Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY KEGG GENES KEGG DRUG DrugBank Disease ID
1 Adrenergic signaling in cardiomyocytes 💬
 [5] CACNA1C, CACNA1D, CACNA1F, CACNA1S, SCN5A 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
2 Adrenergic signaling in cardiomyocytes 💬
 [1] KCNQ1 💬 Ezogabine 💬 Ezogabine [2]  2 , 144 💬 💬
3 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 Lamotrigine 💬 Lamotrigine [5] 13, 34, 38, 114, 144 💬 💬
4 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 Rufinamide 💬 Rufinamide [1] 144 💬 💬
5 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
6 Alzheimer disease 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
7 Amphetamine addiction 💬
 [6] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
8 Amphetamine addiction 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Perampanel 💬 Perampanel [3]  2 ,  6 , 144 💬 💬
9 Amyotrophic lateral sclerosis 💬
 [2] GRIA1, GRIA2 💬 Perampanel 💬 Perampanel [3]  2 ,  6 , 144 💬 💬
10 Amyotrophic lateral sclerosis 💬
 [2] GRIA1, GRIA2 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
11 Amyotrophic lateral sclerosis 💬
 [1] SIGMAR1 💬 Fenfluramine 💬 Fenfluramine [4] 140, 144, 145, 149 💬 💬
12 Arrhythmogenic right ventricular cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
13 Bile secretion 💬
 [1] CA2 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
14 Calcium signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
15 Calcium signaling pathway 💬
 [2] HTR2A, HTR2C 💬 Fenfluramine 💬 Fenfluramine [4] 140, 144, 145, 149 💬 💬
16 cAMP signaling pathway 💬
 [8] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GRIA1, GRIA2, GRIA3, GRIA4 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
17 cAMP signaling pathway 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Perampanel 💬 Perampanel [3]  2 ,  6 , 144 💬 💬
18 cAMP signaling pathway 💬
 [1] HTR1D 💬 Fenfluramine 💬 Fenfluramine [4] 140, 144, 145, 149 💬 💬
19 Carbohydrate digestion and absorption 💬
 [1] CACNA1D 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
20 Cardiac muscle contraction 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
21 Cellular senescence 💬
 [1] CACNA1D 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
22 cGMP-PKG signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
23 Chemical carcinogenesis - receptor activation 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
24 Cholinergic synapse 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
25 Cholinergic synapse 💬
 [5] KCNQ1, KCNQ2, KCNQ3, KCNQ4, KCNQ5 💬 Ezogabine 💬 Ezogabine [2]  2 , 144 💬 💬
26 Circadian entrainment 💬
 [6] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
27 Circadian entrainment 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Perampanel 💬 Perampanel [3]  2 ,  6 , 144 💬 💬
28 Cocaine addiction 💬
 [1] GRIA2 💬 Perampanel 💬 Perampanel [3]  2 ,  6 , 144 💬 💬
29 Cocaine addiction 💬
 [1] GRIA2 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
30 Collecting duct acid secretion 💬
 [1] CA2 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
31 Cortisol synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
32 Cushing syndrome 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
33 Dilated cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
34 Dopaminergic synapse 💬
 [7] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, SCN1A 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
35 Dopaminergic synapse 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Perampanel 💬 Perampanel [3]  2 ,  6 , 144 💬 💬
36 Dopaminergic synapse 💬
 [1] SCN1A 💬 Lamotrigine 💬 Lamotrigine [5] 13, 34, 38, 114, 144 💬 💬
37 Dopaminergic synapse 💬
 [1] SCN1A 💬 Rufinamide 💬 Rufinamide [1] 144 💬 💬
38 GABAergic synapse 💬
 [20] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
39 GABAergic synapse 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Clobazam 💬 Clobazam [2] 140, 144 💬 💬
40 Gap junction 💬
 [2] HTR2A, HTR2C 💬 Fenfluramine 💬 Fenfluramine [4] 140, 144, 145, 149 💬 💬
41 Gastric acid secretion 💬
 [1] CA2 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
42 Gastric acid secretion 💬
 [1] KCNQ1 💬 Ezogabine 💬 Ezogabine [2]  2 , 144 💬 💬
43 Glutamatergic synapse 💬
 [11] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
44 Glutamatergic synapse 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Perampanel 💬 Perampanel [3]  2 ,  6 , 144 💬 💬
45 GnRH secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
46 GnRH signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
47 Growth hormone synthesis, secretion and action 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
48 Huntington disease 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Perampanel 💬 Perampanel [3]  2 ,  6 , 144 💬 💬
49 Huntington disease 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
50 Hypertrophic cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
51 Inflammatory mediator regulation of TRP channels 💬
 [2] HTR2A, HTR2C 💬 Fenfluramine 💬 Fenfluramine [4] 140, 144, 145, 149 💬 💬
52 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
53 Long-term depression 💬
 [3] GRIA1, GRIA2, GRIA3 💬 Perampanel 💬 Perampanel [3]  2 ,  6 , 144 💬 💬
54 Long-term depression 💬
 [3] GRIA1, GRIA2, GRIA3 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
55 Long-term potentiation 💬
 [3] CACNA1C, GRIA1, GRIA2 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
56 Long-term potentiation 💬
 [2] GRIA1, GRIA2 💬 Perampanel 💬 Perampanel [3]  2 ,  6 , 144 💬 💬
57 MAPK signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
58 Metabolic pathways 💬
 [2] CA2, CA4 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
59 Morphine addiction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Clobazam 💬 Clobazam [2] 140, 144 💬 💬
60 Morphine addiction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
61 Neuroactive ligand-receptor interaction 💬
 [2] CNR1, CNR2 💬 Cannabidiol 💬 Cannabidiol [20]  2 ,  6 ,  8 , 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬 💬
62 Neuroactive ligand-receptor interaction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Clobazam 💬 Clobazam [2] 140, 144 💬 💬
63 Neuroactive ligand-receptor interaction 💬
 [25] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
64 Neuroactive ligand-receptor interaction 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Perampanel 💬 Perampanel [3]  2 ,  6 , 144 💬 💬
65 Neuroactive ligand-receptor interaction 💬
 [3] HTR1D, HTR2A, HTR2C 💬 Fenfluramine 💬 Fenfluramine [4] 140, 144, 145, 149 💬 💬
66 Nicotine addiction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Clobazam 💬 Clobazam [2] 140, 144 💬 💬
67 Nicotine addiction 💬
 [20] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
68 Nicotine addiction 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Perampanel 💬 Perampanel [3]  2 ,  6 , 144 💬 💬
69 Nitrogen metabolism 💬
 [2] CA2, CA4 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
70 Oxytocin signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
71 Pancreatic secretion 💬
 [1] CA2 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
72 Pancreatic secretion 💬
 [1] KCNQ1 💬 Ezogabine 💬 Ezogabine [2]  2 , 144 💬 💬
73 Pathways of neurodegeneration - multiple diseases 💬
 [8] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GRIA1, GRIA2, GRIA3, GRIA4 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
74 Pathways of neurodegeneration - multiple diseases 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Perampanel 💬 Perampanel [3]  2 ,  6 , 144 💬 💬
75 Pathways of neurodegeneration - multiple diseases 💬
 [1] SIGMAR1 💬 Fenfluramine 💬 Fenfluramine [4] 140, 144, 145, 149 💬 💬
76 Primary bile acid biosynthesis 💬
 [1] CYP46A1 💬 Soticlestat 💬 Soticlestat [2] 140, 144 💬 💬
77 Prion disease 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
78 Protein digestion and absorption 💬
 [1] KCNQ1 💬 Ezogabine 💬 Ezogabine [2]  2 , 144 💬 💬
79 Proximal tubule bicarbonate reclamation 💬
 [2] CA2, CA4 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
80 Rap1 signaling pathway 💬
 [1] CNR1 💬 Cannabidiol 💬 Cannabidiol [20]  2 ,  6 ,  8 , 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬 💬
81 Renin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
82 Retrograde endocannabinoid signaling 💬
 [24] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
83 Retrograde endocannabinoid signaling 💬
 [1] CNR1 💬 Cannabidiol 💬 Cannabidiol [20]  2 ,  6 ,  8 , 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬 💬
84 Retrograde endocannabinoid signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 Clobazam 💬 Clobazam [2] 140, 144 💬 💬
85 Retrograde endocannabinoid signaling 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Perampanel 💬 Perampanel [3]  2 ,  6 , 144 💬 💬
86 Serotonergic synapse 💬
 [7] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRB1, GABRB2, GABRB3 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
87 Serotonergic synapse 💬
 [3] GABRB1, GABRB2, GABRB3 💬 Clobazam 💬 Clobazam [2] 140, 144 💬 💬
88 Serotonergic synapse 💬
 [4] HTR1D, HTR2A, HTR2C, SLC6A4 💬 Fenfluramine 💬 Fenfluramine [4] 140, 144, 145, 149 💬 💬
89 Spinocerebellar ataxia 💬
 [3] GRIA1, GRIA2, GRIA3 💬 Perampanel 💬 Perampanel [3]  2 ,  6 , 144 💬 💬
90 Spinocerebellar ataxia 💬
 [3] GRIA1, GRIA2, GRIA3 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
91 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 Fenfluramine 💬 Fenfluramine [4] 140, 144, 145, 149 💬 💬
92 Taste transduction 💬
 [10] CACNA1C, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, SCN2A, SCN3A, SCN9A 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
93 Taste transduction 💬
 [6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬 Clobazam 💬 Clobazam [2] 140, 144 💬 💬
94 Taste transduction 💬
 [1] HTR1D 💬 Fenfluramine 💬 Fenfluramine [4] 140, 144, 145, 149 💬 💬
95 Taste transduction 💬
 [3] SCN2A, SCN3A, SCN9A 💬 Lamotrigine 💬 Lamotrigine [5] 13, 34, 38, 114, 144 💬 💬
96 Taste transduction 💬
 [3] SCN2A, SCN3A, SCN9A 💬 Rufinamide 💬 Rufinamide [1] 144 💬 💬
97 Thermogenesis 💬
 [1] CNR1 💬 Cannabidiol 💬 Cannabidiol [20]  2 ,  6 ,  8 , 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬 💬
98 Tight junction 💬
 [1] CACNA1D 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
99 Transcriptional misregulation in cancer 💬
 [1] GRIA3 💬 Perampanel 💬 Perampanel [3]  2 ,  6 , 144 💬 💬
100 Transcriptional misregulation in cancer 💬
 [1] GRIA3 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
101 Type II diabetes mellitus 💬
 [2] CACNA1C, CACNA1D 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
102 Vascular smooth muscle contraction 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
103 Vibrio cholerae infection 💬
 [1] KCNQ1 💬 Ezogabine 💬 Ezogabine [2]  2 , 144 💬 💬

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