1 | 1-deoxynojirimycin | [1] Duvoglustat Duvoglustat | [1] D09605
D09605
| [1] GAA GAA 💬 | [4] Galactose metabolism Galactose metabolism, Lysosome, Metabolic pathways, Starch and sucrose metabolism 💬 | [1] 256 256 |
2 | 1-deoxynojirimycin hydrochloride | [1] Duvoglustat Duvoglustat | [1] D09605
D09605
| [1] GAA GAA 💬 | [4] Galactose metabolism Galactose metabolism, Lysosome, Metabolic pathways, Starch and sucrose metabolism 💬 | [1] 256 256 |
3 | A-glucosidasi acida umana ricombinante coniugata con multiple copie di bis-mannosio-6- fosfato-tetra-mannosio glicano sintetico (NEOGAA) | [1] Avalglucosidase alfa Avalglucosidase alfa | [1] D11744
D11744
| [1] GAA GAA 💬 | [4] Galactose metabolism Galactose metabolism, Lysosome, Metabolic pathways, Starch and sucrose metabolism 💬 | [1] 256 256 |
4 | AAV2/8LSPhGAA | - | - | - | - | [1] 256 256 |
5 | Acetaminophen | [1] Acetaminophen Acetaminophen | [1] D00217
D00217
| [2] PTGS1 PTGS1, PTGS2 💬 | [23] Alzheimer disease Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬 | [16] 11 11, 13, 34, 35, 46, 49, 51, 70, 86, 96, 222, 231, 256, 271, 300, 337 |
6 | Albuterol | [1] Salbutamol Salbutamol | [1] D02147
D02147
| [1] ADRB2 ADRB2 💬 | [9] Adrenergic signaling in cardiomyocytes Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬 | [8] 12 12, 13, 86, 89, 113, 231, 256, 299 |
7 | Aldurazyme (laronidase) | [1] Laronidase Laronidase | [1] D04670
D04670
| [1] IDUA IDUA 💬 | [3] Glycosaminoglycan degradation Glycosaminoglycan degradation, Lysosome, Metabolic pathways 💬 | [2] 19 19, 256 |
8 | ALGLUCOSIDASE ALFA | [1] Alglucosidase alfa Alglucosidase alfa | [1] D03207
D03207
| [1] GAA GAA 💬 | [4] Galactose metabolism Galactose metabolism, Lysosome, Metabolic pathways, Starch and sucrose metabolism 💬 | [1] 256 256 |
9 | Alglucosidase Alfa (Genetical Recombination) | [1] Alglucosidase alfa Alglucosidase alfa | [1] D03207
D03207
| [1] GAA GAA 💬 | [4] Galactose metabolism Galactose metabolism, Lysosome, Metabolic pathways, Starch and sucrose metabolism 💬 | [1] 256 256 |
10 | Alglucosidase alfa (GZ419829) | [1] Alglucosidase alfa Alglucosidase alfa | [1] D03207
D03207
| [1] GAA GAA 💬 | [4] Galactose metabolism Galactose metabolism, Lysosome, Metabolic pathways, Starch and sucrose metabolism 💬 | [1] 256 256 |
11 | ALGLUCOSIDASE ALFA (MYOZYME) | [1] Alglucosidase alfa Alglucosidase alfa | [1] D03207
D03207
| [1] GAA GAA 💬 | [4] Galactose metabolism Galactose metabolism, Lysosome, Metabolic pathways, Starch and sucrose metabolism 💬 | [1] 256 256 |
12 | Alglucosidase alfa (recombinant human acid alpha-glucosidase [rhGAA]) | [1] Alglucosidase alfa Alglucosidase alfa | [1] D03207
D03207
| [1] GAA GAA 💬 | [4] Galactose metabolism Galactose metabolism, Lysosome, Metabolic pathways, Starch and sucrose metabolism 💬 | [1] 256 256 |
13 | Alglucosidase alfa GZ419829 | [1] Alglucosidase alfa Alglucosidase alfa | [1] D03207
D03207
| [1] GAA GAA 💬 | [4] Galactose metabolism Galactose metabolism, Lysosome, Metabolic pathways, Starch and sucrose metabolism 💬 | [1] 256 256 |
14 | Alglucosidase alfa GZ419829 (Myozyme) | [1] Alglucosidase alfa Alglucosidase alfa | [1] D03207
D03207
| [1] GAA GAA 💬 | [4] Galactose metabolism Galactose metabolism, Lysosome, Metabolic pathways, Starch and sucrose metabolism 💬 | [1] 256 256 |
15 | Alglucosidase alpha | - | - | - | - | [1] 256 256 |
16 | ALGLUCOSIDASI ALFA UMANA RICOMBINANTE | - | - | - | - | [1] 256 256 |
17 | Alpha-glucosidase | [1] Alglucosidase alfa Alglucosidase alfa | [1] D03207
D03207
| [1] GAA GAA 💬 | [4] Galactose metabolism Galactose metabolism, Lysosome, Metabolic pathways, Starch and sucrose metabolism 💬 | [1] 256 256 |
18 | AT2220 | [1] AT2220 AT2220 | - | - | - | [1] 256 256 |
19 | AT2221 | - | - | - | - | [1] 256 256 |
20 | AT2221 65 mg Formulated Capsules | - | - | - | - | [1] 256 256 |
21 | AT845 | - | - | - | - | [1] 256 256 |
22 | ATB200 | - | - | - | - | [1] 256 256 |
23 | Avalglucosidase Alfa | [1] Avalglucosidase alfa Avalglucosidase alfa | [1] D11744
D11744
| [1] GAA GAA 💬 | [4] Galactose metabolism Galactose metabolism, Lysosome, Metabolic pathways, Starch and sucrose metabolism 💬 | [1] 256 256 |
24 | Avalglucosidase alfa (GZ402666) | [1] Avalglucosidase alfa Avalglucosidase alfa | [1] D11744
D11744
| [1] GAA GAA 💬 | [4] Galactose metabolism Galactose metabolism, Lysosome, Metabolic pathways, Starch and sucrose metabolism 💬 | [1] 256 256 |
25 | Avalglucosidase Alfa (NeoGAA) | [1] Avalglucosidase alfa Avalglucosidase alfa | [1] D11744
D11744
| [1] GAA GAA 💬 | [4] Galactose metabolism Galactose metabolism, Lysosome, Metabolic pathways, Starch and sucrose metabolism 💬 | [1] 256 256 |
26 | Avalglucosidase alfa GZ402666 | [1] Avalglucosidase alfa Avalglucosidase alfa | [1] D11744
D11744
| [1] GAA GAA 💬 | [4] Galactose metabolism Galactose metabolism, Lysosome, Metabolic pathways, Starch and sucrose metabolism 💬 | [1] 256 256 |
27 | Avalglucosidase alfa(GZ402666) | [1] Avalglucosidase alfa Avalglucosidase alfa | [1] D11744
D11744
| [1] GAA GAA 💬 | [4] Galactose metabolism Galactose metabolism, Lysosome, Metabolic pathways, Starch and sucrose metabolism 💬 | [1] 256 256 |
28 | Avalglucosidasi alfa | - | - | - | - | [1] 256 256 |
29 | Beta-hydroxybuturate esters | - | - | - | - | [1] 256 256 |
30 | BMN 701 | - | - | - | - | [1] 256 256 |
31 | BORTEZOMIB | [1] Bortezomib Bortezomib | [1] D03150
D03150
| [1] PSMB5 PSMB5 💬 | [8] Alzheimer disease Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Prion disease, Proteasome, Spinocerebellar ataxia 💬 | [16] 11 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 228, 256, 283, 288, 331 |
32 | Calcium | [1] Calcium Calcium | - | - | - | [30] 3 3, 6, 13, 15, 19, 46, 49, 51, 53, 56, 68, 75, 79, 84, 93, 94, 95, 96, 97, 186, 214, 215, 222, 224, 235, 256, 265, 274, 298, 299 |
33 | Cipaglucosidase Alfa | [1] Cipaglucosidase alfa Cipaglucosidase alfa | [1] D11798
D11798
| [1] GAA GAA 💬 | [4] Galactose metabolism Galactose metabolism, Lysosome, Metabolic pathways, Starch and sucrose metabolism 💬 | [1] 256 256 |
34 | Cipaglucosidase alfa (ATB200) | [1] Cipaglucosidase alfa Cipaglucosidase alfa | [1] D11798
D11798
| [1] GAA GAA 💬 | [4] Galactose metabolism Galactose metabolism, Lysosome, Metabolic pathways, Starch and sucrose metabolism 💬 | [1] 256 256 |
35 | Cipaglucosidasi alfa | - | - | - | - | [1] 256 256 |
36 | Clenbuterol | [1] Clenbuterol Clenbuterol | [1] D07713
D07713
| [1] ADRB2 ADRB2 💬 | [9] Adrenergic signaling in cardiomyocytes Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬 | [4] 1 1, 2, 6, 256 |
37 | Creatine | [1] Creatine Creatine | - | - | - | [16] 1 1, 2, 3, 5, 6, 8, 13, 15, 21, 46, 49, 50, 113, 156, 201, 256 |
38 | Cyclophosphamide | [1] Cyclophosphamide Cyclophosphamide | [2] D00287
D00287
,
D07760
| - | - | [45] 11 11, 13, 14, 16, 19, 20, 26, 28, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 56, 60, 62, 65, 66, 84, 85, 93, 96, 162, 164, 172, 205, 222, 224, 256, 265, 274, 283, 284, 285, 288, 326, 331 |
39 | CYCLOPHOSPHAMIDE MONOHYDRATE | [1] Cyclophosphamide Cyclophosphamide | [2] D00287
D00287
,
D07760
| - | - | [4] 13 13, 60, 96, 256 |
40 | Deoxynojirimycin | [1] Duvoglustat Duvoglustat | [1] D09605
D09605
| [1] GAA GAA 💬 | [4] Galactose metabolism Galactose metabolism, Lysosome, Metabolic pathways, Starch and sucrose metabolism 💬 | [1] 256 256 |
41 | Deprakine | - | - | - | - | [1] 256 256 |
42 | Diagnostic Test: Beck depression inventory fast screen (Questionnaire) | - | - | - | - | [3] 3 3, 15, 256 |
43 | Diagnostic Test: Borg Scale | - | - | - | - | [3] 3 3, 15, 256 |
44 | Diagnostic Test: Brief Pain Inventory (BPI) (Questionnaire) | - | - | - | - | [3] 3 3, 15, 256 |
45 | Diagnostic Test: Fatigue Severity and Disability Scale (FSS) (Questionnaire) | - | - | - | - | [3] 3 3, 15, 256 |
46 | Diagnostic Test: German Pain Inventory (Questionnaire) | - | - | - | - | [3] 3 3, 15, 256 |
47 | Diagnostic Test: Handheld Dynamometry (HHD) | - | - | - | - | [3] 3 3, 15, 256 |
48 | Diagnostic Test: Laboratory assessment: calcium | [1] Calcium Calcium | - | - | - | [3] 3 3, 15, 256 |
49 | Diagnostic Test: Laboratory assessment: Creatine kinase | [1] Creatine Creatine | - | - | - | [3] 3 3, 15, 256 |
50 | Diagnostic Test: Laboratory assessment: magnesium | [1] Magnesium Magnesium | - | - | - | [3] 3 3, 15, 256 |
51 | Diagnostic Test: Laboratory assessment: phosphate | [1] Phosphate ion Phosphate ion | - | - | - | [3] 3 3, 15, 256 |
52 | Diagnostic Test: Laboratory assessment: Vitamin D Level | [1] Vitamin D Vitamin D | - | - | - | [3] 3 3, 15, 256 |
53 | Diagnostic Test: Muscle ultrasound | - | - | - | - | [3] 3 3, 15, 256 |
54 | Diagnostic Test: Pressure pain threshold | - | - | - | - | [4] 3 3, 15, 113, 256 |
55 | Diagnostic Test: Quick Motor Function Test | - | - | - | - | [4] 3 3, 15, 113, 256 |
56 | Diagnostic Test: R-PAct (Questionnaire) | - | - | - | - | [3] 3 3, 15, 256 |
57 | Diagnostic Test: Rotterdam Handicap Scale (RHS) (Questionnaire) | - | - | - | - | [3] 3 3, 15, 256 |
58 | Diagnostic Test: Six-minute walk test (6MWT) | - | - | - | - | [3] 3 3, 15, 256 |
59 | Diagnostic Test: Vital signs | - | - | - | - | [3] 3 3, 15, 256 |
60 | Diphenhydramine | [1] Diphenhydramine Diphenhydramine | [6] D00300
D00300
,
D00669
,
D02419
,
D03285
,
D03360
,
D03854
| [1] HRH1 HRH1 💬 | [3] Calcium signaling pathway Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬 | [10] 11 11, 13, 49, 51, 70, 86, 96, 222, 256, 300 |
61 | Duvoglustat | [1] Duvoglustat Duvoglustat | [1] D09605
D09605
| [1] GAA GAA 💬 | [4] Galactose metabolism Galactose metabolism, Lysosome, Metabolic pathways, Starch and sucrose metabolism 💬 | [1] 256 256 |
62 | Duvoglustat HCl | [1] Duvoglustat Duvoglustat | [1] D09605
D09605
| [1] GAA GAA 💬 | [4] Galactose metabolism Galactose metabolism, Lysosome, Metabolic pathways, Starch and sucrose metabolism 💬 | [1] 256 256 |
63 | Duvoglustat hydrochloride | [1] Duvoglustat Duvoglustat | [1] D09605
D09605
| [1] GAA GAA 💬 | [4] Galactose metabolism Galactose metabolism, Lysosome, Metabolic pathways, Starch and sucrose metabolism 💬 | [1] 256 256 |
64 | Enzyme Replacement Agent | - | - | - | - | [1] 256 256 |
65 | Epilim | - | - | - | - | [1] 256 256 |
66 | Epilim Chrono 200 Controlled Released tablets | - | - | - | - | [1] 256 256 |
67 | Epilim Chrono 300 Controlled Released tablets | - | - | - | - | [1] 256 256 |
68 | Epilim Chrono 500 Controlled Released tablets | - | - | - | - | [1] 256 256 |
69 | Filgrastim | [1] Filgrastim Filgrastim | [1] D03235
D03235
| [1] CSF3R CSF3R 💬 | [5] Cytokine-cytokine receptor interaction Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, JAK-STAT signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer 💬 | [28] 2 2, 6, 13, 25, 26, 28, 34, 35, 38, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 96, 113, 164, 256, 283, 284, 285, 296, 331 |
70 | Folic (or folinic) acid | - | - | - | - | [2] 46 46, 256 |
71 | Genetic: Blood draw for optional genetic exome sequencing | - | - | - | - | [3] 3 3, 15, 256 |
72 | Genetic: Genetic test: ACE polymorphism | - | - | - | - | [3] 3 3, 15, 256 |
73 | Genetic: Genetic test: ACTN3 polymorphism | - | - | - | - | [3] 3 3, 15, 256 |
74 | Genetic: Recombinant Adeno-Associated Virus Acid Alpha-Glucosidase | [1] Alglucosidase alfa Alglucosidase alfa | [1] D03207
D03207
| [1] GAA GAA 💬 | [4] Galactose metabolism Galactose metabolism, Lysosome, Metabolic pathways, Starch and sucrose metabolism 💬 | [1] 256 256 |
75 | GILT-rhGAA | - | - | - | - | [1] 256 256 |
76 | Glucosidase alfa | - | - | - | - | [1] 256 256 |
77 | Glycosade | - | - | - | - | [3] 65 65, 256, 257 |
78 | GSK3196165 (Otilimab) | [1] Otilimab Otilimab | [1] D11343
D11343
| [1] CSF2 CSF2 💬 | [16] Acute myeloid leukemia Acute myeloid leukemia, Amoebiasis, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, IL-17 signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Natural killer cell mediated cytotoxicity, Rheumatoid arthritis, Shigellosis, T cell receptor signaling pathway, TNF signaling pathway, Transcriptional misregulation in cancer 💬 | [2] 46 46, 256 |
79 | GZ402666 | - | - | - | - | [1] 256 256 |
80 | GZ419829 | - | - | - | - | [1] 256 256 |
81 | Intravenous immune globulin | - | - | - | - | [1] 256 256 |
82 | Ketocal 4:1 liquid Nutricia (intervention) | - | - | - | - | [1] 256 256 |
83 | LARONIDASE | [1] Laronidase Laronidase | [1] D04670
D04670
| [1] IDUA IDUA 💬 | [3] Glycosaminoglycan degradation Glycosaminoglycan degradation, Lysosome, Metabolic pathways 💬 | [2] 19 19, 256 |
84 | Lidocaine | [1] Lidocaine Lidocaine | [3] D00358
D00358
,
D02086
,
D08127
| [5] SCN1A SCN1A, SCN2A, SCN3A, SCN5A, SCN9A 💬 | [3] Adrenergic signaling in cardiomyocytes Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬 | [12] 6 6, 13, 34, 46, 51, 70, 86, 107, 168, 226, 231, 256 |
85 | LMX 4 Topical Cream | - | - | - | - | [1] 256 256 |
86 | Low carbohydrate ketogenic diet | - | - | - | - | [1] 256 256 |
87 | Lumizyme | [1] Alglucosidase alfa Alglucosidase alfa | [1] D03207
D03207
| [1] GAA GAA 💬 | [4] Galactose metabolism Galactose metabolism, Lysosome, Metabolic pathways, Starch and sucrose metabolism 💬 | [1] 256 256 |
88 | Lumizyme® | [1] Alglucosidase alfa Alglucosidase alfa | [1] D03207
D03207
| [1] GAA GAA 💬 | [4] Galactose metabolism Galactose metabolism, Lysosome, Metabolic pathways, Starch and sucrose metabolism 💬 | [1] 256 256 |
89 | Magnesium | [1] Magnesium Magnesium | - | - | - | [19] 3 3, 6, 11, 13, 15, 46, 64, 70, 93, 97, 166, 225, 235, 256, 284, 291, 296, 297, 298 |
90 | Mannose | [1] Mannose Mannose | - | - | - | [2] 13 13, 256 |
91 | Methotrexate | [1] Methotrexate Methotrexate | [2] D00142
D00142
,
D02115
| [2] DHFR DHFR, DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [38] 11 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 |
92 | METHOTREXATE SODIUM | [1] Methotrexate Methotrexate | [2] D00142
D00142
,
D02115
| [2] DHFR DHFR, DHFR2 💬 | [5] Antifolate resistance Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬 | [2] 46 46, 256 |
93 | MIGLUSTAT | [1] Miglustat Miglustat | [1] D05032
D05032
| [1] UGCG UGCG 💬 | [2] Metabolic pathways Metabolic pathways, Sphingolipid metabolism 💬 | [3] 19 19, 256, 299 |
94 | Miglustat (AT2221) | [1] Miglustat Miglustat | [1] D05032
D05032
| [1] UGCG UGCG 💬 | [2] Metabolic pathways Metabolic pathways, Sphingolipid metabolism 💬 | [1] 256 256 |
95 | Myozyme | [1] Alglucosidase alfa Alglucosidase alfa | [1] D03207
D03207
| [1] GAA GAA 💬 | [4] Galactose metabolism Galactose metabolism, Lysosome, Metabolic pathways, Starch and sucrose metabolism 💬 | [1] 256 256 |
96 | Myozyme 50 mg powder for concentrate for solution for infusion | [1] Alglucosidase alfa Alglucosidase alfa | [1] D03207
D03207
| [1] GAA GAA 💬 | [4] Galactose metabolism Galactose metabolism, Lysosome, Metabolic pathways, Starch and sucrose metabolism 💬 | [1] 256 256 |
97 | MYOZYME® | [1] Alglucosidase alfa Alglucosidase alfa | [1] D03207
D03207
| [1] GAA GAA 💬 | [4] Galactose metabolism Galactose metabolism, Lysosome, Metabolic pathways, Starch and sucrose metabolism 💬 | [1] 256 256 |
98 | Myozyme® (alglucosidase alfa) | [1] Alglucosidase alfa Alglucosidase alfa | [1] D03207
D03207
| [1] GAA GAA 💬 | [4] Galactose metabolism Galactose metabolism, Lysosome, Metabolic pathways, Starch and sucrose metabolism 💬 | [1] 256 256 |
99 | N.a. | - | - | - | - | [10] 3 3, 6, 8, 13, 46, 96, 97, 240, 256, 271 |
100 | NEO-GAA | - | - | - | - | [1] 256 256 |
101 | NeoGAA | [1] Avalglucosidase alfa Avalglucosidase alfa | [1] D11744
D11744
| [1] GAA GAA 💬 | [4] Galactose metabolism Galactose metabolism, Lysosome, Metabolic pathways, Starch and sucrose metabolism 💬 | [1] 256 256 |
102 | NeoGAA or avalglucosidase alfa | [1] Avalglucosidase alfa Avalglucosidase alfa | [1] D11744
D11744
| [1] GAA GAA 💬 | [4] Galactose metabolism Galactose metabolism, Lysosome, Metabolic pathways, Starch and sucrose metabolism 💬 | [1] 256 256 |
103 | Non applicabile | - | - | - | - | [4] 13 13, 49, 51, 256 |
104 | Other: RMST | - | - | - | - | [1] 256 256 |
105 | Other: Saline | - | - | - | - | [8] 2 2, 6, 46, 97, 98, 256, 274, 301 |
106 | OTILIMAB | [1] Otilimab Otilimab | [1] D11343
D11343
| [1] CSF2 CSF2 💬 | [16] Acute myeloid leukemia Acute myeloid leukemia, Amoebiasis, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, IL-17 signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Natural killer cell mediated cytotoxicity, Rheumatoid arthritis, Shigellosis, T cell receptor signaling pathway, TNF signaling pathway, Transcriptional misregulation in cancer 💬 | [2] 46 46, 256 |
107 | Phosphate | [1] Phosphate ion Phosphate ion | - | - | - | [33] 2 2, 3, 6, 11, 12, 13, 15, 28, 36, 46, 49, 51, 53, 60, 62, 65, 70, 78, 81, 83, 90, 96, 97, 164, 235, 238, 256, 276, 283, 284, 285, 286, 299 |
108 | Plecebo | - | - | - | - | [1] 256 256 |
109 | Pyridostigmine | [1] Pyridostigmine Pyridostigmine | [1] D00487
D00487
| [1] ACHE ACHE 💬 | [2] Cholinergic synapse Cholinergic synapse, Glycerophospholipid metabolism 💬 | [4] 3 3, 6, 11, 256 |
110 | Pyridostigmine Bromide | [1] Pyridostigmine Pyridostigmine | [1] D00487
D00487
| [1] ACHE ACHE 💬 | [2] Cholinergic synapse Cholinergic synapse, Glycerophospholipid metabolism 💬 | [3] 3 3, 6, 256 |
111 | RAAV1-CMV-GAA (study agent) Administration | - | - | - | - | [1] 256 256 |
112 | Rapamycin | [1] Sirolimus Sirolimus | [1] D00753
D00753
| [1] MTOR MTOR 💬 | [51] AMPK signaling pathway AMPK signaling pathway, Acute myeloid leukemia, Adipocytokine signaling pathway, Alzheimer disease, Amyotrophic lateral sclerosis, Apelin signaling pathway, Autophagy - animal, Autophagy - other, Breast cancer, Cellular senescence, Central carbon metabolism in cancer, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Diabetic cardiomyopathy, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, Gastric cancer, Glioma, Growth hormone synthesis, secretion and action, HIF-1 signaling pathway, Hepatocellular carcinoma, Herpes simplex virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Huntington disease, Insulin resistance, Insulin signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Longevity regulating pathway, Longevity regulating pathway - multiple species, MicroRNAs in cancer, Neutrophil extracellular trap formation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Shigellosis, Spinocerebellar ataxia, Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, mTOR signaling pathway 💬 | [19] 2 2, 15, 34, 35, 46, 49, 51, 60, 61, 67, 86, 89, 96, 157, 158, 193, 256, 278, 279 |
113 | RECOMBINANT HUMAN ?-GLUCOSIDASE CONJUGATED WITH SYNTHETIC BISMANNOSE-6-PHOSPHATE-MAN6 GLYCAN | [1] Phosphate ion Phosphate ion | - | - | - | [1] 256 256 |
114 | Recombinant human a-glucosidase conjugated with multiple copies of synthetic bis-mannose-6-phosphate-tetra-mannose glycan (NEOGAA) | [3] Avalglucosidase alfa Avalglucosidase alfa, Mannose, Phosphate ion | [1] D11744
D11744
| [1] GAA GAA 💬 | [4] Galactose metabolism Galactose metabolism, Lysosome, Metabolic pathways, Starch and sucrose metabolism 💬 | [1] 256 256 |
115 | Recombinant human a-glucosidase conjugated with multiple copies of synthetic bis-mannose-6-phosphate-tetra-mannose glycan Avalglucosidase Alfa (NeoGAA) | [3] Avalglucosidase alfa Avalglucosidase alfa, Mannose, Phosphate ion | [1] D11744
D11744
| [1] GAA GAA 💬 | [4] Galactose metabolism Galactose metabolism, Lysosome, Metabolic pathways, Starch and sucrose metabolism 💬 | [1] 256 256 |
116 | Recombinant human acid alfa-glucosidase | - | - | - | - | [1] 256 256 |
117 | Recombinant human acid alfa-glucosidase (ATB200) | - | - | - | - | [1] 256 256 |
118 | Recombinant human acid alfa-glucosidase (rhGAA) | - | - | - | - | [1] 256 256 |
119 | Recombinant human acid alpha-glucosidase (rhGAA) | [1] Alglucosidase alfa Alglucosidase alfa | [1] D03207
D03207
| [1] GAA GAA 💬 | [4] Galactose metabolism Galactose metabolism, Lysosome, Metabolic pathways, Starch and sucrose metabolism 💬 | [1] 256 256 |
120 | RECOMBINANT HUMAN ALFA-GLUCOSIDASE CONJUGATED WITH SYNTHETIC BISMANNOSE-6-PHOSPHATE-MAN6 GLYCAN | [1] Phosphate ion Phosphate ion | - | - | - | [1] 256 256 |
121 | REN001 | [1] ReN001 ReN001 | - | - | - | [1] 256 256 |
122 | Reveglucosidase alfa | - | - | - | - | [1] 256 256 |
123 | Reveglucosidase alpha | - | - | - | - | [1] 256 256 |
124 | RhGAA | - | - | - | - | [1] 256 256 |
125 | RhGAA, acid alpha glucosidase | - | - | - | - | [1] 256 256 |
126 | Rituxan | [1] Rituximab Rituximab | [1] D02994
D02994
| [1] MS4A1 MS4A1 💬 | [1] Hematopoietic cell lineage Hematopoietic cell lineage 💬 | [4] 46 46, 60, 256, 288 |
127 | Rituximab | [1] Rituximab Rituximab | [1] D02994
D02994
| [1] MS4A1 MS4A1 💬 | [1] Hematopoietic cell lineage Hematopoietic cell lineage 💬 | [49] 6 6, 11, 13, 14, 17, 19, 35, 36, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 127, 162, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331 |
128 | Salbutamol | [1] Salbutamol Salbutamol | [1] D02147
D02147
| [1] ADRB2 ADRB2 💬 | [9] Adrenergic signaling in cardiomyocytes Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬 | [9] 3 3, 11, 49, 85, 86, 111, 228, 256, 299 |
129 | Sodium Valproate | [1] Valproic acid Valproic acid | [1] D00399
D00399
| [7] ABAT ABAT, ALDH5A1, CACNA1G, CACNA1H, CACNA1I, GAD1, GAD2 💬 | [17] Alanine, aspartate and glutamate metabolism Alanine, aspartate and glutamate metabolism, Aldosterone synthesis and secretion, Butanoate metabolism, Calcium signaling pathway, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, GABAergic synapse, GnRH secretion, MAPK signaling pathway, Metabolic pathways, Propanoate metabolism, Taurine and hypotaurine metabolism, Type I diabetes mellitus, Type II diabetes mellitus, Valine, leucine and isoleucine degradation, beta-Alanine metabolism 💬 | [4] 2 2, 90, 102, 256 |
130 | SPK-3006 | - | - | - | - | [1] 256 256 |
131 | Ss-hydroxybuturate esters | - | - | - | - | [1] 256 256 |
132 | Tofacitinib | [1] Tofacitinib Tofacitinib | [1] D09970
D09970
| [4] JAK1 JAK1, JAK2, JAK3, TYK2 💬 | [37] AGE-RAGE signaling pathway in diabetic complications AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬 | [15] 11 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271 |
133 | Tofacitinib 5 MG | [1] Tofacitinib Tofacitinib | [1] D09970
D09970
| [4] JAK1 JAK1, JAK2, JAK3, TYK2 💬 | [37] AGE-RAGE signaling pathway in diabetic complications AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Cholinergic synapse, Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Growth hormone synthesis, secretion and action, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Lipid and atherosclerosis, Measles, NOD-like receptor signaling pathway, Necroptosis, Non-small cell lung cancer, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Primary immunodeficiency, Prolactin signaling pathway, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬 | [5] 11 11, 40, 46, 256, 271 |
134 | Triheptanoin | [1] Triheptanoin Triheptanoin | [1] D11465
D11465
| - | - | [10] 2 2, 8, 65, 149, 156, 248, 256, 257, 317, 324 |
135 | UX007 | - | - | - | - | [4] 8 8, 248, 256, 257 |
136 | VAL-1221 | - | - | - | - | [1] 256 256 |
137 | Valproate | [1] Valproic acid Valproic acid | [1] D00399
D00399
| [7] ABAT ABAT, ALDH5A1, CACNA1G, CACNA1H, CACNA1I, GAD1, GAD2 💬 | [17] Alanine, aspartate and glutamate metabolism Alanine, aspartate and glutamate metabolism, Aldosterone synthesis and secretion, Butanoate metabolism, Calcium signaling pathway, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, GABAergic synapse, GnRH secretion, MAPK signaling pathway, Metabolic pathways, Propanoate metabolism, Taurine and hypotaurine metabolism, Type I diabetes mellitus, Type II diabetes mellitus, Valine, leucine and isoleucine degradation, beta-Alanine metabolism 💬 | [6] 2 2, 3, 90, 102, 233, 256 |
138 | Valproic Acid | [1] Valproic acid Valproic acid | [1] D00399
D00399
| [7] ABAT ABAT, ALDH5A1, CACNA1G, CACNA1H, CACNA1I, GAD1, GAD2 💬 | [17] Alanine, aspartate and glutamate metabolism Alanine, aspartate and glutamate metabolism, Aldosterone synthesis and secretion, Butanoate metabolism, Calcium signaling pathway, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, GABAergic synapse, GnRH secretion, MAPK signaling pathway, Metabolic pathways, Propanoate metabolism, Taurine and hypotaurine metabolism, Type I diabetes mellitus, Type II diabetes mellitus, Valine, leucine and isoleucine degradation, beta-Alanine metabolism 💬 | [10] 3 3, 5, 26, 34, 65, 89, 90, 222, 256, 331 |
139 | Vitamin D | [1] Vitamin D Vitamin D | - | - | - | [24] 3 3, 13, 15, 19, 41, 43, 44, 46, 49, 50, 68, 93, 95, 96, 97, 98, 179, 222, 228, 235, 256, 274, 298, 299 |
140 | ZAVESCA | [1] Miglustat Miglustat | [1] D05032
D05032
| [1] UGCG UGCG 💬 | [2] Metabolic pathways Metabolic pathways, Sphingolipid metabolism 💬 | [3] 19 19, 256, 299 |
141 | Zavesca® Prescription | [1] Miglustat Miglustat | [1] D05032
D05032
| [1] UGCG UGCG 💬 | [2] Metabolic pathways Metabolic pathways, Sphingolipid metabolism 💬 | [1] 256 256 |