Target Gene/Pathway Pathway / Gene
Search results
No. | KEGG PATHWAY | KEGG GENES | KEGG DRUG | DrugBank | Disease ID |
---|---|---|---|---|---|
1 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
CD3D [3] CD3D, CD3E, CD3G 💬 |
Otelixizumab Otelixizumab 💬 |
Otelixizumab | 046 [1] 46 💬 💬 |
2 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
CD3D [3] CD3D, CD3E, CD3G 💬 |
Visilizumab Visilizumab 💬 |
Visilizumab | 096 [2] 96, 97 💬 💬 |
3 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
CD3E [1] CD3E 💬 |
Mosunetuzumab Mosunetuzumab 💬 |
Mosunetuzumab | 049 [1] 49 💬 💬 |
4 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
CD4 [1] CD4 💬 |
Zanolimumab Zanolimumab 💬 |
Zanolimumab | 046 [1] 46 💬 💬 |
5 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
CD40LG [1] CD40LG 💬 |
Toralizumab Toralizumab 💬 |
Toralizumab | 063 [1] 63 💬 💬 |
6 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
CDK4 [1] CDK4 💬 |
Abemaciclib Abemaciclib 💬 |
Abemaciclib | 034 [1] 34 💬 💬 |
7 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
CSF2 [1] CSF2 💬 |
Otilimab Otilimab 💬 |
Otilimab | 046 [1] 46 💬 💬 |
8 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
CTLA4 [1] CTLA4 💬 |
Ipilimumab Ipilimumab 💬 |
Ipilimumab | 159 [1] 159 💬 💬 |
9 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
CTLA4 [1] CTLA4 💬 |
Tremelimumab Tremelimumab 💬 |
Tremelimumab | 096 [1] 96 💬 💬 |
10 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
FYN [2] FYN, LCK 💬 |
Dasatinib Dasatinib 💬 |
Dasatinib | 051 [2] 51, 85 💬 💬 |
11 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
FYN [2] FYN, LCK 💬 |
Dasatinib Dasatinib 💬 |
Dasatinib | 051 [2] 51, 85 💬 💬 |
12 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
IFNG [1] IFNG 💬 |
Emapalumab Emapalumab 💬 |
Emapalumab | 049 [3] 49, 65, 107 💬 💬 |
13 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
IFNG [1] IFNG 💬 |
Fontolizumab Fontolizumab 💬 |
Fontolizumab | 046 [1] 46 💬 💬 |
14 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
IL10 [2] IL10, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
15 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
IL4 [1] IL4 💬 |
Binetrakin Binetrakin 💬 |
Binetrakin | 046 [1] 46 💬 💬 |
16 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
IL5 [1] IL5 💬 |
Mepolizumab Mepolizumab 💬 |
Mepolizumab | 044 [4] 44, 45, 98, 162 💬 💬 |
17 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
IL5 [1] IL5 💬 |
Reslizumab Reslizumab 💬 |
Reslizumab | 044 [2] 44, 98 💬 💬 |
18 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Binimetinib Binimetinib 💬 |
Binimetinib | 034 [1] 34 💬 💬 |
19 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Cobimetinib Cobimetinib 💬 |
Cobimetinib | 280 [1] 280 💬 💬 |
20 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Mirdametinib Mirdametinib 💬 |
Mirdametinib | 034 [1] 34 💬 💬 |
21 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Selumetinib Selumetinib 💬 |
Selumetinib | 034 [1] 34 💬 💬 |
22 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
23 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
24 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Neflamapimod Neflamapimod 💬 |
Neflamapimod | 008 [1] 8 💬 💬 |
25 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
NFKB1 [1] NFKB1 💬 |
Iguratimod Iguratimod 💬 |
Iguratimod | 046 [5] 46, 51, 53, 271, 300 💬 💬 |
26 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
PDCD1 [1] PDCD1 💬 |
Nivolumab Nivolumab 💬 |
Nivolumab | 013 [12] 13, 26, 41, 46, 49, 50, 51, 53, 85, 96, 97, 159 💬 💬 |
27 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
PDCD1 [1] PDCD1 💬 |
Pembrolizumab Pembrolizumab 💬 |
Pembrolizumab | 025 [2] 25, 285 💬 💬 |
28 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
PIK3CA [1] PIK3CA 💬 |
Alpelisib Alpelisib 💬 |
Alpelisib | 138 [1] 138 💬 💬 |
29 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
PIK3CA [3] PIK3CA, PIK3CB, PIK3CD 💬 |
Leniolisib Leniolisib 💬 |
Leniolisib | 053 [2] 53, 65 💬 💬 |
30 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
PIK3CD [1] PIK3CD 💬 |
Parsaclisib Parsaclisib 💬 |
Parsaclisib | 035 [3] 35, 53, 61 💬 💬 |
31 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
32 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Pimecrolimus Pimecrolimus 💬 |
Pimecrolimus | 160 [1] 160 💬 💬 |
33 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
34 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
35 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Voclosporin Voclosporin 💬 |
Voclosporin | 049 [2] 49, 222 💬 💬 |
36 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
PRKCQ [1] PRKCQ 💬 |
Sotrastaurin Sotrastaurin 💬 |
Sotrastaurin | 097 [1] 97 💬 💬 |
37 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
RAF1 [1] RAF1 💬 |
Sorafenib Sorafenib 💬 |
Sorafenib | 034 [2] 34, 86 💬 💬 |
38 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
39 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
TNF [1] TNF 💬 |
Adalimumab Adalimumab 💬 |
Adalimumab | 019 [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬 💬 |
40 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
TNF [1] TNF 💬 |
Certolizumab pegol Certolizumab pegol 💬 |
Certolizumab pegol | 037 [8] 37, 46, 49, 96, 97, 107, 226, 271 💬 💬 |
41 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
TNF [1] TNF 💬 |
Etanercept Etanercept 💬 |
Etanercept | 015 [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 💬 |
42 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
TNF [1] TNF 💬 |
Golimumab Golimumab 💬 |
Golimumab | 046 [8] 46, 56, 84, 96, 97, 107, 270, 271 💬 💬 |
43 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
44 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
TNF [1] TNF 💬 |
Lenalidomide Lenalidomide 💬 |
Lenalidomide | 016 [8] 16, 26, 28, 34, 49, 284, 300, 331 💬 💬 |
45 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
TNF [1] TNF 💬 |
Ozoralizumab Ozoralizumab 💬 |
Ozoralizumab | 046 [1] 46 💬 💬 |
46 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
TNF [1] TNF 💬 |
Pegsunercept Pegsunercept 💬 |
Pegsunercept | 046 [1] 46 💬 💬 |
47 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
TNF [1] TNF 💬 |
Pomalidomide Pomalidomide 💬 |
Pomalidomide | 028 [5] 28, 51, 85, 227, 331 💬 💬 |
48 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
49 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
CACNA1C [1] CACNA1C 💬 |
Amlodipine Amlodipine 💬 |
Amlodipine | 013 [4] 13, 51, 67, 298 💬 💬 |
50 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
CACNA1C [1] CACNA1C 💬 |
Cilnidipine Cilnidipine 💬 |
Cilnidipine | 067 [1] 67 💬 💬 |
51 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
CACNA1C [1] CACNA1C 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
52 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
CACNA1C [1] CACNA1C 💬 |
Isradipine Isradipine 💬 |
Isradipine | 006 [1] 6 💬 💬 |
53 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
CACNA1C [1] CACNA1C 💬 |
Nicardipine Nicardipine 💬 |
Nicardipine | 070 [2] 70, 86 💬 💬 |
54 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
CACNA1C [1] CACNA1C 💬 |
Nifedipine Nifedipine 💬 |
Nifedipine | 050 [2] 50, 81 💬 💬 |
55 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
CACNA1C [1] CACNA1C 💬 |
Nilvadipine Nilvadipine 💬 |
Nilvadipine | 090 [1] 90 💬 💬 |
56 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
CACNA1C [1] CACNA1C 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
57 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
CACNA1C [1] CACNA1C 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
58 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
CACNA1C [2] CACNA1C, CHRM3 💬 |
Propiverine Propiverine 💬 |
Propiverine | 226 [1] 226 💬 💬 |
59 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
CACNA1C [10] CACNA1C, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, SCN2A, SCN3A, SCN9A 💬 |
Topiramate Topiramate 💬 |
Topiramate | 006 [6] 6 , 97, 140, 144, 156, 193 💬 💬 |
60 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
CHRM3 [1] CHRM3 💬 |
Atropine Atropine 💬 |
Atropine | 002 [2] 2 , 299 💬 💬 |
61 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
CHRM3 [1] CHRM3 💬 |
Blarcamesine Blarcamesine 💬 |
Blarcamesine | 156 [1] 156 💬 💬 |
62 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
CHRM3 [1] CHRM3 💬 |
Cevimeline Cevimeline 💬 |
Cevimeline | 053 [1] 53 💬 💬 |
63 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
CHRM3 [1] CHRM3 💬 |
Chlorpromazine Chlorpromazine 💬 |
Chlorpromazine | 254 [1] 254 💬 💬 |
64 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
CHRM3 [1] CHRM3 💬 |
Darifenacin Darifenacin 💬 |
Darifenacin | 006 [2] 6 , 13 💬 💬 |
65 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
CHRM3 [1] CHRM3 💬 |
Fesoterodine Fesoterodine 💬 |
Fesoterodine | 006 [1] 6 💬 💬 |
66 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
CHRM3 [1] CHRM3 💬 |
Oxybutynin Oxybutynin 💬 |
Oxybutynin | 006 [3] 6 , 13, 53 💬 💬 |
67 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
CHRM3 [1] CHRM3 💬 |
Pilocarpine Pilocarpine 💬 |
Pilocarpine | 006 [3] 6 , 53, 299 💬 💬 |
68 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
CHRM3 [1] CHRM3 💬 |
Scopolamine Scopolamine 💬 |
Scopolamine | 002 [1] 2 💬 💬 |
69 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
CHRM3 [1] CHRM3 💬 |
Solifenacin Solifenacin 💬 |
Solifenacin | 006 [3] 6 , 13, 53 💬 💬 |
70 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
CHRM3 [1] CHRM3 💬 |
Tolterodine Tolterodine 💬 |
Tolterodine | 017 [2] 17, 53 💬 💬 |
71 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
CHRM3 [1] CHRM3 💬 |
Trihexyphenidyl Trihexyphenidyl 💬 |
Trihexyphenidyl | 005 [2] 5 , 6 💬 💬 |
72 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
CHRM3 [1] CHRM3 💬 |
Tropicamide Tropicamide 💬 |
Tropicamide | 006 [1] 6 💬 💬 |
73 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
GABBR1 [2] GABBR1, GABBR2 💬 |
Arbaclofen Arbaclofen 💬 |
Arbaclofen | 013 [2] 13, 206 💬 💬 |
74 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
GABBR1 [2] GABBR1, GABBR2 💬 |
Arbaclofen placarbil Arbaclofen placarbil 💬 |
Arbaclofen Placarbil | 013 [1] 13 💬 💬 |
75 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
GABBR1 [2] GABBR1, GABBR2 💬 |
Baclofen Baclofen 💬 |
Baclofen | 002 [8] 2 , 10, 13, 18, 65, 70, 149, 206 💬 💬 |
76 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
GABBR1 [2] GABBR1, GABBR2 💬 |
Valiloxybate Valiloxybate 💬 |
Valiloxybate | 006 [1] 6 💬 💬 |
77 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
GABRA1 [1] GABRA1 💬 |
Etomidate Etomidate 💬 |
Etomidate | 006 [1] 6 💬 💬 |
78 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
GABRA1 [6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬 |
Alprazolam Alprazolam 💬 |
Alprazolam | 008 [2] 8 , 75 💬 💬 |
79 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
GABRA1 [6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬 |
Brexanolone Brexanolone 💬 |
Brexanolone | 205 [1] 205 💬 💬 |
80 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
GABRA1 [6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬 |
Clobazam Clobazam 💬 |
Clobazam | 140 [2] 140, 144 💬 💬 |
81 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
GABRA1 [6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬 |
Clonazepam Clonazepam 💬 |
Clonazepam | 006 [1] 6 💬 💬 |
82 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
GABRA1 [6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬 |
Delorazepam Delorazepam 💬 |
Delorazepam | 006 [3] 6 , 46, 97 💬 💬 |
83 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
GABRA1 [6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬 |
Diazepam Diazepam 💬 |
Diazepam | 046 [3] 46, 155, 298 💬 💬 |
84 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
GABRA1 [6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬 |
Eszopiclone Eszopiclone 💬 |
Eszopiclone | 006 [3] 6 , 13, 46 💬 💬 |
85 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
GABRA1 [6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬 |
Flumazenil Flumazenil 💬 |
Flumazenil | 006 [5] 6 , 13, 17, 18, 206 💬 💬 |
86 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
GABRA1 [6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬 |
Gaboxadol Gaboxadol 💬 |
Gaboxadol | 201 [2] 201, 206 💬 💬 |
87 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
GABRA1 [6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬 |
Ganaxolone Ganaxolone 💬 |
Ganaxolone | 145 [4] 145, 152, 158, 206 💬 💬 |
88 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
GABRA1 [6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬 |
Lorazepam Lorazepam 💬 |
Lorazepam | 036 [1] 36 💬 💬 |
89 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
GABRA1 [6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬 |
Midazolam Midazolam 💬 |
Midazolam | 002 [12] 2 , 3 , 6 , 13, 21, 46, 70, 96, 97, 272, 298, 299 💬 💬 |
90 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
GABRA1 [6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬 |
Propofol Propofol 💬 |
Propofol | 006 [9] 6 , 21, 22, 34, 46, 70, 75, 98, 296 💬 💬 |
91 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
GABRA1 [6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬 |
Zolpidem Zolpidem 💬 |
Zolpidem | 005 [3] 5 , 6 , 46 💬 💬 |
92 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
GABRA1 [6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬 |
Zopiclone Zopiclone 💬 |
Zopiclone | 006 [1] 6 💬 💬 |
93 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
HTR1A [1] HTR1A 💬 |
Aripiprazole Aripiprazole 💬 |
Aripiprazole | 006 [2] 6 , 206 💬 💬 |
94 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
HTR1A [1] HTR1A 💬 |
Buspirone Buspirone 💬 |
Buspirone | 006 [2] 6 , 51 💬 💬 |
95 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
HTR1A [1] HTR1A 💬 |
Cariprazine Cariprazine 💬 |
Cariprazine | 021 [1] 21 💬 💬 |
96 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
HTR1A [1] HTR1A 💬 |
Pardoprunox Pardoprunox 💬 |
Pardoprunox | 006 [1] 6 💬 💬 |
97 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
HTR1A [6] HTR1A, HTR3A, HTR3B, HTR3C, HTR3D, HTR3E 💬 |
Vortioxetine Vortioxetine 💬 |
Vortioxetine | 006 [1] 6 💬 💬 |
98 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
HTR1B [2] HTR1B, HTR1D 💬 |
Zolmitriptan Zolmitriptan 💬 |
Zolmitriptan | 006 [1] 6 💬 💬 |
99 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
HTR1D [1] HTR1D 💬 |
Fenfluramine Fenfluramine 💬 |
Fenfluramine | 140 [4] 140, 144, 145, 149 💬 💬 |
100 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
HTR3A [1] HTR3A 💬 |
Cisapride Cisapride 💬 |
Cisapride | 013 [1] 13 💬 💬 |
101 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
HTR3A [1] HTR3A 💬 |
Cisapride Cisapride 💬 |
Cisapride | 013 [1] 13 💬 💬 |
102 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
HTR3A [5] HTR3A, HTR3B, HTR3C, HTR3D, HTR3E 💬 |
Clozapine Clozapine 💬 |
Clozapine | 006 [1] 6 💬 💬 |
103 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
HTR3A [5] HTR3A, HTR3B, HTR3C, HTR3D, HTR3E 💬 |
Dolasetron Dolasetron 💬 |
Dolasetron | 046 [1] 46 💬 💬 |
104 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
HTR3A [5] HTR3A, HTR3B, HTR3C, HTR3D, HTR3E 💬 |
Ondansetron Ondansetron 💬 |
Ondansetron | 006 [3] 6 , 97, 107 💬 💬 |
105 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
P2RX3 [1] P2RX3 💬 |
Gefapixant Gefapixant 💬 |
Gefapixant | 085 [2] 85, 226 💬 💬 |
106 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
PDE1A [3] PDE1A, PDE1B, PDE1C 💬 |
Aminophylline Aminophylline 💬 |
Aminophylline | 063 [1] 63 💬 💬 |
107 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
PDE1A [3] PDE1A, PDE1B, PDE1C 💬 |
Bucladesine Bucladesine 💬 |
Bucladesine | 246 [1] 246 💬 💬 |
108 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
PDE1A [3] PDE1A, PDE1B, PDE1C 💬 |
Flavoxate Flavoxate 💬 |
Flavoxate | 226 [1] 226 💬 💬 |
109 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
PDE1A [3] PDE1A, PDE1B, PDE1C 💬 |
Theophylline Theophylline 💬 |
Theophylline | 236 [2] 236, 299 💬 💬 |
110 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
PDE1A [3] PDE1A, PDE1B, PDE1C 💬 |
Theophylline Theophylline 💬 |
Theophylline | 236 [2] 236, 299 💬 💬 |
111 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
PDE1B [1] PDE1B 💬 |
Caffeine Caffeine 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
112 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
PDE1B [1] PDE1B 💬 |
Caffeine hydrate Caffeine hydrate 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
113 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
SCN2A [3] SCN2A, SCN3A, SCN9A 💬 |
Amiodarone Amiodarone 💬 |
Amiodarone | 028 [2] 28, 127 💬 💬 |
114 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
SCN2A [3] SCN2A, SCN3A, SCN9A 💬 |
Bupivacaine Bupivacaine 💬 |
Bupivacaine | 046 [8] 46, 51, 53, 70, 96, 168, 226, 298 💬 💬 |
115 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
SCN2A [3] SCN2A, SCN3A, SCN9A 💬 |
Carbamazepine Carbamazepine 💬 |
Carbamazepine | 006 [3] 6 , 13, 231 💬 💬 |
116 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
SCN2A [3] SCN2A, SCN3A, SCN9A 💬 |
Cifenline Cifenline 💬 |
Cibenzoline | 058 [1] 58 💬 💬 |
117 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
SCN2A [3] SCN2A, SCN3A, SCN9A 💬 |
Eleclazine Eleclazine 💬 |
Eleclazine | 058 [1] 58 💬 💬 |
118 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
SCN2A [3] SCN2A, SCN3A, SCN9A 💬 |
Flecainide Flecainide 💬 |
Flecainide | 006 [1] 6 💬 💬 |
119 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
SCN2A [3] SCN2A, SCN3A, SCN9A 💬 |
Lamotrigine Lamotrigine 💬 |
Lamotrigine | 013 [5] 13, 34, 38, 114, 144 💬 💬 |
120 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
SCN2A [3] SCN2A, SCN3A, SCN9A 💬 |
Levobupivacaine Levobupivacaine 💬 |
Levobupivacaine | 046 [1] 46 💬 💬 |
121 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
SCN2A [3] SCN2A, SCN3A, SCN9A 💬 |
Lidocaine Lidocaine 💬 |
Lidocaine | 006 [13] 6 , 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬 💬 |
122 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
SCN2A [3] SCN2A, SCN3A, SCN9A 💬 |
Lidocaine hydrochloride monohydrate Lidocaine hydrochloride monohydrate 💬 |
Lidocaine | 006 [13] 6 , 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬 💬 |
123 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
SCN2A [3] SCN2A, SCN3A, SCN9A 💬 |
Mexiletine Mexiletine 💬 |
Mexiletine | 001 [5] 1 , 2 , 10, 113, 114 💬 💬 |
124 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
SCN2A [3] SCN2A, SCN3A, SCN9A 💬 |
Oxcarbazepine Oxcarbazepine 💬 |
Oxcarbazepine | 013 [1] 13 💬 💬 |
125 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
SCN2A [3] SCN2A, SCN3A, SCN9A 💬 |
Oxybuprocaine Oxybuprocaine 💬 |
Oxybuprocaine | 006 [1] 6 💬 💬 |
126 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
SCN2A [3] SCN2A, SCN3A, SCN9A 💬 |
Phenytoin Phenytoin 💬 |
Phenytoin | 013 [1] 13 💬 💬 |
127 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
SCN2A [3] SCN2A, SCN3A, SCN9A 💬 |
Quinidine Quinidine 💬 |
Quinidine | 002 [3] 2 , 8 , 13 💬 💬 |
128 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
SCN2A [3] SCN2A, SCN3A, SCN9A 💬 |
Ropivacaine Ropivacaine 💬 |
Ropivacaine | 022 [4] 22, 36, 46, 70 💬 💬 |
129 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
SCN2A [3] SCN2A, SCN3A, SCN9A 💬 |
Rufinamide Rufinamide 💬 |
Rufinamide | 144 [1] 144 💬 💬 |
130 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
SCN2A [3] SCN2A, SCN3A, SCN9A 💬 |
Zonisamide Zonisamide 💬 |
Zonisamide | 006 [1] 6 💬 💬 |
131 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
SCN3A [2] SCN3A, SCN9A 💬 |
Lacosamide Lacosamide 💬 |
Lacosamide | 002 [4] 2 , 46, 149, 298 💬 💬 |
132 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
SCNN1A [3] SCNN1A, SCNN1B, SCNN1G 💬 |
Amiloride Amiloride 💬 |
Amiloride | 013 [4] 13, 67, 225, 299 💬 💬 |
133 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
TAS1R2 [2] TAS1R2, TAS1R3 💬 |
Aspartame Aspartame 💬 |
Aspartame | 006 [4] 6 , 13, 67, 86 💬 💬 |
134 | Taurine and hypotaurine metabolism 💬 2 genes, 1 drug (DrugBank) and 14 diseases |
GAD1 [2] GAD1, GAD2 💬 |
Valproic acid Valproic acid 💬 |
Valproic acid | 002 [14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬 |
135 | Terpenoid backbone biosynthesis 💬 4 genes, 12 drugs (DrugBank) and 53 diseases |
FDPS [1] FDPS 💬 |
Alendronic acid Alendronic acid 💬 |
Alendronic acid | 019 [7] 19, 41, 46, 50, 271, 274, 299 💬 💬 |
136 | Terpenoid backbone biosynthesis 💬 4 genes, 12 drugs (DrugBank) and 53 diseases |
FDPS [1] FDPS 💬 |
Pamidronic acid Pamidronic acid 💬 |
Pamidronic acid | 270 [3] 270, 271, 274 💬 💬 |
137 | Terpenoid backbone biosynthesis 💬 4 genes, 12 drugs (DrugBank) and 53 diseases |
FDPS [1] FDPS 💬 |
Risedronic acid Risedronic acid 💬 |
Risedronic acid | 046 [9] 46, 50, 66, 93, 95, 96, 107, 113, 274 💬 💬 |
138 | Terpenoid backbone biosynthesis 💬 4 genes, 12 drugs (DrugBank) and 53 diseases |
FDPS [1] FDPS 💬 |
Zoledronic acid Zoledronic acid 💬 |
Zoledronic acid | 005 [13] 5 , 6 , 13, 17, 46, 65, 93, 95, 96, 270, 274, 299, 333 💬 💬 |
139 | Terpenoid backbone biosynthesis 💬 4 genes, 12 drugs (DrugBank) and 53 diseases |
FDPS [1] FDPS 💬 |
Zoledronic acid Zoledronic acid 💬 |
Zoledronic acid | 005 [13] 5 , 6 , 13, 17, 46, 65, 93, 95, 96, 270, 274, 299, 333 💬 💬 |
140 | Terpenoid backbone biosynthesis 💬 4 genes, 12 drugs (DrugBank) and 53 diseases |
FNTA [2] FNTA, FNTB 💬 |
Lonafarnib Lonafarnib 💬 |
Lonafarnib | 113 [2] 113, 333 💬 💬 |
141 | Terpenoid backbone biosynthesis 💬 4 genes, 12 drugs (DrugBank) and 53 diseases |
FNTA [2] FNTA, FNTB 💬 |
Tipifarnib Tipifarnib 💬 |
Tipifarnib | 034 [1] 34 💬 💬 |
142 | Terpenoid backbone biosynthesis 💬 4 genes, 12 drugs (DrugBank) and 53 diseases |
HMGCR [1] HMGCR 💬 |
Atorvastatin Atorvastatin 💬 |
Atorvastatin | 013 [19] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299 💬 💬 |
143 | Terpenoid backbone biosynthesis 💬 4 genes, 12 drugs (DrugBank) and 53 diseases |
HMGCR [1] HMGCR 💬 |
Fluvastatin Fluvastatin 💬 |
Fluvastatin | 079 [3] 79, 218, 222 💬 💬 |
144 | Terpenoid backbone biosynthesis 💬 4 genes, 12 drugs (DrugBank) and 53 diseases |
HMGCR [1] HMGCR 💬 |
Lovastatin Lovastatin 💬 |
Lovastatin | 006 [11] 6 , 34, 46, 79, 156, 160, 195, 206, 263, 280, 310 💬 💬 |
145 | Terpenoid backbone biosynthesis 💬 4 genes, 12 drugs (DrugBank) and 53 diseases |
HMGCR [1] HMGCR 💬 |
Pravastatin Pravastatin 💬 |
Pravastatin | 013 [9] 13, 46, 49, 67, 79, 96, 164, 265, 333 💬 💬 |
146 | Terpenoid backbone biosynthesis 💬 4 genes, 12 drugs (DrugBank) and 53 diseases |
HMGCR [1] HMGCR 💬 |
Rosuvastatin Rosuvastatin 💬 |
Rosuvastatin | 006 [11] 6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬 💬 |
147 | Terpenoid backbone biosynthesis 💬 4 genes, 12 drugs (DrugBank) and 53 diseases |
HMGCR [1] HMGCR 💬 |
Simvastatin Simvastatin 💬 |
Simvastatin | 006 [21] 6 , 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬 💬 |
148 | TGF-beta signaling pathway 💬 10 genes, 20 drugs (DrugBank) and 55 diseases |
ACVR2A [1] ACVR2A 💬 |
Sotatercept Sotatercept 💬 |
Sotatercept | 086 [2] 86, 284 💬 💬 |
149 | TGF-beta signaling pathway 💬 10 genes, 20 drugs (DrugBank) and 55 diseases |
ACVR2A [2] ACVR2A, ACVR2B 💬 |
Bimagrumab Bimagrumab 💬 |
Bimagrumab | 015 [1] 15 💬 💬 |
150 | TGF-beta signaling pathway 💬 10 genes, 20 drugs (DrugBank) and 55 diseases |
ACVR2B [1] ACVR2B 💬 |
Luspatercept Luspatercept 💬 |
Luspatercept | 060 [1] 60 💬 💬 |
151 | TGF-beta signaling pathway 💬 10 genes, 20 drugs (DrugBank) and 55 diseases |
IFNG [1] IFNG 💬 |
Emapalumab Emapalumab 💬 |
Emapalumab | 049 [3] 49, 65, 107 💬 💬 |
152 | TGF-beta signaling pathway 💬 10 genes, 20 drugs (DrugBank) and 55 diseases |
IFNG [1] IFNG 💬 |
Fontolizumab Fontolizumab 💬 |
Fontolizumab | 046 [1] 46 💬 💬 |
153 | TGF-beta signaling pathway 💬 10 genes, 20 drugs (DrugBank) and 55 diseases |
RGMA [1] RGMA 💬 |
Elezanumab Elezanumab 💬 |
Elezanumab | 013 [1] 13 💬 💬 |
154 | TGF-beta signaling pathway 💬 10 genes, 20 drugs (DrugBank) and 55 diseases |
ROCK1 [1] ROCK1 💬 |
Fasudil Fasudil 💬 |
Fasudil | 002 [4] 2 , 5 , 7 , 51 💬 💬 |
155 | TGF-beta signaling pathway 💬 10 genes, 20 drugs (DrugBank) and 55 diseases |
SMAD7 [1] SMAD7 💬 |
Mongersen Mongersen 💬 |
Mongersen | 096 [2] 96, 97 💬 💬 |
156 | TGF-beta signaling pathway 💬 10 genes, 20 drugs (DrugBank) and 55 diseases |
TGFB1 [3] TGFB1, TGFB2, TGFB3 💬 |
Fresolimumab Fresolimumab 💬 |
Fresolimumab | 051 [3] 51, 85, 222 💬 💬 |
157 | TGF-beta signaling pathway 💬 10 genes, 20 drugs (DrugBank) and 55 diseases |
TNF [1] TNF 💬 |
Adalimumab Adalimumab 💬 |
Adalimumab | 019 [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬 💬 |
158 | TGF-beta signaling pathway 💬 10 genes, 20 drugs (DrugBank) and 55 diseases |
TNF [1] TNF 💬 |
Certolizumab pegol Certolizumab pegol 💬 |
Certolizumab pegol | 037 [8] 37, 46, 49, 96, 97, 107, 226, 271 💬 💬 |
159 | TGF-beta signaling pathway 💬 10 genes, 20 drugs (DrugBank) and 55 diseases |
TNF [1] TNF 💬 |
Etanercept Etanercept 💬 |
Etanercept | 015 [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 💬 |
160 | TGF-beta signaling pathway 💬 10 genes, 20 drugs (DrugBank) and 55 diseases |
TNF [1] TNF 💬 |
Golimumab Golimumab 💬 |
Golimumab | 046 [8] 46, 56, 84, 96, 97, 107, 270, 271 💬 💬 |
161 | TGF-beta signaling pathway 💬 10 genes, 20 drugs (DrugBank) and 55 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
162 | TGF-beta signaling pathway 💬 10 genes, 20 drugs (DrugBank) and 55 diseases |
TNF [1] TNF 💬 |
Lenalidomide Lenalidomide 💬 |
Lenalidomide | 016 [8] 16, 26, 28, 34, 49, 284, 300, 331 💬 💬 |
163 | TGF-beta signaling pathway 💬 10 genes, 20 drugs (DrugBank) and 55 diseases |
TNF [1] TNF 💬 |
Ozoralizumab Ozoralizumab 💬 |
Ozoralizumab | 046 [1] 46 💬 💬 |
164 | TGF-beta signaling pathway 💬 10 genes, 20 drugs (DrugBank) and 55 diseases |
TNF [1] TNF 💬 |
Pegsunercept Pegsunercept 💬 |
Pegsunercept | 046 [1] 46 💬 💬 |
165 | TGF-beta signaling pathway 💬 10 genes, 20 drugs (DrugBank) and 55 diseases |
TNF [1] TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
166 | TGF-beta signaling pathway 💬 10 genes, 20 drugs (DrugBank) and 55 diseases |
TNF [1] TNF 💬 |
Pomalidomide Pomalidomide 💬 |
Pomalidomide | 028 [5] 28, 51, 85, 227, 331 💬 💬 |
167 | TGF-beta signaling pathway 💬 10 genes, 20 drugs (DrugBank) and 55 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
168 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
CD3D [3] CD3D, CD3E, CD3G 💬 |
Otelixizumab Otelixizumab 💬 |
Otelixizumab | 046 [1] 46 💬 💬 |
169 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
CD3D [3] CD3D, CD3E, CD3G 💬 |
Visilizumab Visilizumab 💬 |
Visilizumab | 096 [2] 96, 97 💬 💬 |
170 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
CD3E [1] CD3E 💬 |
Mosunetuzumab Mosunetuzumab 💬 |
Mosunetuzumab | 049 [1] 49 💬 💬 |
171 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
CD4 [1] CD4 💬 |
Zanolimumab Zanolimumab 💬 |
Zanolimumab | 046 [1] 46 💬 💬 |
172 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
IFNG [1] IFNG 💬 |
Emapalumab Emapalumab 💬 |
Emapalumab | 049 [3] 49, 65, 107 💬 💬 |
173 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
IFNG [1] IFNG 💬 |
Fontolizumab Fontolizumab 💬 |
Fontolizumab | 046 [1] 46 💬 💬 |
174 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
IFNGR1 [2] IFNGR1, IFNGR2 💬 |
Interferon gamma-1b Interferon gamma-1b 💬 |
Interferon gamma-1b | 018 [7] 18, 65, 85, 228, 299, 301, 326 💬 💬 |
175 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
IL12A [2] IL12A, IL12B 💬 |
Ustekinumab Ustekinumab 💬 |
Ustekinumab | 037 [16] 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬 💬 |
176 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
IL13 [1] IL13 💬 |
Anrukinzumab Anrukinzumab 💬 |
Anrukinzumab | 097 [1] 97 💬 💬 |
177 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
IL13 [1] IL13 💬 |
Lebrikizumab Lebrikizumab 💬 |
Lebrikizumab | 085 [1] 85 💬 💬 |
178 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
IL13 [1] IL13 💬 |
Tralokinumab Tralokinumab 💬 |
Tralokinumab | 085 [2] 85, 97 💬 💬 |
179 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
IL2RA [1] IL2RA 💬 |
Basiliximab Basiliximab 💬 |
Basiliximab | 002 [6] 2 , 50, 66, 97, 222, 228 💬 💬 |
180 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
IL2RA [1] IL2RA 💬 |
Daclizumab Daclizumab 💬 |
Daclizumab | 013 [8] 13, 56, 60, 65, 97, 107, 283, 284 💬 💬 |
181 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
IL2RA [3] IL2RA, IL2RB, IL2RG 💬 |
Aldesleukin Aldesleukin 💬 |
Aldesleukin | 002 [6] 2 , 35, 49, 65, 96, 97 💬 💬 |
182 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
IL4 [1] IL4 💬 |
Binetrakin Binetrakin 💬 |
Binetrakin | 046 [1] 46 💬 💬 |
183 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
IL4R [1] IL4R 💬 |
Dupilumab Dupilumab 💬 |
Dupilumab | 051 [5] 51, 97, 98, 160, 162 💬 💬 |
184 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
IL5 [1] IL5 💬 |
Mepolizumab Mepolizumab 💬 |
Mepolizumab | 044 [4] 44, 45, 98, 162 💬 💬 |
185 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
IL5 [1] IL5 💬 |
Reslizumab Reslizumab 💬 |
Reslizumab | 044 [2] 44, 98 💬 💬 |
186 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
JAK1 [1] JAK1 💬 |
Abrocitinib Abrocitinib 💬 |
Abrocitinib | 084 [1] 84 💬 💬 |
187 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
JAK1 [1] JAK1 💬 |
Filgotinib Filgotinib 💬 |
Filgotinib | 046 [6] 46, 53, 96, 97, 222, 271 💬 💬 |
188 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
JAK1 [1] JAK1 💬 |
Itacitinib Itacitinib 💬 |
Itacitinib | 046 [4] 46, 51, 97, 228 💬 💬 |
189 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
JAK1 [1] JAK1 💬 |
Upadacitinib Upadacitinib 💬 |
Upadacitinib | 040 [8] 40, 41, 46, 49, 96, 97, 107, 271 💬 💬 |
190 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
JAK1 [2] JAK1, JAK2 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
191 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
JAK1 [2] JAK1, JAK2 💬 |
Ruxolitinib Ruxolitinib 💬 |
Ruxolitinib | 060 [3] 60, 65, 228 💬 💬 |
192 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
JAK1 [3] JAK1, JAK2, JAK3 💬 |
Peficitinib Peficitinib 💬 |
Peficitinib | 046 [1] 46 💬 💬 |
193 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
JAK1 [4] JAK1, JAK2, JAK3, TYK2 💬 |
Tofacitinib Tofacitinib 💬 |
Tofacitinib | 011 [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬 💬 |
194 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
LCK [1] LCK 💬 |
Dasatinib Dasatinib 💬 |
Dasatinib | 051 [2] 51, 85 💬 💬 |
195 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
LCK [1] LCK 💬 |
Dasatinib Dasatinib 💬 |
Dasatinib | 051 [2] 51, 85 💬 💬 |
196 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
197 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Neflamapimod Neflamapimod 💬 |
Neflamapimod | 008 [1] 8 💬 💬 |
198 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
NFKB1 [1] NFKB1 💬 |
Iguratimod Iguratimod 💬 |
Iguratimod | 046 [5] 46, 51, 53, 271, 300 💬 💬 |
199 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
200 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Pimecrolimus Pimecrolimus 💬 |
Pimecrolimus | 160 [1] 160 💬 💬 |
201 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
202 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
203 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Voclosporin Voclosporin 💬 |
Voclosporin | 049 [2] 49, 222 💬 💬 |
204 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
PRKCQ [1] PRKCQ 💬 |
Sotrastaurin Sotrastaurin 💬 |
Sotrastaurin | 097 [1] 97 💬 💬 |
205 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
206 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
TYK2 [1] TYK2 💬 |
Deucravacitinib Deucravacitinib 💬 |
Deucravacitinib | 049 [3] 49, 96, 97 💬 💬 |
207 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
CD3D [3] CD3D, CD3E, CD3G 💬 |
Otelixizumab Otelixizumab 💬 |
Otelixizumab | 046 [1] 46 💬 💬 |
208 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
CD3D [3] CD3D, CD3E, CD3G 💬 |
Visilizumab Visilizumab 💬 |
Visilizumab | 096 [2] 96, 97 💬 💬 |
209 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
CD3E [1] CD3E 💬 |
Mosunetuzumab Mosunetuzumab 💬 |
Mosunetuzumab | 049 [1] 49 💬 💬 |
210 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
CD4 [1] CD4 💬 |
Zanolimumab Zanolimumab 💬 |
Zanolimumab | 046 [1] 46 💬 💬 |
211 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IFNG [1] IFNG 💬 |
Emapalumab Emapalumab 💬 |
Emapalumab | 049 [3] 49, 65, 107 💬 💬 |
212 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IFNG [1] IFNG 💬 |
Fontolizumab Fontolizumab 💬 |
Fontolizumab | 046 [1] 46 💬 💬 |
213 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IFNGR1 [2] IFNGR1, IFNGR2 💬 |
Interferon gamma-1b Interferon gamma-1b 💬 |
Interferon gamma-1b | 018 [7] 18, 65, 85, 228, 299, 301, 326 💬 💬 |
214 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IL17A [1] IL17A 💬 |
Ixekizumab Ixekizumab 💬 |
Ixekizumab | 036 [8] 36, 37, 46, 107, 160, 162, 269, 271 💬 💬 |
215 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IL17A [1] IL17A 💬 |
Secukinumab Secukinumab 💬 |
Secukinumab | 013 [8] 13, 37, 41, 46, 107, 160, 269, 271 💬 💬 |
216 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IL17A [1] IL17A 💬 |
Tibulizumab Tibulizumab 💬 |
Tibulizumab | 053 [1] 53 💬 💬 |
217 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IL17A [2] IL17A, IL17F 💬 |
Bimekizumab Bimekizumab 💬 |
Bimekizumab | 046 [3] 46, 97, 271 💬 💬 |
218 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
219 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IL1B [1] IL1B 💬 |
Gevokizumab Gevokizumab 💬 |
Gevokizumab | 041 [4] 41, 50, 56, 269 💬 💬 |
220 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IL1B [1] IL1B 💬 |
Rilonacept Rilonacept 💬 |
Rilonacept | 051 [4] 51, 106, 107, 266 💬 💬 |
221 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IL1B [2] IL1B, IL6 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
222 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IL1R1 [1] IL1R1 💬 |
Anakinra Anakinra 💬 |
Anakinra | 002 [18] 2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 💬 |
223 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IL22 [1] IL22 💬 |
Efmarodocokin alfa Efmarodocokin alfa 💬 |
Efmarodocokin alfa | 096 [2] 96, 97 💬 💬 |
224 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IL23A [1] IL23A 💬 |
Brazikumab Brazikumab 💬 |
Brazikumab | 096 [2] 96, 97 💬 💬 |
225 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IL23A [1] IL23A 💬 |
Guselkumab Guselkumab 💬 |
Guselkumab | 037 [5] 37, 41, 51, 96, 97 💬 💬 |
226 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IL23A [1] IL23A 💬 |
Mirikizumab Mirikizumab 💬 |
Mirikizumab | 037 [3] 37, 96, 97 💬 💬 |
227 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IL23A [1] IL23A 💬 |
Risankizumab Risankizumab 💬 |
Risankizumab | 037 [4] 37, 96, 97, 271 💬 💬 |
228 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IL23A [1] IL23A 💬 |
Tildrakizumab Tildrakizumab 💬 |
Tildrakizumab | 162 [2] 162, 271 💬 💬 |
229 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IL23A [1] IL23A 💬 |
Ustekinumab Ustekinumab 💬 |
Ustekinumab | 037 [16] 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬 💬 |
230 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IL2RA [1] IL2RA 💬 |
Basiliximab Basiliximab 💬 |
Basiliximab | 002 [6] 2 , 50, 66, 97, 222, 228 💬 💬 |
231 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IL2RA [1] IL2RA 💬 |
Daclizumab Daclizumab 💬 |
Daclizumab | 013 [8] 13, 56, 60, 65, 97, 107, 283, 284 💬 💬 |
232 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IL2RA [3] IL2RA, IL2RB, IL2RG 💬 |
Aldesleukin Aldesleukin 💬 |
Aldesleukin | 002 [6] 2 , 35, 49, 65, 96, 97 💬 💬 |
233 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IL4 [1] IL4 💬 |
Binetrakin Binetrakin 💬 |
Binetrakin | 046 [1] 46 💬 💬 |
234 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IL4R [1] IL4R 💬 |
Dupilumab Dupilumab 💬 |
Dupilumab | 051 [5] 51, 97, 98, 160, 162 💬 💬 |
235 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IL6 [1] IL6 💬 |
Olokizumab Olokizumab 💬 |
Olokizumab | 046 [2] 46, 96 💬 💬 |
236 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IL6 [1] IL6 💬 |
Pomalidomide Pomalidomide 💬 |
Pomalidomide | 028 [5] 28, 51, 85, 227, 331 💬 💬 |
237 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IL6 [1] IL6 💬 |
Siltuximab Siltuximab 💬 |
Siltuximab | 028 [2] 28, 331 💬 💬 |
238 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IL6 [1] IL6 💬 |
Sirukumab Sirukumab 💬 |
Sirukumab | 041 [2] 41, 46 💬 💬 |
239 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IL6R [1] IL6R 💬 |
Sarilumab Sarilumab 💬 |
Sarilumab | 041 [5] 41, 46, 84, 107, 271 💬 💬 |
240 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IL6R [1] IL6R 💬 |
Satralizumab Satralizumab 💬 |
Satralizumab | 011 [3] 11, 13, 86 💬 💬 |
241 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IL6R [1] IL6R 💬 |
Tocilizumab Tocilizumab 💬 |
Tocilizumab | 002 [21] 2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬 💬 |
242 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
JAK1 [1] JAK1 💬 |
Abrocitinib Abrocitinib 💬 |
Abrocitinib | 084 [1] 84 💬 💬 |
243 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
JAK1 [1] JAK1 💬 |
Filgotinib Filgotinib 💬 |
Filgotinib | 046 [6] 46, 53, 96, 97, 222, 271 💬 💬 |
244 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
JAK1 [1] JAK1 💬 |
Itacitinib Itacitinib 💬 |
Itacitinib | 046 [4] 46, 51, 97, 228 💬 💬 |
245 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
JAK1 [1] JAK1 💬 |
Upadacitinib Upadacitinib 💬 |
Upadacitinib | 040 [8] 40, 41, 46, 49, 96, 97, 107, 271 💬 💬 |
246 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
JAK1 [2] JAK1, JAK2 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
247 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
JAK1 [2] JAK1, JAK2 💬 |
Ruxolitinib Ruxolitinib 💬 |
Ruxolitinib | 060 [3] 60, 65, 228 💬 💬 |
248 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
JAK1 [3] JAK1, JAK2, JAK3 💬 |
Peficitinib Peficitinib 💬 |
Peficitinib | 046 [1] 46 💬 💬 |
249 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
JAK1 [4] JAK1, JAK2, JAK3, TYK2 💬 |
Tofacitinib Tofacitinib 💬 |
Tofacitinib | 011 [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬 💬 |
250 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
LCK [1] LCK 💬 |
Dasatinib Dasatinib 💬 |
Dasatinib | 051 [2] 51, 85 💬 💬 |
251 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
LCK [1] LCK 💬 |
Dasatinib Dasatinib 💬 |
Dasatinib | 051 [2] 51, 85 💬 💬 |
252 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
253 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Neflamapimod Neflamapimod 💬 |
Neflamapimod | 008 [1] 8 💬 💬 |
254 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
MTOR [1] MTOR 💬 |
Everolimus Everolimus 💬 |
Everolimus | 034 [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 💬 |
255 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
256 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
MTOR [1] MTOR 💬 |
Temsirolimus Temsirolimus 💬 |
Temsirolimus | 013 [1] 13 💬 💬 |
257 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
NFKB1 [1] NFKB1 💬 |
Iguratimod Iguratimod 💬 |
Iguratimod | 046 [5] 46, 51, 53, 271, 300 💬 💬 |
258 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
259 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Pimecrolimus Pimecrolimus 💬 |
Pimecrolimus | 160 [1] 160 💬 💬 |
260 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
261 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
262 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Voclosporin Voclosporin 💬 |
Voclosporin | 049 [2] 49, 222 💬 💬 |
263 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
PRKCQ [1] PRKCQ 💬 |
Sotrastaurin Sotrastaurin 💬 |
Sotrastaurin | 097 [1] 97 💬 💬 |
264 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
RARA [1] RARA 💬 |
Fenretinide Fenretinide 💬 |
Fenretinide | 299 [1] 299 💬 💬 |
265 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
RARA [1] RARA 💬 |
Isotretinoin Isotretinoin 💬 |
Isotretinoin | 036 [4] 36, 39, 159, 160 💬 💬 |
266 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
RARA [1] RARA 💬 |
Tamibarotene Tamibarotene 💬 |
Tamibarotene | 026 [2] 26, 96 💬 💬 |
267 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
RARA [1] RARA 💬 |
Tretinoin Tretinoin 💬 |
Tretinoin | 002 [6] 2 , 62, 63, 75, 94, 231 💬 💬 |
268 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
RARA [1] RARA 💬 |
Vitamin A Vitamin A 💬 |
Vitamin A | 013 [3] 13, 53, 90 💬 💬 |
269 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
RARA [4] RARA, RXRA, RXRB, RXRG 💬 |
Acitretin Acitretin 💬 |
Acitretin | 037 [1] 37 💬 💬 |
270 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
RARA [4] RARA, RXRA, RXRB, RXRG 💬 |
Alitretinoin Alitretinoin 💬 |
Alitretinoin | 049 [1] 49 💬 💬 |
271 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
272 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
RXRA [3] RXRA, RXRB, RXRG 💬 |
Bexarotene Bexarotene 💬 |
Bexarotene | 013 [2] 13, 75 💬 💬 |
273 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
TGFB1 [1] TGFB1 💬 |
Fresolimumab Fresolimumab 💬 |
Fresolimumab | 051 [3] 51, 85, 222 💬 💬 |
274 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
TYK2 [1] TYK2 💬 |
Deucravacitinib Deucravacitinib 💬 |
Deucravacitinib | 049 [3] 49, 96, 97 💬 💬 |
275 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
ADRB3 [1] ADRB3 💬 |
Dipivefrin Dipivefrin 💬 |
Dipivefrin | 006 [1] 6 💬 💬 |
276 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
ADRB3 [1] ADRB3 💬 |
Droxidopa Droxidopa 💬 |
Droxidopa | 005 [5] 5 , 6 , 17, 169, 170 💬 💬 |
277 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
ADRB3 [1] ADRB3 💬 |
Ephedrine Ephedrine 💬 |
Ephedrine | 011 [1] 11 💬 💬 |
278 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
ADRB3 [1] ADRB3 💬 |
Epinephrine Epinephrine 💬 |
Epinephrine | 046 [3] 46, 70, 96 💬 💬 |
279 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
ADRB3 [1] ADRB3 💬 |
Mirabegron Mirabegron 💬 |
Mirabegron | 006 [4] 6 , 13, 53, 226 💬 💬 |
280 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
ADRB3 [1] ADRB3 💬 |
Noradrenaline Noradrenaline 💬 |
Norepinephrine | 022 [2] 22, 296 💬 💬 |
281 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
ADRB3 [1] ADRB3 💬 |
Propranolol Propranolol 💬 |
Propranolol | 006 [6] 6 , 158, 167, 227, 278, 296 💬 💬 |
282 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
ADRB3 [1] ADRB3 💬 |
Pseudoephedrine Pseudoephedrine 💬 |
Pseudoephedrine | 017 [1] 17 💬 💬 |
283 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
CNR1 [1] CNR1 💬 |
Cannabidiol Cannabidiol 💬 |
Cannabidiol | 002 [20] 2 , 6 , 8 , 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬 💬 |
284 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
CNR1 [1] CNR1 💬 |
Dronabinol Dronabinol 💬 |
Dronabinol | 002 [8] 2 , 8 , 13, 36, 46, 96, 271, 298 💬 💬 |
285 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
CNR1 [1] CNR1 💬 |
Nabilone Nabilone 💬 |
Nabilone | 006 [3] 6 , 13, 127 💬 💬 |
286 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
CNR1 [1] CNR1 💬 |
Rimonabant Rimonabant 💬 |
Rimonabant | 193 [1] 193 💬 💬 |
287 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
CPT1A [4] CPT1A, CPT1B, CPT1C, CPT2 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
288 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
FGFR1 [1] FGFR1 💬 |
Infigratinib Infigratinib 💬 |
Infigratinib | 276 [1] 276 💬 💬 |
289 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
FGFR1 [1] FGFR1 💬 |
Nintedanib Nintedanib 💬 |
Nintedanib | 051 [5] 51, 85, 89, 227, 228 💬 💬 |
290 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
MAP3K5 [1] MAP3K5 💬 |
Selonsertib Selonsertib 💬 |
Selonsertib | 086 [1] 86 💬 💬 |
291 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
292 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Neflamapimod Neflamapimod 💬 |
Neflamapimod | 008 [1] 8 💬 💬 |
293 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
MTOR [1] MTOR 💬 |
Everolimus Everolimus 💬 |
Everolimus | 034 [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 💬 |
294 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
295 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
MTOR [1] MTOR 💬 |
Temsirolimus Temsirolimus 💬 |
Temsirolimus | 013 [1] 13 💬 💬 |
296 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
NPR1 [1] NPR1 💬 |
Erythrityl tetranitrate Erythrityl tetranitrate 💬 |
Erythrityl tetranitrate | 046 [1] 46 💬 💬 |
297 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
NPR1 [1] NPR1 💬 |
Nesiritide Nesiritide 💬 |
Nesiritide | 046 [2] 46, 58 💬 💬 |
298 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
PPARG [1] PPARG 💬 |
Bocidelpar Bocidelpar 💬 |
Bocidelpar | 113 [1] 113 💬 💬 |
299 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
PPARG [1] PPARG 💬 |
Leriglitazone Leriglitazone 💬 |
Leriglitazone | 020 [1] 20 💬 💬 |
300 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
PPARG [1] PPARG 💬 |
Pioglitazone Pioglitazone 💬 |
Pioglitazone | 002 [17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬 💬 |
301 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
PPARG [1] PPARG 💬 |
Rosiglitazone Rosiglitazone 💬 |
Rosiglitazone | 046 [5] 46, 75, 97, 222, 265 💬 💬 |
302 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
PPARG [1] PPARG 💬 |
Seladelpar Seladelpar 💬 |
Seladelpar | 093 [2] 93, 94 💬 💬 |
303 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
304 | Thiamine metabolism 💬 1 gene, 1 drug (DrugBank) and 1 disease |
ALPL [1] ALPL 💬 |
Asfotase alfa Asfotase alfa 💬 |
Asfotase alfa | 172 [1] 172 💬 💬 |
305 | Thyroid cancer 💬 8 genes, 16 drugs (DrugBank) and 28 diseases |
BRAF [1] BRAF 💬 |
Dabrafenib Dabrafenib 💬 |
Dabrafenib | 034 [1] 34 💬 💬 |
306 | Thyroid cancer 💬 8 genes, 16 drugs (DrugBank) and 28 diseases |
BRAF [2] BRAF, RET 💬 |
Sorafenib Sorafenib 💬 |
Sorafenib | 034 [2] 34, 86 💬 💬 |
307 | Thyroid cancer 💬 8 genes, 16 drugs (DrugBank) and 28 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Binimetinib Binimetinib 💬 |
Binimetinib | 034 [1] 34 💬 💬 |
308 | Thyroid cancer 💬 8 genes, 16 drugs (DrugBank) and 28 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Cobimetinib Cobimetinib 💬 |
Cobimetinib | 280 [1] 280 💬 💬 |
309 | Thyroid cancer 💬 8 genes, 16 drugs (DrugBank) and 28 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Mirdametinib Mirdametinib 💬 |
Mirdametinib | 034 [1] 34 💬 💬 |
310 | Thyroid cancer 💬 8 genes, 16 drugs (DrugBank) and 28 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Selumetinib Selumetinib 💬 |
Selumetinib | 034 [1] 34 💬 💬 |
311 | Thyroid cancer 💬 8 genes, 16 drugs (DrugBank) and 28 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
312 | Thyroid cancer 💬 8 genes, 16 drugs (DrugBank) and 28 diseases |
PPARG [1] PPARG 💬 |
Bocidelpar Bocidelpar 💬 |
Bocidelpar | 113 [1] 113 💬 💬 |
313 | Thyroid cancer 💬 8 genes, 16 drugs (DrugBank) and 28 diseases |
PPARG [1] PPARG 💬 |
Leriglitazone Leriglitazone 💬 |
Leriglitazone | 020 [1] 20 💬 💬 |
314 | Thyroid cancer 💬 8 genes, 16 drugs (DrugBank) and 28 diseases |
PPARG [1] PPARG 💬 |
Pioglitazone Pioglitazone 💬 |
Pioglitazone | 002 [17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬 💬 |
315 | Thyroid cancer 💬 8 genes, 16 drugs (DrugBank) and 28 diseases |
PPARG [1] PPARG 💬 |
Rosiglitazone Rosiglitazone 💬 |
Rosiglitazone | 046 [5] 46, 75, 97, 222, 265 💬 💬 |
316 | Thyroid cancer 💬 8 genes, 16 drugs (DrugBank) and 28 diseases |
PPARG [1] PPARG 💬 |
Seladelpar Seladelpar 💬 |
Seladelpar | 093 [2] 93, 94 💬 💬 |
317 | Thyroid cancer 💬 8 genes, 16 drugs (DrugBank) and 28 diseases |
RET [1] RET 💬 |
Sunitinib Sunitinib 💬 |
Sunitinib | 028 [2] 28, 34 💬 💬 |
318 | Thyroid cancer 💬 8 genes, 16 drugs (DrugBank) and 28 diseases |
RXRA [3] RXRA, RXRB, RXRG 💬 |
Acitretin Acitretin 💬 |
Acitretin | 037 [1] 37 💬 💬 |
319 | Thyroid cancer 💬 8 genes, 16 drugs (DrugBank) and 28 diseases |
RXRA [3] RXRA, RXRB, RXRG 💬 |
Alitretinoin Alitretinoin 💬 |
Alitretinoin | 049 [1] 49 💬 💬 |
320 | Thyroid cancer 💬 8 genes, 16 drugs (DrugBank) and 28 diseases |
RXRA [3] RXRA, RXRB, RXRG 💬 |
Bexarotene Bexarotene 💬 |
Bexarotene | 013 [2] 13, 75 💬 💬 |
321 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
ATP1A1 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 |
Digitoxin Digitoxin 💬 |
Digitoxin | 299 [1] 299 💬 💬 |
322 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
ATP1A1 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 |
Digoxin Digoxin 💬 |
Digoxin | 008 [3] 8 , 46, 210 💬 💬 |
323 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
CASP9 [1] CASP9 💬 |
Rimiducid Rimiducid 💬 |
Rimiducid | 019 [6] 19, 60, 65, 284, 285, 326 💬 💬 |
324 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
ESR1 [1] ESR1 💬 |
Clomifene Clomifene 💬 |
Clomifene | 074 [1] 74 💬 💬 |
325 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
ESR1 [1] ESR1 💬 |
Danazol Danazol 💬 |
Danazol | 060 [5] 60, 63, 64, 65, 285 💬 💬 |
326 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
ESR1 [1] ESR1 💬 |
Desogestrel Desogestrel 💬 |
Desogestrel | 230 [1] 230 💬 💬 |
327 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
ESR1 [1] ESR1 💬 |
Estetrol Estetrol 💬 |
Estetrol | 053 [1] 53 💬 💬 |
328 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
ESR1 [1] ESR1 💬 |
Estetrol Estetrol 💬 |
Estetrol | 053 [1] 53 💬 💬 |
329 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
ESR1 [1] ESR1 💬 |
Estradiol Estradiol 💬 |
Estradiol | 013 [7] 13, 46, 49, 65, 76, 226, 299 💬 💬 |
330 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
ESR1 [1] ESR1 💬 |
Estradiol valerate Estradiol valerate 💬 |
Estradiol valerate | 065 [1] 65 💬 💬 |
331 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
ESR1 [1] ESR1 💬 |
Estriol Estriol 💬 |
Estriol | 013 [2] 13, 227 💬 💬 |
332 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
ESR1 [1] ESR1 💬 |
Estriol tripropionate Estriol tripropionate 💬 |
Estriol | 013 [2] 13, 227 💬 💬 |
333 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
ESR1 [1] ESR1 💬 |
Ethinyl estradiol Ethinyl estradiol 💬 |
Ethinylestradiol | 013 [4] 13, 46, 49, 299 💬 💬 |
334 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
ESR1 [1] ESR1 💬 |
Fulvestrant Fulvestrant 💬 |
Fulvestrant | 049 [2] 49, 86 💬 💬 |
335 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
ESR1 [1] ESR1 💬 |
Mestranol Mestranol 💬 |
Mestranol | 046 [2] 46, 49 💬 💬 |
336 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
ESR1 [1] ESR1 💬 |
Prasterone Prasterone 💬 |
Prasterone | 049 [6] 49, 53, 83, 86, 96, 113 💬 💬 |
337 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
ESR1 [1] ESR1 💬 |
Raloxifene Raloxifene 💬 |
Raloxifene | 046 [1] 46 💬 💬 |
338 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
ESR1 [1] ESR1 💬 |
Tamoxifen Tamoxifen 💬 |
Tamoxifen | 002 [3] 2 , 113, 227 💬 💬 |
339 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
HDAC1 [3] HDAC1, HDAC2, HDAC3 💬 |
Vorinostat Vorinostat 💬 |
Vorinostat | 075 [2] 75, 96 💬 💬 |
340 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Binimetinib Binimetinib 💬 |
Binimetinib | 034 [1] 34 💬 💬 |
341 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Cobimetinib Cobimetinib 💬 |
Cobimetinib | 280 [1] 280 💬 💬 |
342 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Mirdametinib Mirdametinib 💬 |
Mirdametinib | 034 [1] 34 💬 💬 |
343 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Selumetinib Selumetinib 💬 |
Selumetinib | 034 [1] 34 💬 💬 |
344 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
345 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
MTOR [1] MTOR 💬 |
Everolimus Everolimus 💬 |
Everolimus | 034 [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 💬 |
346 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
347 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
MTOR [1] MTOR 💬 |
Temsirolimus Temsirolimus 💬 |
Temsirolimus | 013 [1] 13 💬 💬 |
348 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
MYH7 [1] MYH7 💬 |
Mavacamten Mavacamten 💬 |
Mavacamten | 058 [1] 58 💬 💬 |
349 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
PIK3CA [1] PIK3CA 💬 |
Alpelisib Alpelisib 💬 |
Alpelisib | 138 [1] 138 💬 💬 |
350 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
PIK3CA [3] PIK3CA, PIK3CB, PIK3CD 💬 |
Leniolisib Leniolisib 💬 |
Leniolisib | 053 [2] 53, 65 💬 💬 |
351 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
PIK3CD [1] PIK3CD 💬 |
Parsaclisib Parsaclisib 💬 |
Parsaclisib | 035 [3] 35, 53, 61 💬 💬 |
352 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
PRKCB [1] PRKCB 💬 |
Enzastaurin Enzastaurin 💬 |
Enzastaurin | 168 [1] 168 💬 💬 |
353 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
RAF1 [1] RAF1 💬 |
Sorafenib Sorafenib 💬 |
Sorafenib | 034 [2] 34, 86 💬 💬 |
354 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
RXRA [3] RXRA, RXRB, RXRG 💬 |
Acitretin Acitretin 💬 |
Acitretin | 037 [1] 37 💬 💬 |
355 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
RXRA [3] RXRA, RXRB, RXRG 💬 |
Alitretinoin Alitretinoin 💬 |
Alitretinoin | 049 [1] 49 💬 💬 |
356 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
RXRA [3] RXRA, RXRB, RXRG 💬 |
Bexarotene Bexarotene 💬 |
Bexarotene | 013 [2] 13, 75 💬 💬 |
357 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
358 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
SRC [1] SRC 💬 |
Dasatinib Dasatinib 💬 |
Dasatinib | 051 [2] 51, 85 💬 💬 |
359 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
SRC [1] SRC 💬 |
Dasatinib Dasatinib 💬 |
Dasatinib | 051 [2] 51, 85 💬 💬 |
360 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
SRC [1] SRC 💬 |
Saracatinib Saracatinib 💬 |
Saracatinib | 006 [3] 6 , 89, 272 💬 💬 |
361 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
THRA [2] THRA, THRB 💬 |
Levothyroxine Levothyroxine 💬 |
Levothyroxine | 019 [5] 19, 49, 78, 80, 222 💬 💬 |
362 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
THRA [2] THRA, THRB 💬 |
Liothyronine Liothyronine 💬 |
Liothyronine | 013 [4] 13, 78, 210, 212 💬 💬 |
363 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
THRA [2] THRA, THRB 💬 |
Tiratricol Tiratricol 💬 |
Tiratricol | 078 [2] 78, 139 💬 💬 |
364 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
THRB [1] THRB 💬 |
Sobetirome Sobetirome 💬 |
Sobetirome | 020 [1] 20 💬 💬 |
365 | Thyroid hormone synthesis 💬 7 genes, 6 drugs (DrugBank) and 7 diseases |
ATP1A1 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 |
Digitoxin Digitoxin 💬 |
Digitoxin | 299 [1] 299 💬 💬 |
366 | Thyroid hormone synthesis 💬 7 genes, 6 drugs (DrugBank) and 7 diseases |
ATP1A1 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 |
Digoxin Digoxin 💬 |
Digoxin | 008 [3] 8 , 46, 210 💬 💬 |
367 | Thyroid hormone synthesis 💬 7 genes, 6 drugs (DrugBank) and 7 diseases |
PRKCB [1] PRKCB 💬 |
Enzastaurin Enzastaurin 💬 |
Enzastaurin | 168 [1] 168 💬 💬 |
368 | Thyroid hormone synthesis 💬 7 genes, 6 drugs (DrugBank) and 7 diseases |
TPO [1] TPO 💬 |
Methimazole Methimazole 💬 |
Methimazole | 050 [1] 50 💬 💬 |
369 | Thyroid hormone synthesis 💬 7 genes, 6 drugs (DrugBank) and 7 diseases |
TTR [1] TTR 💬 |
Inotersen Inotersen 💬 |
Inotersen | 028 [1] 28 💬 💬 |
370 | Thyroid hormone synthesis 💬 7 genes, 6 drugs (DrugBank) and 7 diseases |
TTR [1] TTR 💬 |
Tafamidis Tafamidis 💬 |
Tafamidis | 028 [1] 28 💬 💬 |
371 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
CACNA1D [1] CACNA1D 💬 |
Amlodipine Amlodipine 💬 |
Amlodipine | 013 [4] 13, 51, 67, 298 💬 💬 |
372 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
CACNA1D [1] CACNA1D 💬 |
Cilnidipine Cilnidipine 💬 |
Cilnidipine | 067 [1] 67 💬 💬 |
373 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
CACNA1D [1] CACNA1D 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
374 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
CACNA1D [1] CACNA1D 💬 |
Isradipine Isradipine 💬 |
Isradipine | 006 [1] 6 💬 💬 |
375 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
CACNA1D [1] CACNA1D 💬 |
Nicardipine Nicardipine 💬 |
Nicardipine | 070 [2] 70, 86 💬 💬 |
376 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
CACNA1D [1] CACNA1D 💬 |
Nifedipine Nifedipine 💬 |
Nifedipine | 050 [2] 50, 81 💬 💬 |
377 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
CACNA1D [1] CACNA1D 💬 |
Nilvadipine Nilvadipine 💬 |
Nilvadipine | 090 [1] 90 💬 💬 |
378 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
CACNA1D [1] CACNA1D 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
379 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
CACNA1D [1] CACNA1D 💬 |
Propiverine Propiverine 💬 |
Propiverine | 226 [1] 226 💬 💬 |
380 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
CACNA1D [1] CACNA1D 💬 |
Topiramate Topiramate 💬 |
Topiramate | 006 [6] 6 , 97, 140, 144, 156, 193 💬 💬 |
381 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
CACNA1D [1] CACNA1D 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
382 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
CDK4 [1] CDK4 💬 |
Abemaciclib Abemaciclib 💬 |
Abemaciclib | 034 [1] 34 💬 💬 |
383 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
CFTR [1] CFTR 💬 |
Deutivacaftor Deutivacaftor 💬 |
Deutivacaftor | 299 [1] 299 💬 💬 |
384 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
CFTR [1] CFTR 💬 |
Elexacaftor Elexacaftor 💬 |
Elexacaftor | 299 [1] 299 💬 💬 |
385 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
CFTR [1] CFTR 💬 |
Galicaftor Galicaftor 💬 |
Galicaftor | 299 [1] 299 💬 💬 |
386 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
CFTR [1] CFTR 💬 |
Ivacaftor Ivacaftor 💬 |
Ivacaftor | 299 [1] 299 💬 💬 |
387 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
CFTR [1] CFTR 💬 |
Lumacaftor Lumacaftor 💬 |
Lumacaftor | 299 [1] 299 💬 💬 |
388 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
CFTR [1] CFTR 💬 |
Tezacaftor Tezacaftor 💬 |
Tezacaftor | 299 [1] 299 💬 💬 |
389 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
ERBB2 [1] ERBB2 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
390 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
ERBB2 [1] ERBB2 💬 |
Neratinib Neratinib 💬 |
Neratinib | 034 [1] 34 💬 💬 |
391 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
ERBB2 [1] ERBB2 💬 |
Tesevatinib Tesevatinib 💬 |
Tesevatinib | 067 [1] 67 💬 💬 |
392 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
MAP3K5 [1] MAP3K5 💬 |
Selonsertib Selonsertib 💬 |
Selonsertib | 086 [1] 86 💬 💬 |
393 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
394 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
PRKCE [1] PRKCE 💬 |
Sotrastaurin Sotrastaurin 💬 |
Sotrastaurin | 097 [1] 97 💬 💬 |
395 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
ROCK1 [2] ROCK1, ROCK2 💬 |
Fasudil Fasudil 💬 |
Fasudil | 002 [4] 2 , 5 , 7 , 51 💬 💬 |
396 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
ROCK2 [1] ROCK2 💬 |
Belumosudil Belumosudil 💬 |
Belumosudil | 051 [2] 51, 85 💬 💬 |
397 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
398 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
SRC [1] SRC 💬 |
Dasatinib Dasatinib 💬 |
Dasatinib | 051 [2] 51, 85 💬 💬 |
399 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
SRC [1] SRC 💬 |
Dasatinib Dasatinib 💬 |
Dasatinib | 051 [2] 51, 85 💬 💬 |
400 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
SRC [1] SRC 💬 |
Saracatinib Saracatinib 💬 |
Saracatinib | 006 [3] 6 , 89, 272 💬 💬 |
401 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
CCL2 [4] CCL2, IL1B, IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
402 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
CSF2 [1] CSF2 💬 |
Otilimab Otilimab 💬 |
Otilimab | 046 [1] 46 💬 💬 |
403 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
404 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
IL1B [1] IL1B 💬 |
Gevokizumab Gevokizumab 💬 |
Gevokizumab | 041 [4] 41, 50, 56, 269 💬 💬 |
405 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
IL1B [1] IL1B 💬 |
Rilonacept Rilonacept 💬 |
Rilonacept | 051 [4] 51, 106, 107, 266 💬 💬 |
406 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
IL6 [1] IL6 💬 |
Olokizumab Olokizumab 💬 |
Olokizumab | 046 [2] 46, 96 💬 💬 |
407 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
IL6 [1] IL6 💬 |
Siltuximab Siltuximab 💬 |
Siltuximab | 028 [2] 28, 331 💬 💬 |
408 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
IL6 [1] IL6 💬 |
Sirukumab Sirukumab 💬 |
Sirukumab | 041 [2] 41, 46 💬 💬 |
409 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
IL6 [2] IL6, TNF 💬 |
Pomalidomide Pomalidomide 💬 |
Pomalidomide | 028 [5] 28, 51, 85, 227, 331 💬 💬 |
410 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
LTA [1] LTA 💬 |
Pateclizumab Pateclizumab 💬 |
Pateclizumab | 046 [1] 46 💬 💬 |
411 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
LTA [2] LTA, TNF 💬 |
Etanercept Etanercept 💬 |
Etanercept | 015 [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 💬 |
412 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
MAP2K1 [1] MAP2K1 💬 |
Binimetinib Binimetinib 💬 |
Binimetinib | 034 [1] 34 💬 💬 |
413 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
MAP2K1 [1] MAP2K1 💬 |
Cobimetinib Cobimetinib 💬 |
Cobimetinib | 280 [1] 280 💬 💬 |
414 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
MAP2K1 [1] MAP2K1 💬 |
Mirdametinib Mirdametinib 💬 |
Mirdametinib | 034 [1] 34 💬 💬 |
415 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
MAP2K1 [1] MAP2K1 💬 |
Selumetinib Selumetinib 💬 |
Selumetinib | 034 [1] 34 💬 💬 |
416 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
MAP2K1 [1] MAP2K1 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
417 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
MAP3K5 [1] MAP3K5 💬 |
Selonsertib Selonsertib 💬 |
Selonsertib | 086 [1] 86 💬 💬 |
418 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
419 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Neflamapimod Neflamapimod 💬 |
Neflamapimod | 008 [1] 8 💬 💬 |
420 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
NFKB1 [1] NFKB1 💬 |
Iguratimod Iguratimod 💬 |
Iguratimod | 046 [5] 46, 51, 53, 271, 300 💬 💬 |
421 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
PIK3CA [1] PIK3CA 💬 |
Alpelisib Alpelisib 💬 |
Alpelisib | 138 [1] 138 💬 💬 |
422 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
PIK3CA [3] PIK3CA, PIK3CB, PIK3CD 💬 |
Leniolisib Leniolisib 💬 |
Leniolisib | 053 [2] 53, 65 💬 💬 |
423 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
PIK3CD [1] PIK3CD 💬 |
Parsaclisib Parsaclisib 💬 |
Parsaclisib | 035 [3] 35, 53, 61 💬 💬 |
424 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
PTGS2 [1] PTGS2 💬 |
Aceclofenac Aceclofenac 💬 |
Aceclofenac | 046 [1] 46 💬 💬 |
425 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
PTGS2 [1] PTGS2 💬 |
Acetaminophen Acetaminophen 💬 |
Acetaminophen | 003 [15] 3 , 6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 💬 |
426 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
427 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
PTGS2 [1] PTGS2 💬 |
Celecoxib Celecoxib 💬 |
Celecoxib | 002 [10] 2 , 3 , 34, 46, 70, 89, 107, 161, 171, 271 💬 💬 |
428 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
PTGS2 [1] PTGS2 💬 |
Diclofenac Diclofenac 💬 |
Diclofenac | 013 [5] 13, 34, 46, 78, 271 💬 💬 |
429 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
PTGS2 [1] PTGS2 💬 |
Diflunisal Diflunisal 💬 |
Diflunisal | 028 [1] 28 💬 💬 |
430 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
PTGS2 [1] PTGS2 💬 |
Etodolac Etodolac 💬 |
Etodolac | 046 [1] 46 💬 💬 |
431 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
PTGS2 [1] PTGS2 💬 |
Etoricoxib Etoricoxib 💬 |
Etoricoxib | 046 [2] 46, 271 💬 💬 |
432 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
PTGS2 [1] PTGS2 💬 |
Flurbiprofen Flurbiprofen 💬 |
Flurbiprofen | 013 [3] 13, 21, 46 💬 💬 |
433 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
PTGS2 [1] PTGS2 💬 |
Ibuprofen Ibuprofen 💬 |
Ibuprofen | 013 [7] 13, 46, 65, 107, 113, 271, 299 💬 💬 |
434 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
PTGS2 [1] PTGS2 💬 |
Indomethacin Indomethacin 💬 |
Indomethacin | 225 [3] 225, 271, 298 💬 💬 |
435 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
PTGS2 [1] PTGS2 💬 |
Ketoprofen Ketoprofen 💬 |
Ketoprofen | 046 [1] 46 💬 💬 |
436 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
PTGS2 [1] PTGS2 💬 |
Ketorolac Ketorolac 💬 |
Ketorolac | 070 [2] 70, 226 💬 💬 |
437 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
PTGS2 [1] PTGS2 💬 |
Loxoprofen Loxoprofen 💬 |
Loxoprofen | 046 [2] 46, 271 💬 💬 |
438 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
PTGS2 [1] PTGS2 💬 |
Lumiracoxib Lumiracoxib 💬 |
Lumiracoxib | 046 [1] 46 💬 💬 |
439 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
PTGS2 [1] PTGS2 💬 |
Meloxicam Meloxicam 💬 |
Meloxicam | 046 [4] 46, 49, 271, 296 💬 💬 |
440 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
PTGS2 [1] PTGS2 💬 |
Naproxen Naproxen 💬 |
Naproxen | 013 [4] 13, 46, 107, 271 💬 💬 |
441 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
PTGS2 [1] PTGS2 💬 |
Nimesulide Nimesulide 💬 |
Nimesulide | 046 [1] 46 💬 💬 |
442 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
PTGS2 [1] PTGS2 💬 |
Parecoxib Parecoxib 💬 |
Parecoxib | 046 [2] 46, 271 💬 💬 |
443 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
PTGS2 [1] PTGS2 💬 |
Rofecoxib Rofecoxib 💬 |
Rofecoxib | 046 [1] 46 💬 💬 |
444 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
PTGS2 [1] PTGS2 💬 |
Salsalate Salsalate 💬 |
Salsalate | 005 [1] 5 💬 💬 |
445 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
PTGS2 [1] PTGS2 💬 |
Sulindac Sulindac 💬 |
Sulindac | 206 [1] 206 💬 💬 |
446 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
PTGS2 [1] PTGS2 💬 |
Tolfenamic acid Tolfenamic acid 💬 |
Tolfenamic acid | 005 [1] 5 💬 💬 |
447 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
PTGS2 [1] PTGS2 💬 |
Valdecoxib Valdecoxib 💬 |
Valdecoxib | 046 [1] 46 💬 💬 |
448 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
449 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
TNF [1] TNF 💬 |
Adalimumab Adalimumab 💬 |
Adalimumab | 019 [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬 💬 |
450 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
TNF [1] TNF 💬 |
Certolizumab pegol Certolizumab pegol 💬 |
Certolizumab pegol | 037 [8] 37, 46, 49, 96, 97, 107, 226, 271 💬 💬 |
451 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
TNF [1] TNF 💬 |
Golimumab Golimumab 💬 |
Golimumab | 046 [8] 46, 56, 84, 96, 97, 107, 270, 271 💬 💬 |
452 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
453 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
TNF [1] TNF 💬 |
Lenalidomide Lenalidomide 💬 |
Lenalidomide | 016 [8] 16, 26, 28, 34, 49, 284, 300, 331 💬 💬 |
454 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
TNF [1] TNF 💬 |
Ozoralizumab Ozoralizumab 💬 |
Ozoralizumab | 046 [1] 46 💬 💬 |
455 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
TNF [1] TNF 💬 |
Pegsunercept Pegsunercept 💬 |
Pegsunercept | 046 [1] 46 💬 💬 |
456 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
457 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
CD40 [1] CD40 💬 |
Bleselumab Bleselumab 💬 |
Bleselumab | 222 [1] 222 💬 💬 |
458 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
CD40 [1] CD40 💬 |
Iscalimab Iscalimab 💬 |
Iscalimab | 049 [2] 49, 53 💬 💬 |
459 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
CD40 [1] CD40 💬 |
Ravagalimab Ravagalimab 💬 |
Ravagalimab | 053 [2] 53, 97 💬 💬 |
460 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
CD80 [2] CD80, CD86 💬 |
Abatacept Abatacept 💬 |
Abatacept | 011 [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬 💬 |
461 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
CD80 [2] CD80, CD86 💬 |
Belatacept Belatacept 💬 |
Belatacept | 046 [1] 46 💬 💬 |
462 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
IFNA1 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 |
Rontalizumab Rontalizumab 💬 |
Rontalizumab | 049 [1] 49 💬 💬 |
463 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
IFNA1 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 |
Sifalimumab Sifalimumab 💬 |
Sifalimumab | 049 [1] 49 💬 💬 |
464 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
IFNAR1 [2] IFNAR1, IFNAR2 💬 |
Anifrolumab Anifrolumab 💬 |
Anifrolumab | 046 [3] 46, 49, 53 💬 💬 |
465 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
IFNAR1 [2] IFNAR1, IFNAR2 💬 |
Interferon alfa Interferon alfa 💬 |
Interferon alfa | 013 [6] 13, 25, 26, 28, 56, 96 💬 💬 |
466 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
IFNAR1 [2] IFNAR1, IFNAR2 💬 |
Interferon alfa-2a Interferon alfa-2a 💬 |
Interferon alfa-2a | 056 [1] 56 💬 💬 |
467 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
IFNAR1 [2] IFNAR1, IFNAR2 💬 |
Interferon alfa-2b Interferon alfa-2b 💬 |
Interferon alfa-2b | 025 [2] 25, 34 💬 💬 |
468 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
IFNAR1 [2] IFNAR1, IFNAR2 💬 |
Interferon beta-1a Interferon beta-1a 💬 |
Interferon beta-1a | 013 [4] 13, 26, 96, 97 💬 💬 |
469 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
IFNAR1 [2] IFNAR1, IFNAR2 💬 |
Interferon beta-1b Interferon beta-1b 💬 |
Interferon beta-1b | 013 [1] 13 💬 💬 |
470 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
IFNAR1 [2] IFNAR1, IFNAR2 💬 |
Peginterferon beta-1a Peginterferon beta-1a 💬 |
Peginterferon beta-1a | 013 [1] 13 💬 💬 |
471 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
IL12A [2] IL12A, IL12B 💬 |
Ustekinumab Ustekinumab 💬 |
Ustekinumab | 037 [16] 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬 💬 |
472 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
473 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
IL1B [1] IL1B 💬 |
Gevokizumab Gevokizumab 💬 |
Gevokizumab | 041 [4] 41, 50, 56, 269 💬 💬 |
474 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
IL1B [1] IL1B 💬 |
Rilonacept Rilonacept 💬 |
Rilonacept | 051 [4] 51, 106, 107, 266 💬 💬 |
475 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
IL1B [3] IL1B, IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
476 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
IL6 [1] IL6 💬 |
Olokizumab Olokizumab 💬 |
Olokizumab | 046 [2] 46, 96 💬 💬 |
477 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
IL6 [1] IL6 💬 |
Siltuximab Siltuximab 💬 |
Siltuximab | 028 [2] 28, 331 💬 💬 |
478 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
IL6 [1] IL6 💬 |
Sirukumab Sirukumab 💬 |
Sirukumab | 041 [2] 41, 46 💬 💬 |
479 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
IL6 [2] IL6, TNF 💬 |
Pomalidomide Pomalidomide 💬 |
Pomalidomide | 028 [5] 28, 51, 85, 227, 331 💬 💬 |
480 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Binimetinib Binimetinib 💬 |
Binimetinib | 034 [1] 34 💬 💬 |
481 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Cobimetinib Cobimetinib 💬 |
Cobimetinib | 280 [1] 280 💬 💬 |
482 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Mirdametinib Mirdametinib 💬 |
Mirdametinib | 034 [1] 34 💬 💬 |
483 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Selumetinib Selumetinib 💬 |
Selumetinib | 034 [1] 34 💬 💬 |
484 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
485 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
486 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Neflamapimod Neflamapimod 💬 |
Neflamapimod | 008 [1] 8 💬 💬 |
487 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
NFKB1 [1] NFKB1 💬 |
Iguratimod Iguratimod 💬 |
Iguratimod | 046 [5] 46, 51, 53, 271, 300 💬 💬 |
488 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
PIK3CA [1] PIK3CA 💬 |
Alpelisib Alpelisib 💬 |
Alpelisib | 138 [1] 138 💬 💬 |
489 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
PIK3CA [3] PIK3CA, PIK3CB, PIK3CD 💬 |
Leniolisib Leniolisib 💬 |
Leniolisib | 053 [2] 53, 65 💬 💬 |
490 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
PIK3CD [1] PIK3CD 💬 |
Parsaclisib Parsaclisib 💬 |
Parsaclisib | 035 [3] 35, 53, 61 💬 💬 |
491 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
492 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
TLR7 [1] TLR7 💬 |
Imiquimod Imiquimod 💬 |
Imiquimod | 034 [2] 34, 51 💬 💬 |
493 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
TLR9 [1] TLR9 💬 |
Cobitolimod Cobitolimod 💬 |
Cobitolimod | 097 [1] 97 💬 💬 |
494 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
TNF [1] TNF 💬 |
Adalimumab Adalimumab 💬 |
Adalimumab | 019 [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬 💬 |
495 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
TNF [1] TNF 💬 |
Certolizumab pegol Certolizumab pegol 💬 |
Certolizumab pegol | 037 [8] 37, 46, 49, 96, 97, 107, 226, 271 💬 💬 |
496 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
TNF [1] TNF 💬 |
Etanercept Etanercept 💬 |
Etanercept | 015 [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 💬 |
497 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
TNF [1] TNF 💬 |
Golimumab Golimumab 💬 |
Golimumab | 046 [8] 46, 56, 84, 96, 97, 107, 270, 271 💬 💬 |
498 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
499 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
TNF [1] TNF 💬 |
Lenalidomide Lenalidomide 💬 |
Lenalidomide | 016 [8] 16, 26, 28, 34, 49, 284, 300, 331 💬 💬 |
500 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
TNF [1] TNF 💬 |
Ozoralizumab Ozoralizumab 💬 |
Ozoralizumab | 046 [1] 46 💬 💬 |
501 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
TNF [1] TNF 💬 |
Pegsunercept Pegsunercept 💬 |
Pegsunercept | 046 [1] 46 💬 💬 |
502 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
503 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
ALOX5 [1] ALOX5 💬 |
Oxatomide Oxatomide 💬 |
Oxatomide | 113 [1] 113 💬 💬 |
504 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
ALOX5 [1] ALOX5 💬 |
Zileuton Zileuton 💬 |
Zileuton | 085 [3] 85, 160, 164 💬 💬 |
505 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
BCL2 [1] BCL2 💬 |
Venetoclax Venetoclax 💬 |
Venetoclax | 028 [1] 28 💬 💬 |
506 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
CASP9 [1] CASP9 💬 |
Rimiducid Rimiducid 💬 |
Rimiducid | 019 [6] 19, 60, 65, 284, 285, 326 💬 💬 |
507 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
CCR5 [1] CCR5 💬 |
Cenicriviroc Cenicriviroc 💬 |
Cenicriviroc | 094 [1] 94 💬 💬 |
508 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
CCR5 [1] CCR5 💬 |
Maraviroc Maraviroc 💬 |
Maraviroc | 046 [2] 46, 84 💬 💬 |
509 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
CD40 [1] CD40 💬 |
Bleselumab Bleselumab 💬 |
Bleselumab | 222 [1] 222 💬 💬 |
510 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
CD40 [1] CD40 💬 |
Iscalimab Iscalimab 💬 |
Iscalimab | 049 [2] 49, 53 💬 💬 |
511 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
CD40 [1] CD40 💬 |
Ravagalimab Ravagalimab 💬 |
Ravagalimab | 053 [2] 53, 97 💬 💬 |
512 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
CD40LG [1] CD40LG 💬 |
Toralizumab Toralizumab 💬 |
Toralizumab | 063 [1] 63 💬 💬 |
513 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
IFNG [1] IFNG 💬 |
Emapalumab Emapalumab 💬 |
Emapalumab | 049 [3] 49, 65, 107 💬 💬 |
514 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
IFNG [1] IFNG 💬 |
Fontolizumab Fontolizumab 💬 |
Fontolizumab | 046 [1] 46 💬 💬 |
515 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
IFNGR1 [2] IFNGR1, IFNGR2 💬 |
Interferon gamma-1b Interferon gamma-1b 💬 |
Interferon gamma-1b | 018 [7] 18, 65, 85, 228, 299, 301, 326 💬 💬 |
516 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
IL10 [2] IL10, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
517 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
IL12A [2] IL12A, IL12B 💬 |
Ustekinumab Ustekinumab 💬 |
Ustekinumab | 037 [16] 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬 💬 |
518 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
JAK1 [1] JAK1 💬 |
Abrocitinib Abrocitinib 💬 |
Abrocitinib | 084 [1] 84 💬 💬 |
519 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
JAK1 [1] JAK1 💬 |
Filgotinib Filgotinib 💬 |
Filgotinib | 046 [6] 46, 53, 96, 97, 222, 271 💬 💬 |
520 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
JAK1 [1] JAK1 💬 |
Itacitinib Itacitinib 💬 |
Itacitinib | 046 [4] 46, 51, 97, 228 💬 💬 |
521 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
JAK1 [1] JAK1 💬 |
Upadacitinib Upadacitinib 💬 |
Upadacitinib | 040 [8] 40, 41, 46, 49, 96, 97, 107, 271 💬 💬 |
522 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
JAK1 [2] JAK1, JAK2 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
523 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
JAK1 [2] JAK1, JAK2 💬 |
Peficitinib Peficitinib 💬 |
Peficitinib | 046 [1] 46 💬 💬 |
524 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
JAK1 [2] JAK1, JAK2 💬 |
Ruxolitinib Ruxolitinib 💬 |
Ruxolitinib | 060 [3] 60, 65, 228 💬 💬 |
525 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
JAK1 [3] JAK1, JAK2, TYK2 💬 |
Tofacitinib Tofacitinib 💬 |
Tofacitinib | 011 [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬 💬 |
526 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
527 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Neflamapimod Neflamapimod 💬 |
Neflamapimod | 008 [1] 8 💬 💬 |
528 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
NFKB1 [1] NFKB1 💬 |
Iguratimod Iguratimod 💬 |
Iguratimod | 046 [5] 46, 51, 53, 271, 300 💬 💬 |
529 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
530 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
TGFB1 [3] TGFB1, TGFB2, TGFB3 💬 |
Fresolimumab Fresolimumab 💬 |
Fresolimumab | 051 [3] 51, 85, 222 💬 💬 |
531 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
TNF [1] TNF 💬 |
Adalimumab Adalimumab 💬 |
Adalimumab | 019 [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬 💬 |
532 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
TNF [1] TNF 💬 |
Certolizumab pegol Certolizumab pegol 💬 |
Certolizumab pegol | 037 [8] 37, 46, 49, 96, 97, 107, 226, 271 💬 💬 |
533 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
TNF [1] TNF 💬 |
Etanercept Etanercept 💬 |
Etanercept | 015 [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 💬 |
534 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
TNF [1] TNF 💬 |
Golimumab Golimumab 💬 |
Golimumab | 046 [8] 46, 56, 84, 96, 97, 107, 270, 271 💬 💬 |
535 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
536 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
TNF [1] TNF 💬 |
Lenalidomide Lenalidomide 💬 |
Lenalidomide | 016 [8] 16, 26, 28, 34, 49, 284, 300, 331 💬 💬 |
537 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
TNF [1] TNF 💬 |
Ozoralizumab Ozoralizumab 💬 |
Ozoralizumab | 046 [1] 46 💬 💬 |
538 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
TNF [1] TNF 💬 |
Pegsunercept Pegsunercept 💬 |
Pegsunercept | 046 [1] 46 💬 💬 |
539 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
TNF [1] TNF 💬 |
Pomalidomide Pomalidomide 💬 |
Pomalidomide | 028 [5] 28, 51, 85, 227, 331 💬 💬 |
540 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
541 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
TYK2 [1] TYK2 💬 |
Deucravacitinib Deucravacitinib 💬 |
Deucravacitinib | 049 [3] 49, 96, 97 💬 💬 |
542 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
CD40 [1] CD40 💬 |
Bleselumab Bleselumab 💬 |
Bleselumab | 222 [1] 222 💬 💬 |
543 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
CD40 [1] CD40 💬 |
Iscalimab Iscalimab 💬 |
Iscalimab | 049 [2] 49, 53 💬 💬 |
544 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
CD40 [1] CD40 💬 |
Ravagalimab Ravagalimab 💬 |
Ravagalimab | 053 [2] 53, 97 💬 💬 |
545 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
CD86 [1] CD86 💬 |
Abatacept Abatacept 💬 |
Abatacept | 011 [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬 💬 |
546 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
CD86 [1] CD86 💬 |
Belatacept Belatacept 💬 |
Belatacept | 046 [1] 46 💬 💬 |
547 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
CSF1R [3] CSF1R, FLT1, FLT3 💬 |
Sunitinib Sunitinib 💬 |
Sunitinib | 028 [2] 28, 34 💬 💬 |
548 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
CSF1R [2] CSF1R, FLT3 💬 |
Pexidartinib Pexidartinib 💬 |
Pexidartinib | 034 [1] 34 💬 💬 |
549 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
CSF2 [1] CSF2 💬 |
Otilimab Otilimab 💬 |
Otilimab | 046 [1] 46 💬 💬 |
550 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
ELANE [1] ELANE 💬 |
Sivelestat Sivelestat 💬 |
Sivelestat | 013 [3] 13, 85, 96 💬 💬 |
551 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
FLT1 [1] FLT1 💬 |
Axitinib Axitinib 💬 |
Axitinib | 034 [1] 34 💬 💬 |
552 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
FLT1 [1] FLT1 💬 |
Cediranib Cediranib 💬 |
Cediranib | 034 [1] 34 💬 💬 |
553 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
FLT1 [1] FLT1 💬 |
Nintedanib Nintedanib 💬 |
Nintedanib | 051 [5] 51, 85, 89, 227, 228 💬 💬 |
554 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
FLT3 [1] FLT3 💬 |
Sorafenib Sorafenib 💬 |
Sorafenib | 034 [2] 34, 86 💬 💬 |
555 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
GRIA3 [1] GRIA3 💬 |
Perampanel Perampanel 💬 |
Perampanel | 002 [3] 2 , 6 , 144 💬 💬 |
556 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
GRIA3 [1] GRIA3 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
557 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
GRIA3 [1] GRIA3 💬 |
Talampanel Talampanel 💬 |
Talampanel | 002 [2] 2 , 6 💬 💬 |
558 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
GRIA3 [1] GRIA3 💬 |
Topiramate Topiramate 💬 |
Topiramate | 006 [6] 6 , 97, 140, 144, 156, 193 💬 💬 |
559 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
HDAC1 [2] HDAC1, HDAC2 💬 |
Vorinostat Vorinostat 💬 |
Vorinostat | 075 [2] 75, 96 💬 💬 |
560 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
IGF1R [1] IGF1R 💬 |
Linsitinib Linsitinib 💬 |
Linsitinib | 232 [1] 232 💬 💬 |
561 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
IGF1R [1] IGF1R 💬 |
Mecasermin Mecasermin 💬 |
Mecasermin | 065 [6] 65, 78, 96, 168, 265, 299 💬 💬 |
562 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
IGF1R [1] IGF1R 💬 |
Teprotumumab Teprotumumab 💬 |
Teprotumumab | 051 [1] 51 💬 💬 |
563 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
IL1R2 [1] IL1R2 💬 |
Anakinra Anakinra 💬 |
Anakinra | 002 [18] 2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 💬 |
564 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
IL2RB [1] IL2RB 💬 |
Aldesleukin Aldesleukin 💬 |
Aldesleukin | 002 [6] 2 , 35, 49, 65, 96, 97 💬 💬 |
565 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
IL6 [1] IL6 💬 |
Olokizumab Olokizumab 💬 |
Olokizumab | 046 [2] 46, 96 💬 💬 |
566 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
IL6 [1] IL6 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
567 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
IL6 [1] IL6 💬 |
Pomalidomide Pomalidomide 💬 |
Pomalidomide | 028 [5] 28, 51, 85, 227, 331 💬 💬 |
568 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
IL6 [1] IL6 💬 |
Siltuximab Siltuximab 💬 |
Siltuximab | 028 [2] 28, 331 💬 💬 |
569 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
IL6 [1] IL6 💬 |
Sirukumab Sirukumab 💬 |
Sirukumab | 041 [2] 41, 46 💬 💬 |
570 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
ITGB7 [1] ITGB7 💬 |
Abrilumab Abrilumab 💬 |
Abrilumab | 096 [2] 96, 97 💬 💬 |
571 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
ITGB7 [1] ITGB7 💬 |
Etrolizumab Etrolizumab 💬 |
Etrolizumab | 096 [2] 96, 97 💬 💬 |
572 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
ITGB7 [1] ITGB7 💬 |
Vedolizumab Vedolizumab 💬 |
Vedolizumab | 094 [3] 94, 96, 97 💬 💬 |
573 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
MET [1] MET 💬 |
Cabozantinib Cabozantinib 💬 |
Cabozantinib | 034 [1] 34 💬 💬 |
574 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
MPO [1] MPO 💬 |
Verdiperstat Verdiperstat 💬 |
Verdiperstat | 002 [3] 2 , 17, 127 💬 💬 |
575 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
NFKB1 [1] NFKB1 💬 |
Iguratimod Iguratimod 💬 |
Iguratimod | 046 [5] 46, 51, 53, 271, 300 💬 💬 |
576 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
NGFR [1] NGFR 💬 |
Cenegermin Cenegermin 💬 |
Cenegermin | 053 [2] 53, 90 💬 💬 |
577 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
PML [2] PML, RARA 💬 |
Tretinoin Tretinoin 💬 |
Tretinoin | 002 [6] 2 , 62, 63, 75, 94, 231 💬 💬 |
578 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
PPARG [1] PPARG 💬 |
Bocidelpar Bocidelpar 💬 |
Bocidelpar | 113 [1] 113 💬 💬 |
579 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
PPARG [1] PPARG 💬 |
Leriglitazone Leriglitazone 💬 |
Leriglitazone | 020 [1] 20 💬 💬 |
580 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
PPARG [1] PPARG 💬 |
Pioglitazone Pioglitazone 💬 |
Pioglitazone | 002 [17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬 💬 |
581 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
PPARG [1] PPARG 💬 |
Rosiglitazone Rosiglitazone 💬 |
Rosiglitazone | 046 [5] 46, 75, 97, 222, 265 💬 💬 |
582 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
PPARG [1] PPARG 💬 |
Seladelpar Seladelpar 💬 |
Seladelpar | 093 [2] 93, 94 💬 💬 |
583 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
RARA [1] RARA 💬 |
Fenretinide Fenretinide 💬 |
Fenretinide | 299 [1] 299 💬 💬 |
584 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
RARA [1] RARA 💬 |
Isotretinoin Isotretinoin 💬 |
Isotretinoin | 036 [4] 36, 39, 159, 160 💬 💬 |
585 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
RARA [1] RARA 💬 |
Tamibarotene Tamibarotene 💬 |
Tamibarotene | 026 [2] 26, 96 💬 💬 |
586 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
RARA [1] RARA 💬 |
Vitamin A Vitamin A 💬 |
Vitamin A | 013 [3] 13, 53, 90 💬 💬 |
587 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
RARA [4] RARA, RXRA, RXRB, RXRG 💬 |
Acitretin Acitretin 💬 |
Acitretin | 037 [1] 37 💬 💬 |
588 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
RARA [4] RARA, RXRA, RXRB, RXRG 💬 |
Alitretinoin Alitretinoin 💬 |
Alitretinoin | 049 [1] 49 💬 💬 |
589 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
590 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
RXRA [3] RXRA, RXRB, RXRG 💬 |
Bexarotene Bexarotene 💬 |
Bexarotene | 013 [2] 13, 75 💬 💬 |
591 | Tryptophan metabolism 💬 5 genes, 10 drugs (DrugBank) and 12 diseases |
DDC [1] DDC 💬 |
Benserazide Benserazide 💬 |
Benserazide | 006 [1] 6 💬 💬 |
592 | Tryptophan metabolism 💬 5 genes, 10 drugs (DrugBank) and 12 diseases |
DDC [1] DDC 💬 |
Carbidopa Carbidopa 💬 |
Carbidopa | 006 [7] 6 , 13, 17, 90, 140, 164, 201 💬 💬 |
593 | Tryptophan metabolism 💬 5 genes, 10 drugs (DrugBank) and 12 diseases |
MAOA [1] MAOA 💬 |
Moclobemide Moclobemide 💬 |
Moclobemide | 006 [1] 6 💬 💬 |
594 | Tryptophan metabolism 💬 5 genes, 10 drugs (DrugBank) and 12 diseases |
MAOA [2] MAOA, MAOB 💬 |
Iproniazid Iproniazid 💬 |
Iproniazid | 006 [1] 6 💬 💬 |
595 | Tryptophan metabolism 💬 5 genes, 10 drugs (DrugBank) and 12 diseases |
MAOA [2] MAOA, MAOB 💬 |
Phenelzine Phenelzine 💬 |
Phenelzine | 006 [1] 6 💬 💬 |
596 | Tryptophan metabolism 💬 5 genes, 10 drugs (DrugBank) and 12 diseases |
MAOA [2] MAOA, MAOB 💬 |
Phentermine Phentermine 💬 |
Phentermine | 097 [1] 97 💬 💬 |
597 | Tryptophan metabolism 💬 5 genes, 10 drugs (DrugBank) and 12 diseases |
MAOB [1] MAOB 💬 |
Rasagiline Rasagiline 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
598 | Tryptophan metabolism 💬 5 genes, 10 drugs (DrugBank) and 12 diseases |
MAOB [1] MAOB 💬 |
Rasagiline tartrate Rasagiline tartrate 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
599 | Tryptophan metabolism 💬 5 genes, 10 drugs (DrugBank) and 12 diseases |
MAOB [1] MAOB 💬 |
Safinamide Safinamide 💬 |
Safinamide | 006 [2] 6 , 17 💬 💬 |
600 | Tryptophan metabolism 💬 5 genes, 10 drugs (DrugBank) and 12 diseases |
MAOB [1] MAOB 💬 |
Selegiline Selegiline 💬 |
Selegiline | 006 [1] 6 💬 💬 |
601 | Tryptophan metabolism 💬 5 genes, 10 drugs (DrugBank) and 12 diseases |
TPH1 [2] TPH1, TPH2 💬 |
Telotristat Telotristat 💬 |
Telotristat | 097 [1] 97 💬 💬 |
602 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
BCL2 [1] BCL2 💬 |
Venetoclax Venetoclax 💬 |
Venetoclax | 028 [1] 28 💬 💬 |
603 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
C3 [1] C3 💬 |
Pegcetacoplan Pegcetacoplan 💬 |
Pegcetacoplan | 002 [4] 2 , 61, 62, 222 💬 💬 |
604 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
CASP9 [1] CASP9 💬 |
Rimiducid Rimiducid 💬 |
Rimiducid | 019 [6] 19, 60, 65, 284, 285, 326 💬 💬 |
605 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
CD74 [1] CD74 💬 |
Milatuzumab Milatuzumab 💬 |
Milatuzumab | 049 [1] 49 💬 💬 |
606 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
IFNA1 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 |
Rontalizumab Rontalizumab 💬 |
Rontalizumab | 049 [1] 49 💬 💬 |
607 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
IFNA1 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 |
Sifalimumab Sifalimumab 💬 |
Sifalimumab | 049 [1] 49 💬 💬 |
608 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
IFNG [1] IFNG 💬 |
Emapalumab Emapalumab 💬 |
Emapalumab | 049 [3] 49, 65, 107 💬 💬 |
609 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
IFNG [1] IFNG 💬 |
Fontolizumab Fontolizumab 💬 |
Fontolizumab | 046 [1] 46 💬 💬 |
610 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
IFNGR1 [2] IFNGR1, IFNGR2 💬 |
Interferon gamma-1b Interferon gamma-1b 💬 |
Interferon gamma-1b | 018 [7] 18, 65, 85, 228, 299, 301, 326 💬 💬 |
611 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
IL10 [5] IL10, IL1A, IL1B, IL6, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
612 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
IL12A [3] IL12A, IL12B, IL23A 💬 |
Ustekinumab Ustekinumab 💬 |
Ustekinumab | 037 [16] 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬 💬 |
613 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
IL1A [1] IL1A 💬 |
Bermekimab Bermekimab 💬 |
Bermekimab | 051 [1] 51 💬 💬 |
614 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
IL1A [2] IL1A, IL1B 💬 |
Rilonacept Rilonacept 💬 |
Rilonacept | 051 [4] 51, 106, 107, 266 💬 💬 |
615 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
616 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
IL1B [1] IL1B 💬 |
Gevokizumab Gevokizumab 💬 |
Gevokizumab | 041 [4] 41, 50, 56, 269 💬 💬 |
617 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
IL23A [1] IL23A 💬 |
Brazikumab Brazikumab 💬 |
Brazikumab | 096 [2] 96, 97 💬 💬 |
618 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
IL23A [1] IL23A 💬 |
Guselkumab Guselkumab 💬 |
Guselkumab | 037 [5] 37, 41, 51, 96, 97 💬 💬 |
619 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
IL23A [1] IL23A 💬 |
Mirikizumab Mirikizumab 💬 |
Mirikizumab | 037 [3] 37, 96, 97 💬 💬 |
620 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
IL23A [1] IL23A 💬 |
Risankizumab Risankizumab 💬 |
Risankizumab | 037 [4] 37, 96, 97, 271 💬 💬 |
621 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
IL23A [1] IL23A 💬 |
Tildrakizumab Tildrakizumab 💬 |
Tildrakizumab | 162 [2] 162, 271 💬 💬 |
622 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
IL6 [1] IL6 💬 |
Olokizumab Olokizumab 💬 |
Olokizumab | 046 [2] 46, 96 💬 💬 |
623 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
IL6 [1] IL6 💬 |
Siltuximab Siltuximab 💬 |
Siltuximab | 028 [2] 28, 331 💬 💬 |
624 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
IL6 [1] IL6 💬 |
Sirukumab Sirukumab 💬 |
Sirukumab | 041 [2] 41, 46 💬 💬 |
625 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
IL6 [2] IL6, TNF 💬 |
Pomalidomide Pomalidomide 💬 |
Pomalidomide | 028 [5] 28, 51, 85, 227, 331 💬 💬 |
626 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
JAK1 [1] JAK1 💬 |
Abrocitinib Abrocitinib 💬 |
Abrocitinib | 084 [1] 84 💬 💬 |
627 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
JAK1 [1] JAK1 💬 |
Filgotinib Filgotinib 💬 |
Filgotinib | 046 [6] 46, 53, 96, 97, 222, 271 💬 💬 |
628 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
JAK1 [1] JAK1 💬 |
Itacitinib Itacitinib 💬 |
Itacitinib | 046 [4] 46, 51, 97, 228 💬 💬 |
629 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
JAK1 [1] JAK1 💬 |
Upadacitinib Upadacitinib 💬 |
Upadacitinib | 040 [8] 40, 41, 46, 49, 96, 97, 107, 271 💬 💬 |
630 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
JAK1 [2] JAK1, JAK2 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
631 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
JAK1 [2] JAK1, JAK2 💬 |
Peficitinib Peficitinib 💬 |
Peficitinib | 046 [1] 46 💬 💬 |
632 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
JAK1 [2] JAK1, JAK2 💬 |
Ruxolitinib Ruxolitinib 💬 |
Ruxolitinib | 060 [3] 60, 65, 228 💬 💬 |
633 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
JAK1 [2] JAK1, JAK2 💬 |
Tofacitinib Tofacitinib 💬 |
Tofacitinib | 011 [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬 💬 |
634 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
635 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Neflamapimod Neflamapimod 💬 |
Neflamapimod | 008 [1] 8 💬 💬 |
636 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
NFKB1 [1] NFKB1 💬 |
Iguratimod Iguratimod 💬 |
Iguratimod | 046 [5] 46, 51, 53, 271, 300 💬 💬 |
637 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
638 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Pimecrolimus Pimecrolimus 💬 |
Pimecrolimus | 160 [1] 160 💬 💬 |
639 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
640 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
641 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Voclosporin Voclosporin 💬 |
Voclosporin | 049 [2] 49, 222 💬 💬 |
642 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
RAF1 [1] RAF1 💬 |
Sorafenib Sorafenib 💬 |
Sorafenib | 034 [2] 34, 86 💬 💬 |
643 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
644 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
645 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
SRC [1] SRC 💬 |
Dasatinib Dasatinib 💬 |
Dasatinib | 051 [2] 51, 85 💬 💬 |
646 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
SRC [1] SRC 💬 |
Dasatinib Dasatinib 💬 |
Dasatinib | 051 [2] 51, 85 💬 💬 |
647 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
SRC [1] SRC 💬 |
Saracatinib Saracatinib 💬 |
Saracatinib | 006 [3] 6 , 89, 272 💬 💬 |
648 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
SYK [1] SYK 💬 |
Fostamatinib Fostamatinib 💬 |
Fostamatinib | 046 [4] 46, 49, 61, 66 💬 💬 |
649 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
TGFB1 [3] TGFB1, TGFB2, TGFB3 💬 |
Fresolimumab Fresolimumab 💬 |
Fresolimumab | 051 [3] 51, 85, 222 💬 💬 |
650 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
TLR9 [1] TLR9 💬 |
Cobitolimod Cobitolimod 💬 |
Cobitolimod | 097 [1] 97 💬 💬 |
651 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
TNF [1] TNF 💬 |
Adalimumab Adalimumab 💬 |
Adalimumab | 019 [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬 💬 |
652 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
TNF [1] TNF 💬 |
Certolizumab pegol Certolizumab pegol 💬 |
Certolizumab pegol | 037 [8] 37, 46, 49, 96, 97, 107, 226, 271 💬 💬 |
653 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
TNF [1] TNF 💬 |
Etanercept Etanercept 💬 |
Etanercept | 015 [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 💬 |
654 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
TNF [1] TNF 💬 |
Golimumab Golimumab 💬 |
Golimumab | 046 [8] 46, 56, 84, 96, 97, 107, 270, 271 💬 💬 |
655 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
656 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
TNF [1] TNF 💬 |
Lenalidomide Lenalidomide 💬 |
Lenalidomide | 016 [8] 16, 26, 28, 34, 49, 284, 300, 331 💬 💬 |
657 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
TNF [1] TNF 💬 |
Ozoralizumab Ozoralizumab 💬 |
Ozoralizumab | 046 [1] 46 💬 💬 |
658 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
TNF [1] TNF 💬 |
Pegsunercept Pegsunercept 💬 |
Pegsunercept | 046 [1] 46 💬 💬 |
659 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
660 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
VDR [1] VDR 💬 |
Alfacalcidol Alfacalcidol 💬 |
Alfacalcidol | 041 [8] 41, 46, 49, 50, 96, 107, 235, 238 💬 💬 |
661 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
VDR [1] VDR 💬 |
Calcifediol Calcifediol 💬 |
Calcifediol | 113 [2] 113, 299 💬 💬 |
662 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
VDR [1] VDR 💬 |
Calcipotriene Calcipotriene 💬 |
Calcipotriol | 036 [2] 36, 51 💬 💬 |
663 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
VDR [1] VDR 💬 |
Calcitriol Calcitriol 💬 |
Calcitriol | 018 [9] 18, 37, 46, 49, 66, 96, 158, 235, 326 💬 💬 |
664 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
VDR [1] VDR 💬 |
Cholecalciferol Cholecalciferol 💬 |
Cholecalciferol | 006 [24] 6 , 13, 19, 20, 28, 34, 46, 49, 51, 53, 56, 60, 65, 84, 85, 96, 97, 98, 162, 202, 228, 271, 298, 299 💬 💬 |
665 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
VDR [1] VDR 💬 |
Dihydrotachysterol Dihydrotachysterol 💬 |
Dihydrotachysterol | 006 [2] 6 , 85 💬 💬 |
666 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
VDR [1] VDR 💬 |
Eldecalcitol Eldecalcitol 💬 |
Eldecalcitol | 046 [1] 46 💬 💬 |
667 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
VDR [1] VDR 💬 |
Ergocalciferol Ergocalciferol 💬 |
Ergocalciferol | 046 [6] 46, 49, 84, 96, 97, 299 💬 💬 |
668 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
VDR [1] VDR 💬 |
Paricalcitol Paricalcitol 💬 |
Paricalcitol | 019 [5] 19, 66, 218, 238, 298 💬 💬 |
669 | Type I diabetes mellitus 💬 11 genes, 22 drugs (DrugBank) and 68 diseases |
CD80 [2] CD80, CD86 💬 |
Abatacept Abatacept 💬 |
Abatacept | 011 [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬 💬 |
670 | Type I diabetes mellitus 💬 11 genes, 22 drugs (DrugBank) and 68 diseases |
CD80 [2] CD80, CD86 💬 |
Belatacept Belatacept 💬 |
Belatacept | 046 [1] 46 💬 💬 |
671 | Type I diabetes mellitus 💬 11 genes, 22 drugs (DrugBank) and 68 diseases |
GAD1 [2] GAD1, GAD2 💬 |
Valproic acid Valproic acid 💬 |
Valproic acid | 002 [14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬 |
672 | Type I diabetes mellitus 💬 11 genes, 22 drugs (DrugBank) and 68 diseases |
IFNG [1] IFNG 💬 |
Emapalumab Emapalumab 💬 |
Emapalumab | 049 [3] 49, 65, 107 💬 💬 |
673 | Type I diabetes mellitus 💬 11 genes, 22 drugs (DrugBank) and 68 diseases |
IFNG [1] IFNG 💬 |
Fontolizumab Fontolizumab 💬 |
Fontolizumab | 046 [1] 46 💬 💬 |
674 | Type I diabetes mellitus 💬 11 genes, 22 drugs (DrugBank) and 68 diseases |
IL12A [2] IL12A, IL12B 💬 |
Ustekinumab Ustekinumab 💬 |
Ustekinumab | 037 [16] 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬 💬 |
675 | Type I diabetes mellitus 💬 11 genes, 22 drugs (DrugBank) and 68 diseases |
IL1A [1] IL1A 💬 |
Bermekimab Bermekimab 💬 |
Bermekimab | 051 [1] 51 💬 💬 |
676 | Type I diabetes mellitus 💬 11 genes, 22 drugs (DrugBank) and 68 diseases |
IL1A [2] IL1A, IL1B 💬 |
Rilonacept Rilonacept 💬 |
Rilonacept | 051 [4] 51, 106, 107, 266 💬 💬 |
677 | Type I diabetes mellitus 💬 11 genes, 22 drugs (DrugBank) and 68 diseases |
IL1A [3] IL1A, IL1B, TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
678 | Type I diabetes mellitus 💬 11 genes, 22 drugs (DrugBank) and 68 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
679 | Type I diabetes mellitus 💬 11 genes, 22 drugs (DrugBank) and 68 diseases |
IL1B [1] IL1B 💬 |
Gevokizumab Gevokizumab 💬 |
Gevokizumab | 041 [4] 41, 50, 56, 269 💬 💬 |
680 | Type I diabetes mellitus 💬 11 genes, 22 drugs (DrugBank) and 68 diseases |
LTA [1] LTA 💬 |
Pateclizumab Pateclizumab 💬 |
Pateclizumab | 046 [1] 46 💬 💬 |
681 | Type I diabetes mellitus 💬 11 genes, 22 drugs (DrugBank) and 68 diseases |
LTA [2] LTA, TNF 💬 |
Etanercept Etanercept 💬 |
Etanercept | 015 [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 💬 |
682 | Type I diabetes mellitus 💬 11 genes, 22 drugs (DrugBank) and 68 diseases |
TNF [1] TNF 💬 |
Adalimumab Adalimumab 💬 |
Adalimumab | 019 [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬 💬 |
683 | Type I diabetes mellitus 💬 11 genes, 22 drugs (DrugBank) and 68 diseases |
TNF [1] TNF 💬 |
Certolizumab pegol Certolizumab pegol 💬 |
Certolizumab pegol | 037 [8] 37, 46, 49, 96, 97, 107, 226, 271 💬 💬 |
684 | Type I diabetes mellitus 💬 11 genes, 22 drugs (DrugBank) and 68 diseases |
TNF [1] TNF 💬 |
Golimumab Golimumab 💬 |
Golimumab | 046 [8] 46, 56, 84, 96, 97, 107, 270, 271 💬 💬 |
685 | Type I diabetes mellitus 💬 11 genes, 22 drugs (DrugBank) and 68 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
686 | Type I diabetes mellitus 💬 11 genes, 22 drugs (DrugBank) and 68 diseases |
TNF [1] TNF 💬 |
Lenalidomide Lenalidomide 💬 |
Lenalidomide | 016 [8] 16, 26, 28, 34, 49, 284, 300, 331 💬 💬 |
687 | Type I diabetes mellitus 💬 11 genes, 22 drugs (DrugBank) and 68 diseases |
TNF [1] TNF 💬 |
Ozoralizumab Ozoralizumab 💬 |
Ozoralizumab | 046 [1] 46 💬 💬 |
688 | Type I diabetes mellitus 💬 11 genes, 22 drugs (DrugBank) and 68 diseases |
TNF [1] TNF 💬 |
Pegsunercept Pegsunercept 💬 |
Pegsunercept | 046 [1] 46 💬 💬 |
689 | Type I diabetes mellitus 💬 11 genes, 22 drugs (DrugBank) and 68 diseases |
TNF [1] TNF 💬 |
Pomalidomide Pomalidomide 💬 |
Pomalidomide | 028 [5] 28, 51, 85, 227, 331 💬 💬 |
690 | Type I diabetes mellitus 💬 11 genes, 22 drugs (DrugBank) and 68 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
691 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
ABCC8 [2] ABCC8, KCNJ11 💬 |
Diazoxide Diazoxide 💬 |
Diazoxide | 013 [2] 13, 193 💬 💬 |
692 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
ABCC8 [2] ABCC8, KCNJ11 💬 |
Minoxidil Minoxidil 💬 |
Minoxidil | 179 [1] 179 💬 💬 |
693 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
ABCC8 [2] ABCC8, KCNJ11 💬 |
Repaglinide Repaglinide 💬 |
Repaglinide | 006 [4] 6 , 21, 46, 299 💬 💬 |
694 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
CACNA1B [3] CACNA1B, CACNA1C, CACNA1D 💬 |
Cilnidipine Cilnidipine 💬 |
Cilnidipine | 067 [1] 67 💬 💬 |
695 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
CACNA1C [2] CACNA1C, CACNA1D 💬 |
Amlodipine Amlodipine 💬 |
Amlodipine | 013 [4] 13, 51, 67, 298 💬 💬 |
696 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
CACNA1C [2] CACNA1C, CACNA1D 💬 |
Diltiazem Diltiazem 💬 |
Diltiazem | 051 [3] 51, 58, 86 💬 💬 |
697 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
CACNA1C [2] CACNA1C, CACNA1D 💬 |
Isradipine Isradipine 💬 |
Isradipine | 006 [1] 6 💬 💬 |
698 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
CACNA1C [2] CACNA1C, CACNA1D 💬 |
Nicardipine Nicardipine 💬 |
Nicardipine | 070 [2] 70, 86 💬 💬 |
699 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
CACNA1C [2] CACNA1C, CACNA1D 💬 |
Nifedipine Nifedipine 💬 |
Nifedipine | 050 [2] 50, 81 💬 💬 |
700 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
CACNA1C [2] CACNA1C, CACNA1D 💬 |
Nilvadipine Nilvadipine 💬 |
Nilvadipine | 090 [1] 90 💬 💬 |
701 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
CACNA1C [2] CACNA1C, CACNA1D 💬 |
Perhexiline Perhexiline 💬 |
Perhexiline | 058 [2] 58, 272 💬 💬 |
702 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
CACNA1C [2] CACNA1C, CACNA1D 💬 |
Propiverine Propiverine 💬 |
Propiverine | 226 [1] 226 💬 💬 |
703 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
CACNA1C [2] CACNA1C, CACNA1D 💬 |
Topiramate Topiramate 💬 |
Topiramate | 006 [6] 6 , 97, 140, 144, 156, 193 💬 💬 |
704 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
CACNA1C [2] CACNA1C, CACNA1D 💬 |
Verapamil Verapamil 💬 |
Verapamil | 058 [4] 58, 96, 140, 167 💬 💬 |
705 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
CACNA1G [1] CACNA1G 💬 |
Flunarizine Flunarizine 💬 |
Flunarizine | 149 [1] 149 💬 💬 |
706 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
CACNA1G [1] CACNA1G 💬 |
Valproic acid Valproic acid 💬 |
Valproic acid | 002 [14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬 |
707 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
CACNA1G [1] CACNA1G 💬 |
Zonisamide Zonisamide 💬 |
Zonisamide | 006 [1] 6 💬 💬 |
708 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
INSR [1] INSR 💬 |
Insulin detemir Insulin detemir 💬 |
Insulin detemir | 299 [1] 299 💬 💬 |
709 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
INSR [1] INSR 💬 |
Insulin glargine Insulin glargine 💬 |
Insulin glargine | 299 [1] 299 💬 💬 |
710 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
INSR [1] INSR 💬 |
Insulin human Insulin human 💬 |
Insulin human | 096 [2] 96, 156 💬 💬 |
711 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
KCNJ11 [1] KCNJ11 💬 |
Amiodarone Amiodarone 💬 |
Amiodarone | 028 [2] 28, 127 💬 💬 |
712 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
MTOR [1] MTOR 💬 |
Everolimus Everolimus 💬 |
Everolimus | 034 [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 💬 |
713 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
714 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
MTOR [1] MTOR 💬 |
Temsirolimus Temsirolimus 💬 |
Temsirolimus | 013 [1] 13 💬 💬 |
715 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
PIK3CA [1] PIK3CA 💬 |
Alpelisib Alpelisib 💬 |
Alpelisib | 138 [1] 138 💬 💬 |
716 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
PIK3CA [3] PIK3CA, PIK3CB, PIK3CD 💬 |
Leniolisib Leniolisib 💬 |
Leniolisib | 053 [2] 53, 65 💬 💬 |
717 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
PIK3CD [1] PIK3CD 💬 |
Parsaclisib Parsaclisib 💬 |
Parsaclisib | 035 [3] 35, 53, 61 💬 💬 |
718 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
PRKCD [2] PRKCD, PRKCE 💬 |
Sotrastaurin Sotrastaurin 💬 |
Sotrastaurin | 097 [1] 97 💬 💬 |
719 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
TNF [1] TNF 💬 |
Adalimumab Adalimumab 💬 |
Adalimumab | 019 [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬 💬 |
720 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
TNF [1] TNF 💬 |
Certolizumab pegol Certolizumab pegol 💬 |
Certolizumab pegol | 037 [8] 37, 46, 49, 96, 97, 107, 226, 271 💬 💬 |
721 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
TNF [1] TNF 💬 |
Etanercept Etanercept 💬 |
Etanercept | 015 [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 💬 |
722 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
TNF [1] TNF 💬 |
Golimumab Golimumab 💬 |
Golimumab | 046 [8] 46, 56, 84, 96, 97, 107, 270, 271 💬 💬 |
723 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
TNF [1] TNF 💬 |
Infliximab Infliximab 💬 |
Infliximab | 035 [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬 |
724 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
TNF [1] TNF 💬 |
Lenalidomide Lenalidomide 💬 |
Lenalidomide | 016 [8] 16, 26, 28, 34, 49, 284, 300, 331 💬 💬 |
725 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
TNF [1] TNF 💬 |
Ozoralizumab Ozoralizumab 💬 |
Ozoralizumab | 046 [1] 46 💬 💬 |
726 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
TNF [1] TNF 💬 |
Pegsunercept Pegsunercept 💬 |
Pegsunercept | 046 [1] 46 💬 💬 |
727 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
TNF [1] TNF 💬 |
Pirfenidone Pirfenidone 💬 |
Pirfenidone | 013 [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬 |
728 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
TNF [1] TNF 💬 |
Pomalidomide Pomalidomide 💬 |
Pomalidomide | 028 [5] 28, 51, 85, 227, 331 💬 💬 |
729 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
730 | Tyrosine metabolism 💬 10 genes, 16 drugs (DrugBank) and 18 diseases |
ADH1A [3] ADH1A, ADH1B, ADH1C 💬 |
Fomepizole Fomepizole 💬 |
Fomepizole | 301 [1] 301 💬 💬 |
731 | Tyrosine metabolism 💬 10 genes, 16 drugs (DrugBank) and 18 diseases |
AOC3 [1] AOC3 💬 |
Hydralazine Hydralazine 💬 |
Hydralazine | 067 [1] 67 💬 💬 |
732 | Tyrosine metabolism 💬 10 genes, 16 drugs (DrugBank) and 18 diseases |
COMT [1] COMT 💬 |
Entacapone Entacapone 💬 |
Entacapone | 006 [2] 6 , 17 💬 💬 |
733 | Tyrosine metabolism 💬 10 genes, 16 drugs (DrugBank) and 18 diseases |
COMT [1] COMT 💬 |
Opicapone Opicapone 💬 |
Opicapone | 006 [1] 6 💬 💬 |
734 | Tyrosine metabolism 💬 10 genes, 16 drugs (DrugBank) and 18 diseases |
COMT [1] COMT 💬 |
Tolcapone Tolcapone 💬 |
Tolcapone | 006 [3] 6 , 28, 127 💬 💬 |
735 | Tyrosine metabolism 💬 10 genes, 16 drugs (DrugBank) and 18 diseases |
DDC [1] DDC 💬 |
Benserazide Benserazide 💬 |
Benserazide | 006 [1] 6 💬 💬 |
736 | Tyrosine metabolism 💬 10 genes, 16 drugs (DrugBank) and 18 diseases |
DDC [1] DDC 💬 |
Carbidopa Carbidopa 💬 |
Carbidopa | 006 [7] 6 , 13, 17, 90, 140, 164, 201 💬 💬 |
737 | Tyrosine metabolism 💬 10 genes, 16 drugs (DrugBank) and 18 diseases |
HPD [1] HPD 💬 |
Nitisinone Nitisinone 💬 |
Nitisinone | 006 [3] 6 , 164, 241 💬 💬 |
738 | Tyrosine metabolism 💬 10 genes, 16 drugs (DrugBank) and 18 diseases |
MAOA [1] MAOA 💬 |
Moclobemide Moclobemide 💬 |
Moclobemide | 006 [1] 6 💬 💬 |
739 | Tyrosine metabolism 💬 10 genes, 16 drugs (DrugBank) and 18 diseases |
MAOA [2] MAOA, MAOB 💬 |
Iproniazid Iproniazid 💬 |
Iproniazid | 006 [1] 6 💬 💬 |
740 | Tyrosine metabolism 💬 10 genes, 16 drugs (DrugBank) and 18 diseases |
MAOA [2] MAOA, MAOB 💬 |
Phenelzine Phenelzine 💬 |
Phenelzine | 006 [1] 6 💬 💬 |
741 | Tyrosine metabolism 💬 10 genes, 16 drugs (DrugBank) and 18 diseases |
MAOA [2] MAOA, MAOB 💬 |
Phentermine Phentermine 💬 |
Phentermine | 097 [1] 97 💬 💬 |
742 | Tyrosine metabolism 💬 10 genes, 16 drugs (DrugBank) and 18 diseases |
MAOB [1] MAOB 💬 |
Rasagiline Rasagiline 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
743 | Tyrosine metabolism 💬 10 genes, 16 drugs (DrugBank) and 18 diseases |
MAOB [1] MAOB 💬 |
Rasagiline tartrate Rasagiline tartrate 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
744 | Tyrosine metabolism 💬 10 genes, 16 drugs (DrugBank) and 18 diseases |
MAOB [1] MAOB 💬 |
Safinamide Safinamide 💬 |
Safinamide | 006 [2] 6 , 17 💬 💬 |
745 | Tyrosine metabolism 💬 10 genes, 16 drugs (DrugBank) and 18 diseases |
MAOB [1] MAOB 💬 |
Selegiline Selegiline 💬 |
Selegiline | 006 [1] 6 💬 💬 |
746 | Tyrosine metabolism 💬 10 genes, 16 drugs (DrugBank) and 18 diseases |
TPO [1] TPO 💬 |
Methimazole Methimazole 💬 |
Methimazole | 050 [1] 50 💬 💬 |