Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY KEGG GENES KEGG DRUG DrugBank Disease ID
1 Dopaminergic synapse 💬
 [3] CACNA1B, CACNA1C, CACNA1D 💬 Cilnidipine 💬 Cilnidipine [1] 67 💬 💬
2 Dopaminergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 Amlodipine 💬 Amlodipine [4] 13, 51, 67, 298 💬 💬
3 Dopaminergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 Diltiazem 💬 Diltiazem [3] 51, 58, 86 💬 💬
4 Dopaminergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 Isradipine 💬 Isradipine [1]  6  💬 💬
5 Dopaminergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 Nicardipine 💬 Nicardipine [2] 70, 86 💬 💬
6 Dopaminergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 Nifedipine 💬 Nifedipine [2] 50, 81 💬 💬
7 Dopaminergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 Nilvadipine 💬 Nilvadipine [1] 90 💬 💬
8 Dopaminergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 Perhexiline 💬 Perhexiline [2] 58, 272 💬 💬
9 Dopaminergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 Propiverine 💬 Propiverine [1] 226 💬 💬
10 Dopaminergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬 💬
11 Dopaminergic synapse 💬
 [7] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, SCN1A 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
12 Dopaminergic synapse 💬
 [1] COMT 💬 Entacapone 💬 Entacapone [2]  6 , 17 💬 💬
13 Dopaminergic synapse 💬
 [1] COMT 💬 Opicapone 💬 Opicapone [1]  6  💬 💬
14 Dopaminergic synapse 💬
 [1] COMT 💬 Tolcapone 💬 Tolcapone [3]  6 , 28, 127 💬 💬
15 Dopaminergic synapse 💬
 [1] DDC 💬 Benserazide 💬 Benserazide [1]  6  💬 💬
16 Dopaminergic synapse 💬
 [1] DDC 💬 Carbidopa 💬 Carbidopa [7]  6 , 13, 17, 90, 140, 164, 201 💬 💬
17 Dopaminergic synapse 💬
 [2] DRD1, DRD2 💬 Apomorphine 💬 Apomorphine [3]  5 ,  6 ,  7  💬 💬
18 Dopaminergic synapse 💬
 [2] DRD1, DRD2 💬 Flupentixol 💬 Flupentixol [1] 97 💬 💬
19 Dopaminergic synapse 💬
 [2] DRD1, DRD2 💬 Pergolide 💬 Pergolide [1]  6  💬 💬
20 Dopaminergic synapse 💬
 [5] DRD1, DRD2, DRD3, DRD4, DRD5 💬 Dexpramipexole 💬 Dexpramipexole [1]  2  💬 💬
21 Dopaminergic synapse 💬
 [5] DRD1, DRD2, DRD3, DRD4, DRD5 💬 Dopamine 💬 Dopamine [4]  6 ,  7 , 74, 299 💬 💬
22 Dopaminergic synapse 💬
 [5] DRD1, DRD2, DRD3, DRD4, DRD5 💬 Foslevodopa 💬 Foslevodopa [1]  6  💬 💬
23 Dopaminergic synapse 💬
 [5] DRD1, DRD2, DRD3, DRD4, DRD5 💬 Levodopa 💬 Levodopa [6]  6 , 17, 90, 140, 164, 201 💬 💬
24 Dopaminergic synapse 💬
 [2] DRD1, DRD5 💬 Tavapadon 💬 Tavapadon [1]  6  💬 💬
25 Dopaminergic synapse 💬
 [1] DRD2 💬 Bromocriptine 💬 Bromocriptine [2]  6 , 74 💬 💬
26 Dopaminergic synapse 💬
 [1] DRD2 💬 Buspirone 💬 Buspirone [2]  6 , 51 💬 💬
27 Dopaminergic synapse 💬
 [1] DRD2 💬 Cabergoline 💬 Cabergoline [3]  6 , 74, 75 💬 💬
28 Dopaminergic synapse 💬
 [1] DRD2 💬 Cariprazine 💬 Cariprazine [1] 21 💬 💬
29 Dopaminergic synapse 💬
 [1] DRD2 💬 Chlorpromazine 💬 Chlorpromazine [1] 254 💬 💬
30 Dopaminergic synapse 💬
 [1] DRD2 💬 Domperidone 💬 Domperidone [5]  6 , 13, 17, 51, 230 💬 💬
31 Dopaminergic synapse 💬
 [1] DRD2 💬 Domperidone maleate 💬 Domperidone [5]  6 , 13, 17, 51, 230 💬 💬
32 Dopaminergic synapse 💬
 [1] DRD2 💬 Haloperidol 💬 Haloperidol [1]  8  💬 💬
33 Dopaminergic synapse 💬
 [1] DRD2 💬 Iloperidone 💬 Iloperidone [1]  6  💬 💬
34 Dopaminergic synapse 💬
 [1] DRD2 💬 Melperone 💬 Melperone [1]  6  💬 💬
35 Dopaminergic synapse 💬
 [1] DRD2 💬 Metoclopramide 💬 Metoclopramide [2] 46, 51 💬 💬
36 Dopaminergic synapse 💬
 [1] DRD2 💬 Pimozide 💬 Pimozide [1]  2  💬 💬
37 Dopaminergic synapse 💬
 [1] DRD2 💬 Pridopidine 💬 Pridopidine [3]  2 ,  6 ,  8  💬 💬
38 Dopaminergic synapse 💬
 [1] DRD2 💬 Quetiapine 💬 Quetiapine [2]  6 , 13 💬 💬
39 Dopaminergic synapse 💬
 [1] DRD2 💬 Risperidone 💬 Risperidone [5]  8 , 156, 179, 187, 206 💬 💬
40 Dopaminergic synapse 💬
 [1] DRD2 💬 Rotigotine 💬 Rotigotine [1]  6  💬 💬
41 Dopaminergic synapse 💬
 [1] DRD2 💬 Sulpiride 💬 Sulpiride [2]  6 , 70 💬 💬
42 Dopaminergic synapse 💬
 [1] DRD2 💬 Terguride 💬 Terguride [2] 51, 86 💬 💬
43 Dopaminergic synapse 💬
 [1] DRD2 💬 Tiapride 💬 Tiapride [1]  8  💬 💬
44 Dopaminergic synapse 💬
 [1] DRD2 💬 Trifluoperazine maleate 💬 Trifluoperazine [2] 283, 284 💬 💬
45 Dopaminergic synapse 💬
 [1] DRD2 💬 Trifluoperazine 💬 Trifluoperazine [2] 283, 284 💬 💬
46 Dopaminergic synapse 💬
 [2] DRD2, DRD3 💬 Aripiprazole 💬 Aripiprazole [2]  6 , 206 💬 💬
47 Dopaminergic synapse 💬
 [2] DRD2, DRD3 💬 Pardoprunox 💬 Pardoprunox [1]  6  💬 💬
48 Dopaminergic synapse 💬
 [2] DRD2, DRD3 💬 Piribedil 💬 Piribedil [1]  6  💬 💬
49 Dopaminergic synapse 💬
 [3] DRD2, DRD3, DRD4 💬 Lisuride 💬 Lisuride [2]  6 , 86 💬 💬
50 Dopaminergic synapse 💬
 [3] DRD2, DRD3, DRD4 💬 Olanzapine 💬 Olanzapine [2]  2 ,  8  💬 💬
51 Dopaminergic synapse 💬
 [3] DRD2, DRD3, DRD4 💬 Pramipexole 💬 Pramipexole [3]  2 ,  6 , 20 💬 💬
52 Dopaminergic synapse 💬
 [3] DRD2, DRD3, DRD4 💬 Ropinirole 💬 Ropinirole [4]  2 ,  6 , 74, 309 💬 💬
53 Dopaminergic synapse 💬
 [1] DRD4 💬 Clozapine 💬 Clozapine [1]  6  💬 💬
54 Dopaminergic synapse 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Perampanel 💬 Perampanel [3]  2 ,  6 , 144 💬 💬
55 Dopaminergic synapse 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 Talampanel 💬 Talampanel [2]  2 ,  6  💬 💬
56 Dopaminergic synapse 💬
 [6] GRIA1, GRIA2, GRIA3, GRIA4, GRIN2A, GRIN2B 💬 Riluzole 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬 💬
57 Dopaminergic synapse 💬
 [2] GRIN2A, GRIN2B 💬 Acamprosate 💬 Acamprosate [2]  6 , 206 💬 💬
58 Dopaminergic synapse 💬
 [2] GRIN2A, GRIN2B 💬 Amantadine 💬 Amantadine [4]  6 ,  8 , 13, 127 💬 💬
59 Dopaminergic synapse 💬
 [2] GRIN2A, GRIN2B 💬 Dextromethorphan 💬 Dextromethorphan [11]  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬 💬
60 Dopaminergic synapse 💬
 [2] GRIN2A, GRIN2B 💬 Esketamine 💬 Esketamine [3]  2 ,  4 , 70 💬 💬
61 Dopaminergic synapse 💬
 [2] GRIN2A, GRIN2B 💬 Ketamine 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬 💬
62 Dopaminergic synapse 💬
 [2] GRIN2A, GRIN2B 💬 Latrepirdine 💬 Latrepirdine [1]  8  💬 💬
63 Dopaminergic synapse 💬
 [2] GRIN2A, GRIN2B 💬 Memantine 💬 Memantine [8]  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬 💬
64 Dopaminergic synapse 💬
 [3] KCNJ3, KCNJ5, SCN1A 💬 Amiodarone 💬 Amiodarone [2] 28, 127 💬 💬
65 Dopaminergic synapse 💬
 [1] MAOA 💬 Moclobemide 💬 Moclobemide [1]  6  💬 💬
66 Dopaminergic synapse 💬
 [2] MAOA, MAOB 💬 Iproniazid 💬 Iproniazid [1]  6  💬 💬
67 Dopaminergic synapse 💬
 [2] MAOA, MAOB 💬 Phenelzine 💬 Phenelzine [1]  6  💬 💬
68 Dopaminergic synapse 💬
 [3] MAOA, MAOB, SLC6A3 💬 Phentermine 💬 Phentermine [1] 97 💬 💬
69 Dopaminergic synapse 💬
 [1] MAOB 💬 Rasagiline 💬 Rasagiline [6]  2 ,  5 ,  6 , 17, 58, 66 💬 💬
70 Dopaminergic synapse 💬
 [1] MAOB 💬 Rasagiline tartrate 💬 Rasagiline [6]  2 ,  5 ,  6 , 17, 58, 66 💬 💬
71 Dopaminergic synapse 💬
 [1] MAOB 💬 Safinamide 💬 Safinamide [2]  6 , 17 💬 💬
72 Dopaminergic synapse 💬
 [1] MAOB 💬 Selegiline 💬 Selegiline [1]  6  💬 💬
73 Dopaminergic synapse 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Losmapimod 💬 Losmapimod [2] 113, 222 💬 💬
74 Dopaminergic synapse 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Neflamapimod 💬 Neflamapimod [1]  8  💬 💬
75 Dopaminergic synapse 💬
 [3] PPP3CA, PPP3CB, PPP3CC 💬 Cyclosporine 💬 Cyclosporine [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬
76 Dopaminergic synapse 💬
 [3] PPP3CA, PPP3CB, PPP3CC 💬 Pimecrolimus 💬 Pimecrolimus [1] 160 💬 💬
77 Dopaminergic synapse 💬
 [3] PPP3CA, PPP3CB, PPP3CC 💬 Tacrolimus 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬
78 Dopaminergic synapse 💬
 [3] PPP3CA, PPP3CB, PPP3CC 💬 Tacrolimus 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬
79 Dopaminergic synapse 💬
 [3] PPP3CA, PPP3CB, PPP3CC 💬 Voclosporin 💬 Voclosporin [2] 49, 222 💬 💬
80 Dopaminergic synapse 💬
 [1] PRKCB 💬 Enzastaurin 💬 Enzastaurin [1] 168 💬 💬
81 Dopaminergic synapse 💬
 [1] SCN1A 💬 Bupivacaine 💬 Bupivacaine [8] 46, 51, 53, 70, 96, 168, 226, 298 💬 💬
82 Dopaminergic synapse 💬
 [1] SCN1A 💬 Carbamazepine 💬 Carbamazepine [3]  6 , 13, 231 💬 💬
83 Dopaminergic synapse 💬
 [1] SCN1A 💬 Cifenline 💬 Cibenzoline [1] 58 💬 💬
84 Dopaminergic synapse 💬
 [1] SCN1A 💬 Eleclazine 💬 Eleclazine [1] 58 💬 💬
85 Dopaminergic synapse 💬
 [1] SCN1A 💬 Flecainide 💬 Flecainide [1]  6  💬 💬
86 Dopaminergic synapse 💬
 [1] SCN1A 💬 Lamotrigine 💬 Lamotrigine [5] 13, 34, 38, 114, 144 💬 💬
87 Dopaminergic synapse 💬
 [1] SCN1A 💬 Levobupivacaine 💬 Levobupivacaine [1] 46 💬 💬
88 Dopaminergic synapse 💬
 [1] SCN1A 💬 Lidocaine 💬 Lidocaine [13]  6 , 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬 💬
89 Dopaminergic synapse 💬
 [1] SCN1A 💬 Lidocaine hydrochloride monohydrate 💬 Lidocaine [13]  6 , 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬 💬
90 Dopaminergic synapse 💬
 [1] SCN1A 💬 Mexiletine 💬 Mexiletine [5]  1 ,  2 , 10, 113, 114 💬 💬
91 Dopaminergic synapse 💬
 [1] SCN1A 💬 Oxcarbazepine 💬 Oxcarbazepine [1] 13 💬 💬
92 Dopaminergic synapse 💬
 [1] SCN1A 💬 Oxybuprocaine 💬 Oxybuprocaine [1]  6  💬 💬
93 Dopaminergic synapse 💬
 [1] SCN1A 💬 Phenytoin 💬 Phenytoin [1] 13 💬 💬
94 Dopaminergic synapse 💬
 [1] SCN1A 💬 Quinidine 💬 Quinidine [3]  2 ,  8 , 13 💬 💬
95 Dopaminergic synapse 💬
 [1] SCN1A 💬 Ropivacaine 💬 Ropivacaine [4] 22, 36, 46, 70 💬 💬
96 Dopaminergic synapse 💬
 [1] SCN1A 💬 Rufinamide 💬 Rufinamide [1] 144 💬 💬
97 Dopaminergic synapse 💬
 [1] SCN1A 💬 Zonisamide 💬 Zonisamide [1]  6  💬 💬
98 Dopaminergic synapse 💬
 [1] SLC18A2 💬 Deutetrabenazine 💬 Deutetrabenazine [1]  8  💬 💬
99 Dopaminergic synapse 💬
 [1] SLC18A2 💬 Tetrabenazine 💬 Tetrabenazine [1]  8  💬 💬
100 Dopaminergic synapse 💬
 [1] SLC18A2 💬 Valbenazine 💬 Valbenazine [1]  8  💬 💬
101 Dopaminergic synapse 💬
 [1] SLC6A3 💬 Armodafinil 💬 Armodafinil [3]  6 , 13, 84 💬 💬
102 Dopaminergic synapse 💬
 [1] SLC6A3 💬 Bupropion 💬 Bupropion [5]  8 , 18, 21, 96, 171 💬 💬
103 Dopaminergic synapse 💬
 [1] SLC6A3 💬 Lisdexamfetamine 💬 Lisdexamfetamine [1] 13 💬 💬
104 Dopaminergic synapse 💬
 [1] SLC6A3 💬 Methylphenidate 💬 Methylphenidate [7]  6 , 13, 34, 84, 113, 179, 206 💬 💬