,prednisone,methylprednisolone[4] Azathioprine,
Cyclophosphamide,
Methylprednisolone,
Prednisone		[5] Azathioprine ,
Cyclophosphamide ,
Methylprednisolone ,
Prednisone ,
Cyclophosphamide 💬		[1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[3] 42, 43, 45 💬
19DELTACORTENE----[2] 43, 97 💬
20ENDOXAN----[7] 13, 28, 43, 44, 85, 96, 222 💬
21ENDOXAN BAXTER----[3] 13, 43, 96 💬
22Freeze-Dried Sulfonated Human Normal Immunoglobulin (GGS)[1] Human immunoglobulin G---[3] 14, 43, 45 💬
23GALEN® tablet----[2] 43, 44 💬
24Glucocorticoid (GC)----[2] 43, 44 💬
25Glucocorticoids----[8] 40, 41, 43, 44, 60, 62, 75, 300 💬
26Glucocorticoids (GC)----[2] 43, 44 💬
27Glucocorticoids - Reduced Dose----[2] 43, 44 💬
28Glucocorticoids - Standard Dose----[2] 43, 44 💬
29Glucocorticoids [Reduced Dose]----[2] 43, 44 💬
30Glucocorticoids [Standard Dose]----[2] 43, 44 💬
31Human normal immunoglobulin[1] Human immunoglobulin G---[9] 11, 13, 14, 43, 45, 50, 51, 63, 65 💬
32Hydroxychloroquine[1] Hydroxychloroquine[1] Hydroxychloroquine 💬--[27] 13, 34, 41, 43, 44, 45, 46, 48, 49, 53, 56, 63, 66, 84, 89, 90, 96, 97, 107, 218, 222, 224, 234, 254, 271, 298, 299 💬
33IFX-1[1] Vilobelimab[1] Vilobelimab 💬[1] C5 💬[11] Alcoholic liver disease, Complement and coagulation cascades, Coronavirus disease - COVID-19, Herpes simplex virus 1 infection, Neuroactive ligand-receptor interaction, Neutrophil extracellular trap formation, Pertussis, Prion disease, Regulation of actin cytoskeleton, Staphylococcus aureus infection, Systemic lupus erythematosus 💬[3] 43, 44, 269 💬
34Infliximab[1] Infliximab[1] Infliximab 💬[1] TNF 💬[67] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[26] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
35Intravenous immunoglobulins (human immunoglobulins G)----[1] 43 💬
36Intravenous methyl prednisolone[1] Prednisolone[1] Prednisolone 💬[1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[1] 43 💬
37MabThera[1] Rituximab[1] Rituximab 💬[1] MS4A1 💬[1] Hematopoietic cell lineage 💬[22] 11, 13, 14, 19, 35, 43, 44, 46, 49, 50, 51, 52, 53, 61, 63, 64, 65, 83, 93, 162, 222, 271 💬
38Mabthera®[1] Rituximab[1] Rituximab 💬[1] MS4A1 💬[1] Hematopoietic cell lineage 💬[6] 13, 35, 43, 44, 46, 93 💬
39MabThera® 100MG[1] Rituximab[1] Rituximab 💬[1] MS4A1 💬[1] Hematopoietic cell lineage 💬[1] 43 💬
40MabThera® 500MG[1] Rituximab[1] Rituximab 💬[1] MS4A1 💬[1] Hematopoietic cell lineage 💬[1] 43 💬
41Methotrexate[1] Methotrexate[1] Methotrexate 💬[2] DHFR,
DHFR2 💬		[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬[38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬
42Methyl prednisolone[1] Prednisolone[1] Prednisolone 💬[1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[3] 43, 49, 96 💬
43Methylprednisolone[1] Methylprednisolone[1] Methylprednisolone 💬[1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[46] 2, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 95, 96, 97, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬
44Methylprednisolone (or other glucocorticoid)[1] Methylprednisolone[1] Methylprednisolone 💬[1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[1] 43 💬
45Mycophenolate[1] Mycophenolic acid[1] Mycophenolic acid 💬[2] IMPDH1,
IMPDH2 💬		[4] Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism, Purine metabolism 💬[36] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 💬
46Mycophenolate mofetil[2] Mycophenolate mofetil,
Mycophenolic acid		[2] Mycophenolate mofetil ,
Mycophenolic acid 💬		[2] IMPDH1,
IMPDH2 💬		[4] Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism, Purine metabolism 💬[34] 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬
47Mycophenolate mofetil,methotrexate[3] Methotrexate,
Mycophenolate mofetil,
Mycophenolic acid		[3] Methotrexate ,
Mycophenolate mofetil ,
Mycophenolic acid 💬		[4] DHFR,
DHFR2,
IMPDH1,
IMPDH2 💬		[8] Antifolate resistance, Biosynthesis of cofactors, Drug metabolism - other enzymes, Folate biosynthesis, Metabolic pathways, Nucleotide metabolism, One carbon pool by folate, Purine metabolism 💬[3] 42, 43, 45 💬
48Mycophenolic acid[1] Mycophenolic acid[1] Mycophenolic acid 💬[2] IMPDH1,
IMPDH2 💬		[4] Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism, Purine metabolism 💬[8] 11, 43, 49, 51, 60, 66, 96, 222 💬
49Naltrexone[1] Naltrexone[1] Naltrexone 💬[3] OPRD1,
OPRK1,
OPRM1 💬		[5] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬[12] 6, 10, 13, 40, 41, 42, 43, 44, 45, 96, 97, 226 💬
50NALTREXONE HYDROCHLORIDE[1] Naltrexone[1] Naltrexone 💬[3] OPRD1,
OPRK1,
OPRM1 💬		[5] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬[8] 10, 40, 41, 42, 43, 44, 45, 96 💬
51Obinutuzumab[1] Obinutuzumab[1] Obinutuzumab 💬[1] MS4A1 💬[1] Hematopoietic cell lineage 💬[4] 43, 44, 49, 222 💬
52Pednisone----[2] 43, 44 💬
53Placebo (physiological saline)----[2] 43, 45 💬
54Plaquenil - Hydroxychloroquine 200mg Film coated tablets[1] Hydroxychloroquine[1] Hydroxychloroquine 💬--[3] 43, 44, 45 💬
55PREDNISOLONE[1] Prednisolone[1] Prednisolone 💬[1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[42] 3, 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬
56Prednison acis® 20 mg----[2] 43, 44 💬
57Prednison acis® 5 mg----[2] 43, 44 💬
58Prednison acis¿ 20 mg----[2] 43, 44 💬
59Prednison acis¿ 5 mg----[2] 43, 44 💬
60Prednisone[1] Prednisone[1] Prednisone 💬[1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[45] 2, 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 95, 96, 97, 113, 162, 164, 205, 222, 224, 228, 283, 284, 288, 299, 300, 307, 331 💬
61Prednisone (and methylprednisolone)[2] Methylprednisolone,
Prednisone		[2] Methylprednisolone ,
Prednisone 💬		[1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[1] 43 💬
62PredniSONE Tablets, USP[1] Prednisone[1] Prednisone 💬[1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[3] 41, 43, 44 💬
63Prednisone, methylprednisolone,cyclophosphamides[2] Methylprednisolone,
Prednisone		[2] Methylprednisolone ,
Prednisone 💬		[1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[3] 42, 43, 45 💬
64Remission induction therapy----[2] 43, 44 💬
65RITUXIMAB[1] Rituximab[1] Rituximab 💬[1] MS4A1 💬[1] Hematopoietic cell lineage 💬[48] 11, 13, 14, 19, 26, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331 💬
66Rituximab (Arm A)[1] Rituximab[1] Rituximab 💬[1] MS4A1 💬[1] Hematopoietic cell lineage 💬[2] 43, 44 💬
67Rituximab (Arm B)[1] Rituximab[1] Rituximab 💬[1] MS4A1 💬[1] Hematopoietic cell lineage 💬[2] 43, 44 💬
68RIXATHON 500mg----[1] 43 💬
69RO0452294/V01----[2] 43, 44 💬
70RO0452294/V02----[3] 35, 43, 44 💬
71Ro106-1443----[1] 43 💬
72Sendoxan----[2] 13, 43 💬
73Tocilizumab[1] Tocilizumab[1] Tocilizumab 💬[1] IL6R 💬[12] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Non-alcoholic fatty liver disease, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬[21] 2, 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬
74Vilobelimab[1] Vilobelimab[1] Vilobelimab 💬[1] C5 💬[11] Alcoholic liver disease, Complement and coagulation cascades, Coronavirus disease - COVID-19, Herpes simplex virus 1 infection, Neuroactive ligand-receptor interaction, Neutrophil extracellular trap formation, Pertussis, Prion disease, Regulation of actin cytoskeleton, Staphylococcus aureus infection, Systemic lupus erythematosus 💬[2] 43, 44 💬
75Vitamin D[2] Cholecalciferol,
Vitamin D		[1] Cholecalciferol 💬[1] VDR 💬[5] Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Mineral absorption, Parathyroid hormone synthesis, secretion and action, Tuberculosis 💬[20] 13, 19, 41, 43, 44, 46, 49, 50, 68, 93, 95, 96, 97, 179, 222, 228, 235, 274, 298, 299 💬