Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY KEGG GENES KEGG DRUG DrugBank Disease ID
1 GnRH secretion 💬
[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine 💬 Amlodipine [4] 13, 51, 67, 298 💬 💬
2 GnRH secretion 💬
[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cilnidipine 💬 Cilnidipine [1] 67 💬 💬
3 GnRH secretion 💬
[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem 💬 Diltiazem [3] 51, 58, 86 💬 💬
4 GnRH secretion 💬
[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Isradipine 💬 Isradipine [1]  6  💬 💬
5 GnRH secretion 💬
[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nicardipine 💬 Nicardipine [2] 70, 86 💬 💬
6 GnRH secretion 💬
[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nifedipine 💬 Nifedipine [2] 50, 81 💬 💬
7 GnRH secretion 💬
[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nilvadipine 💬 Nilvadipine [1] 90 💬 💬
8 GnRH secretion 💬
[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Perhexiline 💬 Perhexiline [2] 58, 272 💬 💬
9 GnRH secretion 💬
[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Propiverine 💬 Propiverine [1] 226 💬 💬
10 GnRH secretion 💬
[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
11 GnRH secretion 💬
[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬 💬
12 GnRH secretion 💬
[3] CACNA1G, CACNA1H, CACNA1I 💬 Flunarizine 💬 Flunarizine [1] 149 💬 💬
13 GnRH secretion 💬
[3] CACNA1G, CACNA1H, CACNA1I 💬 Valproic acid 💬 Valproic acid [14]  2 ,  3 ,  5 ,  6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬
14 GnRH secretion 💬
[3] CACNA1G, CACNA1H, CACNA1I 💬 Zonisamide 💬 Zonisamide [1]  6  💬 💬
15 GnRH secretion 💬
[1] ESR2 💬 Clomifene 💬 Clomifene [1] 74 💬 💬
16 GnRH secretion 💬
[1] ESR2 💬 Estetrol 💬 Estetrol [1] 53 💬 💬
17 GnRH secretion 💬
[1] ESR2 💬 Estetrol 💬 Estetrol [1] 53 💬 💬
18 GnRH secretion 💬
[1] ESR2 💬 Estradiol 💬 Estradiol [7] 13, 46, 49, 65, 76, 226, 299 💬 💬
19 GnRH secretion 💬
[1] ESR2 💬 Estradiol valerate 💬 Estradiol valerate [1] 65 💬 💬
20 GnRH secretion 💬
[1] ESR2 💬 Estriol 💬 Estriol [2] 13, 227 💬 💬
21 GnRH secretion 💬
[1] ESR2 💬 Estriol tripropionate 💬 Estriol [2] 13, 227 💬 💬
22 GnRH secretion 💬
[1] ESR2 💬 Fulvestrant 💬 Fulvestrant [2] 49, 86 💬 💬
23 GnRH secretion 💬
[1] ESR2 💬 Mestranol 💬 Mestranol [2] 46, 49 💬 💬
24 GnRH secretion 💬
[1] ESR2 💬 Prasterone 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬 💬
25 GnRH secretion 💬
[1] ESR2 💬 Raloxifene 💬 Raloxifene [1] 46 💬 💬
26 GnRH secretion 💬
[1] ESR2 💬 Tamoxifen 💬 Tamoxifen [3]  2 , 113, 227 💬 💬
27 GnRH secretion 💬
[2] GABBR1, GABBR2 💬 Arbaclofen 💬 Arbaclofen [2] 13, 206 💬 💬
28 GnRH secretion 💬
[2] GABBR1, GABBR2 💬 Arbaclofen placarbil 💬 Arbaclofen Placarbil [1] 13 💬 💬
29 GnRH secretion 💬
[2] GABBR1, GABBR2 💬 Baclofen 💬 Baclofen [8]  2 , 10, 13, 18, 65, 70, 149, 206 💬 💬
30 GnRH secretion 💬
[2] GABBR1, GABBR2 💬 Valiloxybate 💬 Valiloxybate [1]  6  💬 💬
31 GnRH secretion 💬
[1] KCNJ11 💬 Diazoxide 💬 Diazoxide [2] 13, 193 💬 💬
32 GnRH secretion 💬
[1] KCNJ11 💬 Minoxidil 💬 Minoxidil [1] 179 💬 💬
33 GnRH secretion 💬
[1] KCNJ11 💬 Repaglinide 💬 Repaglinide [4]  6 , 21, 46, 299 💬 💬
34 GnRH secretion 💬
[3] KCNJ11, KCNJ3, KCNJ5 💬 Amiodarone 💬 Amiodarone [2] 28, 127 💬 💬
35 GnRH secretion 💬
[2] MAP2K1, MAP2K2 💬 Binimetinib 💬 Binimetinib [1] 34 💬 💬
36 GnRH secretion 💬
[2] MAP2K1, MAP2K2 💬 Cobimetinib 💬 Cobimetinib [1] 280 💬 💬
37 GnRH secretion 💬
[2] MAP2K1, MAP2K2 💬 Mirdametinib 💬 Mirdametinib [1] 34 💬 💬
38 GnRH secretion 💬
[2] MAP2K1, MAP2K2 💬 Selumetinib 💬 Selumetinib [1] 34 💬 💬
39 GnRH secretion 💬
[2] MAP2K1, MAP2K2 💬 Trametinib 💬 Trametinib [4]  2 , 34, 279, 280 💬 💬
40 GnRH secretion 💬
[1] PIK3CA 💬 Alpelisib 💬 Alpelisib [1] 138 💬 💬
41 GnRH secretion 💬
[3] PIK3CA, PIK3CB, PIK3CD 💬 Leniolisib 💬 Leniolisib [2] 53, 65 💬 💬
42 GnRH secretion 💬
[1] PIK3CD 💬 Parsaclisib 💬 Parsaclisib [3] 35, 53, 61 💬 💬
43 GnRH secretion 💬
[1] PRKCB 💬 Enzastaurin 💬 Enzastaurin [1] 168 💬 💬
44 GnRH secretion 💬
[1] RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬 💬