Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. KEGG DRUG DrugBank Drug (Description in trials) KEGG GENES KEGG PATHWAY Disease ID
1 Isoflurophate -[0] ---
2 Inosine [1] Inosine[1] Inosine; --[6] 2, 6, 13, 17, 85, 122
3 Isoleucine -[0] ---
4 Insulin [1] Insulin human[1] Human insulin; [1] INSR 💬[22] AMPK signaling pathway, Adherens junction, Aldosterone-regulated sodium reabsorption, Alzheimer disease, Diabetic cardiomyopathy, FoxO signaling pathway, HIF-1 signaling pathway, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, MAPK signaling pathway, Non-alcoholic fatty liver disease, Ovarian steroidogenesis, PI3K-Akt signaling pathway, Phospholipase D signaling pathway, Rap1 signaling pathway, Ras signaling pathway, Regulation of lipolysis in adipocytes, Type II diabetes mellitus, cGMP-PKG signaling pathway, mTOR signaling pathway 💬[2] 96, 156
5 Iodine [1] Iodine[2] Iodine; Iodo; --[3] 28, 46, 88
6 Ibuprofen [1] Ibuprofen[2] Ibuprofen; IBUPROFEN 200MG; [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[7] 13, 46, 65, 107, 113, 271, 299
7 Isopropyl alcohol -[0] ---
8 Indomethacin [1] Indomethacin[2] INDOMETACIN; Indomethacin; [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[3] 225, 271, 298
9 Inulin [1] Inulin[1] Inulin; --[2] 96, 299
10 Imipenem [1] Imipenem[1] IMIPENEM; --[1] 60
11 Inamrinone -[0] ---
12 Idoxuridine -[0] ---
13 Ifosfamide [1] Ifosfamide[1] Ifosfamide; --[1] 34
14 Indapamide [1] Indapamide[1] Indapamide; [1] SLC12A3 💬-[1] 13
15 Isoniazid [1] Isoniazid[1] Isoniazid; --[2] 65, 254
16 Isosorbide [1] Isosorbide[1] Isosorbide; --[1] 113
17 Isotretinoin [1] Isotretinoin[1] Isotretinoin; [2] RARA,
RARB 💬		[8] Acute myeloid leukemia, Estrogen signaling pathway, Gastric cancer, Non-small cell lung cancer, Pathways in cancer, Small cell lung cancer, Th17 cell differentiation, Transcriptional misregulation in cancer 💬[4] 36, 39, 159, 160
18 Isradipine [1] Isradipine[1] Isradipine; [4] CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬		[37] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 6
19 Itraconazole [1] Itraconazole[2] Itraconazole; Sporanox; --[5] 3, 65, 96, 227, 299
20 Isosorbide dinitrate [1] Isosorbide dinitrate[2] Isosorbide; ISOSORBIDE DINITRATE; --[1] 113
21 Irbesartan [1] Irbesartan[2] Aprovel; IRBESARTAN; [1] AGTR1 💬[16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[4] 66, 167, 168, 222
22 Isoflurane [1] Isoflurane[1] Isoflurane; --[1] 6
23 Iodoquinol -[0] ---
24 Isosorbide mononitrate -[0] ---
25 Ibutilide fumarate -[0] ---
26 Interferon alfa-2a [1] Interferon alfa-2a[3] Interferon Alfa-2A; Interferon alpha-2a; Roferon-A; [2] IFNAR1,
IFNAR2 💬		[18] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Measles, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Osteoclast differentiation, PI3K-Akt signaling pathway, Pathways in cancer, Toll-like receptor signaling pathway 💬[1] 56
27 Interferon beta-1b [1] Interferon beta-1b[7] BETAFERON; Betaseron; EXTAVIA; Interferon beta 1B; INTERFERON BETA-1B; Interferon-beta-1b; RECOMBINANT INTERFERON BETA-1B; [2] IFNAR1,
IFNAR2 💬		[18] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Measles, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Osteoclast differentiation, PI3K-Akt signaling pathway, Pathways in cancer, Toll-like receptor signaling pathway 💬[1] 13
28 Interferon gamma-1b [1] Interferon gamma-1b[2] ACTIMMUNE; Interferon Gamma-1B; [2] IFNGR1,
IFNGR2 💬		[18] Chagas disease, Cytokine-cytokine receptor interaction, HIF-1 signaling pathway, Herpes simplex virus 1 infection, Inflammatory bowel disease, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Natural killer cell mediated cytotoxicity, Necroptosis, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways in cancer, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis 💬[7] 18, 65, 85, 228, 299, 301, 326
29 Ivermectin -[0] ---
30 Imipramine hydrochloride -[0] ---
31 Indinavir sulfate [1] Indinavir[1] Indinavir; --[1] 265
32 Iopanoic acid -[0] ---
33 Irinotecan hydrochloride -[0] ---
34 Iocarmic acid -[0] ---
35 Ibuprofen piconol [1] Ibuprofen[2] IBUPROFEN; IBUPROFEN 200MG; [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[7] 13, 46, 65, 107, 113, 271, 299
36 Iguratimod [1] Iguratimod[1] Iguratimod; [1] NFKB1 💬[76] AGE-RAGE signaling pathway in diabetic complications, Acute myeloid leukemia, Adipocytokine signaling pathway, Alcoholic liver disease, Alzheimer disease, Amoebiasis, Antifolate resistance, Apoptosis, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Cellular senescence, Chagas disease, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Chronic myeloid leukemia, Cocaine addiction, Coronavirus disease - COVID-19, Cytosolic DNA-sensing pathway, Diabetic cardiomyopathy, Epithelial cell signaling in Helicobacter pylori infection, Epstein-Barr virus infection, Fluid shear stress and atherosclerosis, HIF-1 signaling pathway, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Kaposi sarcoma-associated herpesvirus infection, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, Longevity regulating pathway, MAPK signaling pathway, Measles, MicroRNAs in cancer, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Neurotrophin signaling pathway, Neutrophil extracellular trap formation, Non-alcoholic fatty liver disease, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathogenic Escherichia coli infection, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Pertussis, Prolactin signaling pathway, Prostate cancer, RIG-I-like receptor signaling pathway, Ras signaling pathway, Relaxin signaling pathway, Salmonella infection, Shigellosis, Small cell lung cancer, Sphingolipid signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toll-like receptor signaling pathway, Toxoplasmosis, Transcriptional misregulation in cancer, Tuberculosis, Viral carcinogenesis, Yersinia infection, cAMP signaling pathway 💬[4] 46, 51, 53, 271
37 Iobitridol -[0] ---
38 Iothalamic acid -[0] ---
39 Iodoxamic acid -[0] ---
40 Iobenzamic acid -[0] ---
41 Ipriflavone -[0] ---
42 Indocyanine green [1] Indocyanine green[1] Indocyanine Green; --[8] 22, 46, 51, 96, 235, 278, 291, 296
43 Iodamide -[0] ---
44 Isopropylantipyrine -[0] ---
45 Ibudilast [1] Ibudilast[1] IBUDILAST; [8] CYSLTR1,
PDE3A,
PDE3B,
PDE4A,
PDE4B,
PDE4C,
PDE4D,
PTGIR 💬		[16] Apelin signaling pathway, Calcium signaling pathway, Glucagon signaling pathway, Insulin signaling pathway, Metabolic pathways, Morphine addiction, Neuroactive ligand-receptor interaction, Parathyroid hormone synthesis, secretion and action, Platelet activation, Progesterone-mediated oocyte maturation, Purine metabolism, Regulation of lipolysis in adipocytes, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[2] 2, 13
46 Iotroxic acid -[0] ---
47 Isoproterenol hydrochloride -[0] ---
48 Imatinib mesylate [1] Imatinib[4] Gleevec; GLIVEC; Imatinib; IMATINIB MESYLATE; [3] ABL1,
KIT,
PDGFRA 💬		[32] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
49 Iodixanol -[0] ---
50 Isoniazid calcium pyruvinate [1] Isoniazid[1] Isoniazid; --[2] 65, 254
51 Ioversol -[0] ---
52 Indometacin farnesil [1] Indomethacin[2] INDOMETACIN; Indomethacin; [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[3] 225, 271, 298
53 Iotrolan -[0] ---
54 Iomeprol -[0] ---
55 Idarubicin hydrochloride -[0] ---
56 Idebenone [1] Idebenone[2] Idebenone; Raxone; --[6] 6, 8, 13, 18, 113, 302
57 Ioxaglic acid -[0] ---
58 Iodipamide -[0] ---
59 Iopamidol [1] Iopamidol[0] --[1] 279
60 Inositol niacinate -[0] ---
61 Iohexol [1] Iohexol[2] Iohexol; OMNIPAQUE; --[3] 19, 67, 222
62 Icosapent ethyl [1] Icosapent ethyl[2] Ethyl-EPA; Icosapent; --[2] 8, 296
63 Iopromide -[0] ---
64 Iodoform -[0] ---
65 Inosine pranobex -[0] ---
66 Isoniazid sodium methanesulfonate hydrate [1] Isoniazid[1] Isoniazid; --[2] 65, 254
67 Isoproterenol sulfate -[0] ---
68 Indomethacin sodium [1] Indomethacin[2] INDOMETACIN; Indomethacin; [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[3] 225, 271, 298
69 Iron dextran [1] Iron Dextran[1] Iron Dextran; --[4] 62, 86, 96, 97
70 Ioxilan -[0] ---
71 Ipratropium bromide [1] Ipratropium[1] Ipratropium; [5] CHRM1,
CHRM2,
CHRM3,
CHRM4,
CHRM5 💬		[13] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction, cAMP signaling pathway 💬[2] 6, 86
72 Iomazenil -[0] ---
73 Isopropyl myristate -[0] ---
74 Imiquimod [1] Imiquimod[1] Imiquimod; [1] TLR7 💬[5] Coronavirus disease - COVID-19, Influenza A, Measles, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway 💬[2] 34, 51
75 Isepamicin -[0] ---
76 Iproniazid [1] Iproniazid[1] IPRONIAZID; [2] MAOA,
MAOB 💬		[14] Alcoholism, Amphetamine addiction, Arginine and proline metabolism, Cocaine addiction, Dopaminergic synapse, Drug metabolism - cytochrome P450, Glycine, serine and threonine metabolism, Histidine metabolism, Metabolic pathways, Parkinson disease, Phenylalanine metabolism, Serotonergic synapse, Tryptophan metabolism, Tyrosine metabolism 💬[1] 6
77 Isocarboxazid -[0] ---
78 Infliximab [1] Infliximab[6] Flixabi; Inflectra; Infliximab; Remicade; REMSIMA; Zessly; [1] TNF 💬[67] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271
79 Indiplon -[0] ---
80 Iloperidone -[0] ---
81 Iloprost [1] Iloprost[2] Iloprost; Ventavis; [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[4] 51, 84, 85, 86
82 Interferon alfacon-1 -[0] ---
83 Interferon alfa-2b [1] Interferon alfa-2b[2] Interferon alfa-2b; Interferon alpha-2B; [2] IFNAR1,
IFNAR2 💬		[18] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Measles, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Osteoclast differentiation, PI3K-Akt signaling pathway, Pathways in cancer, Toll-like receptor signaling pathway 💬[2] 25, 34
84 Indinavir sulfate ethanolate [1] Indinavir[1] Indinavir; --[1] 265
85 Imiglucerase [1] Imiglucerase[3] CEREZYME; IMIGLUCERASA; IMIGLUCERASE; [1] GBA 💬[4] Lysosome, Metabolic pathways, Other glycan degradation, Sphingolipid metabolism 💬[1] 19
86 Insulin human [1] Insulin human[1] Human insulin; [1] INSR 💬[22] AMPK signaling pathway, Adherens junction, Aldosterone-regulated sodium reabsorption, Alzheimer disease, Diabetic cardiomyopathy, FoxO signaling pathway, HIF-1 signaling pathway, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, MAPK signaling pathway, Non-alcoholic fatty liver disease, Ovarian steroidogenesis, PI3K-Akt signaling pathway, Phospholipase D signaling pathway, Rap1 signaling pathway, Ras signaling pathway, Regulation of lipolysis in adipocytes, Type II diabetes mellitus, cGMP-PKG signaling pathway, mTOR signaling pathway 💬[2] 96, 156
87 Insulin glargine [1] Insulin glargine[1] Insulin glargine; [1] INSR 💬[22] AMPK signaling pathway, Adherens junction, Aldosterone-regulated sodium reabsorption, Alzheimer disease, Diabetic cardiomyopathy, FoxO signaling pathway, HIF-1 signaling pathway, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, MAPK signaling pathway, Non-alcoholic fatty liver disease, Ovarian steroidogenesis, PI3K-Akt signaling pathway, Phospholipase D signaling pathway, Rap1 signaling pathway, Ras signaling pathway, Regulation of lipolysis in adipocytes, Type II diabetes mellitus, cGMP-PKG signaling pathway, mTOR signaling pathway 💬[1] 299
88 Icodextrin -[0] ---
89 Interferon alfa [1] Interferon alfa[1] Interferon alfa; [2] IFNAR1,
IFNAR2 💬		[18] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Measles, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Osteoclast differentiation, PI3K-Akt signaling pathway, Pathways in cancer, Toll-like receptor signaling pathway 💬[6] 13, 25, 26, 28, 56, 96
90 Ilomastat -[0] ---
91 Indinavir [1] Indinavir[1] Indinavir; --[1] 265
92 Ipecac -[0] ---
93 Insulin aspart -[0] ---
94 Insulin lispro -[0] ---
95 Iboctadekin -[0] ---
96 Ibopamine -[0] ---
97 Ibritumomab tiuxetan -[0] ---
98 Ibuprofen aluminum [1] Ibuprofen[2] Ibuprofen; IBUPROFEN 200MG; [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[7] 13, 46, 65, 107, 113, 271, 299
99 Ichthammol -[0] ---
100 Idronoxil -[0] ---
101 Idursulfase [1] Idursulfase[4] Elaprase; Iduronate 2-sulfatase; IDURSULFASA; IDURSULFASE; [1] IDS 💬[3] Glycosaminoglycan degradation, Lysosome, Metabolic pathways 💬[1] 19
102 Ifetroban [1] Ifetroban[1] Ifetroban; [1] TBXA2R 💬[3] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Platelet activation 💬[3] 51, 86, 113
103 Ilodecakin -[0] ---
104 Imidurea -[0] ---
105 Imipenem [1] Imipenem[1] IMIPENEM; --[1] 60
106 Incyclinide -[0] ---
107 Indecainide hydrochloride -[0] ---
108 Indisulam -[0] ---
109 Indoprofen -[0] ---
110 Indoramin -[0] ---
111 Insulin detemir [1] Insulin detemir[4] Detemir; Insulin detemir; Levemir; Levemir Penfill; [1] INSR 💬[22] AMPK signaling pathway, Adherens junction, Aldosterone-regulated sodium reabsorption, Alzheimer disease, Diabetic cardiomyopathy, FoxO signaling pathway, HIF-1 signaling pathway, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, MAPK signaling pathway, Non-alcoholic fatty liver disease, Ovarian steroidogenesis, PI3K-Akt signaling pathway, Phospholipase D signaling pathway, Rap1 signaling pathway, Ras signaling pathway, Regulation of lipolysis in adipocytes, Type II diabetes mellitus, cGMP-PKG signaling pathway, mTOR signaling pathway 💬[1] 299
112 Insulin glulisine -[0] ---
113 Interferon alfa-n1 -[0] ---
114 Interferon alfa-n3 -[0] ---
115 Interferon beta-1a [1] Interferon beta-1a[6] AVONEX; Interferon Beta 1-A; Interferon Beta 1a; Interferon beta-1a; Interferon-beta-1a; REBIF; [2] IFNAR1,
IFNAR2 💬		[18] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Measles, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Osteoclast differentiation, PI3K-Akt signaling pathway, Pathways in cancer, Toll-like receptor signaling pathway 💬[4] 13, 26, 96, 97
116 Iocetamic acid -[0] ---
117 Ioglicic acid -[0] ---
118 Ioglycamic acid -[0] ---
119 Iopentol -[0] ---
120 Iofendylate -[0] ---
121 Iopydol -[0] ---
122 Ipilimumab [1] Ipilimumab[1] Ipilimumab; [1] CTLA4 💬[4] Autoimmune thyroid disease, Cell adhesion molecules, Rheumatoid arthritis, T cell receptor signaling pathway 💬[1] 159
123 Iprindole -[0] ---
124 Iratumumab -[0] ---
125 Irofulven -[0] ---
126 Iron sucrose [1] Iron sucrose[1] Iron sucrose; --[3] 62, 96, 97
127 Isatoribine -[0] ---
128 Isoconazole -[0] ---
129 Isoetharine -[0] ---
130 Isoflupredone acetate -[0] ---
131 Isosulfan blue -[0] ---
132 Isoxicam -[0] ---
133 Istradefylline [1] Istradefylline[1] ISTRADEFYLLINE; [1] ADORA2A 💬[7] Alcoholism, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Vascular smooth muscle contraction, cAMP signaling pathway 💬[1] 6
134 Ixabepilone -[0] ---
135 Imidafenacin -[0] ---
136 Indapamide hydrate [1] Indapamide[1] Indapamide; [1] SLC12A3 💬-[1] 13
137 Ibuprofen lysine [1] Ibuprofen[2] Ibuprofen; IBUPROFEN 200MG; [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[7] 13, 46, 65, 107, 113, 271, 299
138 Indobufen -[0] ---
139 Imolamine -[0] ---
140 Ivabradine -[0] ---
141 Ibacitabine -[0] ---
142 Ibuproxam -[0] ---
143 Isobromindione -[0] ---
144 Imidazole salicylate -[0] ---
145 Iprazochrome -[0] ---
146 Iproclozide -[0] ---
147 Ioxitalamic acid -[0] ---
148 Ibandronic acid [1] Ibandronate[2] Ibandronate; Ibandronic acid; [1] FDPS 💬[4] Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis 💬[3] 46, 49, 274
149 Ibutilide -[0] ---
150 Icosapent [1] Icosapent[2] Eicosapentaenoic acid; Icosapent; --[11] 8, 46, 48, 49, 96, 97, 113, 296, 297, 301, 338
151 Idarubicin -[0] ---
152 Idrocilamide -[0] ---
153 Ifenprodil [1] Ifenprodil[1] Ifenprodil; [3] ADRA1A,
ADRA1B,
ADRA1D 💬		[7] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 85
154 Imatinib [1] Imatinib[4] Gleevec; GLIVEC; Imatinib; Imatinib mesylate; [3] ABL1,
KIT,
PDGFRA 💬		[32] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
155 Imidapril [1] Imidapril[1] Imidapril; [1] ACE 💬[6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[1] 67
156 Imidocarb -[0] ---
157 Imipramine -[0] ---
158 Incadronic acid -[0] ---
159 Indanazoline -[0] ---
160 Indenolol -[0] ---
161 Inositol [1] Inositol[1] Inositol; --[2] 96, 97
162 Irinotecan -[0] ---
163 Irsogladine -[0] ---
164 Isoaminile -[0] ---
165 Isoprenaline -[0] ---
166 Isothipendyl -[0] ---
167 Isoxsuprine [1] Isoxsuprine[2] Isoxsuprine; Isoxsuprine Hydrochloride; [1] ADRB2 💬[9] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 13
168 Itopride -[0] ---
169 Iclaprim -[0] ---
170 Imexon -[0] ---
171 Inotuzumab ozogamicin -[0] ---
172 Ispronicline -[0] ---
173 Indacaterol -[0] ---
174 Ibipinabant -[0] ---
175 Indeglitazar -[0] ---
176 Ingenol mebutate -[0] ---
177 Ibalizumab -[0] ---
178 Imagabalin -[0] ---
179 Imetelstat -[0] ---
180 Intetumumab -[0] ---
181 Iscotrizinol -[0] ---
182 Insulin degludec -[0] ---
183 Iniparib -[0] ---
184 Irosustat -[0] ---
185 Ivacaftor [1] Ivacaftor[7] IVACAFTOR; Kaftrio; Kalydeco; Orkambi; Symdeko; Symkevi; Trikafta; [1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
186 Icrucumab -[0] ---
187 Indibulin -[0] ---
188 Ixekizumab [1] Ixekizumab[2] IXEKIZUMAB; TALTZ; [1] IL17A 💬[6] Alcoholic liver disease, Cytokine-cytokine receptor interaction, IL-17 signaling pathway, Inflammatory bowel disease, Rheumatoid arthritis, Th17 cell differentiation 💬[6] 36, 37, 107, 162, 269, 271
189 Irdabisant -[0] ---
190 Ixazomib [1] Ixazomib[2] Ixazomib; Ninlaro; [1] PSMB5 💬[8] Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Prion disease, Proteasome, Spinocerebellar ataxia 💬[5] 13, 16, 28, 51, 61
191 Ipragliflozin -[0] ---
192 Ibrutinib [1] Ibrutinib[1] Ibrutinib; [1] BTK 💬[7] B cell receptor signaling pathway, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, NF-kappa B signaling pathway, Osteoclast differentiation, Platelet activation, Primary immunodeficiency 💬[3] 28, 60, 61
193 Inclacumab -[0] ---
194 Ilorasertib -[0] ---
195 Imgatuzumab -[0] ---
196 Insulin peglispro -[0] ---
197 Iodine povacrylex -[0] ---
198 Ioforminol -[0] ---
199 Idelalisib -[0] ---
200 Indoximod -[0] ---
201 Ipatasertib -[0] ---
202 Isavuconazonium -[0] ---
203 Idalopirdine -[0] ---
204 Idarucizumab -[0] ---
205 Isavuconazole -[0] ---
206 Inotersen [1] Inotersen[1] INOTERSEN; [1] TTR 💬[1] Thyroid hormone synthesis 💬[1] 28
207 Intepirdine -[0] ---
208 Istiratumab -[0] ---
209 Itacitinib [1] Itacitinib[1] Itacitinib; [1] JAK1 💬[27] Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Measles, NOD-like receptor signaling pathway, Necroptosis, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬[5] 46, 51, 60, 97, 228
210 Idursulfase beta [1] Idursulfase beta[3] Hunterase; Iduronate 2-sulfatase; Idursulfase beta; [1] IDS 💬[3] Glycosaminoglycan degradation, Lysosome, Metabolic pathways 💬[1] 19
211 Isatuximab [1] Isatuximab[1] Isatuximab; [1] CD38 💬[7] Calcium signaling pathway, Hematopoietic cell lineage, Metabolic pathways, Nicotinate and nicotinamide metabolism, Oxytocin signaling pathway, Pancreatic secretion, Salivary secretion 💬[2] 28, 61
212 Ivosidenib -[0] ---
213 Ingenol disoxate -[0] ---
214 Icosabutate -[0] ---
215 Idasanutlin -[0] ---
216 Icotinib [1] Icotinib[1] Icotinib; [1] EGFR 💬[48] Adherens junction, Bladder cancer, Breast cancer, Calcium signaling pathway, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Coronavirus disease - COVID-19, Cushing syndrome, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Endocytosis, Endometrial cancer, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Estrogen signaling pathway, Focal adhesion, FoxO signaling pathway, Gap junction, Gastric cancer, Glioma, GnRH signaling pathway, HIF-1 signaling pathway, Hepatitis C, Hepatocellular carcinoma, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanoma, MicroRNAs in cancer, Non-small cell lung cancer, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis 💬[1] 34
217 Inarigivir soproxil -[0] ---
218 Islatravir -[0] ---
219 Imlifidase [1] Imlifidase[2] HMED-IdeS; IdeS; --[2] 64, 221
220 Ibrexafungerp -[0] ---
221 Idecabtagene vicleucel -[0] ---
222 Infigratinib [1] Infigratinib[1] INFIGRATINIB; [3] FGFR1,
FGFR2,
FGFR3 💬		[21] Adherens junction, Bladder cancer, Breast cancer, Calcium signaling pathway, Central carbon metabolism in cancer, EGFR tyrosine kinase inhibitor resistance, Endocytosis, Gastric cancer, MAPK signaling pathway, Melanoma, MicroRNAs in cancer, PI3K-Akt signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Signaling pathways regulating pluripotency of stem cells, Thermogenesis 💬[1] 276
223 Iscalimab [1] Iscalimab[1] ISCALIMAB; [1] CD40 💬[17] Allograft rejection, Asthma, Autoimmune thyroid disease, Cell adhesion molecules, Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Human T-cell leukemia virus 1 infection, Intestinal immune network for IgA production, Lipid and atherosclerosis, Malaria, NF-kappa B signaling pathway, Primary immunodeficiency, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Toxoplasmosis, Transcriptional misregulation in cancer, Viral myocarditis 💬[2] 49, 53
224 Inbakicept -[0] ---
225 Inebilizumab [1] Inebilizumab[2] INEBILIZUMAB; Uplizna; [1] CD19 💬[5] B cell receptor signaling pathway, Epstein-Barr virus infection, Hematopoietic cell lineage, PI3K-Akt signaling pathway, Primary immunodeficiency 💬[4] 11, 13, 51, 300
226 Ipafricept -[0] ---
227 Isunakinra -[0] ---
228 Ibezapolstat -[0] ---
229 Imsidolimab -[0] ---
230 Inclisiran [1] Inclisiran[2] ALN-PCSSC; Inclisiran; [1] PCSK9 💬[1] Cholesterol metabolism 💬[1] 79
231 Imdevimab -[0] ---
232 Itepekimab -[0] ---
233 Ianalumab [1] Ianalumab[1] IANALUMAB; [1] TNFRSF13C 💬[5] Cytokine-cytokine receptor interaction, Human T-cell leukemia virus 1 infection, Intestinal immune network for IgA production, NF-kappa B signaling pathway, Primary immunodeficiency 💬[5] 35, 46, 49, 53, 95
234 Ieramilimab -[0] ---
235 Iptacopan [1] Iptacopan[1] Iptacopan; [1] CFB 💬[3] Complement and coagulation cascades, Coronavirus disease - COVID-19, Staphylococcus aureus infection 💬[5] 61, 62, 66, 109, 222