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36 / 2,001 drugs

No. DrugBank Drug (Description in trials) KEGG DRUG KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target genes		 Disease ID
 1  Albendazole [2] Albendazole; Albendazole (eskazole);  [1] D00134 💬  -  -  [11]  5 ,  6 ,  7 , 28, 51, 67, 86, 96, 97, 114, 127 💬
 2  Botulinum toxin type A [6] Botulinum toxin type a; Botulinum toxin type a (nabota®) injection into the gastrocnemius muscle; Botulinum toxin type a 200u; Botulinum toxin type a 300u; Botulinum toxin type a infiltrations; Clostridium botulinum toxin type a;  [1] D00783 💬 [1] SNAP25 💬 [2] Insulin secretion, Synaptic vesicle cycle  [13]  2 ,  5 ,  6 ,  7 , 13, 15, 17, 36, 51, 70, 113, 149, 226 💬
 3  Creatine [4] Creatine; Creatine monohydrate; Creatine-13c; Pyruvate, creatine, niacinamide;  -  -  -  [12]  1 ,  2 ,  5 ,  6 ,  8 , 13, 46, 49, 50, 113, 156, 201 💬
 4  Davunetide [2] Davunetide; Davunetide (al-108, nap);  [1] D09401 💬  -  -  [3]  5 ,  7 , 127 💬
 5  Donepezil [7] Donepezil; Donepezil hci (drug); Donepezil hydrochloride; Donepezil sandoz; Other: [11c]donepezil pet; Pridia (donepezil hydrochloride) 5mg; Prior donepezil 5mg;  [2] D00670
D07869 💬		 [1] ACHE 💬 [2] Cholinergic synapse, Glycerophospholipid metabolism  [9]  5 ,  6 , 13, 46, 78, 124, 127, 156, 206 💬
 6  Droxidopa [2] Droxidopa; Droxidopa 100 mg [northera];  [1] D01277 💬 [9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 💬 [13] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Thermogenesis, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway  [3]  5 ,  6 , 17 💬
 7  Emeramide [1] Emeramide;  -  -  -  [2]  5 , 17 💬
 8  Flortaucipir [2] Flortaucipir; Flortaucipir f18;  [1] D11210 💬  -  -  [3]  5 ,  7 , 127 💬
 9  Fludeoxyglucose (18F) - -  -  -  [13]  5 ,  6 ,  7 , 13, 34, 41, 46, 53, 84, 85, 96, 127, 300 💬
 10  Flutemetamol [4] Diagnostic test: flutemetamol f18 injection; Flutemetamol; Flutemetamol f18; Vizamyl (flutemetamol(f-18));  -  -  -  [5]  5 ,  6 ,  7 , 17, 127 💬
 11  Flutemetamol (18F) - [1] D10231 💬  -  -  [5]  5 ,  6 ,  7 , 17, 127 💬
 12  Gold [7] Gold; Gold nanocrystals; Mtx goldshield tablets; Other: comparator: cpet cycle ergometer (gold standard); Procedure: quantiferon-tb gold assay; Procedure: repair of cdh w/sis gold; Sodium aurothiomalate (intramuscular gold);  -  -  -  [38]  2 ,  5 ,  6 , 13, 17, 34, 46, 49, 50, 53, 65, 68, 76, 84, 86, 91, 93, 95, 96, 97, 98, 113, 158, 162, 171, 218, 222, 224, 227, 230, 271, 291, 294, 296, 298, 299, 310, 318 💬
 13  Gosuranemab - [1] D11293 💬 [1] MAPT 💬 [4] Alzheimer disease, MAPK signaling pathway, Parkinson disease, Pathways of neurodegeneration - multiple diseases  [1]  5  💬
 14  Hydrogen [8] 3- (9,10- didehydro- 6- methyl- 8?- ergolinyl)-1,1- diethylurea hydrogenmaleate; Hydrocortisone hydrogen succinate; Hydrogen; Hydrogen peroxide; Lisuride hydrogenmaleate; Methylprednisolon-21-hydrogensuccinat, natriumsalz; Other: hydrogen peroxide; Tch346 (dibenz[b,f]oxepin-10-ylmethyl-prop-2-ynyl-amine, hydrogen maleate salt);  -  -  -  [7]  5 ,  6 , 13, 17, 83, 97, 226 💬
 15  Ioflupane I-123 - [1] D10014 💬  -  -  [4]  2 ,  5 ,  6 , 17 💬
 16  Isoxaflutole - -  -  -  [9]  5 ,  6 , 13, 46, 81, 113, 122, 149, 299 💬
 17  Leucine [8] Administration of stable isotope-labelled leucine-; Diagnostic test: serum leucine-rich alpha-2 glycoprotein (lrg) levels; Essential amino acid intake + leucine vs total aa supplement; L-leucine; Leucine; N acetyl l leucine; N-acetyl-l-leucine; Other: 13c6 leucine;  [1] D00030 💬  -  -  [10]  5 ,  6 ,  7 , 19, 96, 97, 127, 283, 284, 299 💬
 18  Levocarnitine [4] Levocarnitine; Levocarnitine propyl hydrochloride; Valproate, levocarnitine; Valproic acid and levocarnitine;  [3] D02030
D02176
D04713 💬		  -  -  [10]  3 ,  5 , 13, 53, 58, 96, 97, 265, 298, 316 💬
 19  Lipoic acid [9] Alpha lipoic acid; Alpha-lipoic acid; Alpha-lipoic acid and l-acetyl carnitine; Lipoic acid; Lipoic acid (la) with fish oil and la without fish oil; Lipoic acid and omega-3 fatty acids; Lipoic acid group; Oral lipoic acid (la); R lipoic acid;  [2] D00048
D00086 💬		  -  -  [5]  2 ,  5 , 13, 14, 20 💬
 20  Lithium citrate [1] Lithium citrate;  [1] D04749 💬  -  -  [5]  2 ,  5 ,  6 ,  7 ,  8  💬
 21  Masitinib [12] Masitinib; Masitinib (3.0); Masitinib (4.5); Masitinib (6.0); Masitinib (ab1010); Masitinib 100 mg tablets; Masitinib 100mg; Masitinib 200 mg tablets; Masitinib 200mg; Masitinib 3 mg; Masitinib 6.0 mg; Masitinib mesylate;  [1] D10229 💬 [1] KIT 💬 [11] Acute myeloid leukemia, Breast cancer, Central carbon metabolism in cancer, Hematopoietic cell lineage, MAPK signaling pathway, Melanogenesis, PI3K-Akt signaling pathway, Pathways in cancer, Phospholipase D signaling pathway, Rap1 signaling pathway, Ras signaling pathway  [6]  2 ,  5 ,  6 , 13, 46, 96 💬
 22  Nicotinamide [3] Eh301 (nicotinamide riboside/pterostilbene); Nicotinamide; Nicotinamide riboside;  [1] D00036 💬  -  -  [9]  2 ,  5 ,  6 , 13, 18, 49, 67, 162, 191 💬
 23  Nitrogen [3] Device: perform three multiple breath nitrogen washout tests (n2-mbw-test); Nitrogen; Procedure: functional hepatic nitrogen clearance;  [1] D00083 💬  -  -  [6]  5 ,  6 , 17, 171, 211, 299 💬
 24  Raclopride [2] 11c-raclopride; Raclopride;  -  -  -  [4]  5 ,  6 ,  7 , 17 💬
 25  Rasagiline [16] 1.0 mg rasagiline mesylate; Group r rasagiline; Group r+ad rasagiline + antidepressant; P2b001 once daily (pramipexole 0.3 mg / rasagiline 0.75 mg),; P2b001 once daily (pramipexole 0.6 mg / rasagiline 0.75 mg),; Rasagiline; Rasagiline 1 mg capsule; Rasagiline 1mg tablet; Rasagiline 2 mg tablet; Rasagiline mesilate; Rasagiline mesylate; Rasagiline mesylate 1.0 mg; Rasagiline mesylate plus mirapex; Rasagiline mesylate with levodopa; Rasagiline mesylate with requip; Rasagiline tablets;  [3] D02562
D08469
D10829 💬		 [1] MAOB 💬 [14] Alcoholism, Amphetamine addiction, Arginine and proline metabolism, Cocaine addiction, Dopaminergic synapse, Drug metabolism - cytochrome P450, Glycine, serine and threonine metabolism, Histidine metabolism, Metabolic pathways, Parkinson disease, Phenylalanine metabolism, Serotonergic synapse, Tryptophan metabolism, Tyrosine metabolism  [6]  2 ,  5 ,  6 , 13, 17, 66 💬
 26  Riluzole [8] Plasma from healthy young people treatment + riluzole; Riluzole; Riluzole (100 mg); Riluzole 50 mg; Riluzole 50 mg (part b); Riluzole oral soluble film; Riluzole oral soluble film (rosf) 50 mg; Riluzole pmcs;  [1] D00775 💬 [14] GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 [23] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term depression, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Retrograde endocannabinoid signaling, Spinocerebellar ataxia, Systemic lupus erythematosus, Transcriptional misregulation in cancer, cAMP signaling pathway  [8]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 206 💬
 27  Rivastigmine [9] Exelon patch (rivastigmine transdermal system); Rivastigmine; Rivastigmine capsule; Rivastigmine cf; Rivastigmine luye transdermal patch- 9.5mg/24h; Rivastigmine patch 9.5 cm2; Rivastigmine transdermal patch; Rivastigmine transdermal system; Rivastigmine transdermal system 13.3 mg/24 h;  [2] D02558
D03822 💬		 [1] ACHE 💬 [2] Cholinergic synapse, Glycerophospholipid metabolism  [3]  5 ,  6 , 13 💬
 28  Salsalate [1] Salsalate;  [1] D00428 💬 [2] PTGS1, PTGS2 💬 [23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway  [1]  5  💬
 29  Suvorexant [1] Suvorexant;  [1] D10082 💬 [2] HCRTR1, HCRTR2 💬 [1] Neuroactive ligand-receptor interaction  [3]  5 ,  6 , 13 💬
 30  Tideglusib [1] Tideglusib;  -  -  -  [2]  5 , 113 💬
 31  Tolfenamic acid [1] Tolfenamic acid;  [1] D01183 💬 [2] PTGS1, PTGS2 💬 [23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway  [1]  5  💬
 32  Trihexyphenidyl [3] Other: controls primary cervical dystonia (trihexyphenidyl); Primary cervical dystonia (trihexyphenidyl); Trihexyphenidyl;  [2] D00787
D08638 💬		 [5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 [13] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction, cAMP signaling pathway  [2]  5 ,  6  💬
 33  Ubidecarenone - [1] D01065 💬  -  -  [13]  2 ,  5 ,  6 ,  8 , 10, 18, 46, 57, 86, 113, 193, 214, 215 💬
 34  Valproic acid [3] Valproic acid; Valproic acid (vpa); Valproic acid and levocarnitine;  [1] D00399 💬 [7] ABAT, ALDH5A1, CACNA1G, CACNA1H, CACNA1I, GAD1, GAD2 💬 [17] Alanine, aspartate and glutamate metabolism, Aldosterone synthesis and secretion, Butanoate metabolism, Calcium signaling pathway, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, GABAergic synapse, GnRH secretion, MAPK signaling pathway, Metabolic pathways, Propanoate metabolism, Taurine and hypotaurine metabolism, Type I diabetes mellitus, Type II diabetes mellitus, Valine, leucine and isoleucine degradation, beta-Alanine metabolism  [16]  2 ,  3 ,  5 ,  6 , 13, 26, 34, 65, 85, 89, 90, 102, 222, 233, 256, 331 💬
 35  Water [31] 15 o water; 15-o labeled water; 5% glucose water solution; Behavioral: diet and water adjustment; Behavioral: water tracking; Cholecalciferol concentrate (water-dispersible form); Device: manual toothbrush and water flosser (philips sonicare airfloss); Device: sonic toothbrush (philips sonicare) and water flosser (philips sonicare airfloss); Dextrose, 5% in water; High water intake; Lactose in water; Other: ad libitum water intake; Other: dead sea solar and water treatment; Other: dextrose water 5%; Other: exercise followed cold water immersion; Other: harkány medicinal water; Other: high water intake; Other: potable water; Other: water; Other: water prescription; Pl 12185/0002 & pl 12185/0005(water for injection); Procedure: water exercises; Pseudoephedrine + 480 ml water; Pseudoephedrine + 50 ml water; Sterile water; Sterile water for injection; Sterilised water for injections; Water; Water for injection; Water for injections; Water for injections, ep;  [1] D00001 💬  -  -  [22]  2 ,  5 ,  6 , 13, 17, 19, 35, 46, 51, 53, 56, 57, 63, 65, 67, 78, 84, 96, 97, 226, 278, 299 💬
 36  Zolpidem [4] Zolpidem; Zolpidem first dose; Zolpidem second dose; Zolpidem tartrate;  [2] D00706
D08690 💬		 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 [7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction  [3]  5 ,  6 , 46 💬