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No.	KEGG PATHWAY	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Legionellosis 💬	[1] C3 💬	Pegcetacoplan 💬	Pegcetacoplan	[4] 2 , 61, 62, 222 💬 💬
2	Legionellosis 💬	[1] CASP9 💬	Rimiducid 💬	Rimiducid	[6] 19, 60, 65, 284, 285, 326 💬 💬
3	Legionellosis 💬	[2] IL12A, IL12B 💬	Ustekinumab 💬	Ustekinumab	[16] 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬 💬
4	Legionellosis 💬	[1] IL1B 💬	Canakinumab 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬
5	Legionellosis 💬	[1] IL1B 💬	Gevokizumab 💬	Gevokizumab	[4] 41, 50, 56, 269 💬 💬
6	Legionellosis 💬	[1] IL1B 💬	Rilonacept 💬	Rilonacept	[4] 51, 106, 107, 266 💬 💬
7	Legionellosis 💬	[3] IL1B, IL6, TNF 💬	Pirfenidone 💬	Pirfenidone	[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬
8	Legionellosis 💬	[1] IL6 💬	Olokizumab 💬	Olokizumab	[2] 46, 96 💬 💬
9	Legionellosis 💬	[1] IL6 💬	Siltuximab 💬	Siltuximab	[2] 28, 331 💬 💬
10	Legionellosis 💬	[1] IL6 💬	Sirukumab 💬	Sirukumab	[2] 41, 46 💬 💬
11	Legionellosis 💬	[2] IL6, TNF 💬	Pomalidomide 💬	Pomalidomide	[5] 28, 51, 85, 227, 331 💬 💬
12	Legionellosis 💬	[1] NFKB1 💬	Iguratimod 💬	Iguratimod	[5] 46, 51, 53, 271, 300 💬 💬
13	Legionellosis 💬	[1] RELA 💬	Edasalonexent 💬	Edasalonexent	[1] 113 💬 💬
14	Legionellosis 💬	[1] TNF 💬	Adalimumab 💬	Adalimumab	[17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬 💬
15	Legionellosis 💬	[1] TNF 💬	Certolizumab pegol 💬	Certolizumab pegol	[8] 37, 46, 49, 96, 97, 107, 226, 271 💬 💬
16	Legionellosis 💬	[1] TNF 💬	Etanercept 💬	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 💬
17	Legionellosis 💬	[1] TNF 💬	Golimumab 💬	Golimumab	[8] 46, 56, 84, 96, 97, 107, 270, 271 💬 💬
18	Legionellosis 💬	[1] TNF 💬	Infliximab 💬	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬
19	Legionellosis 💬	[1] TNF 💬	Lenalidomide 💬	Lenalidomide	[8] 16, 26, 28, 34, 49, 284, 300, 331 💬 💬
20	Legionellosis 💬	[1] TNF 💬	Ozoralizumab 💬	Ozoralizumab	[1] 46 💬 💬
21	Legionellosis 💬	[1] TNF 💬	Pegsunercept 💬	Pegsunercept	[1] 46 💬 💬
22	Legionellosis 💬	[1] TNF 💬	Thalidomide 💬	Thalidomide	[20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬
23	Leishmaniasis 💬	[1] C3 💬	Pegcetacoplan 💬	Pegcetacoplan	[4] 2 , 61, 62, 222 💬 💬
24	Leishmaniasis 💬	[1] IFNG 💬	Emapalumab 💬	Emapalumab	[3] 49, 65, 107 💬 💬
25	Leishmaniasis 💬	[1] IFNG 💬	Fontolizumab 💬	Fontolizumab	[1] 46 💬 💬
26	Leishmaniasis 💬	[2] IFNGR1, IFNGR2 💬	Interferon gamma-1b 💬	Interferon gamma-1b	[7] 18, 65, 85, 228, 299, 301, 326 💬 💬
27	Leishmaniasis 💬	[4] IL10, IL1A, IL1B, TNF 💬	Pirfenidone 💬	Pirfenidone	[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬
28	Leishmaniasis 💬	[2] IL12A, IL12B 💬	Ustekinumab 💬	Ustekinumab	[16] 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬 💬
29	Leishmaniasis 💬	[1] IL1A 💬	Bermekimab 💬	Bermekimab	[1] 51 💬 💬
30	Leishmaniasis 💬	[2] IL1A, IL1B 💬	Rilonacept 💬	Rilonacept	[4] 51, 106, 107, 266 💬 💬
31	Leishmaniasis 💬	[1] IL1B 💬	Canakinumab 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬
32	Leishmaniasis 💬	[1] IL1B 💬	Gevokizumab 💬	Gevokizumab	[4] 41, 50, 56, 269 💬 💬
33	Leishmaniasis 💬	[1] IL4 💬	Binetrakin 💬	Binetrakin	[1] 46 💬 💬
34	Leishmaniasis 💬	[1] ITGA4 💬	Abrilumab 💬	Abrilumab	[2] 96, 97 💬 💬
35	Leishmaniasis 💬	[1] ITGA4 💬	Firategrast 💬	Firategrast	[1] 13 💬 💬
36	Leishmaniasis 💬	[1] ITGA4 💬	Natalizumab 💬	Natalizumab	[6] 13, 15, 25, 46, 63, 96 💬 💬
37	Leishmaniasis 💬	[1] ITGA4 💬	Vedolizumab 💬	Vedolizumab	[3] 94, 96, 97 💬 💬
38	Leishmaniasis 💬	[1] JAK1 💬	Abrocitinib 💬	Abrocitinib	[1] 84 💬 💬
39	Leishmaniasis 💬	[1] JAK1 💬	Filgotinib 💬	Filgotinib	[6] 46, 53, 96, 97, 222, 271 💬 💬
40	Leishmaniasis 💬	[1] JAK1 💬	Itacitinib 💬	Itacitinib	[4] 46, 51, 97, 228 💬 💬
41	Leishmaniasis 💬	[1] JAK1 💬	Upadacitinib 💬	Upadacitinib	[8] 40, 41, 46, 49, 96, 97, 107, 271 💬 💬
42	Leishmaniasis 💬	[2] JAK1, JAK2 💬	Baricitinib 💬	Baricitinib	[13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬
43	Leishmaniasis 💬	[2] JAK1, JAK2 💬	Peficitinib 💬	Peficitinib	[1] 46 💬 💬
44	Leishmaniasis 💬	[2] JAK1, JAK2 💬	Ruxolitinib 💬	Ruxolitinib	[3] 60, 65, 228 💬 💬
45	Leishmaniasis 💬	[2] JAK1, JAK2 💬	Tofacitinib 💬	Tofacitinib	[15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬 💬
46	Leishmaniasis 💬	[4] MAPK11, MAPK12, MAPK13, MAPK14 💬	Losmapimod 💬	Losmapimod	[2] 113, 222 💬 💬
47	Leishmaniasis 💬	[4] MAPK11, MAPK12, MAPK13, MAPK14 💬	Neflamapimod 💬	Neflamapimod	[1] 8 💬 💬
48	Leishmaniasis 💬	[1] NFKB1 💬	Iguratimod 💬	Iguratimod	[5] 46, 51, 53, 271, 300 💬 💬
49	Leishmaniasis 💬	[1] PRKCB 💬	Enzastaurin 💬	Enzastaurin	[1] 168 💬 💬
50	Leishmaniasis 💬	[1] PTGS2 💬	Aceclofenac 💬	Aceclofenac	[1] 46 💬 💬
51	Leishmaniasis 💬	[1] PTGS2 💬	Acetaminophen 💬	Acetaminophen	[15] 3 , 6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 💬
52	Leishmaniasis 💬	[1] PTGS2 💬	Aspirin 💬	Acetylsalicylic acid	[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬
53	Leishmaniasis 💬	[1] PTGS2 💬	Celecoxib 💬	Celecoxib	[10] 2 , 3 , 34, 46, 70, 89, 107, 161, 171, 271 💬 💬
54	Leishmaniasis 💬	[1] PTGS2 💬	Diclofenac 💬	Diclofenac	[5] 13, 34, 46, 78, 271 💬 💬
55	Leishmaniasis 💬	[1] PTGS2 💬	Diflunisal 💬	Diflunisal	[1] 28 💬 💬
56	Leishmaniasis 💬	[1] PTGS2 💬	Etodolac 💬	Etodolac	[1] 46 💬 💬
57	Leishmaniasis 💬	[1] PTGS2 💬	Etoricoxib 💬	Etoricoxib	[2] 46, 271 💬 💬
58	Leishmaniasis 💬	[1] PTGS2 💬	Flurbiprofen 💬	Flurbiprofen	[3] 13, 21, 46 💬 💬
59	Leishmaniasis 💬	[1] PTGS2 💬	Ibuprofen 💬	Ibuprofen	[7] 13, 46, 65, 107, 113, 271, 299 💬 💬
60	Leishmaniasis 💬	[1] PTGS2 💬	Indomethacin 💬	Indomethacin	[3] 225, 271, 298 💬 💬
61	Leishmaniasis 💬	[1] PTGS2 💬	Ketoprofen 💬	Ketoprofen	[1] 46 💬 💬
62	Leishmaniasis 💬	[1] PTGS2 💬	Ketorolac 💬	Ketorolac	[2] 70, 226 💬 💬
63	Leishmaniasis 💬	[1] PTGS2 💬	Loxoprofen 💬	Loxoprofen	[2] 46, 271 💬 💬
64	Leishmaniasis 💬	[1] PTGS2 💬	Lumiracoxib 💬	Lumiracoxib	[1] 46 💬 💬
65	Leishmaniasis 💬	[1] PTGS2 💬	Meloxicam 💬	Meloxicam	[4] 46, 49, 271, 296 💬 💬
66	Leishmaniasis 💬	[1] PTGS2 💬	Naproxen 💬	Naproxen	[4] 13, 46, 107, 271 💬 💬
67	Leishmaniasis 💬	[1] PTGS2 💬	Nimesulide 💬	Nimesulide	[1] 46 💬 💬
68	Leishmaniasis 💬	[1] PTGS2 💬	Parecoxib 💬	Parecoxib	[2] 46, 271 💬 💬
69	Leishmaniasis 💬	[1] PTGS2 💬	Rofecoxib 💬	Rofecoxib	[1] 46 💬 💬
70	Leishmaniasis 💬	[1] PTGS2 💬	Salsalate 💬	Salsalate	[1] 5 💬 💬
71	Leishmaniasis 💬	[1] PTGS2 💬	Sulindac 💬	Sulindac	[1] 206 💬 💬
72	Leishmaniasis 💬	[1] PTGS2 💬	Tolfenamic acid 💬	Tolfenamic acid	[1] 5 💬 💬
73	Leishmaniasis 💬	[1] PTGS2 💬	Valdecoxib 💬	Valdecoxib	[1] 46 💬 💬
74	Leishmaniasis 💬	[1] RELA 💬	Edasalonexent 💬	Edasalonexent	[1] 113 💬 💬
75	Leishmaniasis 💬	[3] TGFB1, TGFB2, TGFB3 💬	Fresolimumab 💬	Fresolimumab	[3] 51, 85, 222 💬 💬
76	Leishmaniasis 💬	[1] TNF 💬	Adalimumab 💬	Adalimumab	[17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬 💬
77	Leishmaniasis 💬	[1] TNF 💬	Certolizumab pegol 💬	Certolizumab pegol	[8] 37, 46, 49, 96, 97, 107, 226, 271 💬 💬
78	Leishmaniasis 💬	[1] TNF 💬	Etanercept 💬	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 💬
79	Leishmaniasis 💬	[1] TNF 💬	Golimumab 💬	Golimumab	[8] 46, 56, 84, 96, 97, 107, 270, 271 💬 💬
80	Leishmaniasis 💬	[1] TNF 💬	Infliximab 💬	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬
81	Leishmaniasis 💬	[1] TNF 💬	Lenalidomide 💬	Lenalidomide	[8] 16, 26, 28, 34, 49, 284, 300, 331 💬 💬
82	Leishmaniasis 💬	[1] TNF 💬	Ozoralizumab 💬	Ozoralizumab	[1] 46 💬 💬
83	Leishmaniasis 💬	[1] TNF 💬	Pegsunercept 💬	Pegsunercept	[1] 46 💬 💬
84	Leishmaniasis 💬	[1] TNF 💬	Pomalidomide 💬	Pomalidomide	[5] 28, 51, 85, 227, 331 💬 💬
85	Leishmaniasis 💬	[1] TNF 💬	Thalidomide 💬	Thalidomide	[20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬
86	Leukocyte transendothelial migration 💬	[1] CXCR4 💬	Plerixafor 💬	Plerixafor	[5] 19, 20, 65, 285, 299 💬 💬
87	Leukocyte transendothelial migration 💬	[1] ITGA4 💬	Abrilumab 💬	Abrilumab	[2] 96, 97 💬 💬
88	Leukocyte transendothelial migration 💬	[1] ITGA4 💬	Firategrast 💬	Firategrast	[1] 13 💬 💬
89	Leukocyte transendothelial migration 💬	[1] ITGA4 💬	Natalizumab 💬	Natalizumab	[6] 13, 15, 25, 46, 63, 96 💬 💬
90	Leukocyte transendothelial migration 💬	[1] ITGA4 💬	Vedolizumab 💬	Vedolizumab	[3] 94, 96, 97 💬 💬
91	Leukocyte transendothelial migration 💬	[1] ITGAL 💬	Efalizumab 💬	Efalizumab	[9] 11, 13, 37, 46, 49, 53, 61, 95, 96 💬 💬
92	Leukocyte transendothelial migration 💬	[4] MAPK11, MAPK12, MAPK13, MAPK14 💬	Losmapimod 💬	Losmapimod	[2] 113, 222 💬 💬
93	Leukocyte transendothelial migration 💬	[4] MAPK11, MAPK12, MAPK13, MAPK14 💬	Neflamapimod 💬	Neflamapimod	[1] 8 💬 💬
94	Leukocyte transendothelial migration 💬	[1] PIK3CA 💬	Alpelisib 💬	Alpelisib	[1] 138 💬 💬
95	Leukocyte transendothelial migration 💬	[3] PIK3CA, PIK3CB, PIK3CD 💬	Leniolisib 💬	Leniolisib	[2] 53, 65 💬 💬
96	Leukocyte transendothelial migration 💬	[1] PIK3CD 💬	Parsaclisib 💬	Parsaclisib	[3] 35, 53, 61 💬 💬
97	Leukocyte transendothelial migration 💬	[1] PRKCB 💬	Enzastaurin 💬	Enzastaurin	[1] 168 💬 💬
98	Leukocyte transendothelial migration 💬	[2] ROCK1, ROCK2 💬	Fasudil 💬	Fasudil	[4] 2 , 5 , 7 , 51 💬 💬
99	Leukocyte transendothelial migration 💬	[1] ROCK2 💬	Belumosudil 💬	Belumosudil	[2] 51, 85 💬 💬
100	Lipid and atherosclerosis 💬	[1] BCL2 💬	Venetoclax 💬	Venetoclax	[1] 28 💬 💬
101	Lipid and atherosclerosis 💬	[1] CASP9 💬	Rimiducid 💬	Rimiducid	[6] 19, 60, 65, 284, 285, 326 💬 💬
102	Lipid and atherosclerosis 💬	[4] CCL2, IL1B, IL6, TNF 💬	Pirfenidone 💬	Pirfenidone	[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬
103	Lipid and atherosclerosis 💬	[1] CD40 💬	Bleselumab 💬	Bleselumab	[1] 222 💬 💬
104	Lipid and atherosclerosis 💬	[1] CD40 💬	Iscalimab 💬	Iscalimab	[2] 49, 53 💬 💬
105	Lipid and atherosclerosis 💬	[1] CD40 💬	Ravagalimab 💬	Ravagalimab	[2] 53, 97 💬 💬
106	Lipid and atherosclerosis 💬	[1] CD40LG 💬	Toralizumab 💬	Toralizumab	[1] 63 💬 💬
107	Lipid and atherosclerosis 💬	[13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬	Rontalizumab 💬	Rontalizumab	[1] 49 💬 💬
108	Lipid and atherosclerosis 💬	[13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬	Sifalimumab 💬	Sifalimumab	[1] 49 💬 💬
109	Lipid and atherosclerosis 💬	[2] IL12A, IL12B 💬	Ustekinumab 💬	Ustekinumab	[16] 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬 💬
110	Lipid and atherosclerosis 💬	[1] IL1B 💬	Canakinumab 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬
111	Lipid and atherosclerosis 💬	[1] IL1B 💬	Gevokizumab 💬	Gevokizumab	[4] 41, 50, 56, 269 💬 💬
112	Lipid and atherosclerosis 💬	[1] IL1B 💬	Rilonacept 💬	Rilonacept	[4] 51, 106, 107, 266 💬 💬
113	Lipid and atherosclerosis 💬	[1] IL6 💬	Olokizumab 💬	Olokizumab	[2] 46, 96 💬 💬
114	Lipid and atherosclerosis 💬	[1] IL6 💬	Siltuximab 💬	Siltuximab	[2] 28, 331 💬 💬
115	Lipid and atherosclerosis 💬	[1] IL6 💬	Sirukumab 💬	Sirukumab	[2] 41, 46 💬 💬
116	Lipid and atherosclerosis 💬	[2] IL6, TNF 💬	Pomalidomide 💬	Pomalidomide	[5] 28, 51, 85, 227, 331 💬 💬
117	Lipid and atherosclerosis 💬	[1] JAK2 💬	Baricitinib 💬	Baricitinib	[13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬
118	Lipid and atherosclerosis 💬	[1] JAK2 💬	Peficitinib 💬	Peficitinib	[1] 46 💬 💬
119	Lipid and atherosclerosis 💬	[1] JAK2 💬	Ruxolitinib 💬	Ruxolitinib	[3] 60, 65, 228 💬 💬
120	Lipid and atherosclerosis 💬	[1] JAK2 💬	Tofacitinib 💬	Tofacitinib	[15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬 💬
121	Lipid and atherosclerosis 💬	[1] MAP3K5 💬	Selonsertib 💬	Selonsertib	[1] 86 💬 💬
122	Lipid and atherosclerosis 💬	[4] MAPK11, MAPK12, MAPK13, MAPK14 💬	Losmapimod 💬	Losmapimod	[2] 113, 222 💬 💬
123	Lipid and atherosclerosis 💬	[4] MAPK11, MAPK12, MAPK13, MAPK14 💬	Neflamapimod 💬	Neflamapimod	[1] 8 💬 💬
124	Lipid and atherosclerosis 💬	[1] NFE2L2 💬	Omaveloxolone 💬	Omaveloxolone	[1] 18 💬 💬
125	Lipid and atherosclerosis 💬	[1] NFKB1 💬	Iguratimod 💬	Iguratimod	[5] 46, 51, 53, 271, 300 💬 💬
126	Lipid and atherosclerosis 💬	[1] PIK3CA 💬	Alpelisib 💬	Alpelisib	[1] 138 💬 💬
127	Lipid and atherosclerosis 💬	[3] PIK3CA, PIK3CB, PIK3CD 💬	Leniolisib 💬	Leniolisib	[2] 53, 65 💬 💬
128	Lipid and atherosclerosis 💬	[1] PIK3CD 💬	Parsaclisib 💬	Parsaclisib	[3] 35, 53, 61 💬 💬
129	Lipid and atherosclerosis 💬	[1] PPARG 💬	Bocidelpar 💬	Bocidelpar	[1] 113 💬 💬
130	Lipid and atherosclerosis 💬	[1] PPARG 💬	Leriglitazone 💬	Leriglitazone	[1] 20 💬 💬
131	Lipid and atherosclerosis 💬	[1] PPARG 💬	Pioglitazone 💬	Pioglitazone	[17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬 💬
132	Lipid and atherosclerosis 💬	[1] PPARG 💬	Rosiglitazone 💬	Rosiglitazone	[5] 46, 75, 97, 222, 265 💬 💬
133	Lipid and atherosclerosis 💬	[1] PPARG 💬	Seladelpar 💬	Seladelpar	[2] 93, 94 💬 💬
134	Lipid and atherosclerosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	Cyclosporine 💬	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬
135	Lipid and atherosclerosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	Pimecrolimus 💬	Pimecrolimus	[1] 160 💬 💬
136	Lipid and atherosclerosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	Tacrolimus 💬	Tacrolimus	[34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬
137	Lipid and atherosclerosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	Tacrolimus 💬	Tacrolimus	[34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬
138	Lipid and atherosclerosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	Voclosporin 💬	Voclosporin	[2] 49, 222 💬 💬
139	Lipid and atherosclerosis 💬	[1] RELA 💬	Edasalonexent 💬	Edasalonexent	[1] 113 💬 💬
140	Lipid and atherosclerosis 💬	[1] ROCK2 💬	Belumosudil 💬	Belumosudil	[2] 51, 85 💬 💬
141	Lipid and atherosclerosis 💬	[1] ROCK2 💬	Fasudil 💬	Fasudil	[4] 2 , 5 , 7 , 51 💬 💬
142	Lipid and atherosclerosis 💬	[3] RXRA, RXRB, RXRG 💬	Acitretin 💬	Acitretin	[1] 37 💬 💬
143	Lipid and atherosclerosis 💬	[3] RXRA, RXRB, RXRG 💬	Alitretinoin 💬	Alitretinoin	[1] 49 💬 💬
144	Lipid and atherosclerosis 💬	[3] RXRA, RXRB, RXRG 💬	Bexarotene 💬	Bexarotene	[2] 13, 75 💬 💬
145	Lipid and atherosclerosis 💬	[1] SRC 💬	Bosutinib 💬	Bosutinib	[2] 2 , 67 💬 💬
146	Lipid and atherosclerosis 💬	[1] SRC 💬	Dasatinib 💬	Dasatinib	[2] 51, 85 💬 💬
147	Lipid and atherosclerosis 💬	[1] SRC 💬	Dasatinib 💬	Dasatinib	[2] 51, 85 💬 💬
148	Lipid and atherosclerosis 💬	[1] SRC 💬	Saracatinib 💬	Saracatinib	[3] 6 , 89, 272 💬 💬
149	Lipid and atherosclerosis 💬	[1] TNF 💬	Adalimumab 💬	Adalimumab	[17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬 💬
150	Lipid and atherosclerosis 💬	[1] TNF 💬	Certolizumab pegol 💬	Certolizumab pegol	[8] 37, 46, 49, 96, 97, 107, 226, 271 💬 💬
151	Lipid and atherosclerosis 💬	[1] TNF 💬	Etanercept 💬	Etanercept	[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 💬
152	Lipid and atherosclerosis 💬	[1] TNF 💬	Golimumab 💬	Golimumab	[8] 46, 56, 84, 96, 97, 107, 270, 271 💬 💬
153	Lipid and atherosclerosis 💬	[1] TNF 💬	Infliximab 💬	Infliximab	[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬
154	Lipid and atherosclerosis 💬	[1] TNF 💬	Lenalidomide 💬	Lenalidomide	[8] 16, 26, 28, 34, 49, 284, 300, 331 💬 💬
155	Lipid and atherosclerosis 💬	[1] TNF 💬	Ozoralizumab 💬	Ozoralizumab	[1] 46 💬 💬
156	Lipid and atherosclerosis 💬	[1] TNF 💬	Pegsunercept 💬	Pegsunercept	[1] 46 💬 💬
157	Lipid and atherosclerosis 💬	[1] TNF 💬	Thalidomide 💬	Thalidomide	[20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬
158	Long-term depression 💬	[1] BRAF 💬	Dabrafenib 💬	Dabrafenib	[1] 34 💬 💬
159	Long-term depression 💬	[2] BRAF, RAF1 💬	Sorafenib 💬	Sorafenib	[2] 34, 86 💬 💬
160	Long-term depression 💬	[1] CRHR1 💬	Corticorelin 💬	Corticorelin	[1] 75 💬 💬
161	Long-term depression 💬	[1] CRHR1 💬	Corticorelin ovine triflutate 💬	Corticorelin ovine triflutate	[1] 75 💬 💬
162	Long-term depression 💬	[3] GRIA1, GRIA2, GRIA3 💬	Perampanel 💬	Perampanel	[3] 2 , 6 , 144 💬 💬
163	Long-term depression 💬	[3] GRIA1, GRIA2, GRIA3 💬	Riluzole 💬	Riluzole	[9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬
164	Long-term depression 💬	[3] GRIA1, GRIA2, GRIA3 💬	Talampanel 💬	Talampanel	[2] 2 , 6 💬 💬
165	Long-term depression 💬	[3] GRIA1, GRIA2, GRIA3 💬	Topiramate 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬 💬
166	Long-term depression 💬	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	Amyl nitrite 💬	Amyl Nitrite	[1] 58 💬 💬
167	Long-term depression 💬	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	Riociguat 💬	Riociguat	[6] 51, 84, 86, 88, 225, 299 💬 💬
168	Long-term depression 💬	[1] IGF1R 💬	Linsitinib 💬	Linsitinib	[1] 232 💬 💬
169	Long-term depression 💬	[1] IGF1R 💬	Mecasermin 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬 💬
170	Long-term depression 💬	[1] IGF1R 💬	Teprotumumab 💬	Teprotumumab	[1] 51 💬 💬
171	Long-term depression 💬	[2] MAP2K1, MAP2K2 💬	Binimetinib 💬	Binimetinib	[1] 34 💬 💬
172	Long-term depression 💬	[2] MAP2K1, MAP2K2 💬	Cobimetinib 💬	Cobimetinib	[1] 280 💬 💬
173	Long-term depression 💬	[2] MAP2K1, MAP2K2 💬	Mirdametinib 💬	Mirdametinib	[1] 34 💬 💬
174	Long-term depression 💬	[2] MAP2K1, MAP2K2 💬	Selumetinib 💬	Selumetinib	[1] 34 💬 💬
175	Long-term depression 💬	[2] MAP2K1, MAP2K2 💬	Trametinib 💬	Trametinib	[4] 2 , 34, 279, 280 💬 💬
176	Long-term depression 💬	[1] PRKCB 💬	Enzastaurin 💬	Enzastaurin	[1] 168 💬 💬
177	Long-term potentiation 💬	[1] BRAF 💬	Dabrafenib 💬	Dabrafenib	[1] 34 💬 💬
178	Long-term potentiation 💬	[2] BRAF, RAF1 💬	Sorafenib 💬	Sorafenib	[2] 34, 86 💬 💬
179	Long-term potentiation 💬	[1] CACNA1C 💬	Amlodipine 💬	Amlodipine	[4] 13, 51, 67, 298 💬 💬
180	Long-term potentiation 💬	[1] CACNA1C 💬	Cilnidipine 💬	Cilnidipine	[1] 67 💬 💬
181	Long-term potentiation 💬	[1] CACNA1C 💬	Diltiazem 💬	Diltiazem	[3] 51, 58, 86 💬 💬
182	Long-term potentiation 💬	[1] CACNA1C 💬	Isradipine 💬	Isradipine	[1] 6 💬 💬
183	Long-term potentiation 💬	[1] CACNA1C 💬	Nicardipine 💬	Nicardipine	[2] 70, 86 💬 💬
184	Long-term potentiation 💬	[1] CACNA1C 💬	Nifedipine 💬	Nifedipine	[2] 50, 81 💬 💬
185	Long-term potentiation 💬	[1] CACNA1C 💬	Nilvadipine 💬	Nilvadipine	[1] 90 💬 💬
186	Long-term potentiation 💬	[1] CACNA1C 💬	Perhexiline 💬	Perhexiline	[2] 58, 272 💬 💬
187	Long-term potentiation 💬	[1] CACNA1C 💬	Propiverine 💬	Propiverine	[1] 226 💬 💬
188	Long-term potentiation 💬	[1] CACNA1C 💬	Verapamil 💬	Verapamil	[4] 58, 96, 140, 167 💬 💬
189	Long-term potentiation 💬	[3] CACNA1C, GRIA1, GRIA2 💬	Topiramate 💬	Topiramate	[6] 6 , 97, 140, 144, 156, 193 💬 💬
190	Long-term potentiation 💬	[2] GRIA1, GRIA2 💬	Perampanel 💬	Perampanel	[3] 2 , 6 , 144 💬 💬
191	Long-term potentiation 💬	[2] GRIA1, GRIA2 💬	Talampanel 💬	Talampanel	[2] 2 , 6 💬 💬
192	Long-term potentiation 💬	[7] GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬	Riluzole 💬	Riluzole	[9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬
193	Long-term potentiation 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬	Acamprosate 💬	Acamprosate	[2] 6 , 206 💬 💬
194	Long-term potentiation 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬	Amantadine 💬	Amantadine	[4] 6 , 8 , 13, 127 💬 💬
195	Long-term potentiation 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬	Dextromethorphan 💬	Dextromethorphan	[11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬 💬
196	Long-term potentiation 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬	Esketamine 💬	Esketamine	[3] 2 , 4 , 70 💬 💬
197	Long-term potentiation 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬	Ketamine 💬	Ketamine	[8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬
198	Long-term potentiation 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬	Latrepirdine 💬	Latrepirdine	[1] 8 💬 💬
199	Long-term potentiation 💬	[5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬	Memantine 💬	Memantine	[8] 2 , 6 , 8 , 13, 49, 127, 205, 206 💬 💬
200	Long-term potentiation 💬	[2] MAP2K1, MAP2K2 💬	Binimetinib 💬	Binimetinib	[1] 34 💬 💬
201	Long-term potentiation 💬	[2] MAP2K1, MAP2K2 💬	Cobimetinib 💬	Cobimetinib	[1] 280 💬 💬
202	Long-term potentiation 💬	[2] MAP2K1, MAP2K2 💬	Mirdametinib 💬	Mirdametinib	[1] 34 💬 💬
203	Long-term potentiation 💬	[2] MAP2K1, MAP2K2 💬	Selumetinib 💬	Selumetinib	[1] 34 💬 💬
204	Long-term potentiation 💬	[2] MAP2K1, MAP2K2 💬	Trametinib 💬	Trametinib	[4] 2 , 34, 279, 280 💬 💬
205	Long-term potentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	Cyclosporine 💬	Cyclosporine	[44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬
206	Long-term potentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	Pimecrolimus 💬	Pimecrolimus	[1] 160 💬 💬
207	Long-term potentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	Tacrolimus 💬	Tacrolimus	[34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬
208	Long-term potentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	Tacrolimus 💬	Tacrolimus	[34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬
209	Long-term potentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	Voclosporin 💬	Voclosporin	[2] 49, 222 💬 💬
210	Long-term potentiation 💬	[1] PRKCB 💬	Enzastaurin 💬	Enzastaurin	[1] 168 💬 💬
211	Longevity regulating pathway 💬	[1] IGF1R 💬	Linsitinib 💬	Linsitinib	[1] 232 💬 💬
212	Longevity regulating pathway 💬	[1] IGF1R 💬	Mecasermin 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬 💬
213	Longevity regulating pathway 💬	[1] IGF1R 💬	Teprotumumab 💬	Teprotumumab	[1] 51 💬 💬
214	Longevity regulating pathway 💬	[1] INSR 💬	Insulin detemir 💬	Insulin detemir	[1] 299 💬 💬
215	Longevity regulating pathway 💬	[1] INSR 💬	Insulin glargine 💬	Insulin glargine	[1] 299 💬 💬
216	Longevity regulating pathway 💬	[1] INSR 💬	Insulin human 💬	Insulin human	[2] 96, 156 💬 💬
217	Longevity regulating pathway 💬	[1] MTOR 💬	Everolimus 💬	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 💬
218	Longevity regulating pathway 💬	[1] MTOR 💬	Sirolimus 💬	Sirolimus	[40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
219	Longevity regulating pathway 💬	[1] MTOR 💬	Temsirolimus 💬	Temsirolimus	[1] 13 💬 💬
220	Longevity regulating pathway 💬	[1] NFKB1 💬	Iguratimod 💬	Iguratimod	[5] 46, 51, 53, 271, 300 💬 💬
221	Longevity regulating pathway 💬	[1] PIK3CA 💬	Alpelisib 💬	Alpelisib	[1] 138 💬 💬
222	Longevity regulating pathway 💬	[3] PIK3CA, PIK3CB, PIK3CD 💬	Leniolisib 💬	Leniolisib	[2] 53, 65 💬 💬
223	Longevity regulating pathway 💬	[1] PIK3CD 💬	Parsaclisib 💬	Parsaclisib	[3] 35, 53, 61 💬 💬
224	Longevity regulating pathway 💬	[1] PPARG 💬	Bocidelpar 💬	Bocidelpar	[1] 113 💬 💬
225	Longevity regulating pathway 💬	[1] PPARG 💬	Leriglitazone 💬	Leriglitazone	[1] 20 💬 💬
226	Longevity regulating pathway 💬	[1] PPARG 💬	Pioglitazone 💬	Pioglitazone	[17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬 💬
227	Longevity regulating pathway 💬	[1] PPARG 💬	Rosiglitazone 💬	Rosiglitazone	[5] 46, 75, 97, 222, 265 💬 💬
228	Longevity regulating pathway 💬	[1] PPARG 💬	Seladelpar 💬	Seladelpar	[2] 93, 94 💬 💬
229	Longevity regulating pathway 💬	[2] PRKAA1, PRKAA2 💬	Metformin 💬	Metformin	[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
230	Longevity regulating pathway 💬	[1] RELA 💬	Edasalonexent 💬	Edasalonexent	[1] 113 💬 💬
231	Longevity regulating pathway - multiple species 💬	[2] HDAC1, HDAC2 💬	Vorinostat 💬	Vorinostat	[2] 75, 96 💬 💬
232	Longevity regulating pathway - multiple species 💬	[1] IGF1R 💬	Linsitinib 💬	Linsitinib	[1] 232 💬 💬
233	Longevity regulating pathway - multiple species 💬	[1] IGF1R 💬	Mecasermin 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬 💬
234	Longevity regulating pathway - multiple species 💬	[1] IGF1R 💬	Teprotumumab 💬	Teprotumumab	[1] 51 💬 💬
235	Longevity regulating pathway - multiple species 💬	[1] INSR 💬	Insulin detemir 💬	Insulin detemir	[1] 299 💬 💬
236	Longevity regulating pathway - multiple species 💬	[1] INSR 💬	Insulin glargine 💬	Insulin glargine	[1] 299 💬 💬
237	Longevity regulating pathway - multiple species 💬	[1] INSR 💬	Insulin human 💬	Insulin human	[2] 96, 156 💬 💬
238	Longevity regulating pathway - multiple species 💬	[1] MTOR 💬	Everolimus 💬	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 💬
239	Longevity regulating pathway - multiple species 💬	[1] MTOR 💬	Sirolimus 💬	Sirolimus	[40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
240	Longevity regulating pathway - multiple species 💬	[1] MTOR 💬	Temsirolimus 💬	Temsirolimus	[1] 13 💬 💬
241	Longevity regulating pathway - multiple species 💬	[1] PIK3CA 💬	Alpelisib 💬	Alpelisib	[1] 138 💬 💬
242	Longevity regulating pathway - multiple species 💬	[3] PIK3CA, PIK3CB, PIK3CD 💬	Leniolisib 💬	Leniolisib	[2] 53, 65 💬 💬
243	Longevity regulating pathway - multiple species 💬	[1] PIK3CD 💬	Parsaclisib 💬	Parsaclisib	[3] 35, 53, 61 💬 💬
244	Longevity regulating pathway - multiple species 💬	[2] PRKAA1, PRKAA2 💬	Metformin 💬	Metformin	[25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬
245	Longevity regulating pathway - multiple species 💬	[1] SOD1 💬	Tofersen 💬	Tofersen	[1] 2 💬 💬
246	Lysosome 💬	[1] ARSB 💬	Galsulfase 💬	Galsulfase	[1] 19 💬 💬
247	Lysosome 💬	[1] CTSC 💬	Brensocatib 💬	Brensocatib	[1] 299 💬 💬
248	Lysosome 💬	[1] GAA 💬	Acarbose 💬	Acarbose	[1] 298 💬 💬
249	Lysosome 💬	[1] GAA 💬	Alglucosidase alfa 💬	Alglucosidase alfa	[1] 256 💬 💬
250	Lysosome 💬	[1] GAA 💬	Avalglucosidase alfa 💬	Avalglucosidase alfa	[1] 256 💬 💬
251	Lysosome 💬	[1] GAA 💬	Cipaglucosidase alfa 💬	Cipaglucosidase alfa	[1] 256 💬 💬
252	Lysosome 💬	[1] GAA 💬	Duvoglustat 💬	Duvoglustat	[1] 256 💬 💬
253	Lysosome 💬	[1] GALNS 💬	Elosulfase alfa 💬	Elosulfase alfa	[1] 19 💬 💬
254	Lysosome 💬	[1] GBA1 💬	Alglucerase 💬	Alglucerase	[1] 19 💬 💬
255	Lysosome 💬	[1] GBA1 💬	Imiglucerase 💬	Imiglucerase	[1] 19 💬 💬
256	Lysosome 💬	[1] GBA1 💬	Taliglucerase alfa 💬	Taliglucerase alfa	[1] 19 💬 💬
257	Lysosome 💬	[1] GBA1 💬	Velaglucerase alfa 💬	Velaglucerase alfa	[1] 19 💬 💬
258	Lysosome 💬	[1] GLA 💬	Agalsidase alfa 💬	Agalsidase alfa	[1] 19 💬 💬
259	Lysosome 💬	[1] GLA 💬	Agalsidase beta 💬	Agalsidase beta	[1] 19 💬 💬
260	Lysosome 💬	[1] GUSB 💬	Vestronidase alfa 💬	Vestronidase alfa	[1] 19 💬 💬
261	Lysosome 💬	[1] IDS 💬	Idursulfase 💬	Idursulfase	[1] 19 💬 💬
262	Lysosome 💬	[1] IDS 💬	Idursulfase beta 💬	Idursulfase beta	[1] 19 💬 💬
263	Lysosome 💬	[1] IDS 💬	Pabinafusp alfa 💬	Pabinafusp alfa	[1] 19 💬 💬
264	Lysosome 💬	[1] IDUA 💬	Laronidase 💬	Laronidase	[2] 19, 256 💬 💬
265	Lysosome 💬	[1] LIPA 💬	Sebelipase alfa 💬	Sebelipase alfa	[1] 19 💬 💬
266	Lysosome 💬	[1] MAN2B1 💬	Velmanase alfa 💬	Velmanase alfa	[1] 19 💬 💬
267	Lysosome 💬	[1] SMPD1 💬	Olipudase alfa 💬	Olipudase alfa	[1] 19 💬 💬
268	Lysosome 💬	[1] SORT1 💬	Latozinemab 💬	Latozinemab	[2] 2 , 127 💬 💬
269	Lysosome 💬	[1] TPP1 💬	Cerliponase alfa 💬	Cerliponase alfa	[1] 19 💬 💬