62. Paroxysmal nocturnal hemoglobinuria Disease details / Clinical trials / Drug dev / DR info
Clinical trials : 292 / Drugs : 151 - (DrugBank : 49) / Drug target genes : 22 - Drug target pathways : 108
Paroxysmal nocturnal hemoglobinuria and other diseases between which drug repositioning might occur (Sakate and Kimura 2021) . Circle size: Number of drugs, Line breadth: Drug repositionability
| ID | Diseases (Sorted by drug repositionability) |
|---|---|
| 62 | Paroxysmal nocturnal hemoglobinuria |
| 13 | Multiple sclerosis/Neuromyelitis optica |
| 283 | Acquired pure red cell aplasia |
| 285 | Fanconi anemia |
| 49 | Systemic lupus erythematosus |
| 96 | Crohn disease |
| 2 | Amyotrophic lateral sclerosis |
| 60 | Aplastic anemia |
| 46 | Malignant rheumatoid arthritis |
| 284 | Diamond-Blackfan anemia |
| 11 | Myasthenia gravis |
| 61 | Autoimmune hemolytic anemia |
| 222 | Primary nephrotic syndrome |
| 19 | Lysosomal storage disease |
| 45 | Eosinophilic granulomatosis with Polyangiitis |
| 65 | Primary immunodeficiency |
| 164 | Oculocutaneous albinism |
| 51 | Scleroderma |
| 36 | Epidermolysis bullosa |
| 286 | Hereditary sideroblastic anemia |
| 53 | Sjogren syndrome |
| 42 | Polyarteritis nodosa |
| 162 | Pemphigoid |
| 66 | IgA nephropathy |
| 40 | Takayasu arteritis |
| 39 | Toxic epidermal necrolysis |
| 28 | Systemic amyloidosis |
| 41 | Giant cell arteritis |
| 234 | Peroxisomal disease (except Adrenoleukodystrophy) |
| 85 | Idiopathic interstitial pneumonia |
| 93 | Primary biliary cholangitis |
| 63 | Idiopathic thrombocytopenic purpura |
| 224 | Purpura nephritis |
| 326 | Osteopetrosis |
| 228 | Bronchiolitis obliterans |
| 95 | Autoimmune hepatitis |
| 55 | Relapsing polychondritis |
| 302 | Leber hereditary optic neuropathy |
| 20 | Adrenoleukodystrophy |
| 50 | Dermatomyositis |
| 38 | Stevens-Johnson syndrome |
| 269 | Pyogenic arthritis |
| 151 | Rasmussen encephalitis |
| 299 | Cystic fibrosis |
| 97 | Ulcerative colitis |
| 160 | Congenital ichthyosis |
| 56 | Behcet disease |
| 6 | Parkinson disease |
| 26 | HTLV-1-associated myelopathy |
| 94 | Primary sclerosing cholangitis |
| 90 | Retinitis pigmentosa |
| 35 | Pemphigus |
| 107 | Juvenile idiopathic arthritis |
| 226 | Interstitial cystitis with Hunners ulcer |
| 43 | Microscopic polyangiitis |
| 64 | Thrombotic thrombocytopenic purpura |
| 44 | Wegener granulomatosis |
| 113 | Muscular dystrophy |
| 274 | Osteogenesis Imperfecta |
| 158 | Tuberous sclerosis |
| 84 | Sarcoidosis |
| 227 | Osler disease |
| 331 | Idiopathic multicentric castleman disease |
| 58 | Hypertrophic cardiomyopathy |
| 109 | Atypical hemolytic uremic syndrome |
| 172 | Hypophosphatasia |
| 256 | Muscle glycogenosis |
| 137 | Focal cortical dysplasia |
| 192 | Cockayne syndrome |
| 277 | Lymphangiomatosis |
| 281 | Klippel-Trenaunay-Weber syndrome |
| 220 | Rapidly progressive glomerulonephritis |
| 30 | Distal myopathy |