274. 骨形成不全症
[臨床試験数:78,薬物数:87(DrugBank:19),標的遺伝子数:14,標的パスウェイ数:74

Searched query = "Osteogenesis Imperfecta"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

Search in Page e.g. "Phase 3", "Not recruiting", "Japan"
3 trials found
No.TrialIDDate_
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Public_titleScientific_titleConditionInterventionPrimary_
sponsor
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agemin
Inclusion_
agemax
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PhaseCountries
1NCT03706482
(ClinicalTrials.gov)
August 12, 20195/10/2018Boost Brittle Bones Before BirthAn Exploratory, Open Label, Multiple Dose, Multicentre Phase I/II Trial Evaluating Safety and Efficacy of Postnatal or Prenatal and Postnatal Intravenous Administration of Allogeneic Expanded Fetal Mesenchymal Stem Cells for the Treatment of Severe Osteogenesis Imperfecta Compared With a Combination of Historical and Untreated Prospective ControlsOsteogenesis ImperfectaBiological: BOOST cellsCecilia GötherströmKarolinska University Hospital;Great Ormond Street Hospital for Children NHS Foundation Trust;University College, London;Universitätsklinikum Köln;UMC Utrecht;Leiden University Medical Center;Lund UniversityRecruitingN/A12 MonthsAll210Phase 1/Phase 2Sweden
2EUCTR2015-003699-60-SE
(EUCTR)
28/09/201823/07/2018Treatment of severe congenital Brittle bone disease after or before and after birth.An exploratory, open label, multiple dose, multicentre phase I/II trial evaluating safety and efficacy of postnatal or prenatal and postnatal intravenous administration of allogeneic expanded fetal mesenchymal stem cells for the treatment of severe Osteogenesis Imperfecta compared with a combination of historical and untreated prospective controls. Treatment of Osteogenesis Imperfecta (OI) type III and severe type IV.;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]Karolinska InstitutetNULLAuthorised-recruitment may be ongoing or finished Female: yes
Male: yes
210 Human pharmacology (Phase 1): yes Therapeutic exploratory (Phase 2): yes Therapeutic confirmatory - (Phase 3): no Therapeutic use (Phase 4): noSweden
3NCT02172885
(ClinicalTrials.gov)
April 201412/6/2014Mesenchymal Stem Cell Based Therapy for the Treatment of Osteogenesis ImperfectaMesenchymal Stem Cell Based Therapy for the Treatment of Osteogenesis ImperfectaOsteogenesis ImperfectaBiological: Mesenchymal Stem CellsHospital de CrucesHospital Universitario Getafe;Hospital Infantil Universitario Niño Jesús, Madrid, SpainCompleted6 Months12 YearsAll2Phase 1Spain