DDrare: Database of Drug Development for Rare Diseases

Sb12 (proposed eculizumab biosimilar) (DrugBank: Eculizumab)

8 diseases

ID	Disease name (Link within this page)	Number of trials
11	Myasthenia	0
13	Multiple sclerosis/Neuromyelitis optica	0
14	Chronic inflammatory demyelinating polyneuropathy	0
61	Autoimmune hemolytic anemia	0
62	Paroxysmal nocturnal hemoglobinuria	1
109	Atypical hemolytic uremic syndrome	0
222	Primary nephrotic syndrome	0
223	Primary membranoproliferative glomerulonephritis	0

11. Myasthenia [ 226 clinical trials, 172 drugs, (DrugBank: 45 drugs), 43 drug target genes, 118 drug target pathways]

Searched query = "Myasthenia", "MG"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 226 trial found

13. Multiple sclerosis/Neuromyelitis optica [ 3,050 clinical trials, 2,147 drugs, (DrugBank: 348 drugs), 244 drug target genes, 228 drug target pathways]

Searched query = "Multiple sclerosis/Neuromyelitis optica", "Multiple sclerosis", "Neuromyelitis optica", "MS", "NMOSD", "Devic disease", "Balo concentric sclerosis", "Baló concentric sclerosis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 3,050 trial found

14. Chronic inflammatory demyelinating polyneuropathy [ 145 clinical trials, 139 drugs, (DrugBank: 23 drugs), 12 drug target genes, 21 drug target pathways]

Searched query = "Chronic inflammatory demyelinating polyneuropathy", "Chronic inflammatory demyelinating poly (radiculo) neuropathy", "Multifocal motor neuropathy", "CIDP"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 145 trial found

61. Autoimmune hemolytic anemia [ 90 clinical trials, 72 drugs, (DrugBank: 23 drugs), 19 drug target genes, 147 drug target pathways]

Searched query = "Autoimmune hemolytic anemia", "AIHA", "WAIHA", "Cold agglutinin disease", "CAD", "Paroxysmal cold hemoglobinuria", "MAIHA", "Evans syndrome"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 90 trial found

62. Paroxysmal nocturnal hemoglobinuria [ 202 clinical trials, 120 drugs, (DrugBank: 25 drugs), 15 drug target genes, 90 drug target pathways]

Searched query = "Paroxysmal nocturnal hemoglobinuria", "PNH"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

1 / 202 trial found

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04058158 (ClinicalTrials.gov)	August 7, 2019	12/8/2019	A Study to Compare SB12 (Proposed Eculizumab Biosimilar) to Soliris in Subjects With Paroxysmal Nocturnal Haemoglobinuria	A Phase III Randomised, Double-blind, Multicentre Study to Compare the Efficacy, Safety, Pharmacokinetics, and Immunogenicity Between SB12 (Proposed Eculizumab Biosimilar) and Soliris® in Subjects With Paroxysmal Nocturnal Haemoglobinuria	Paroxysmal Nocturnal Hemoglobinuria	Drug: SB12 (proposed eculizumab biosimilar);Drug: Soliris (eculizumab)	Samsung Bioepis Co., Ltd.	NULL	Active, not recruiting	18 Years	N/A	All	50	Phase 3	India;Korea, Republic of;Malaysia;Mexico;Romania;Taiwan;Thailand;Ukraine

109. Atypical hemolytic uremic syndrome [ 95 clinical trials, 27 drugs, (DrugBank: 5 drugs), 2 drug target genes, 9 drug target pathways]

Searched query = "Atypical hemolytic uremic syndrome", "aHUS"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 95 trial found

222. Primary nephrotic syndrome [ 234 clinical trials, 241 drugs, (DrugBank: 78 drugs), 59 drug target genes, 185 drug target pathways]

Searched query = "Primary nephrotic syndrome", "Minimal change nephrotic syndrome", "MCNS", "Membranous nephropathy", "Focal segmental glomerulosclerosis", "FSGS", "Membranoproliferative glomerulonephritis", "MPGN"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 234 trial found

223. Primary membranoproliferative glomerulonephritis [ 18 clinical trials, 14 drugs, (DrugBank: 7 drugs), 7 drug target genes, 14 drug target pathways]

Searched query = "Primary membranoproliferative glomerulonephritis", "Dense deposit disease"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 18 trial found