215. Tetralogy of Fallot
19 clinical trials,   35 drugs   (DrugBank: 16 drugs),   16 drug target genes,   47 drug target pathways

Searched query = "Tetralogy of Fallot", "Fallot tetralogy"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

Search in Page e.g. "Phase 3", "Not recruiting", "Japan"
No.TrialIDDate_
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1ChiCTR2000033234
2020-06-052020-05-25Comprehensive study for surgical effect and prognosis of Tetralogy of FallotA single-center ambispective cohort study for surgical effect and prognostic factors of Tetralogy of Fallot after surgical repair Tetralogy of FallotTOF AS:annlus-sparing repair;TOF TAPE:transannular patch enlargement;Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeNULLPendingBothTOF AS:247;TOF TAPE:247;N/AChina
2NCT04017975
(ClinicalTrials.gov)
December 20, 201910/7/2019Optical Tissue Identification for Myocardial ArchitectureOptical Tissue Identification for Myocardial Architecture (OPTIMA Study)Ventricular Septal Defect;Complete Atrioventricular Canal;Tetralogy of Fallot With Pulmonary StenosisDrug: Fluorescite;Device: Cellvizio 100 Series System with Confocal MiniprobesAditya KazaNational Heart, Lung, and Blood Institute (NHLBI)RecruitingN/A18 YearsAll70Phase 2United States
3ChiCTR1900025513
2019-09-012019-08-31The safety and efficacy of preoperative oral supplementation of coenzyme Q10 in improving postoperative cardiac function in children with tetralogy of fallot (pulmonary atresia): a preliminary studyThe safety and efficacy of preoperative oral supplementation of coenzyme Q10 in improving postoperative cardiac function in children with tetralogy of fallot (pulmonary atresia): a preliminary study tetralogy of fallot (pulmonary atresia)01:N/A ;02:Oral coenzyme Q10, 2.5mg, t.i.d.;03:Oral coenzyme Q10, 5mg, t.i.d.;04:Oral coenzyme Q10, 10mg, t.i.d.;05:Oral coenzyme Q10, 20mg, t.i.d.;Fuwai Central China Cardiovascualr HospitalNULLPending02Both01:8;02:8;03:8;04:8;05:8;China
4ChiCTR1800019578
2018-12-012018-11-18Effects of different tranexamic acid regimen in cyanotic pediatric cardiac surgeryEffects of different tranexamic acid regimen in cyanotic pediatric cardiac surgery Tetralogy of FallotConventional treatment group:Childen did not receive an antifibrinolytic agent during surgery;Low dose of tranexamic acid group:Loading dose: 10mg/kg (infant), 5mg/kg (children); Infusion: 2mg/kg.h; CPB prime dose: 20ug/mL of prime volume;High dose of tranexamic acid group:Loading dose: 30mg/kg (infant), 15mg/kg (children); Infusion: 6mg/kg.h; CPB prime dose: 60ug/mL of prime volume;National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeNULLPendingBothConventional treatment group:225;Low dose of tranexamic acid group:225;High dose of tranexamic acid group:225;China
5NCT03835494
(ClinicalTrials.gov)
November 1, 20188/1/2019Analysis of RV-Dysfunction in Fallot PatientsTissue Doppler Imaging - A Promising Technique To Assess Myocardial Function In Adult Fallot PatientsTetralogy of FallotOther: Transthoracic echocardiography at rest, during PLR, HG and CPX (including blood gas analysis in both groups). Additionally Fallot patients will undergo routine blood testings.Klinik für Kardiologie, Pneumologie und AngiologieNULLCompleted18 Years80 YearsAll60N/AGermany
No.TrialIDDate_
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6NCT03732742
(ClinicalTrials.gov)
November 201822/10/2018Comparison of Mid-term Results of Total Correction of TOF Between Preservation of PV and Trans-annular Patch.Comparison of Mid-term Results of Total Correction of Tetralogy of Fallot Between Preservation of Pulmonary Valve and Trans-annular PatchingTetrology of FallotProcedure: TOF repair with trans-annular patch VS preservation of PVAssiut UniversityNULLUnknown statusN/AN/AAll50N/ANULL
7NCT03049995
(ClinicalTrials.gov)
November 20162/2/2017Stress Echo 2020 - The International Stress Echo StudyThe International Stress Echo Study in Ischemic and Non-ischemic Heart DiseaseCoronary Artery Disease;Heart Failure;Hypertrophic Cardiomyopathy;Aortic Valve Disease;Athletes Heart;Tetralogy of Fallot;Pulmonary Arterial HypertensionProcedure: Left ventricular contractile reserve SE;Procedure: B-lines SE;Procedure: Left ventricular outflow tract gradient SE;Procedure: Diastolic function SE;Procedure: Mitral regurgitation SE;Procedure: Pulmonary hemodynamics SE;Procedure: Coronary flow reserve SEFatebenefratelli HospitalInstitute of Clinical Physiology, CNR, Pisa,Italy;Salerno Hospital, Italy;Monaldi Hospital, Napoli, Italy;University of Pisa, Italy;San Luca Hospital, Lucca, Italy;Careggi University Hospital, Florence, Italy;Federico II University, Napoli, Italy;San Carlo Public Hospital, Potenza, Italy;Royal Brompton & Harefield NHS Foundation Trust;Ospedale dell'Angelo, Venezia-Mestre, Italy;University of Parma;Hospital Clinics, Trieste, Italy;Hospital de Clinicas de Porto Alegre - Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil;Hospital San José, Criciuma, Brasil;Hospital San Vicente de Paulo, Passo Fundo, Brasil;University of Belgrade,Serbia;University of Szeged, Hungary;Elisabeth Hospital, Hodmezovasarhely, Hungary;Sandro Pertini Hospital, Rome, Italy;Hospital Clinics, Bari, Italy;Ospedale Nottola, Siena, Italy;University of Catania, Italy;Medika Cardiocenter, Saint Petersburg, Russian Federation;Acibadem City Clinic, University Hospital,Sofia,Bulgaria;Investigaciones Medicas, Buenos Aires, Argentina;Tomsk National Research Scientific Centre of Russian Academy of Sciences, Tomsk, Russian FederationRecruiting18 Years85 YearsAll300N/AItaly
8ChiCTR-IOR-16008571
2016-06-062016-05-31Premedication for children with Tetralogy of FallotA comparative evalution of varies premedication regimes on children with Tetralogy of Fallot Tetralogy of Fallotoral dexmedetomidine:oral dexmedetomidine;oral ketamine:oral ketamine;oral dexmedetomidine mixed with ketamine:oral dexmedetomidine mixed with ketamine;Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong UniversityNULLRecruitingBothoral dexmedetomidine:20;oral ketamine:20;oral dexmedetomidine mixed with ketamine:20;China
9EUCTR2013-002091-41-NL
(EUCTR)
09/10/201405/11/2013Research into the effect of the drug losartan in adult patients with a reduced function of the right cardiac chamber and a cardiac birth defectRight vEntricular Dysfunction in tEtralogy of Fallot: INhibition of the rEnin-angiotensin-aldosterone system - Redefine trial To study the effect of losartan in adult patients with Tetralogy of Fallot and right ventricular dysfunction, defined as right ventricular ejection fraction <50%. Without severe valvular lesions.;Therapeutic area: Diseases [C] - Cardiovascular Diseases [C14]Trade Name: Losartan
Product Name: Losartan
INN or Proposed INN: Losartan Potassium
Other descriptive name: LOSARTAN POTASSIUM
Academisch medisch centrumNULLAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes
Netherlands
10NCT01915277
(ClinicalTrials.gov)
April 2, 201430/7/2013A Phase I Study of Dexmedetomidine Bolus and Infusion in Corrective Infant Cardiac Surgery: Safety and PharmacokineticsA Phase I Study of Dexmedetomidine Bolus and Infusion in Corrective Infant Cardiac Surgery: Safety and PharmacokineticsTransposition of the Great Arteries;Tetralogy of Fallot;Ventricular Septal DefectDrug: DexmedetomidineHealthCore-NERINational Heart, Lung, and Blood Institute (NHLBI)CompletedN/A180 DaysAll119Phase 1United States
No.TrialIDDate_
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Public_titleScientific_titleConditionInterventionPrimary_
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11NCT02010905
(ClinicalTrials.gov)
December 20136/12/2013Right Ventricular Dysfunction in Tetralogy of Fallot: Inhibition of the Renin-angiotensin-aldosterone SystemRight Ventricular Dysfunction in Tetralogy of Fallot: Inhibition of the Renin-angiotensin-aldosterone SystemTetralogy of Fallot;Heart Defects, Congenital;Ventricular Dysfunction, RightDrug: Losartan;Drug: PlaceboAcademisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)The Interuniversity Cardiology Institute of the NetherlandsRecruiting18 Years80 YearsBoth120Phase 2Netherlands
12NCT01941576
(ClinicalTrials.gov)
September 1, 20133/9/2013Effects of rhBNP in Pediatrics After Corrective Repair of Tetralogy Of FallotEffects of rhBNP in Pediatrics After Corrective Repair of Tetralogy Of FallotCongenital Heart Defects;Tetralogy Of FallotDrug: recombinant human brain natriuretic peptide (rhBNP);Drug: Placebo (0.9% sodium chloride)Shanghai Jiao Tong University School of MedicineNULLCompleted1 Month18 YearsAll120N/AChina
13NCT01971593
(ClinicalTrials.gov)
August 201323/10/2013The Effects of Eplerenone on Markers of Myocardial Fibrosis in Adult Congenital Heart DiseaseEplerenone to Prevent Myocardial Fibrosis in Congenital Heart DiseaseTetralogy of Fallot;Transposition of the Great Vessels With an Arterial Switch;Single Ventricle With a Fontan PalliationDrug: EplerenoneWashington University School of MedicinePfizerTerminated18 Years80 YearsAll26Phase 4United States
14NCT00848393
(ClinicalTrials.gov)
November 200819/2/2009Measures to Lower the Stress Response in Pediatric Cardiac SurgeryStress Response in Children Undergoing Cardiac Surgery: a Prospective Randomized Comparison Between Low Dose Fentanyl (LDF), Low Dose Fentanyl Plus Dexmedetomidine (LDF + Dex) and High Dose Fentanyl (HDF).Tetralogy of Fallot (TOF);Ventricular Septal Defects (VSD);Atrioventricular Septal Defects (AVSD)Drug: Fentanyl (High Dose);Drug: Fentanyl (Low Dose);Drug: Fentanyl (Low Dose) + DexmedetomidineNationwide Children's HospitalNULLCompleted1 Month3 YearsAll52Phase 2United States
15EUCTR2007-003461-41-DE
(EUCTR)
13/11/200710/09/2007Cardiac imaging under dobutamine stress for early assessment of right ventricular function in patients with tetralogy of Fallot and pulmonary regurgitation - Fallot-stressCardiac imaging under dobutamine stress for early assessment of right ventricular function in patients with tetralogy of Fallot and pulmonary regurgitation - Fallot-stress Fallot tetralogy late after repair with marked pulmonary valve incompetenceINN or Proposed INN: DobutamineDeutsche Herzzentrum Berlin, Kompetenznetz Angeborene HerzfehlerNULLNot RecruitingFemale: yes
Male: yes
80Germany
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
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agemin
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16NCT00564993
(ClinicalTrials.gov)
November 200728/11/2007Cardiac Function Under Stress for Early Detection of the Right Ventricular Insufficiency After Repair of Tetralogy of FallotCardiac Imaging Under Exercise Stress Test for Early Assessment of Right Ventricular Function in Patients With Tetralogy of Fallot and Pulmonary RegurgitationTetralogy of FallotDrug: DobutaminCompetence Network for Congenital Heart DefectsGerman Federal Ministry of Education and ResearchTerminated14 YearsN/ABoth53Phase 3Germany
17NCT00557934
(ClinicalTrials.gov)
October 200713/11/2007Right Ventricular Contractility Reserve Following Repair of Tetralogy of FallotEvaluation of Right Ventricular Contractility Reserve Function During Dobutamine Stress in Patients Following Surgical Repair of Tetralogy of FallotRight Ventricular DysfunctionOther: dobutamineUniversity Hospital TuebingenFördergemeinschaft Deutsche Kinderherzzentren, Bonn, GermanyCompleted4 YearsN/ABoth16N/AGermany
18NCT00573066
(ClinicalTrials.gov)
May 200411/12/2007Understanding Dexmedetomidine In Infants Post-Operative From Cardiac SurgeryThe Pharmacokinetics, Pharmacogenetics, and Pharmacodynamics of Dexmedetomidine In Infants Post-Operative From Cardiac SurgeryHypoplastic Left Heart;Tetralogy of Fallot;Tricuspid AtresiaDrug: DexmedetomidineAthena ZuppaNULLCompleted1 Month24 MonthsAll56Phase 1NULL
19NCT00004361
(ClinicalTrials.gov)
July 199518/10/1999Study of the Relationship Between Calcium Levels and Intact Parathyroid Hormone (iPTH) in Adults With Repaired or Palliated Conotruncal Cardiac DefectsHypoparathyroidism;Tetralogy of Fallot;Pulmonary Valve Stenosis;Conotruncal Cardiac Defects;Heart Defects, Congenital;Pulmonary AtresiaDrug: calcium gluconate;Drug: sodium citrateNational Center for Research Resources (NCRR)Ann & Robert H Lurie Children's Hospital of ChicagoCompleted18 YearsN/ABoth150N/ANULL