Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY KEGG GENES KEGG DRUG DrugBank Disease ID
1 Leishmaniasis 💬
[1] C3 💬 Pegcetacoplan 💬 Pegcetacoplan [4]  2 , 61, 62, 222 💬 💬
2 Leishmaniasis 💬
[1] IFNG 💬 Emapalumab 💬 Emapalumab [3] 49, 65, 107 💬 💬
3 Leishmaniasis 💬
[1] IFNG 💬 Fontolizumab 💬 Fontolizumab [1] 46 💬 💬
4 Leishmaniasis 💬
[2] IFNGR1, IFNGR2 💬 Interferon gamma-1b 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬 💬
5 Leishmaniasis 💬
[4] IL10, IL1A, IL1B, TNF 💬 Pirfenidone 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬
6 Leishmaniasis 💬
[2] IL12A, IL12B 💬 Ustekinumab 💬 Ustekinumab [16] 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬 💬
7 Leishmaniasis 💬
[1] IL1A 💬 Bermekimab 💬 Bermekimab [1] 51 💬 💬
8 Leishmaniasis 💬
[2] IL1A, IL1B 💬 Rilonacept 💬 Rilonacept [4] 51, 106, 107, 266 💬 💬
9 Leishmaniasis 💬
[1] IL1B 💬 Canakinumab 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬
10 Leishmaniasis 💬
[1] IL1B 💬 Gevokizumab 💬 Gevokizumab [4] 41, 50, 56, 269 💬 💬
11 Leishmaniasis 💬
[1] IL4 💬 Binetrakin 💬 Binetrakin [1] 46 💬 💬
12 Leishmaniasis 💬
[1] ITGA4 💬 Abrilumab 💬 Abrilumab [2] 96, 97 💬 💬
13 Leishmaniasis 💬
[1] ITGA4 💬 Firategrast 💬 Firategrast [1] 13 💬 💬
14 Leishmaniasis 💬
[1] ITGA4 💬 Natalizumab 💬 Natalizumab [6] 13, 15, 25, 46, 63, 96 💬 💬
15 Leishmaniasis 💬
[1] ITGA4 💬 Vedolizumab 💬 Vedolizumab [3] 94, 96, 97 💬 💬
16 Leishmaniasis 💬
[1] JAK1 💬 Abrocitinib 💬 Abrocitinib [1] 84 💬 💬
17 Leishmaniasis 💬
[1] JAK1 💬 Filgotinib 💬 Filgotinib [6] 46, 53, 96, 97, 222, 271 💬 💬
18 Leishmaniasis 💬
[1] JAK1 💬 Itacitinib 💬 Itacitinib [4] 46, 51, 97, 228 💬 💬
19 Leishmaniasis 💬
[1] JAK1 💬 Upadacitinib 💬 Upadacitinib [8] 40, 41, 46, 49, 96, 97, 107, 271 💬 💬
20 Leishmaniasis 💬
[2] JAK1, JAK2 💬 Baricitinib 💬 Baricitinib [13]  2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬
21 Leishmaniasis 💬
[2] JAK1, JAK2 💬 Peficitinib 💬 Peficitinib [1] 46 💬 💬
22 Leishmaniasis 💬
[2] JAK1, JAK2 💬 Ruxolitinib 💬 Ruxolitinib [3] 60, 65, 228 💬 💬
23 Leishmaniasis 💬
[2] JAK1, JAK2 💬 Tofacitinib 💬 Tofacitinib [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬 💬
24 Leishmaniasis 💬
[4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Losmapimod 💬 Losmapimod [2] 113, 222 💬 💬
25 Leishmaniasis 💬
[4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Neflamapimod 💬 Neflamapimod [1]  8  💬 💬
26 Leishmaniasis 💬
[1] NFKB1 💬 Iguratimod 💬 Iguratimod [5] 46, 51, 53, 271, 300 💬 💬
27 Leishmaniasis 💬
[1] PRKCB 💬 Enzastaurin 💬 Enzastaurin [1] 168 💬 💬
28 Leishmaniasis 💬
[1] PTGS2 💬 Aceclofenac 💬 Aceclofenac [1] 46 💬 💬
29 Leishmaniasis 💬
[1] PTGS2 💬 Acetaminophen 💬 Acetaminophen [15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 💬
30 Leishmaniasis 💬
[1] PTGS2 💬 Aspirin 💬 Acetylsalicylic acid [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬
31 Leishmaniasis 💬
[1] PTGS2 💬 Celecoxib 💬 Celecoxib [10]  2 ,  3 , 34, 46, 70, 89, 107, 161, 171, 271 💬 💬
32 Leishmaniasis 💬
[1] PTGS2 💬 Diclofenac 💬 Diclofenac [5] 13, 34, 46, 78, 271 💬 💬
33 Leishmaniasis 💬
[1] PTGS2 💬 Diflunisal 💬 Diflunisal [1] 28 💬 💬
34 Leishmaniasis 💬
[1] PTGS2 💬 Etodolac 💬 Etodolac [1] 46 💬 💬
35 Leishmaniasis 💬
[1] PTGS2 💬 Etoricoxib 💬 Etoricoxib [2] 46, 271 💬 💬
36 Leishmaniasis 💬
[1] PTGS2 💬 Flurbiprofen 💬 Flurbiprofen [3] 13, 21, 46 💬 💬
37 Leishmaniasis 💬
[1] PTGS2 💬 Ibuprofen 💬 Ibuprofen [7] 13, 46, 65, 107, 113, 271, 299 💬 💬
38 Leishmaniasis 💬
[1] PTGS2 💬 Indomethacin 💬 Indomethacin [3] 225, 271, 298 💬 💬
39 Leishmaniasis 💬
[1] PTGS2 💬 Ketoprofen 💬 Ketoprofen [1] 46 💬 💬
40 Leishmaniasis 💬
[1] PTGS2 💬 Ketorolac 💬 Ketorolac [2] 70, 226 💬 💬
41 Leishmaniasis 💬
[1] PTGS2 💬 Loxoprofen 💬 Loxoprofen [2] 46, 271 💬 💬
42 Leishmaniasis 💬
[1] PTGS2 💬 Lumiracoxib 💬 Lumiracoxib [1] 46 💬 💬
43 Leishmaniasis 💬
[1] PTGS2 💬 Meloxicam 💬 Meloxicam [4] 46, 49, 271, 296 💬 💬
44 Leishmaniasis 💬
[1] PTGS2 💬 Naproxen 💬 Naproxen [4] 13, 46, 107, 271 💬 💬
45 Leishmaniasis 💬
[1] PTGS2 💬 Nimesulide 💬 Nimesulide [1] 46 💬 💬
46 Leishmaniasis 💬
[1] PTGS2 💬 Parecoxib 💬 Parecoxib [2] 46, 271 💬 💬
47 Leishmaniasis 💬
[1] PTGS2 💬 Rofecoxib 💬 Rofecoxib [1] 46 💬 💬
48 Leishmaniasis 💬
[1] PTGS2 💬 Salsalate 💬 Salsalate [1]  5  💬 💬
49 Leishmaniasis 💬
[1] PTGS2 💬 Sulindac 💬 Sulindac [1] 206 💬 💬
50 Leishmaniasis 💬
[1] PTGS2 💬 Tolfenamic acid 💬 Tolfenamic acid [1]  5  💬 💬
51 Leishmaniasis 💬
[1] PTGS2 💬 Valdecoxib 💬 Valdecoxib [1] 46 💬 💬
52 Leishmaniasis 💬
[1] RELA 💬 Edasalonexent 💬 Edasalonexent [1] 113 💬 💬
53 Leishmaniasis 💬
[3] TGFB1, TGFB2, TGFB3 💬 Fresolimumab 💬 Fresolimumab [3] 51, 85, 222 💬 💬
54 Leishmaniasis 💬
[1] TNF 💬 Adalimumab 💬 Adalimumab [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬 💬
55 Leishmaniasis 💬
[1] TNF 💬 Certolizumab pegol 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬 💬
56 Leishmaniasis 💬
[1] TNF 💬 Etanercept 💬 Etanercept [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 💬
57 Leishmaniasis 💬
[1] TNF 💬 Golimumab 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬 💬
58 Leishmaniasis 💬
[1] TNF 💬 Infliximab 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬
59 Leishmaniasis 💬
[1] TNF 💬 Lenalidomide 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬 💬
60 Leishmaniasis 💬
[1] TNF 💬 Ozoralizumab 💬 Ozoralizumab [1] 46 💬 💬
61 Leishmaniasis 💬
[1] TNF 💬 Pegsunercept 💬 Pegsunercept [1] 46 💬 💬
62 Leishmaniasis 💬
[1] TNF 💬 Pomalidomide 💬 Pomalidomide [5] 28, 51, 85, 227, 331 💬 💬
63 Leishmaniasis 💬
[1] TNF 💬 Thalidomide 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬