THIAMINE ( DrugBank: Thiamine )
3 diseases
| ID | Disease name (Link within this page) | Number of trials |
|---|---|---|
| 8 | Huntington disease | 2 |
| 93 | Primary biliary cholangitis | 2 |
| 265 | Lipodystrophy | 1 |
8. Huntington disease
Clinical trials : 242 / Drugs : 205 - (DrugBank : 62) / Drug target genes : 85 - Drug target pathways : 159
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT04478734 (ClinicalTrials.gov) | June 1, 2022 | 11/2/2020 | Trial of the Combined Use of Thiamine and Biotin in Patients With Huntington's Disease | Multicentric Trial on the Use of Combined Therapy of Thiamine and Biotine in Patients With Huntington´s Disease | Huntington Disease | Drug: Moderate doses of Thiamine y Biotin;Drug: High doses of Thiamine y Biotin | Fundación Pública Andaluza para la gestión de la Investigación en Sevilla | Ciberned (Centro de Investigación Biomédica en Red) | Not yet recruiting | 18 Years | N/A | All | 24 | Phase 2 | Spain |
| 2 | EUCTR2019-004360-22-ES (EUCTR) | 22/10/2021 | 10/01/2020 | Trial on the use of thiamine and biotin in patients with Huntington's disease. | MULTI-TECHNICAL TEST ON THE USE OF COMBINED THERAPY OF THEMIN AND BIOTINE IN PATIENTS WITH HUNTINGTON'S DISEASE - Huntiam | Huntington´s disease MedDRA version: 20.0;Level: PT;Classification code 10070668;Term: Huntington's disease;System Organ Class: 10010331 - Congenital, familial and genetic disorders;Therapeutic area: Diseases [C] - Nervous System Diseases [C10] | Trade Name: Benerva Product Name: Benerva Product Name: Biotina INN or Proposed INN: BIOTIN Other descriptive name: Vitamin B7 | Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (Ciberned) | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 24 | Phase 2 | Spain |
93. Primary biliary cholangitis
Clinical trials : 298 / Drugs : 252 - (DrugBank : 59) / Drug target genes : 35 - Drug target pathways : 115
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT04893993 (ClinicalTrials.gov) | May 12, 2021 | 4/5/2021 | PBC Induced Fatigue Treated With Thiamine | PBC Induced Fatigue Treated With Thiamine (PIFT) - The Effect of Oral Thiamine Supplement in 4 Weeks to Patients With Primary Biliary Cholangitis (PBC) and Chronic Fatigue. A Randomised Placebo Controlled Crossover Study | Primary Biliary Cirrhosis | Drug: Thiamine;Drug: Placebo | Henning Grønbæk | Aarhus University Hospital;Hospitalsapoteket Region Midtjylland;GCP-unit at Aarhus University Hospital, Aarhus, Denmark;Region Hovedstadens Apotek | Recruiting | 18 Years | N/A | All | 36 | Phase 4 | Denmark |
| 2 | EUCTR2020-004935-26-DK (EUCTR) | 25/02/2021 | 09/12/2020 | Vitamin B1 as treatment for chronic fatigue in patients with primary biliary cholangitis | PBC induced fatigue treated with thiamine- The effect of oral thiamine supplement in 4 weeks to patients with primary biliary cholangitis (PBC) and chronic fatigue.A randomised, double-blinded, placebo-controlled, crossover study - PIFT | Primary biliary cholangitis MedDRA version: 21.0;Level: PT;Classification code 10080429;Term: Primary biliary cholangitis;System Organ Class: 10019805 - Hepatobiliary disorders MedDRA version: 20.1;Level: LLT;Classification code 10066564;Term: Chronic fatigue;System Organ Class: 100000004867;Therapeutic area: Diseases [C] - Symptoms and general pathology [C23] | Trade Name: Tiamin SAD INN or Proposed INN: THIAMINE Other descriptive name: Tiamin DAK | Aarhus University Hospital | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 36 | Phase 2 | Denmark |
265. Lipodystrophy
Clinical trials : 112 / Drugs : 155 - (DrugBank : 55) / Drug target genes : 25 - Drug target pathways : 97
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT00202228 (ClinicalTrials.gov) | July 2002 | 13/9/2005 | Lactate Metabolism Study in HIV Infected Persons | Lactic Acid Metabolism in HIV-Infected Persons. Predicting Abnormalities in Lactate Production and Clearance Related to Treatment and Liver Disease and Measuring the Impact of Vitamin Supplementation. | HIV Infections;AIDS;Lactic Acidosis;Lipodystrophy | Drug: cofactor supplementation (thiamine, riboflavin, L-carnitine) | Queen's University | Ontario HIV Treatment Network | Completed | 18 Years | N/A | Both | 30 | Phase 4 | Canada |