Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY KEGG GENES KEGG DRUG DrugBank Disease ID
1 Aldosterone synthesis and secretion 💬
[1] AGTR1 💬 Angiotensin II 💬 Angiotensin II [7] 17, 19, 46, 66, 86, 222, 224 💬 💬
2 Aldosterone synthesis and secretion 💬
[1] AGTR1 💬 Angiotensin II 💬 Angiotensin II [7] 17, 19, 46, 66, 86, 222, 224 💬 💬
3 Aldosterone synthesis and secretion 💬
[1] AGTR1 💬 Candesartan 💬 Candesartan [2] 58, 67 💬 💬
4 Aldosterone synthesis and secretion 💬
[1] AGTR1 💬 Candesartan cilexetil 💬 Candesartan cilexetil [1] 67 💬 💬
5 Aldosterone synthesis and secretion 💬
[1] AGTR1 💬 Irbesartan 💬 Irbesartan [4] 66, 167, 168, 222 💬 💬
6 Aldosterone synthesis and secretion 💬
[1] AGTR1 💬 Losartan 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬
7 Aldosterone synthesis and secretion 💬
[1] AGTR1 💬 Sparsentan 💬 Sparsentan [3] 66, 218, 222 💬 💬
8 Aldosterone synthesis and secretion 💬
[1] AGTR1 💬 Telmisartan 💬 Telmisartan [2] 66, 67 💬 💬
9 Aldosterone synthesis and secretion 💬
[1] AGTR1 💬 Valsartan 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬 💬
10 Aldosterone synthesis and secretion 💬
[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 Digitoxin 💬 Digitoxin [1] 299 💬 💬
11 Aldosterone synthesis and secretion 💬
[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 Digoxin 💬 Digoxin [3]  8 , 46, 210 💬 💬
12 Aldosterone synthesis and secretion 💬
[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine 💬 Amlodipine [4] 13, 51, 67, 298 💬 💬
13 Aldosterone synthesis and secretion 💬
[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cilnidipine 💬 Cilnidipine [1] 67 💬 💬
14 Aldosterone synthesis and secretion 💬
[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem 💬 Diltiazem [3] 51, 58, 86 💬 💬
15 Aldosterone synthesis and secretion 💬
[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Isradipine 💬 Isradipine [1]  6  💬 💬
16 Aldosterone synthesis and secretion 💬
[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nicardipine 💬 Nicardipine [2] 70, 86 💬 💬
17 Aldosterone synthesis and secretion 💬
[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nifedipine 💬 Nifedipine [2] 50, 81 💬 💬
18 Aldosterone synthesis and secretion 💬
[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nilvadipine 💬 Nilvadipine [1] 90 💬 💬
19 Aldosterone synthesis and secretion 💬
[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Perhexiline 💬 Perhexiline [2] 58, 272 💬 💬
20 Aldosterone synthesis and secretion 💬
[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Propiverine 💬 Propiverine [1] 226 💬 💬
21 Aldosterone synthesis and secretion 💬
[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
22 Aldosterone synthesis and secretion 💬
[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬 💬
23 Aldosterone synthesis and secretion 💬
[3] CACNA1G, CACNA1H, CACNA1I 💬 Flunarizine 💬 Flunarizine [1] 149 💬 💬
24 Aldosterone synthesis and secretion 💬
[3] CACNA1G, CACNA1H, CACNA1I 💬 Valproic acid 💬 Valproic acid [14]  2 ,  3 ,  5 ,  6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬
25 Aldosterone synthesis and secretion 💬
[3] CACNA1G, CACNA1H, CACNA1I 💬 Zonisamide 💬 Zonisamide [1]  6  💬 💬
26 Aldosterone synthesis and secretion 💬
[1] CYP11A1 💬 Levoketoconazole 💬 Levoketoconazole [1] 75 💬 💬
27 Aldosterone synthesis and secretion 💬
[1] CYP11B2 💬 Osilodrostat 💬 Osilodrostat [1] 75 💬 💬
28 Aldosterone synthesis and secretion 💬
[1] KCNJ5 💬 Amiodarone 💬 Amiodarone [2] 28, 127 💬 💬
29 Aldosterone synthesis and secretion 💬
[1] MC2R 💬 Corticotropin 💬 Corticotropin [12]  2 , 13, 14, 46, 49, 50, 66, 75, 81, 84, 145, 222 💬 💬
30 Aldosterone synthesis and secretion 💬
[1] MC2R 💬 Cosyntropin 💬 Tetracosactide [5] 78, 83, 113, 145, 222 💬 💬
31 Aldosterone synthesis and secretion 💬
[1] NPR1 💬 Erythrityl tetranitrate 💬 Erythrityl tetranitrate [1] 46 💬 💬
32 Aldosterone synthesis and secretion 💬
[1] NPR1 💬 Nesiritide 💬 Nesiritide [2] 46, 58 💬 💬
33 Aldosterone synthesis and secretion 💬
[1] PDE2A 💬 Aminophylline 💬 Aminophylline [1] 63 💬 💬
34 Aldosterone synthesis and secretion 💬
[1] PDE2A 💬 Bucladesine 💬 Bucladesine [1] 246 💬 💬
35 Aldosterone synthesis and secretion 💬
[1] PDE2A 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬 💬
36 Aldosterone synthesis and secretion 💬
[1] PDE2A 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬 💬
37 Aldosterone synthesis and secretion 💬
[1] PDE2A 💬 Flavoxate 💬 Flavoxate [1] 226 💬 💬
38 Aldosterone synthesis and secretion 💬
[1] PDE2A 💬 Theophylline 💬 Theophylline [2] 236, 299 💬 💬
39 Aldosterone synthesis and secretion 💬
[1] PDE2A 💬 Theophylline 💬 Theophylline [2] 236, 299 💬 💬
40 Aldosterone synthesis and secretion 💬
[1] PRKCB 💬 Enzastaurin 💬 Enzastaurin [1] 168 💬 💬
41 Aldosterone synthesis and secretion 💬
[1] PRKCE 💬 Sotrastaurin 💬 Sotrastaurin [1] 97 💬 💬