Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 CNR1 3件: Rap1 signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling D00306 Dronabinol 8件: 2, 8, 13, 36, 46, 96, 271, 298
2 CNR1 3件: Rap1 signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling D05099 Nabilone 3件: 6, 13, 127
3 CNR1 3件: Rap1 signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling D05731 Rimonabant 1件: 193
4 CNR1 3件: Rap1 signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling D10915 Cannabidiol 20件: 2, 6, 8, 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271
5 ADORA2A 2件: Rap1 signaling pathway, Vascular smooth muscle contraction D00045 Adenosine 3件: 13, 58, 65
6 ADORA2A 2件: Rap1 signaling pathway, Vascular smooth muscle contraction D00528 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
7 ADORA2A 2件: Rap1 signaling pathway, Vascular smooth muscle contraction D01453 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
8 ADORA2A 2件: Rap1 signaling pathway, Vascular smooth muscle contraction D02769 Adenosine phosphate 1件: 46
9 ADORA2A 2件: Rap1 signaling pathway, Vascular smooth muscle contraction D04641 Istradefylline 1件: 6
10 ADORA2A 2件: Rap1 signaling pathway, Vascular smooth muscle contraction D05711 Regadenoson 1件: 58
11 ADORA2A 2件: Rap1 signaling pathway, Vascular smooth muscle contraction D09717 Preladenant 1件: 6
12 ADORA2A 2件: Rap1 signaling pathway, Vascular smooth muscle contraction D10174 Tozadenant 1件: 6
13 ADORA2A 2件: Rap1 signaling pathway, Vascular smooth muscle contraction D12568 Regadenoson 1件: 58
14 ADORA2B 2件: Rap1 signaling pathway, Vascular smooth muscle contraction D00045 Adenosine 3件: 13, 58, 65
15 ADORA2B 2件: Rap1 signaling pathway, Vascular smooth muscle contraction D00227 Aminophylline 1件: 63
16 ADORA2B 2件: Rap1 signaling pathway, Vascular smooth muscle contraction D00371 Theophylline 2件: 236, 299
17 ADORA2B 2件: Rap1 signaling pathway, Vascular smooth muscle contraction D02769 Adenosine phosphate 1件: 46
18 ADORA2B 2件: Rap1 signaling pathway, Vascular smooth muscle contraction D06103 Theophylline 2件: 236, 299
19 MAPK14 18件: Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling, Relaxin signaling pathway, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod 2件: 113, 222
20 MAPK14 18件: Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling, Relaxin signaling pathway, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod 1件: 8
21 CSF1R 4件: Ras signaling pathway, Rap1 signaling pathway, Viral protein interaction with cytokine and cytokine receptor, Transcriptional misregulation in cancer D08552 Sunitinib 2件: 28, 34
22 CSF1R 4件: Ras signaling pathway, Rap1 signaling pathway, Viral protein interaction with cytokine and cytokine receptor, Transcriptional misregulation in cancer D11270 Pexidartinib 1件: 34
23 DRD2 1件: Rap1 signaling pathway D00059 Levodopa 6件: 6, 17, 90, 140, 164, 201
24 DRD2 1件: Rap1 signaling pathway D00136 Haloperidol 1件: 8
25 DRD2 1件: Rap1 signaling pathway D00270 Chlorpromazine 1件: 254
26 DRD2 1件: Rap1 signaling pathway D00426 Risperidone 5件: 8, 156, 179, 187, 206
27 DRD2 1件: Rap1 signaling pathway D00454 Olanzapine 2件: 2, 8
28 DRD2 1件: Rap1 signaling pathway D00560 Pimozide 1件: 2
29 DRD2 1件: Rap1 signaling pathway D00726 Metoclopramide 2件: 46, 51
30 DRD2 1件: Rap1 signaling pathway D00987 Cabergoline 3件: 6, 74, 75
31 DRD2 1件: Rap1 signaling pathway D01044 Flupentixol 1件: 97
32 DRD2 1件: Rap1 signaling pathway D01164 Aripiprazole 2件: 6, 206
33 DRD2 1件: Rap1 signaling pathway D01226 Sulpiride 2件: 6, 70
34 DRD2 1件: Rap1 signaling pathway D01348 Terguride 2件: 51, 86
35 DRD2 1件: Rap1 signaling pathway D01448 Trifluoperazine 2件: 283, 284
36 DRD2 1件: Rap1 signaling pathway D01745 Domperidone 5件: 6, 13, 17, 51, 230
37 DRD2 1件: Rap1 signaling pathway D02666 Iloperidone 1件: 6
38 DRD2 1件: Rap1 signaling pathway D03165 Bromocriptine 2件: 6, 74
39 DRD2 1件: Rap1 signaling pathway D05575 Pramipexole 3件: 2, 6, 20
40 DRD2 1件: Rap1 signaling pathway D05768 Rotigotine 1件: 6
41 DRD2 1件: Rap1 signaling pathway D07305 Piribedil 1件: 6
42 DRD2 1件: Rap1 signaling pathway D07309 Melperone 1件: 6
43 DRD2 1件: Rap1 signaling pathway D07460 Apomorphine 3件: 5, 6, 7
44 DRD2 1件: Rap1 signaling pathway D07593 Buspirone 2件: 6, 51
45 DRD2 1件: Rap1 signaling pathway D07868 Domperidone 5件: 6, 13, 17, 51, 230
46 DRD2 1件: Rap1 signaling pathway D07870 Dopamine 4件: 6, 7, 74, 299
47 DRD2 1件: Rap1 signaling pathway D08132 Lisuride 2件: 6, 86
48 DRD2 1件: Rap1 signaling pathway D08339 Pergolide 1件: 6
49 DRD2 1件: Rap1 signaling pathway D08456 Quetiapine 2件: 6, 13
50 DRD2 1件: Rap1 signaling pathway D08489 Ropinirole 4件: 2, 6, 74, 309
51 DRD2 1件: Rap1 signaling pathway D08590 Tiapride 1件: 8
52 DRD2 1件: Rap1 signaling pathway D08636 Trifluoperazine 2件: 283, 284
53 DRD2 1件: Rap1 signaling pathway D09397 Pardoprunox 1件: 6
54 DRD2 1件: Rap1 signaling pathway D09886 Dexpramipexole 1件: 2
55 DRD2 1件: Rap1 signaling pathway D09953 Pridopidine 3件: 2, 6, 8
56 DRD2 1件: Rap1 signaling pathway D09997 Cariprazine 1件: 21
57 DRD2 1件: Rap1 signaling pathway D11839 Foslevodopa 1件: 6
58 EGFR 5件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis D01977 Gefitinib 1件: 75
59 EGFR 5件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis D03455 Cetuximab 2件: 51, 86
60 EGFR 5件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis D07907 Erlotinib 1件: 94
61 EGFR 5件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis D08108 Lapatinib 3件: 34, 74, 75
62 EGFR 5件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis D08950 Neratinib 1件: 34
63 EGFR 5件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis D11251 Icotinib 1件: 34
64 EGFR 5件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis D11772 Tesevatinib 1件: 67
65 EPHA2 2件: Ras signaling pathway, Rap1 signaling pathway D03658 Dasatinib 2件: 51, 85
66 EPHA2 2件: Ras signaling pathway, Rap1 signaling pathway D06414 Dasatinib 2件: 51, 85
67 FGFR1 5件: Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Thermogenesis, Regulation of actin cytoskeleton D10481 Nintedanib 5件: 51, 85, 89, 227, 228
68 FGFR1 5件: Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Thermogenesis, Regulation of actin cytoskeleton D11589 Infigratinib 1件: 276
69 FGFR3 4件: Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton D10481 Nintedanib 5件: 51, 85, 89, 227, 228
70 FGFR3 4件: Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton D11589 Infigratinib 1件: 276
71 FGFR2 4件: Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton D05338 Palifermin 5件: 13, 36, 38, 39, 65
72 FGFR2 4件: Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton D10481 Nintedanib 5件: 51, 85, 89, 227, 228
73 FGFR2 4件: Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton D11589 Infigratinib 1件: 276
74 FLT1 4件: Ras signaling pathway, Rap1 signaling pathway, Transcriptional misregulation in cancer, Rheumatoid arthritis D03218 Axitinib 1件: 34
75 FLT1 4件: Ras signaling pathway, Rap1 signaling pathway, Transcriptional misregulation in cancer, Rheumatoid arthritis D08552 Sunitinib 2件: 28, 34
76 FLT1 4件: Ras signaling pathway, Rap1 signaling pathway, Transcriptional misregulation in cancer, Rheumatoid arthritis D08881 Cediranib 1件: 34
77 FLT1 4件: Ras signaling pathway, Rap1 signaling pathway, Transcriptional misregulation in cancer, Rheumatoid arthritis D10481 Nintedanib 5件: 51, 85, 89, 227, 228
78 FLT4 2件: Ras signaling pathway, Rap1 signaling pathway D03218 Axitinib 1件: 34
79 FLT4 2件: Ras signaling pathway, Rap1 signaling pathway D08524 Sorafenib 2件: 34, 86
80 FLT4 2件: Ras signaling pathway, Rap1 signaling pathway D08552 Sunitinib 2件: 28, 34
81 FLT4 2件: Ras signaling pathway, Rap1 signaling pathway D08881 Cediranib 1件: 34
82 FLT4 2件: Ras signaling pathway, Rap1 signaling pathway D10481 Nintedanib 5件: 51, 85, 89, 227, 228
83 FLT4 2件: Ras signaling pathway, Rap1 signaling pathway D11772 Tesevatinib 1件: 67
84 GRIN1 3件: Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia D00775 Riluzole 9件: 2, 3, 5, 8, 13, 17, 18, 203, 206
85 GRIN1 3件: Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia D03742 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
86 GRIN1 3件: Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia D07058 Acamprosate 2件: 6, 206
87 GRIN1 3件: Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia D07283 Esketamine 3件: 2, 4, 70
88 GRIN1 3件: Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia D07441 Amantadine 4件: 6, 8, 13, 127
89 GRIN1 3件: Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia D08098 Ketamine 8件: 2, 4, 6, 13, 70, 113, 156, 215
90 GRIN1 3件: Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia D08174 Memantine 8件: 2, 6, 8, 13, 49, 127, 205, 206
91 GRIN1 3件: Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia D09917 Latrepirdine 1件: 8
92 GRIN2A 4件: Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D00775 Riluzole 9件: 2, 3, 5, 8, 13, 17, 18, 203, 206
93 GRIN2A 4件: Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D03742 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
94 GRIN2A 4件: Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D07058 Acamprosate 2件: 6, 206
95 GRIN2A 4件: Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D07283 Esketamine 3件: 2, 4, 70
96 GRIN2A 4件: Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D07441 Amantadine 4件: 6, 8, 13, 127
97 GRIN2A 4件: Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D08098 Ketamine 8件: 2, 4, 6, 13, 70, 113, 156, 215
98 GRIN2A 4件: Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D08174 Memantine 8件: 2, 6, 8, 13, 49, 127, 205, 206
99 GRIN2A 4件: Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D09917 Latrepirdine 1件: 8
100 GRIN2B 4件: Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D00775 Riluzole 9件: 2, 3, 5, 8, 13, 17, 18, 203, 206
101 GRIN2B 4件: Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D03742 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
102 GRIN2B 4件: Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D07058 Acamprosate 2件: 6, 206
103 GRIN2B 4件: Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D07283 Esketamine 3件: 2, 4, 70
104 GRIN2B 4件: Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D07441 Amantadine 4件: 6, 8, 13, 127
105 GRIN2B 4件: Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D08098 Ketamine 8件: 2, 4, 6, 13, 70, 113, 156, 215
106 GRIN2B 4件: Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D08174 Memantine 8件: 2, 6, 8, 13, 49, 127, 205, 206
107 GRIN2B 4件: Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D09917 Latrepirdine 1件: 8
108 IGF1R 4件: Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Transcriptional misregulation in cancer D03297 Mecasermin 6件: 65, 78, 96, 168, 265, 299
109 IGF1R 4件: Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Transcriptional misregulation in cancer D09680 Teprotumumab 1件: 51
110 IGF1R 4件: Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Transcriptional misregulation in cancer D09925 Linsitinib 1件: 232
111 INSR 4件: Ras signaling pathway, Rap1 signaling pathway, Regulation of lipolysis in adipocytes, Type II diabetes mellitus D03230 Insulin human 2件: 96, 156
112 INSR 4件: Ras signaling pathway, Rap1 signaling pathway, Regulation of lipolysis in adipocytes, Type II diabetes mellitus D03250 Insulin glargine 1件: 299
113 INSR 4件: Ras signaling pathway, Rap1 signaling pathway, Regulation of lipolysis in adipocytes, Type II diabetes mellitus D04539 Insulin detemir 1件: 299
114 ITGAL 5件: Rap1 signaling pathway, Regulation of actin cytoskeleton, Staphylococcus aureus infection, Rheumatoid arthritis, Viral myocarditis D03959 Efalizumab 9件: 11, 13, 37, 46, 49, 53, 61, 95, 96
115 KDR 3件: Ras signaling pathway, Rap1 signaling pathway, VEGF signaling pathway D03218 Axitinib 1件: 34
116 KDR 3件: Ras signaling pathway, Rap1 signaling pathway, VEGF signaling pathway D08524 Sorafenib 2件: 34, 86
117 KDR 3件: Ras signaling pathway, Rap1 signaling pathway, VEGF signaling pathway D08552 Sunitinib 2件: 28, 34
118 KDR 3件: Ras signaling pathway, Rap1 signaling pathway, VEGF signaling pathway D08881 Cediranib 1件: 34
119 KDR 3件: Ras signaling pathway, Rap1 signaling pathway, VEGF signaling pathway D10062 Cabozantinib 1件: 34
120 KDR 3件: Ras signaling pathway, Rap1 signaling pathway, VEGF signaling pathway D10481 Nintedanib 5件: 51, 85, 89, 227, 228
121 KDR 3件: Ras signaling pathway, Rap1 signaling pathway, VEGF signaling pathway D11772 Tesevatinib 1件: 67
122 KIT 2件: Ras signaling pathway, Rap1 signaling pathway D03658 Dasatinib 2件: 51, 85
123 KIT 2件: Ras signaling pathway, Rap1 signaling pathway D06414 Dasatinib 2件: 51, 85
124 KIT 2件: Ras signaling pathway, Rap1 signaling pathway D08066 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
125 KIT 2件: Ras signaling pathway, Rap1 signaling pathway D08524 Sorafenib 2件: 34, 86
126 KIT 2件: Ras signaling pathway, Rap1 signaling pathway D08552 Sunitinib 2件: 28, 34
127 KIT 2件: Ras signaling pathway, Rap1 signaling pathway D08953 Nilotinib 5件: 6, 8, 34, 51, 86
128 KIT 2件: Ras signaling pathway, Rap1 signaling pathway D10229 Masitinib 6件: 2, 5, 6, 13, 46, 96
129 KIT 2件: Ras signaling pathway, Rap1 signaling pathway D11270 Pexidartinib 1件: 34
130 MET 4件: Ras signaling pathway, Rap1 signaling pathway, Transcriptional misregulation in cancer, Renal cell carcinoma D10062 Cabozantinib 1件: 34
131 NGF 2件: Ras signaling pathway, Rap1 signaling pathway D09387 Tanezumab 2件: 226, 298
132 NGFR 4件: Virion - Lyssavirus, Ras signaling pathway, Rap1 signaling pathway, Transcriptional misregulation in cancer D11028 Cenegermin 2件: 53, 90
133 PDGFRA 3件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton D08066 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
134 PDGFRA 3件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton D08552 Sunitinib 2件: 28, 34
135 PDGFRA 3件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton D08953 Nilotinib 5件: 6, 8, 34, 51, 86
136 PDGFRA 3件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton D10481 Nintedanib 5件: 51, 85, 89, 227, 228
137 PDGFRB 3件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton D03658 Dasatinib 2件: 51, 85
138 PDGFRB 3件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton D06414 Dasatinib 2件: 51, 85
139 PDGFRB 3件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton D08524 Sorafenib 2件: 34, 86
140 PDGFRB 3件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton D08552 Sunitinib 2件: 28, 34
141 PDGFRB 3件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton D08953 Nilotinib 5件: 6, 8, 34, 51, 86
142 PDGFRB 3件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton D10481 Nintedanib 5件: 51, 85, 89, 227, 228
143 PGF 2件: Ras signaling pathway, Rap1 signaling pathway D09574 Aflibercept 2件: 90, 166
144 PIK3CA 20件: Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Renal cell carcinoma, Small cell lung cancer D11011 Alpelisib 1件: 138
145 PIK3CA 20件: Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Renal cell carcinoma, Small cell lung cancer D11158 Leniolisib 2件: 53, 65
146 PIK3CB 20件: Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Renal cell carcinoma, Small cell lung cancer D11158 Leniolisib 2件: 53, 65
147 PIK3CD 20件: Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Renal cell carcinoma, Small cell lung cancer D11158 Leniolisib 2件: 53, 65
148 PIK3CD 20件: Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Renal cell carcinoma, Small cell lung cancer D11437 Parsaclisib 3件: 35, 53, 61
149 PRKCB 12件: Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, Wnt signaling pathway, VEGF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Salivary secretion, Spinocerebellar ataxia D11935 Enzastaurin 1件: 168
150 MAPK11 18件: Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling, Relaxin signaling pathway, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod 2件: 113, 222
151 MAPK11 18件: Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling, Relaxin signaling pathway, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod 1件: 8
152 MAPK13 18件: Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling, Relaxin signaling pathway, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod 2件: 113, 222
153 MAPK13 18件: Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling, Relaxin signaling pathway, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod 1件: 8
154 MAP2K1 17件: Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D09666 Selumetinib 1件: 34
155 MAP2K1 17件: Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D10175 Trametinib 4件: 2, 34, 279, 280
156 MAP2K1 17件: Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D10405 Cobimetinib 1件: 280
157 MAP2K1 17件: Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D10604 Binimetinib 1件: 34
158 MAP2K1 17件: Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D11675 Mirdametinib 1件: 34
159 MAP2K2 15件: Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D09666 Selumetinib 1件: 34
160 MAP2K2 15件: Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D10175 Trametinib 4件: 2, 34, 279, 280
161 MAP2K2 15件: Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D10405 Cobimetinib 1件: 280
162 MAP2K2 15件: Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D10604 Binimetinib 1件: 34
163 MAP2K2 15件: Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D11675 Mirdametinib 1件: 34
164 RAF1 14件: Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, T cell receptor signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Tuberculosis, Renal cell carcinoma D08524 Sorafenib 2件: 34, 86
165 MAPK12 18件: Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling, Relaxin signaling pathway, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod 2件: 113, 222
166 MAPK12 18件: Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling, Relaxin signaling pathway, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod 1件: 8
167 SRC 10件: Rap1 signaling pathway, VEGF signaling pathway, Tight junction, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Shigellosis, Yersinia infection, Tuberculosis, Viral carcinogenesis D03252 Bosutinib 2件: 2, 67
168 SRC 10件: Rap1 signaling pathway, VEGF signaling pathway, Tight junction, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Shigellosis, Yersinia infection, Tuberculosis, Viral carcinogenesis D03658 Dasatinib 2件: 51, 85
169 SRC 10件: Rap1 signaling pathway, VEGF signaling pathway, Tight junction, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Shigellosis, Yersinia infection, Tuberculosis, Viral carcinogenesis D06414 Dasatinib 2件: 51, 85
170 SRC 10件: Rap1 signaling pathway, VEGF signaling pathway, Tight junction, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Shigellosis, Yersinia infection, Tuberculosis, Viral carcinogenesis D09664 Saracatinib 3件: 6, 89, 272
171 BRAF 6件: Rap1 signaling pathway, Vascular smooth muscle contraction, Serotonergic synapse, Regulation of actin cytoskeleton, Renal cell carcinoma, Thyroid cancer D08524 Sorafenib 2件: 34, 86
172 BRAF 6件: Rap1 signaling pathway, Vascular smooth muscle contraction, Serotonergic synapse, Regulation of actin cytoskeleton, Renal cell carcinoma, Thyroid cancer D10064 Dabrafenib 1件: 34
173 VEGFA 6件: Ras signaling pathway, Rap1 signaling pathway, VEGF signaling pathway, Relaxin signaling pathway, Renal cell carcinoma, Rheumatoid arthritis D05697 Ranibizumab 4件: 34, 166, 227, 301
174 VEGFA 6件: Ras signaling pathway, Rap1 signaling pathway, VEGF signaling pathway, Relaxin signaling pathway, Renal cell carcinoma, Rheumatoid arthritis D06409 Bevacizumab 6件: 13, 34, 85, 87, 227, 280
175 VEGFA 6件: Ras signaling pathway, Rap1 signaling pathway, VEGF signaling pathway, Relaxin signaling pathway, Renal cell carcinoma, Rheumatoid arthritis D09574 Aflibercept 2件: 90, 166
176 VEGFB 3件: Ras signaling pathway, Rap1 signaling pathway, Relaxin signaling pathway D09574 Aflibercept 2件: 90, 166
177 FGF23 3件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton D10913 Burosumab 1件: 238