Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] AGTR1 💬 Angiotensin II 💬 Angiotensin II [7] 17, 19, 46, 66, 86, 222, 224 💬
2 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] AGTR1 💬 Angiotensin II 💬 Angiotensin II [7] 17, 19, 46, 66, 86, 222, 224 💬
3 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] AGTR1 💬 Candesartan 💬 Candesartan [2] 58, 67 💬
4 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] AGTR1 💬 Candesartan cilexetil 💬 Candesartan cilexetil [1] 67 💬
5 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] AGTR1 💬 Irbesartan 💬 Irbesartan [4] 66, 167, 168, 222 💬
6 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] AGTR1 💬 Losartan 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
7 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] AGTR1 💬 Sparsentan 💬 Sparsentan [3] 66, 218, 222 💬
8 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] AGTR1 💬 Telmisartan 💬 Telmisartan [2] 66, 67 💬
9 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] AGTR1 💬 Valsartan 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬
10 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] BCL2 💬 Venetoclax 💬 Venetoclax [1] 28 💬
11 AGE-RAGE signaling pathway in diabetic complications 💬
 [5] CCL2, IL1A, IL1B, IL6, TNF 💬 Pirfenidone 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
12 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] CDK4 💬 Abemaciclib 💬 Abemaciclib [1] 34 💬
13 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] IL1A 💬 Bermekimab 💬 Bermekimab [1] 51 💬
14 AGE-RAGE signaling pathway in diabetic complications 💬
 [2] IL1A, IL1B 💬 Rilonacept 💬 Rilonacept [4] 51, 106, 107, 266 💬
15 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] IL1B 💬 Canakinumab 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
16 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] IL1B 💬 Gevokizumab 💬 Gevokizumab [4] 41, 50, 56, 269 💬
17 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] IL6 💬 Olokizumab 💬 Olokizumab [2] 46, 96 💬
18 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] IL6 💬 Siltuximab 💬 Siltuximab [2] 28, 331 💬
19 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] IL6 💬 Sirukumab 💬 Sirukumab [2] 41, 46 💬
20 AGE-RAGE signaling pathway in diabetic complications 💬
 [2] IL6, TNF 💬 Pomalidomide 💬 Pomalidomide [5] 28, 51, 85, 227, 331 💬
21 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] JAK2 💬 Baricitinib 💬 Baricitinib [13]  2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬
22 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] JAK2 💬 Peficitinib 💬 Peficitinib [1] 46 💬
23 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] JAK2 💬 Ruxolitinib 💬 Ruxolitinib [3] 60, 65, 228 💬
24 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] JAK2 💬 Tofacitinib 💬 Tofacitinib [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬
25 AGE-RAGE signaling pathway in diabetic complications 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Losmapimod 💬 Losmapimod [2] 113, 222 💬
26 AGE-RAGE signaling pathway in diabetic complications 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Neflamapimod 💬 Neflamapimod [1]  8  💬
27 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] NFKB1 💬 Iguratimod 💬 Iguratimod [5] 46, 51, 53, 271, 300 💬
28 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] PIK3CA 💬 Alpelisib 💬 Alpelisib [1] 138 💬
29 AGE-RAGE signaling pathway in diabetic complications 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 Leniolisib 💬 Leniolisib [2] 53, 65 💬
30 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] PIK3CD 💬 Parsaclisib 💬 Parsaclisib [3] 35, 53, 61 💬
31 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] PRKCB 💬 Enzastaurin 💬 Enzastaurin [1] 168 💬
32 AGE-RAGE signaling pathway in diabetic complications 💬
 [2] PRKCD, PRKCE 💬 Sotrastaurin 💬 Sotrastaurin [1] 97 💬
33 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] RELA 💬 Edasalonexent 💬 Edasalonexent [1] 113 💬
34 AGE-RAGE signaling pathway in diabetic complications 💬
 [3] TGFB1, TGFB2, TGFB3 💬 Fresolimumab 💬 Fresolimumab [3] 51, 85, 222 💬
35 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] TNF 💬 Adalimumab 💬 Adalimumab [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬
36 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] TNF 💬 Certolizumab pegol 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
37 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] TNF 💬 Etanercept 💬 Etanercept [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬
38 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] TNF 💬 Golimumab 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
39 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] TNF 💬 Infliximab 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
40 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] TNF 💬 Lenalidomide 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
41 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] TNF 💬 Ozoralizumab 💬 Ozoralizumab [1] 46 💬
42 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] TNF 💬 Pegsunercept 💬 Pegsunercept [1] 46 💬
43 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] TNF 💬 Thalidomide 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
44 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] VEGFA 💬 Bevacizumab 💬 Bevacizumab [6] 13, 34, 85, 87, 227, 280 💬
45 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] VEGFA 💬 Ranibizumab 💬 Ranibizumab [4] 34, 166, 227, 301 💬
46 AGE-RAGE signaling pathway in diabetic complications 💬
 [2] VEGFA, VEGFB 💬 Aflibercept 💬 Aflibercept [2] 90, 166 💬