Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Alcoholism 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00775 💬 Riluzole 9件:  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
2 Alcoholism 💬
1件: SLC6A3 💬 D07591 💬 Bupropion 5件:  8 , 18, 21, 96, 171 💬
3 Alzheimer disease 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00775 💬 Riluzole 9件:  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
4 Amphetamine addiction 💬
9件: GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00775 💬 Riluzole 9件:  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
5 Amphetamine addiction 💬
1件: SLC6A3 💬 D07591 💬 Bupropion 5件:  8 , 18, 21, 96, 171 💬
6 AMPK signaling pathway 💬
1件: HMGCR 💬 D08492 💬 Rosuvastatin 11件:  6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
7 Amyotrophic lateral sclerosis 💬
7件: GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00775 💬 Riluzole 9件:  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
8 Bile secretion 💬
1件: HMGCR 💬 D08492 💬 Rosuvastatin 11件:  6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
9 Calcium signaling pathway 💬
4件: GRIN1, GRIN2A, GRIN2C, GRIN2D 💬 D00775 💬 Riluzole 9件:  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
10 cAMP signaling pathway 💬
2件: GABBR1, GABBR2 💬 D00241 💬 Baclofen 8件:  2 , 10, 13, 18, 65, 70, 149, 206 💬
11 cAMP signaling pathway 💬
9件: GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00775 💬 Riluzole 9件:  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
12 Chagas disease 💬
2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
13 Chemical carcinogenesis - reactive oxygen species 💬
1件: NFE2L2 💬 D10964 💬 Omaveloxolone 1件: 18 💬
14 Chemical carcinogenesis - receptor activation 💬
2件: CHRNA4, CHRNB2 💬 D08669 💬 Varenicline 3件:  6 , 18, 53 💬
15 Chemical carcinogenesis - receptor activation 💬
1件: VDR 💬 D00129 💬 Calcitriol 9件: 18, 37, 46, 49, 66, 96, 158, 235, 326 💬
16 Cholinergic synapse 💬
2件: CHRNA4, CHRNB2 💬 D08669 💬 Varenicline 3件:  6 , 18, 53 💬
17 Circadian entrainment 💬
9件: GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00775 💬 Riluzole 9件:  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
18 Cocaine addiction 💬
6件: GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00775 💬 Riluzole 9件:  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
19 Cocaine addiction 💬
1件: SLC6A3 💬 D07591 💬 Bupropion 5件:  8 , 18, 21, 96, 171 💬
20 Cytokine-cytokine receptor interaction 💬
1件: CSF3R 💬 D03247 💬 Lenograstim 7件:  2 , 13, 16, 18, 19, 57, 65 💬
21 Cytokine-cytokine receptor interaction 💬
2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
22 Dopaminergic synapse 💬
6件: GRIA1, GRIA2, GRIA3, GRIA4, GRIN2A, GRIN2B 💬 D00775 💬 Riluzole 9件:  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
23 Dopaminergic synapse 💬
1件: SLC6A3 💬 D07591 💬 Bupropion 5件:  8 , 18, 21, 96, 171 💬
24 Endocrine and other factor-regulated calcium reabsorption 💬
1件: VDR 💬 D00129 💬 Calcitriol 9件: 18, 37, 46, 49, 66, 96, 158, 235, 326 💬
25 Estrogen signaling pathway 💬
2件: GABBR1, GABBR2 💬 D00241 💬 Baclofen 8件:  2 , 10, 13, 18, 65, 70, 149, 206 💬
26 Fluid shear stress and atherosclerosis 💬
1件: NFE2L2 💬 D10964 💬 Omaveloxolone 1件: 18 💬
27 GABAergic synapse 💬
2件: GABBR1, GABBR2 💬 D00241 💬 Baclofen 8件:  2 , 10, 13, 18, 65, 70, 149, 206 💬
28 GABAergic synapse 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00697 💬 Flumazenil 5件:  6 , 13, 17, 18, 206 💬
29 Glutamatergic synapse 💬
14件: GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00775 💬 Riluzole 9件:  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
30 GnRH secretion 💬
2件: GABBR1, GABBR2 💬 D00241 💬 Baclofen 8件:  2 , 10, 13, 18, 65, 70, 149, 206 💬
31 Hematopoietic cell lineage 💬
1件: CSF3R 💬 D03247 💬 Lenograstim 7件:  2 , 13, 16, 18, 19, 57, 65 💬
32 Hepatocellular carcinoma 💬
1件: NFE2L2 💬 D10964 💬 Omaveloxolone 1件: 18 💬
33 Herpes simplex virus 1 infection 💬
2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
34 HIF-1 signaling pathway 💬
2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
35 Huntington disease 💬
6件: GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2B 💬 D00775 💬 Riluzole 9件:  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
36 Inflammatory bowel disease 💬
2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
37 Influenza A 💬
2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
38 JAK-STAT signaling pathway 💬
1件: CSF3R 💬 D03247 💬 Lenograstim 7件:  2 , 13, 16, 18, 19, 57, 65 💬
39 JAK-STAT signaling pathway 💬
2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
40 Kaposi sarcoma-associated herpesvirus infection 💬
1件: IFNGR1 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
41 Leishmaniasis 💬
2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
42 Lipid and atherosclerosis 💬
1件: NFE2L2 💬 D10964 💬 Omaveloxolone 1件: 18 💬
43 Long-term depression 💬
3件: GRIA1, GRIA2, GRIA3 💬 D00775 💬 Riluzole 9件:  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
44 Long-term potentiation 💬
7件: GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00775 💬 Riluzole 9件:  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
45 Metabolic pathways 💬
1件: HMGCR 💬 D08492 💬 Rosuvastatin 11件:  6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
46 Mineral absorption 💬
1件: VDR 💬 D00129 💬 Calcitriol 9件: 18, 37, 46, 49, 66, 96, 158, 235, 326 💬
47 Morphine addiction 💬
2件: GABBR1, GABBR2 💬 D00241 💬 Baclofen 8件:  2 , 10, 13, 18, 65, 70, 149, 206 💬
48 Morphine addiction 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00697 💬 Flumazenil 5件:  6 , 13, 17, 18, 206 💬
49 Natural killer cell mediated cytotoxicity 💬
2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
50 Necroptosis 💬
2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
51 Neuroactive ligand-receptor interaction 💬
2件: CHRNA4, CHRNB2 💬 D08669 💬 Varenicline 3件:  6 , 18, 53 💬
52 Neuroactive ligand-receptor interaction 💬
2件: GABBR1, GABBR2 💬 D00241 💬 Baclofen 8件:  2 , 10, 13, 18, 65, 70, 149, 206 💬
53 Neuroactive ligand-receptor interaction 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00697 💬 Flumazenil 5件:  6 , 13, 17, 18, 206 💬
54 Neuroactive ligand-receptor interaction 💬
14件: GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00775 💬 Riluzole 9件:  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
55 Neuroactive ligand-receptor interaction 💬
1件: NR3C1 💬 D00407 💬 Methylprednisolone 46件:  2 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 95, 96, 97, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬
56 Nicotine addiction 💬
2件: CHRNA4, CHRNB2 💬 D08669 💬 Varenicline 3件:  6 , 18, 53 💬
57 Nicotine addiction 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00697 💬 Flumazenil 5件:  6 , 13, 17, 18, 206 💬
58 Nicotine addiction 💬
9件: GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00775 💬 Riluzole 9件:  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
59 Osteoclast differentiation 💬
2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
60 Parathyroid hormone synthesis, secretion and action 💬
1件: VDR 💬 D00129 💬 Calcitriol 9件: 18, 37, 46, 49, 66, 96, 158, 235, 326 💬
61 Parkinson disease 💬
1件: NFE2L2 💬 D10964 💬 Omaveloxolone 1件: 18 💬
62 Parkinson disease 💬
1件: SLC6A3 💬 D07591 💬 Bupropion 5件:  8 , 18, 21, 96, 171 💬
63 Pathways in cancer 💬
1件: CSF3R 💬 D03247 💬 Lenograstim 7件:  2 , 13, 16, 18, 19, 57, 65 💬
64 Pathways in cancer 💬
2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
65 Pathways in cancer 💬
1件: NFE2L2 💬 D10964 💬 Omaveloxolone 1件: 18 💬
66 Pathways of neurodegeneration - multiple diseases 💬
9件: GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00775 💬 Riluzole 9件:  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
67 Pathways of neurodegeneration - multiple diseases 💬
1件: SLC6A3 💬 D07591 💬 Bupropion 5件:  8 , 18, 21, 96, 171 💬
68 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
69 PI3K-Akt signaling pathway 💬
1件: CSF3R 💬 D03247 💬 Lenograstim 7件:  2 , 13, 16, 18, 19, 57, 65 💬
70 Prion disease 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00775 💬 Riluzole 9件:  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
71 Protein processing in endoplasmic reticulum 💬
1件: NFE2L2 💬 D10964 💬 Omaveloxolone 1件: 18 💬
72 Rap1 signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 D00775 💬 Riluzole 9件:  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
73 Ras signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 D00775 💬 Riluzole 9件:  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
74 Retrograde endocannabinoid signaling 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00697 💬 Flumazenil 5件:  6 , 13, 17, 18, 206 💬
75 Retrograde endocannabinoid signaling 💬
4件: GRIA1, GRIA2, GRIA3, GRIA4 💬 D00775 💬 Riluzole 9件:  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
76 Serotonergic synapse 💬
3件: GABRB1, GABRB2, GABRB3 💬 D00697 💬 Flumazenil 5件:  6 , 13, 17, 18, 206 💬
77 Serotonergic synapse 💬
1件: SLC6A4 💬 D07704 💬 Citalopram 7件:  6 ,  8 , 13, 18, 46, 98, 127 💬
78 Spinocerebellar ataxia 💬
3件: GRIA1, GRIA2, GRIA3 💬 D08964 💬 Perampanel 3件:  2 ,  6 , 144 💬
79 Spinocerebellar ataxia 💬
3件: GRIA1, GRIA2, GRIA3 💬 D02696 💬 Talampanel 2件:  2 ,  6  💬
80 Spinocerebellar ataxia 💬
3件: GRIA1, GRIA2, GRIA3 💬 D00537 💬 Topiramate 6件:  6 , 97, 140, 144, 156, 193 💬
81 Spinocerebellar ataxia 💬
8件: GRIA1, GRIA2, GRIA3, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D00775 💬 Riluzole 9件:  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
82 Spinocerebellar ataxia 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D07058 💬 Acamprosate 2件:  6 , 206 💬
83 Spinocerebellar ataxia 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D07441 💬 Amantadine 4件:  6 ,  8 , 13, 127 💬
84 Spinocerebellar ataxia 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D03742 💬 Dextromethorphan 11件:  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
85 Spinocerebellar ataxia 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D07283 💬 Esketamine 3件:  2 ,  4 , 70 💬
86 Spinocerebellar ataxia 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08098 💬 Ketamine 8件:  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
87 Spinocerebellar ataxia 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D09917 💬 Latrepirdine 1件:  8  💬
88 Spinocerebellar ataxia 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 D08174 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
89 Spinocerebellar ataxia 💬
2件: KCNC3, KCND3 💬 D10228 💬 Amifampridine 3件:  3 , 11, 12 💬
90 Spinocerebellar ataxia 💬
2件: KCNC3, KCND3 💬 D04127 💬 Dalfampridine 5件:  3 ,  4 ,  6 , 13, 14 💬
91 Spinocerebellar ataxia 💬
1件: KCND3 💬 D02910 💬 Amiodarone 2件: 28, 127 💬
92 Spinocerebellar ataxia 💬
1件: MAP3K5 💬 D10988 💬 Selonsertib 1件: 86 💬
93 Spinocerebellar ataxia 💬
1件: MTOR 💬 D02714 💬 Everolimus 9件: 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
94 Spinocerebellar ataxia 💬
1件: MTOR 💬 D00753 💬 Sirolimus 40件:  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬
95 Spinocerebellar ataxia 💬
1件: MTOR 💬 D06068 💬 Temsirolimus 1件: 13 💬
96 Spinocerebellar ataxia 💬
1件: PIK3CA 💬 D11011 💬 Alpelisib 1件: 138 💬
97 Spinocerebellar ataxia 💬
3件: PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib 2件: 53, 65 💬
98 Spinocerebellar ataxia 💬
1件: PIK3CD 💬 D11437 💬 Parsaclisib 3件: 35, 53, 61 💬
99 Spinocerebellar ataxia 💬
1件: PRKCB 💬 D11935 💬 Enzastaurin 1件: 168 💬
100 Spinocerebellar ataxia 💬
1件: PSMB5 💬 D03150 💬 Bortezomib 17件: 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 222, 228, 256, 283, 288, 331 💬
101 Spinocerebellar ataxia 💬
1件: PSMB5 💬 D08880 💬 Carfilzomib 1件: 28 💬
102 Spinocerebellar ataxia 💬
1件: PSMB5 💬 D10130 💬 Ixazomib 5件: 13, 16, 28, 51, 61 💬
103 Synaptic vesicle cycle 💬
2件: SLC6A2, SLC6A3 💬 D07591 💬 Bupropion 5件:  8 , 18, 21, 96, 171 💬
104 Synaptic vesicle cycle 💬
1件: SLC6A4 💬 D07704 💬 Citalopram 7件:  6 ,  8 , 13, 18, 46, 98, 127 💬
105 Systemic lupus erythematosus 💬
2件: GRIN2A, GRIN2B 💬 D00775 💬 Riluzole 9件:  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
106 Taste transduction 💬
2件: GABBR1, GABBR2 💬 D00241 💬 Baclofen 8件:  2 , 10, 13, 18, 65, 70, 149, 206 💬
107 Taste transduction 💬
6件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬 D00697 💬 Flumazenil 5件:  6 , 13, 17, 18, 206 💬
108 Terpenoid backbone biosynthesis 💬
1件: HMGCR 💬 D08492 💬 Rosuvastatin 11件:  6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
109 Th1 and Th2 cell differentiation 💬
2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
110 Th17 cell differentiation 💬
2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
111 Toxoplasmosis 💬
2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
112 Transcriptional misregulation in cancer 💬
1件: GRIA3 💬 D00775 💬 Riluzole 9件:  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
113 Tuberculosis 💬
2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
114 Tuberculosis 💬
1件: VDR 💬 D00129 💬 Calcitriol 9件: 18, 37, 46, 49, 66, 96, 158, 235, 326 💬