Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 MASP2 [1] Staphylococcus aureus infection D11531 Narsoplimab [4] 64, 66, 109, 222
2 CFD [1] Staphylococcus aureus infection D11641 Danicopan [2] 62, 222
3 HLA-DMA [8] Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Staphylococcus aureus infection, Tuberculosis, Systemic lupus erythematosus, Viral myocarditis D04318 Glatiramer [4] 2, 13, 96, 156
4 HLA-DMB [8] Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Staphylococcus aureus infection, Tuberculosis, Systemic lupus erythematosus, Viral myocarditis D04318 Glatiramer [4] 2, 13, 96, 156
5 HLA-DOA [8] Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Staphylococcus aureus infection, Tuberculosis, Systemic lupus erythematosus, Viral myocarditis D04318 Glatiramer [4] 2, 13, 96, 156
6 HLA-DOB [8] Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Staphylococcus aureus infection, Tuberculosis, Systemic lupus erythematosus, Viral myocarditis D04318 Glatiramer [4] 2, 13, 96, 156
7 HLA-DPA1 [8] Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Staphylococcus aureus infection, Tuberculosis, Systemic lupus erythematosus, Viral myocarditis D04318 Glatiramer [4] 2, 13, 96, 156
8 HLA-DPB1 [8] Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Staphylococcus aureus infection, Tuberculosis, Systemic lupus erythematosus, Viral myocarditis D04318 Glatiramer [4] 2, 13, 96, 156
9 HLA-DQA1 [8] Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Staphylococcus aureus infection, Tuberculosis, Systemic lupus erythematosus, Viral myocarditis D04318 Glatiramer [4] 2, 13, 96, 156
10 HLA-DQA2 [8] Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Staphylococcus aureus infection, Tuberculosis, Systemic lupus erythematosus, Viral myocarditis D04318 Glatiramer [4] 2, 13, 96, 156
11 HLA-DQB1 [8] Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Staphylococcus aureus infection, Tuberculosis, Systemic lupus erythematosus, Viral myocarditis D04318 Glatiramer [4] 2, 13, 96, 156
12 HLA-DRA [8] Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Staphylococcus aureus infection, Tuberculosis, Systemic lupus erythematosus, Viral myocarditis D04318 Glatiramer [4] 2, 13, 96, 156
13 HLA-DRB1 [8] Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Staphylococcus aureus infection, Tuberculosis, Systemic lupus erythematosus, Viral myocarditis D04318 Glatiramer [4] 2, 13, 96, 156
14 HLA-DRB3 [8] Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Staphylococcus aureus infection, Tuberculosis, Systemic lupus erythematosus, Viral myocarditis D04318 Glatiramer [4] 2, 13, 96, 156
15 HLA-DRB4 [8] Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Staphylococcus aureus infection, Tuberculosis, Systemic lupus erythematosus, Viral myocarditis D04318 Glatiramer [4] 2, 13, 96, 156
16 HLA-DRB5 [8] Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Staphylococcus aureus infection, Tuberculosis, Systemic lupus erythematosus, Viral myocarditis D04318 Glatiramer [4] 2, 13, 96, 156
17 IL10 [7] Viral protein interaction with cytokine and cytokine receptor, T cell receptor signaling pathway, Yersinia infection, Toxoplasmosis, Staphylococcus aureus infection, Tuberculosis, Systemic lupus erythematosus D01583 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
18 ITGAL [2] Staphylococcus aureus infection, Viral myocarditis D03959 Efalizumab [9] 11, 13, 37, 46, 49, 53, 61, 95, 96
19 PLG [1] Staphylococcus aureus infection D00160 Aminocaproic acid [1] 70
20 PLG [1] Staphylococcus aureus infection D01136 Tranexamic acid [6] 46, 70, 215, 227, 288, 299
21 PTAFR [1] Staphylococcus aureus infection D07407 Rupatadine [1] 46
22 CFB [1] Staphylococcus aureus infection D12251 Iptacopan [5] 61, 62, 66, 109, 222
23 C1R [2] Staphylococcus aureus infection, Systemic lupus erythematosus D10845 Conestat alfa [1] 61
24 C1S [2] Staphylococcus aureus infection, Systemic lupus erythematosus D10845 Conestat alfa [1] 61
25 C1S [2] Staphylococcus aureus infection, Systemic lupus erythematosus D11530 Sutimlimab [1] 61
26 C3 [4] Staphylococcus aureus infection, Tuberculosis, Viral carcinogenesis, Systemic lupus erythematosus D11613 Pegcetacoplan [3] 2, 62, 222
27 C5 [2] Staphylococcus aureus infection, Systemic lupus erythematosus D03940 Eculizumab [7] 11, 13, 14, 61, 62, 109, 222
28 C5 [2] Staphylococcus aureus infection, Systemic lupus erythematosus D11054 Ravulizumab [7] 2, 11, 13, 50, 62, 66, 109
29 C5 [2] Staphylococcus aureus infection, Systemic lupus erythematosus D11473 Nomacopan [3] 62, 109, 162
30 C5 [2] Staphylococcus aureus infection, Systemic lupus erythematosus D11477 Pozelimab [2] 11, 62
31 C5 [2] Staphylococcus aureus infection, Systemic lupus erythematosus D11696 Crovalimab [2] 62, 109
32 C5 [2] Staphylococcus aureus infection, Systemic lupus erythematosus D11838 Vilobelimab [3] 43, 44, 269
33 C5AR1 [1] Staphylococcus aureus infection D11093 Avacopan [3] 43, 44, 222