DDrare: Database of Drug Development for Rare Diseases

Niacin (DrugBank: Niacin)

4 diseases

ID	Disease name (Link within this page)	Number of trials
6	Parkinson disease	2
78	Hypopituitarism	1
79	Homozygous familial hypercholesterolemia	0
265	Lipodystrophy	1

6. Parkinson disease [ 2,123 clinical trials, 2,046 drugs, (DrugBank: 324 drugs), 183 drug target genes, 198 drug target pathways]

Searched query = "Parkinson disease"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

2 / 2,123 trials found

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT03808961 (ClinicalTrials.gov)	January 1, 2020	16/1/2019	Niacin for Parkinsons Disease	NAPS: Niacin for Parkinsons Disease	Parkinson's Disease	Dietary Supplement: Niacin;Dietary Supplement: Niacinamide;Other: Placebo	VA Office of Research and Development	NULL	Recruiting	35 Years	N/A	All	100	N/A	United States
2	NCT03462680 (ClinicalTrials.gov)	September 28, 2016	22/2/2018	GPR109A and Parkinson's Disease: Role of Niacin in Outcome Measures	GPR109A and Parkinson's Disease: Role of Niacin in Outcome Measures	Parkinson's Disease	Dietary Supplement: niacin;Other: placebo	VA Office of Research and Development	NULL	Completed	35 Years	N/A	All	47	N/A	United States

78. Hypopituitarism [ 462 clinical trials, 346 drugs, (DrugBank: 45 drugs), 41 drug target genes, 80 drug target pathways]

Searched query = "Hypopituitarism", "Anterior pituitary hypothyroidism", "Syndrome of abnormal secretion of gonadotropin", "Hyposecretion of gonadotropins", "Adrenocorticotropic hormone deficiency", "ACTH deficiency", "Thyroid-stimulating hormone deficiency", "TSH deficiency", "Growth hormone deficiency", "GH deficiency", "GHD", "CGHD", "AGHD", "Prolactin deficiency", "PRL deficiency"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

1 / 462 trial found

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT01237041 (ClinicalTrials.gov)	July 1, 2011	6/11/2010	Free Fatty Acids, Body Weight, and Growth Hormones Secretion in Children	Free Fatty Acids, Body Weight, and Growth Hormone Secretion in Children	Obesity;Short Stature;Growth Hormone Deficiency	Drug: Niacin First;Drug: Placebo First;Drug: Dose-Establishing Study 1 Niacin 250mg;Drug: Dose-Establishing Study 1 Niacin 500mg;Drug: Dose-Establishing Study 2 Niacin 500mg	Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	NULL	Terminated	7 Years	14 Years	All	37	Phase 1;Phase 2	United States

79. Homozygous familial hypercholesterolemia [ 128 clinical trials, 105 drugs, (DrugBank: 29 drugs), 8 drug target genes, 15 drug target pathways]

Searched query = "Homozygous familial hypercholesterolemia"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.

0 / 128 trial found

265. Lipodystrophy [ 109 clinical trials, 164 drugs, (DrugBank: 59 drugs), 26 drug target genes, 94 drug target pathways]

Searched query = "Lipodystrophy", "Berardinelli-Seip syndrome", "Lawrence syndrome", "Barraquer-Simons syndrome"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

1 / 109 trial found

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00246376 (ClinicalTrials.gov)	January 2004	27/10/2005	Diet, Exercise, Niacin, and Fenofibrate to Reduce Heart Disease Risk Factors in Individuals With HIV Lipodystrophy or Dyslipidemia	Diet/Exercise, Niacin, Fenofibrate for HIV Lipodystrophy	Cardiovascular Diseases;Heart Diseases;HIV Infections;Hyperlipidemia;Hypertriglyceridemia;Insulin Resistance;Atherosclerosis	Behavioral: Diet;Behavioral: Exercise;Drug: Niacin;Drug: Fenofibrate;Other: Placebos	Baylor College of Medicine	National Heart, Lung, and Blood Institute (NHLBI);Legacy Community Health Center	Completed	18 Years	65 Years	All	221	N/A	United States