Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY KEGG GENES KEGG DRUG DrugBank Disease ID
1 Renin secretion 💬
 [1] ACE 💬 Benazepril 💬 Benazepril [4] 49, 57, 218, 224 💬 💬
2 Renin secretion 💬
 [1] ACE 💬 Captopril 💬 Captopril [8]  6 , 17, 46, 86, 96, 97, 107, 271 💬 💬
3 Renin secretion 💬
 [1] ACE 💬 Cilazapril 💬 Cilazapril [1] 66 💬 💬
4 Renin secretion 💬
 [1] ACE 💬 Cilazapril 💬 Cilazapril [1] 66 💬 💬
5 Renin secretion 💬
 [1] ACE 💬 Enalapril 💬 Enalapril [6] 19, 46, 66, 113, 210, 222 💬 💬
6 Renin secretion 💬
 [1] ACE 💬 Imidapril 💬 Imidapril [1] 67 💬 💬
7 Renin secretion 💬
 [1] ACE 💬 Lisinopril 💬 Lisinopril [7] 19, 46, 49, 66, 67, 113, 222 💬 💬
8 Renin secretion 💬
 [1] ACE 💬 Lisinopril 💬 Lisinopril [7] 19, 46, 49, 66, 67, 113, 222 💬 💬
9 Renin secretion 💬
 [1] ACE 💬 Moexipril 💬 Moexipril [1] 93 💬 💬
10 Renin secretion 💬
 [1] ACE 💬 Perindopril 💬 Perindopril [4] 58, 113, 167, 222 💬 💬
11 Renin secretion 💬
 [1] ACE 💬 Quinapril 💬 Quinapril [1] 19 💬 💬
12 Renin secretion 💬
 [1] ACE 💬 Ramipril 💬 Ramipril [7] 46, 49, 66, 67, 113, 218, 257 💬 💬
13 Renin secretion 💬
 [1] ADORA1 💬 Adenosine 💬 Adenosine [3] 13, 58, 65 💬 💬
14 Renin secretion 💬
 [1] ADORA1 💬 Adenosine phosphate 💬 Adenosine phosphate [1] 46 💬 💬
15 Renin secretion 💬
 [6] ADORA1, PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 Aminophylline 💬 Aminophylline [1] 63 💬 💬
16 Renin secretion 💬
 [6] ADORA1, PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬 💬
17 Renin secretion 💬
 [6] ADORA1, PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 Theophylline 💬 Theophylline [2] 236, 299 💬 💬
18 Renin secretion 💬
 [4] ADORA1, PDE1B, PDE3A, PDE3B 💬 Caffeine 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬 💬
19 Renin secretion 💬
 [4] ADORA1, PDE1B, PDE3A, PDE3B 💬 Caffeine hydrate 💬 Caffeine [8]  2 ,  6 , 21, 46, 78, 96, 97, 265 💬 💬
20 Renin secretion 💬
 [1] ADRB1 💬 Amiodarone 💬 Amiodarone [2] 28, 127 💬 💬
21 Renin secretion 💬
 [1] ADRB1 💬 Atenolol 💬 Atenolol [1] 167 💬 💬
22 Renin secretion 💬
 [1] ADRB1 💬 Bisoprolol 💬 Bisoprolol [4] 58, 67, 86, 113 💬 💬
23 Renin secretion 💬
 [1] ADRB1 💬 Celiprolol 💬 Celiprolol [1] 168 💬 💬
24 Renin secretion 💬
 [1] ADRB1 💬 Dobutamine 💬 Dobutamine [4] 57, 58, 86, 215 💬 💬
25 Renin secretion 💬
 [1] ADRB1 💬 Esmolol 💬 Esmolol [1] 58 💬 💬
26 Renin secretion 💬
 [1] ADRB1 💬 Metoprolol 💬 Metoprolol [6] 17, 57, 58, 113, 193, 226 💬 💬
27 Renin secretion 💬
 [1] ADRB1 💬 Nebivolol 💬 Nebivolol [4] 17, 85, 113, 167 💬 💬
28 Renin secretion 💬
 [2] ADRB1, ADRB2 💬 Carvedilol 💬 Carvedilol [4] 57, 86, 113, 210 💬 💬
29 Renin secretion 💬
 [2] ADRB1, ADRB2 💬 Nadolol 💬 Nadolol [1]  6  💬 💬
30 Renin secretion 💬
 [2] ADRB1, ADRB2 💬 Timolol 💬 Timolol [2] 157, 227 💬 💬
31 Renin secretion 💬
 [2] ADRB1, ADRB2 💬 Timolol 💬 Timolol [2] 157, 227 💬 💬
32 Renin secretion 💬
 [3] ADRB1, ADRB2, ADRB3 💬 Dipivefrin 💬 Dipivefrin [1]  6  💬 💬
33 Renin secretion 💬
 [3] ADRB1, ADRB2, ADRB3 💬 Droxidopa 💬 Droxidopa [5]  5 ,  6 , 17, 169, 170 💬 💬
34 Renin secretion 💬
 [3] ADRB1, ADRB2, ADRB3 💬 Ephedrine 💬 Ephedrine [1] 11 💬 💬
35 Renin secretion 💬
 [3] ADRB1, ADRB2, ADRB3 💬 Epinephrine 💬 Epinephrine [3] 46, 70, 96 💬 💬
36 Renin secretion 💬
 [3] ADRB1, ADRB2, ADRB3 💬 Noradrenaline 💬 Norepinephrine [2] 22, 296 💬 💬
37 Renin secretion 💬
 [3] ADRB1, ADRB2, ADRB3 💬 Propranolol 💬 Propranolol [6]  6 , 158, 167, 227, 278, 296 💬 💬
38 Renin secretion 💬
 [3] ADRB1, ADRB2, ADRB3 💬 Pseudoephedrine 💬 Pseudoephedrine [1] 17 💬 💬
39 Renin secretion 💬
 [1] ADRB2 💬 Clenbuterol 💬 Clenbuterol [5]  1 ,  2 ,  6 , 13, 256 💬 💬
40 Renin secretion 💬
 [1] ADRB2 💬 Formoterol 💬 Formoterol [3] 85, 228, 299 💬 💬
41 Renin secretion 💬
 [1] ADRB2 💬 Isoxsuprine 💬 Isoxsuprine [1] 13 💬 💬
42 Renin secretion 💬
 [1] ADRB2 💬 Levosalbutamol 💬 Levosalbutamol [1] 49 💬 💬
43 Renin secretion 💬
 [1] ADRB2 💬 Albuterol 💬 Salbutamol [12]  3 , 11, 12, 13, 49, 85, 86, 89, 111, 113, 256, 299 💬 💬
44 Renin secretion 💬
 [1] ADRB2 💬 Salmeterol 💬 Salmeterol [1] 299 💬 💬
45 Renin secretion 💬
 [1] ADRB2 💬 Terbutaline 💬 Terbutaline [1] 118 💬 💬
46 Renin secretion 💬
 [1] ADRB2 💬 Tulobuterol 💬 Tulobuterol [1]  6  💬 💬
47 Renin secretion 💬
 [1] ADRB3 💬 Mirabegron 💬 Mirabegron [4]  6 , 13, 53, 226 💬 💬
48 Renin secretion 💬
 [1] AGTR1 💬 Angiotensin II 💬 Angiotensin II [7] 17, 19, 46, 66, 86, 222, 224 💬 💬
49 Renin secretion 💬
 [1] AGTR1 💬 Angiotensin II 💬 Angiotensin II [7] 17, 19, 46, 66, 86, 222, 224 💬 💬
50 Renin secretion 💬
 [1] AGTR1 💬 Candesartan 💬 Candesartan [2] 58, 67 💬 💬
51 Renin secretion 💬
 [1] AGTR1 💬 Candesartan cilexetil 💬 Candesartan cilexetil [1] 67 💬 💬
52 Renin secretion 💬
 [1] AGTR1 💬 Irbesartan 💬 Irbesartan [4] 66, 167, 168, 222 💬 💬
53 Renin secretion 💬
 [1] AGTR1 💬 Losartan 💬 Losartan [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬
54 Renin secretion 💬
 [1] AGTR1 💬 Telmisartan 💬 Telmisartan [2] 66, 67 💬 💬
55 Renin secretion 💬
 [1] AGTR1 💬 Valsartan 💬 Valsartan [7] 57, 58, 66, 75, 218, 222, 224 💬 💬
56 Renin secretion 💬
 [2] AGTR1, EDNRA 💬 Sparsentan 💬 Sparsentan [3] 66, 218, 222 💬 💬
57 Renin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Amlodipine 💬 Amlodipine [4] 13, 51, 67, 298 💬 💬
58 Renin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Cilnidipine 💬 Cilnidipine [1] 67 💬 💬
59 Renin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Diltiazem 💬 Diltiazem [3] 51, 58, 86 💬 💬
60 Renin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Isradipine 💬 Isradipine [1]  6  💬 💬
61 Renin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nicardipine 💬 Nicardipine [2] 70, 86 💬 💬
62 Renin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nifedipine 💬 Nifedipine [2] 50, 81 💬 💬
63 Renin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Nilvadipine 💬 Nilvadipine [1] 90 💬 💬
64 Renin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Perhexiline 💬 Perhexiline [2] 58, 272 💬 💬
65 Renin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Propiverine 💬 Propiverine [1] 226 💬 💬
66 Renin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Topiramate 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬 💬
67 Renin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 Verapamil 💬 Verapamil [4] 58, 96, 140, 167 💬 💬
68 Renin secretion 💬
 [1] EDNRA 💬 Ambrisentan 💬 Ambrisentan [7] 51, 84, 85, 86, 88, 210, 211 💬 💬
69 Renin secretion 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 💬
70 Renin secretion 💬
 [1] EDNRA 💬 Bosentan 💬 Bosentan [10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬 💬
71 Renin secretion 💬
 [1] EDNRA 💬 Macitentan 💬 Macitentan [5] 51, 85, 86, 88, 210 💬 💬
72 Renin secretion 💬
 [1] EDNRA 💬 Sitaxentan 💬 Sitaxentan [1] 86 💬 💬
73 Renin secretion 💬
 [1] EDNRA 💬 Zibotentan 💬 Zibotentan [1] 51 💬 💬
74 Renin secretion 💬
 [3] GUCY1A1, GUCY1A2, GUCY1B1 💬 Amyl nitrite 💬 Amyl Nitrite [1] 58 💬 💬
75 Renin secretion 💬
 [3] GUCY1A1, GUCY1A2, GUCY1B1 💬 Riociguat 💬 Riociguat [6] 51, 84, 86, 88, 225, 299 💬 💬
76 Renin secretion 💬
 [1] NPR1 💬 Erythrityl tetranitrate 💬 Erythrityl tetranitrate [1] 46 💬 💬
77 Renin secretion 💬
 [1] NPR1 💬 Nesiritide 💬 Nesiritide [2] 46, 58 💬 💬
78 Renin secretion 💬
 [5] PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 Bucladesine 💬 Bucladesine [1] 246 💬 💬
79 Renin secretion 💬
 [5] PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 Flavoxate 💬 Flavoxate [1] 226 💬 💬
80 Renin secretion 💬
 [2] PDE3A, PDE3B 💬 Cilostazol 💬 Cilostazol [3] 46, 51, 70 💬 💬
81 Renin secretion 💬
 [2] PDE3A, PDE3B 💬 Ibudilast 💬 Ibudilast [2]  2 , 13 💬 💬
82 Renin secretion 💬
 [2] PDE3A, PDE3B 💬 Levosimendan 💬 Levosimendan [1]  2  💬 💬
83 Renin secretion 💬
 [2] PDE3A, PDE3B 💬 Milrinone 💬 Milrinone [1] 294 💬 💬
84 Renin secretion 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Cyclosporine 💬 Cyclosporine [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬
85 Renin secretion 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Pimecrolimus 💬 Pimecrolimus [1] 160 💬 💬
86 Renin secretion 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Tacrolimus 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬
87 Renin secretion 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Tacrolimus 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬
88 Renin secretion 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Voclosporin 💬 Voclosporin [2] 49, 222 💬 💬
89 Renin secretion 💬
 [2] PTGER2, PTGER4 💬 Misoprostol 💬 Misoprostol [3] 46, 70, 271 💬 💬
90 Renin secretion 💬
 [1] REN 💬 Aliskiren 💬 Aliskiren [3] 66, 167, 222 💬 💬