45. Eosinophilic granulomatosis with Polyangiitis Disease details / Clinical trials / Drug dev / DR info
Clinical trials : 31 / Drugs : 44 - (DrugBank : 18) / Drug target genes : 18 - Drug target pathways : 101
Drugs and their primary sponsors and trial info
Anti-thymocyte globulin
Fairview University Medical Center
2000 - NCT00006055 United States;
Autologous Peripheral Blood Stem Cell Transplantation
Fairview University Medical Center
2000 - NCT00006055 United States;
Azathioprine
Hospices Civils de Lyon
1996 Phase 4 NCT00399399 Switzerland;
Benralizumab
ASTRAZENECA AB
2020 Phase 3 EUCTR2019-001832-77-IT Belgium;Canada;France;Germany;Israel;Italy;Japan;United Kingdom;United States;
AstraZeneca AB
2020 Phase 3 EUCTR2019-001832-77-DE Belgium;Canada;France;Germany;Israel;Italy;Japan;United Kingdom;United States;
2019 Phase 3 EUCTR2019-001832-77-GB Belgium;Canada;France;Germany;Israel;Italy;Japan;United Kingdom;United States;
2019 Phase 3 EUCTR2019-001832-77-FR Belgium;Canada;France;Germany;Israel;Italy;Japan;United Kingdom;United States;
Corticosteroid and azathioprine
Assistance Publique - Hôpitaux de Paris
2008 Phase 3 NCT00647166 France;
Cyclophosphamide
Assistance Publique - Hôpitaux de Paris
2016 Phase 3 NCT02807103 France;
Fairview University Medical Center
2000 - NCT00006055 United States;
Hospices Civils de Lyon
1996 Phase 4 NCT00399399 Switzerland;
University of Parma
2008 Phase 2 NCT00751517 Italy;
Cyclophosphamide, Azathioprine,prednisone,methylprednisolone
Assistance Publique - Hôpitaux de Paris
2005 Phase 4 NCT00307671 France;
Cyclosporine
Fairview University Medical Center
2000 - NCT00006055 United States;
Fasenra
AstraZeneca AB
2020 Phase 3 EUCTR2019-001832-77-DE Belgium;Canada;France;Germany;Israel;Italy;Japan;United Kingdom;United States;
Filgrastim
Fairview University Medical Center
2000 - NCT00006055 United States;
Freeze-Dried Sulfonated Human Normal Immunoglobulin (GGS)
TEIJIN PHARMA LIMITED
2006 Phase 3 JPRN-JapicCTI-060242 -
HPC cell infusion
Mounzer Agha
2016 Early Phase 1 NCT02728271 -
Hydroxychloroquine
Guy's and St Thomas' NHS Foundation Trust
2020 Phase 4 NCT04316494 United Kingdom;
Infliximab
Assistance Publique - Hôpitaux de Paris
2004 - NCT00307593 France;
L04AC06
ASTRAZENECA AB
2020 Phase 3 EUCTR2019-001832-77-IT Belgium;Canada;France;Germany;Israel;Italy;Japan;United Kingdom;United States;
AstraZeneca AB
2020 Phase 3 EUCTR2019-001832-77-DE Belgium;Canada;France;Germany;Israel;Italy;Japan;United Kingdom;United States;
2019 Phase 3 EUCTR2019-001832-77-GB Belgium;Canada;France;Germany;Israel;Italy;Japan;United Kingdom;United States;
2019 Phase 3 EUCTR2019-001832-77-FR Belgium;Canada;France;Germany;Israel;Italy;Japan;United Kingdom;United States;
MEDI-563
ASTRAZENECA AB
2020 Phase 3 EUCTR2019-001832-77-IT Belgium;Canada;France;Germany;Israel;Italy;Japan;United Kingdom;United States;
AstraZeneca AB
2020 Phase 3 EUCTR2019-001832-77-DE Belgium;Canada;France;Germany;Israel;Italy;Japan;United Kingdom;United States;
2019 Phase 3 EUCTR2019-001832-77-GB Belgium;Canada;France;Germany;Israel;Italy;Japan;United Kingdom;United States;
2019 Phase 3 EUCTR2019-001832-77-FR Belgium;Canada;France;Germany;Israel;Italy;Japan;United Kingdom;United States;
Mepolizumab
ASTRAZENECA AB
2020 Phase 3 EUCTR2019-001832-77-IT Belgium;Canada;France;Germany;Israel;Italy;Japan;United Kingdom;United States;
AstraZeneca AB
2020 Phase 3 EUCTR2019-001832-77-DE Belgium;Canada;France;Germany;Israel;Italy;Japan;United Kingdom;United States;
2019 Phase 3 EUCTR2019-001832-77-GB Belgium;Canada;France;Germany;Israel;Italy;Japan;United Kingdom;United States;
2019 Phase 3 EUCTR2019-001832-77-FR Belgium;Canada;France;Germany;Israel;Italy;Japan;United Kingdom;United States;
Brigham and Women's Hospital
2007 Phase 1/Phase 2 NCT00527566 United States;
Children's Hospital Medical Center, Cincinnati
2001 Phase 1/Phase 2 NCT00266565 United States;
GlaxoSmithKline
2015 Phase 3 NCT03298061 Belgium;Canada;France;Germany;Japan;United Kingdom;United States;
2014 Phase 3 NCT02020889 Belgium;Canada;France;Germany;Italy;Japan;Spain;United Kingdom;United States;
University Hospital of Schleswig-Holstein (UKSH), Campus Lübeck
2008 - EUCTR2006-001791-20-DE Germany;
University of Schleswig-Holstein
2008 Phase 2 NCT00716651 Germany;
Methotrexate
University of Parma
2008 Phase 2 NCT00751517 Italy;
Methylprednisolone
Fairview University Medical Center
2000 - NCT00006055 United States;
Mycophenolate mofetil,methotrexate
Assistance Publique - Hôpitaux de Paris
2005 Phase 4 NCT00307671 France;
Naltrexone Hydrochloride
University of Pennsylvania
2019 Phase 2 NCT03482479 United States;
Nucala
GlaxoSmithKline
2018 - NCT03557060 Japan;
Nucala 100 mg powder for solution for injection
AstraZeneca AB
2020 Phase 3 EUCTR2019-001832-77-DE Belgium;Canada;France;Germany;Israel;Italy;Japan;United Kingdom;United States;
Placebo (physiological saline)
TEIJIN PHARMA LIMITED
2006 Phase 3 JPRN-JapicCTI-060242 -
Plaquenil - Hydroxychloroquine 200mg Film coated tablets
Guy's and St. Thomas' NHS Foundation Trust
2020 Phase 4 EUCTR2018-001268-40-GB United Kingdom;
Prednisolone
GlaxoSmithKline
2015 Phase 3 NCT03298061 Belgium;Canada;France;Germany;Japan;United Kingdom;United States;
Prednisone
Fairview University Medical Center
2000 - NCT00006055 United States;
Fernando Fervenza
2007 Phase 2 NCT00424749 United States;
Prednisone, methylprednisolone,cyclophosphamides
Assistance Publique - Hôpitaux de Paris
2005 Phase 4 NCT00307671 France;
Rituximab
Assistance Publique - Hôpitaux de Paris
2016 Phase 3 NCT02807103 France;
2004 - NCT00307593 France;
Fernando Fervenza
2007 Phase 2 NCT00424749 United States;
SB-240563
University Hospital of Schleswig-Holstein (UKSH), Campus Lübeck
2008 - EUCTR2006-001791-20-DE Germany;
SB-240563 (mepolizumab)
GlaxoSmithKline Research Ltd
2015 Phase 3 EUCTR2014-003162-25-GB Belgium;Canada;France;Germany;Japan;United Kingdom;
2015 Phase 3 EUCTR2014-003162-25-DE Belgium;Canada;France;Germany;Japan;United Kingdom;
2015 Phase 3 EUCTR2014-003162-25-BE Belgium;Canada;Germany;Japan;United Kingdom;United States;
Fairview University Medical Center
2000 - NCT00006055 United States;
Autologous Peripheral Blood Stem Cell Transplantation
Fairview University Medical Center
2000 - NCT00006055 United States;
Azathioprine
Hospices Civils de Lyon
1996 Phase 4 NCT00399399 Switzerland;
Benralizumab
ASTRAZENECA AB
2020 Phase 3 EUCTR2019-001832-77-IT Belgium;Canada;France;Germany;Israel;Italy;Japan;United Kingdom;United States;
AstraZeneca AB
2020 Phase 3 EUCTR2019-001832-77-DE Belgium;Canada;France;Germany;Israel;Italy;Japan;United Kingdom;United States;
2019 Phase 3 EUCTR2019-001832-77-GB Belgium;Canada;France;Germany;Israel;Italy;Japan;United Kingdom;United States;
2019 Phase 3 EUCTR2019-001832-77-FR Belgium;Canada;France;Germany;Israel;Italy;Japan;United Kingdom;United States;
Corticosteroid and azathioprine
Assistance Publique - Hôpitaux de Paris
2008 Phase 3 NCT00647166 France;
Cyclophosphamide
Assistance Publique - Hôpitaux de Paris
2016 Phase 3 NCT02807103 France;
Fairview University Medical Center
2000 - NCT00006055 United States;
Hospices Civils de Lyon
1996 Phase 4 NCT00399399 Switzerland;
University of Parma
2008 Phase 2 NCT00751517 Italy;
Cyclophosphamide, Azathioprine,prednisone,methylprednisolone
Assistance Publique - Hôpitaux de Paris
2005 Phase 4 NCT00307671 France;
Cyclosporine
Fairview University Medical Center
2000 - NCT00006055 United States;
Fasenra
AstraZeneca AB
2020 Phase 3 EUCTR2019-001832-77-DE Belgium;Canada;France;Germany;Israel;Italy;Japan;United Kingdom;United States;
Filgrastim
Fairview University Medical Center
2000 - NCT00006055 United States;
Freeze-Dried Sulfonated Human Normal Immunoglobulin (GGS)
TEIJIN PHARMA LIMITED
2006 Phase 3 JPRN-JapicCTI-060242 -
HPC cell infusion
Mounzer Agha
2016 Early Phase 1 NCT02728271 -
Hydroxychloroquine
Guy's and St Thomas' NHS Foundation Trust
2020 Phase 4 NCT04316494 United Kingdom;
Infliximab
Assistance Publique - Hôpitaux de Paris
2004 - NCT00307593 France;
L04AC06
ASTRAZENECA AB
2020 Phase 3 EUCTR2019-001832-77-IT Belgium;Canada;France;Germany;Israel;Italy;Japan;United Kingdom;United States;
AstraZeneca AB
2020 Phase 3 EUCTR2019-001832-77-DE Belgium;Canada;France;Germany;Israel;Italy;Japan;United Kingdom;United States;
2019 Phase 3 EUCTR2019-001832-77-GB Belgium;Canada;France;Germany;Israel;Italy;Japan;United Kingdom;United States;
2019 Phase 3 EUCTR2019-001832-77-FR Belgium;Canada;France;Germany;Israel;Italy;Japan;United Kingdom;United States;
MEDI-563
ASTRAZENECA AB
2020 Phase 3 EUCTR2019-001832-77-IT Belgium;Canada;France;Germany;Israel;Italy;Japan;United Kingdom;United States;
AstraZeneca AB
2020 Phase 3 EUCTR2019-001832-77-DE Belgium;Canada;France;Germany;Israel;Italy;Japan;United Kingdom;United States;
2019 Phase 3 EUCTR2019-001832-77-GB Belgium;Canada;France;Germany;Israel;Italy;Japan;United Kingdom;United States;
2019 Phase 3 EUCTR2019-001832-77-FR Belgium;Canada;France;Germany;Israel;Italy;Japan;United Kingdom;United States;
Mepolizumab
ASTRAZENECA AB
2020 Phase 3 EUCTR2019-001832-77-IT Belgium;Canada;France;Germany;Israel;Italy;Japan;United Kingdom;United States;
AstraZeneca AB
2020 Phase 3 EUCTR2019-001832-77-DE Belgium;Canada;France;Germany;Israel;Italy;Japan;United Kingdom;United States;
2019 Phase 3 EUCTR2019-001832-77-GB Belgium;Canada;France;Germany;Israel;Italy;Japan;United Kingdom;United States;
2019 Phase 3 EUCTR2019-001832-77-FR Belgium;Canada;France;Germany;Israel;Italy;Japan;United Kingdom;United States;
Brigham and Women's Hospital
2007 Phase 1/Phase 2 NCT00527566 United States;
Children's Hospital Medical Center, Cincinnati
2001 Phase 1/Phase 2 NCT00266565 United States;
GlaxoSmithKline
2015 Phase 3 NCT03298061 Belgium;Canada;France;Germany;Japan;United Kingdom;United States;
2014 Phase 3 NCT02020889 Belgium;Canada;France;Germany;Italy;Japan;Spain;United Kingdom;United States;
University Hospital of Schleswig-Holstein (UKSH), Campus Lübeck
2008 - EUCTR2006-001791-20-DE Germany;
University of Schleswig-Holstein
2008 Phase 2 NCT00716651 Germany;
Methotrexate
University of Parma
2008 Phase 2 NCT00751517 Italy;
Methylprednisolone
Fairview University Medical Center
2000 - NCT00006055 United States;
Mycophenolate mofetil,methotrexate
Assistance Publique - Hôpitaux de Paris
2005 Phase 4 NCT00307671 France;
Naltrexone Hydrochloride
University of Pennsylvania
2019 Phase 2 NCT03482479 United States;
Nucala
GlaxoSmithKline
2018 - NCT03557060 Japan;
Nucala 100 mg powder for solution for injection
AstraZeneca AB
2020 Phase 3 EUCTR2019-001832-77-DE Belgium;Canada;France;Germany;Israel;Italy;Japan;United Kingdom;United States;
Placebo (physiological saline)
TEIJIN PHARMA LIMITED
2006 Phase 3 JPRN-JapicCTI-060242 -
Plaquenil - Hydroxychloroquine 200mg Film coated tablets
Guy's and St. Thomas' NHS Foundation Trust
2020 Phase 4 EUCTR2018-001268-40-GB United Kingdom;
Prednisolone
GlaxoSmithKline
2015 Phase 3 NCT03298061 Belgium;Canada;France;Germany;Japan;United Kingdom;United States;
Prednisone
Fairview University Medical Center
2000 - NCT00006055 United States;
Fernando Fervenza
2007 Phase 2 NCT00424749 United States;
Prednisone, methylprednisolone,cyclophosphamides
Assistance Publique - Hôpitaux de Paris
2005 Phase 4 NCT00307671 France;
Rituximab
Assistance Publique - Hôpitaux de Paris
2016 Phase 3 NCT02807103 France;
2004 - NCT00307593 France;
Fernando Fervenza
2007 Phase 2 NCT00424749 United States;
SB-240563
University Hospital of Schleswig-Holstein (UKSH), Campus Lübeck
2008 - EUCTR2006-001791-20-DE Germany;
SB-240563 (mepolizumab)
GlaxoSmithKline Research Ltd
2015 Phase 3 EUCTR2014-003162-25-GB Belgium;Canada;France;Germany;Japan;United Kingdom;
2015 Phase 3 EUCTR2014-003162-25-DE Belgium;Canada;France;Germany;Japan;United Kingdom;
2015 Phase 3 EUCTR2014-003162-25-BE Belgium;Canada;Germany;Japan;United Kingdom;United States;