Gene

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No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

Gastric acid secretion 💬

[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬

Name	Full Name
ATP1A1	ATPase Na+/K+ transporting subunit alpha 1
ATP1A2	ATPase Na+/K+ transporting subunit alpha 2
ATP1A3	ATPase Na+/K+ transporting subunit alpha 3
ATP1A4	ATPase Na+/K+ transporting subunit alpha 4

Digitoxin 💬

Digitoxin

[1] 299 💬

Gastric acid secretion 💬

[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬

Name	Full Name
ATP1A1	ATPase Na+/K+ transporting subunit alpha 1
ATP1A2	ATPase Na+/K+ transporting subunit alpha 2
ATP1A3	ATPase Na+/K+ transporting subunit alpha 3
ATP1A4	ATPase Na+/K+ transporting subunit alpha 4

Digoxin 💬

Digoxin

[3] 8 , 46, 210 💬

Disease ID	Name
8	Huntington disease;Huntington chorea;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;

Gastric acid secretion 💬

[2] ATP4A, ATP4B 💬

Dexlansoprazole 💬

Dexlansoprazole

[1] 98 💬

Gastric acid secretion 💬

[2] ATP4A, ATP4B 💬

Esomeprazole 💬

Esomeprazole

[8] 13, 46, 86, 98, 107, 113, 298, 299 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
86	Pulmonary arterial hypertension;PAH;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
107	Juvenile idiopathic arthritis;JIA;
113	Muscular dystrophy;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;

Gastric acid secretion 💬

[2] ATP4A, ATP4B 💬

Lansoprazole 💬

Lansoprazole

[7] 63, 71, 85, 98, 166, 222, 299 💬

Disease ID	Name
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
71	Idiopathic osteonecrosis of the femoral head;Idiopathic femoral head necrosis;
85	Idiopathic interstitial pneumonia;IIPs;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
166	Pseudoxanthoma elasticum;PXE;
222	Primary nephrotic syndrome;
299	Cystic fibrosis;

Gastric acid secretion 💬

[2] ATP4A, ATP4B 💬

Omeprazole 💬

Omeprazole

[14] 6 , 8 , 21, 46, 51, 85, 96, 97, 225, 271, 282, 294, 298, 299 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
8	Huntington disease;Huntington chorea;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
51	Scleroderma;Systemic sclerosis;SSc;
85	Idiopathic interstitial pneumonia;IIPs;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
282	Congenital dyserythropoietic anemia;CDA;
294	Congenital diaphragmatic hernia;
298	Hereditary pancreatitis;Chronic pancreatitis;
299	Cystic fibrosis;

Gastric acid secretion 💬

[2] ATP4A, ATP4B 💬

Pantoprazole 💬

Pantoprazole

[2] 13, 65 💬

Gastric acid secretion 💬

[2] ATP4A, ATP4B 💬

Rabeprazole 💬

Rabeprazole

[2] 2 , 51 💬

Gastric acid secretion 💬

[2] ATP4A, ATP4B 💬

Vonoprazan 💬

Vonoprazan

[2] 63, 98 💬

Disease ID	Name
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;

Gastric acid secretion 💬

[1] CA2 💬

Acetazolamide 💬

Acetazolamide

[8] 13, 86, 90, 115, 154, 155, 225, 230 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
86	Pulmonary arterial hypertension;PAH;
90	Retinitis pigmentosa;
115	Hereditary periodic paralysis;
154	Epilepsy with continuous spikes and waves during slow sleep;Epileptic encephalopathy with continuous spike-and-wave during sleep;
155	Acquired aphasia with convulsive disorder;Landau-Kleffner syndrome;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
230	Alveolar hypoventilation syndrome;AHS;Hypoventilation syndrome;

Gastric acid secretion 💬

[1] CA2 💬

Dichlorphenamide 💬

Diclofenamide

[1] 114 💬

Gastric acid secretion 💬

[1] CA2 💬

Dorzolamide 💬

Dorzolamide

[1] 90 💬

Gastric acid secretion 💬

[1] CA2 💬

Topiramate 💬

Topiramate

[6] 6 , 97, 140, 144, 156, 193 💬

Gastric acid secretion 💬

[1] CCKBR 💬

Proglumide 💬

Proglumide

[1] 298 💬

Gastric acid secretion 💬

[1] CFTR 💬

Deutivacaftor 💬

Deutivacaftor

[1] 299 💬

Gastric acid secretion 💬

[1] CFTR 💬

Elexacaftor 💬

Elexacaftor

[1] 299 💬

Gastric acid secretion 💬

[1] CFTR 💬

Galicaftor 💬

Galicaftor

[1] 299 💬

Gastric acid secretion 💬

[1] CFTR 💬

Ivacaftor 💬

Ivacaftor

[1] 299 💬

Gastric acid secretion 💬

[1] CFTR 💬

Lumacaftor 💬

Lumacaftor

[1] 299 💬

Gastric acid secretion 💬

[1] CFTR 💬

Tezacaftor 💬

Tezacaftor

[1] 299 💬

Gastric acid secretion 💬

[1] CHRM3 💬

Atropine 💬

Atropine

[2] 2 , 299 💬

Gastric acid secretion 💬

[1] CHRM3 💬

Blarcamesine 💬

Blarcamesine

[1] 156 💬

Gastric acid secretion 💬

[1] CHRM3 💬

Cevimeline 💬

Cevimeline

[1] 53 💬

Gastric acid secretion 💬

[1] CHRM3 💬

Chlorpromazine 💬

Chlorpromazine

[1] 254 💬

Gastric acid secretion 💬

[1] CHRM3 💬

Darifenacin 💬

Darifenacin

[2] 6 , 13 💬

Gastric acid secretion 💬

[1] CHRM3 💬

Fesoterodine 💬

Fesoterodine

[1] 6 💬

Gastric acid secretion 💬

[1] CHRM3 💬

Oxybutynin 💬

Oxybutynin

[3] 6 , 13, 53 💬

Gastric acid secretion 💬

[1] CHRM3 💬

Pilocarpine 💬

Pilocarpine

[3] 6 , 53, 299 💬

Gastric acid secretion 💬

[1] CHRM3 💬

Propiverine 💬

Propiverine

[1] 226 💬

Gastric acid secretion 💬

[1] CHRM3 💬

Scopolamine 💬

Scopolamine

[1] 2 💬

Gastric acid secretion 💬

[1] CHRM3 💬

Solifenacin 💬

Solifenacin

[3] 6 , 13, 53 💬

Gastric acid secretion 💬

[1] CHRM3 💬

Tolterodine 💬

Tolterodine

[2] 17, 53 💬

Gastric acid secretion 💬

[1] CHRM3 💬

Trihexyphenidyl 💬

Trihexyphenidyl

[2] 5 , 6 💬

Gastric acid secretion 💬

[1] CHRM3 💬

Tropicamide 💬

Tropicamide

[1] 6 💬

Gastric acid secretion 💬

[1] HRH2 💬

Cimetidine 💬

Cimetidine

[2] 2 , 254 💬

Gastric acid secretion 💬

[1] HRH2 💬

Famotidine 💬

Famotidine

[6] 6 , 46, 61, 86, 98, 107 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
61	Autoimmune hemolytic anemia;AIHA;
86	Pulmonary arterial hypertension;PAH;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
107	Juvenile idiopathic arthritis;JIA;

Gastric acid secretion 💬

[1] HRH2 💬

Ranitidine 💬

Ranitidine

[2] 13, 65 💬

Gastric acid secretion 💬

[1] KCNQ1 💬

Amiodarone 💬

Amiodarone

[2] 28, 127 💬

Gastric acid secretion 💬

[1] KCNQ1 💬

Ezogabine 💬

Ezogabine

[2] 2 , 144 💬

Gastric acid secretion 💬

[1] PRKCB 💬

Enzastaurin 💬

Enzastaurin

[1] 168 💬

Gastric acid secretion 💬

[1] SSTR2 💬

Octreotide 💬

Octreotide

[7] 67, 75, 84, 85, 89, 193, 227 💬

Disease ID	Name
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
75	Cushing disease;Cushing;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
89	Lymphangioleiomyomatosis;LAM;
193	Prader-Willi syndrome;
227	Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease;

Gastric acid secretion 💬

[1] SSTR2 💬

Pasireotide 💬

Pasireotide

[3] 67, 74, 75 💬

Disease ID	Name
67	Polycystic kidney disease;PKD;PCKD;Polycystic kidney;
74	Prolactin secreting pituitary adenoma;Pituitary PRL secretion hyperthyroidism;Prolactinoma;Prolactin secreting adenoma;
75	Cushing disease;Cushing;

Gastric acid secretion 💬

[1] SSTR2 💬

Somatostatin 💬

Somatostatin

[2] 67, 78 💬