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No.	Drug (Description in trials)	DrugBank	KEGG DRUG	KEGG GENES	KEGG PATHWAY On map, Yellow: Drug target genes	Disease ID
1	Aliskiren	Aliskiren	[1] D03208 💬	[1] REN 💬	[3] Diabetic cardiomyopathy, Renin secretion, Renin-angiotensin system	[4] 66, 167, 222, 223 💬
2	Aprovel	-	-	-	-	[1] 167 💬
3	Atenolol	Atenolol	[1] D00235 💬	[1] ADRB1 💬	[10] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 167 💬
4	Atenolol or propranolol	Atenolol	[3] D00235, D00483, D08443 💬	[3] ADRB1, ADRB2, ADRB3 💬	[11] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Thermogenesis, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 167 💬
5	Blokium 50	-	-	-	-	[1] 167 💬
6	Blokium 50 mg comprimidos	-	-	-	-	[1] 167 💬
7	Coozar	-	-	-	-	[1] 167 💬
8	Coversyl	-	-	-	-	[2] 19, 167 💬
9	Coversyl (perindopril)	Perindopril	[2] D00624, D03753 💬	[1] ACE 💬	[6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system	[1] 167 💬
10	Cozaar	-	-	-	-	[1] 167 💬
11	Cozaar 50	-	-	-	-	[1] 167 💬
12	Cozaar inicio 12,5 mg comprimidos recubiertos con pelicula	-	-	-	-	[1] 167 💬
13	Doxycycline	Doxycycline	[5] D00307, D02129, D03903, D03904, D07876 💬	-	-	[15] 13, 23, 28, 46, 84, 85, 89, 96, 97, 158, 162, 167, 227, 280, 299 💬
14	Doxycycline 100-200mg capsules daily for 6 months	Doxycycline	[5] D00307, D02129, D03903, D03904, D07876 💬	-	-	[1] 167 💬
15	Doxycycline hyclate ph.eur	Doxycycline	[5] D00307, D02129, D03903, D03904, D07876 💬	-	-	[1] 167 💬
16	Irbesartan	Irbesartan	[1] D00523 💬	[1] AGTR1 💬	[16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway	[4] 66, 167, 168, 222 💬
17	Irbesartan 150-300mg capsules daily for 6 months	Irbesartan	[1] D00523 💬	[1] AGTR1 💬	[16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway	[1] 167 💬
18	Lobivon	-	-	-	-	[1] 167 💬
19	Lobivon*28cpr 5mg	-	-	-	-	[1] 167 💬
20	Lortaan	-	-	-	-	[1] 167 💬
21	Lortaan*28cpr riv div 50mg	-	-	-	-	[1] 167 💬
22	Losartan	Losartan	[2] D00357, D08146 💬	[1] AGTR1 💬	[16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway	[18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
23	Losartan and atenolol or propranolol	Atenolol	[5] D00235, D00357, D00483, D08146, D08443 💬	[4] ADRB1, ADRB2, ADRB3, AGTR1 💬	[22] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Renin-angiotensin system, Salivary secretion, Thermogenesis, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 167 💬
24	Losartan and nebivolol	Losartan	[3] D00357, D05127, D08146 💬	[2] ADRB1, AGTR1 💬	[21] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Renin-angiotensin system, Salivary secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 167 💬
25	Losartan potassium	Losartan	[3] D00357, D08146, D08403 💬	[1] AGTR1 💬	[16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway	[5] 36, 98, 167, 179, 215 💬
26	Nebivolol	Nebivolol	[1] D05127 💬	[1] ADRB1 💬	[10] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway	[3] 17, 113, 167 💬
27	Perindopril	Perindopril	[2] D00624, D03753 💬	[1] ACE 💬	[6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system	[3] 113, 167, 222 💬
28	Potassium	Potassium	[1] D08403 💬	-	-	[10] 36, 46, 66, 67, 98, 115, 167, 179, 215, 235 💬
29	Propranolol	Propranolol	[2] D00483, D08443 💬	[3] ADRB1, ADRB2, ADRB3 💬	[11] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Thermogenesis, cAMP signaling pathway, cGMP-PKG signaling pathway	[5]  6 , 158, 167, 227, 278 💬
30	Verapamil	Verapamil	[2] D00619, D02356 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	[36] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[3] 96, 140, 167 💬
31	Verapamil sr	Verapamil	[2] D00619, D02356 💬	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	[36] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 167 💬
32	Vibrox	-	-	-	-	[1] 167 💬
33	Vibrox 100mg capsules	-	-	-	-	[1] 167 💬

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