Gene

Search results

No.

KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

Sphingolipid signaling pathway 💬

[1] ADORA1 💬

Aminophylline 💬

Aminophylline

[1] 63 💬

Sphingolipid signaling pathway 💬

[1] ADORA1 💬

Caffeine 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

Sphingolipid signaling pathway 💬

[1] ADORA1 💬

Caffeine hydrate 💬

Caffeine

[8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
6	Parkinson disease;Disease Parkinson's;
21	Mitochondrial disease;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
265	Lipodystrophy;

Sphingolipid signaling pathway 💬

[1] ADORA1 💬

Theophylline 💬

Theophylline

[2] 236, 299 💬

Sphingolipid signaling pathway 💬

[1] ADORA1 💬

Theophylline 💬

Theophylline

[2] 236, 299 💬

Sphingolipid signaling pathway 💬

[2] ADORA1, ADORA3 💬

Adenosine 💬

Adenosine

[3] 13, 58, 65 💬

Sphingolipid signaling pathway 💬

[2] ADORA1, ADORA3 💬

Adenosine phosphate 💬

Adenosine phosphate

[1] 46 💬

Sphingolipid signaling pathway 💬

[1] ADORA3 💬

Piclidenoson 💬

Piclidenoson

[1] 46 💬

Sphingolipid signaling pathway 💬

[1] BCL2 💬

Venetoclax 💬

Venetoclax

[1] 28 💬

Sphingolipid signaling pathway 💬

[1] FCER1A 💬

Omalizumab 💬

Omalizumab

[7] 46, 53, 65, 98, 162, 226, 299 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
65	Primary immunodeficiency;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
162	Pemphigoid;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
299	Cystic fibrosis;

Sphingolipid signaling pathway 💬

[1] FYN 💬

Dasatinib 💬

Dasatinib

[2] 51, 85 💬

Sphingolipid signaling pathway 💬

[1] FYN 💬

Dasatinib 💬

Dasatinib

[2] 51, 85 💬

Sphingolipid signaling pathway 💬

[2] MAP2K1, MAP2K2 💬

Binimetinib 💬

Binimetinib

[1] 34 💬

Sphingolipid signaling pathway 💬

[2] MAP2K1, MAP2K2 💬

Cobimetinib 💬

Cobimetinib

[1] 280 💬

Sphingolipid signaling pathway 💬

[2] MAP2K1, MAP2K2 💬

Mirdametinib 💬

Mirdametinib

[1] 34 💬

Sphingolipid signaling pathway 💬

[2] MAP2K1, MAP2K2 💬

Selumetinib 💬

Selumetinib

[1] 34 💬

Sphingolipid signaling pathway 💬

[2] MAP2K1, MAP2K2 💬

Trametinib 💬

Trametinib

[4] 2 , 34, 279, 280 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
34	Neurofibromatosis;
279	Huge venous malformation with cervical, oral and pharyngeal diffuse lesion;Huge venous malformation;Venous malformation;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;

Sphingolipid signaling pathway 💬

[1] MAP3K5 💬

Selonsertib 💬

Selonsertib

[1] 86 💬

Sphingolipid signaling pathway 💬

[4] MAPK11, MAPK12, MAPK13, MAPK14 💬

Losmapimod 💬

Losmapimod

[2] 113, 222 💬

Sphingolipid signaling pathway 💬

[4] MAPK11, MAPK12, MAPK13, MAPK14 💬

Neflamapimod 💬

Neflamapimod

[1] 8 💬

Sphingolipid signaling pathway 💬

[1] NFKB1 💬

Iguratimod 💬

Iguratimod

[5] 46, 51, 53, 271, 300 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
300	IgG4-related disease;

Sphingolipid signaling pathway 💬

[1] OPRD1 💬

Loperamide 💬

Loperamide

[2] 13, 97 💬

Sphingolipid signaling pathway 💬

[1] OPRD1 💬

Nalbuphine 💬

Nalbuphine

[1] 85 💬

Sphingolipid signaling pathway 💬

[1] OPRD1 💬

Nalmefene 💬

Nalmefene

[1] 6 💬

Sphingolipid signaling pathway 💬

[1] OPRD1 💬

Naloxone 💬

Naloxone

[2] 6 , 226 💬

Sphingolipid signaling pathway 💬

[1] OPRD1 💬

Naltrexone 💬

Naltrexone

[13] 6 , 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
10	Charcot-Marie-Tooth disease;CMT;
13	Multiple sclerosis/Neuromyelitis optica;
40	Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome;
41	Giant cell arteritis;Temporal arteritis;
42	Polyarteritis nodosa;PAN;
43	Microscopic polyangiitis;MPA;
44	Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis;
45	Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;

Sphingolipid signaling pathway 💬

[1] OPRD1 💬

Oxycodone 💬

Oxycodone

[5] 6 , 13, 70, 226, 298 💬

Disease ID	Name
6	Parkinson disease;Disease Parkinson's;
13	Multiple sclerosis/Neuromyelitis optica;
70	Spinal stenosis;Extensive spinal canal stenosis;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
298	Hereditary pancreatitis;Chronic pancreatitis;

Sphingolipid signaling pathway 💬

[1] PIK3CA 💬

Alpelisib 💬

Alpelisib

[1] 138 💬

Sphingolipid signaling pathway 💬

[3] PIK3CA, PIK3CB, PIK3CD 💬

Name	Full Name
PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
PIK3CB	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

Leniolisib 💬

Leniolisib

[2] 53, 65 💬

Sphingolipid signaling pathway 💬

[1] PIK3CD 💬

Parsaclisib 💬

Parsaclisib

[3] 35, 53, 61 💬

Sphingolipid signaling pathway 💬

[1] PRKCB 💬

Enzastaurin 💬

Enzastaurin

[1] 168 💬

Sphingolipid signaling pathway 💬

[1] PRKCE 💬

Sotrastaurin 💬

Sotrastaurin

[1] 97 💬

Sphingolipid signaling pathway 💬

[1] RAF1 💬

Sorafenib 💬

Sorafenib

[2] 34, 86 💬

Sphingolipid signaling pathway 💬

[1] RELA 💬

Edasalonexent 💬

Edasalonexent

[1] 113 💬

Sphingolipid signaling pathway 💬

[2] ROCK1, ROCK2 💬

Fasudil 💬

Fasudil

[4] 2 , 5 , 7 , 51 💬

Sphingolipid signaling pathway 💬

[1] ROCK2 💬

Belumosudil 💬

Belumosudil

[2] 51, 85 💬

Sphingolipid signaling pathway 💬

[1] S1PR1 💬

Cenerimod 💬

Cenerimod

[1] 49 💬

Sphingolipid signaling pathway 💬

[1] S1PR1 💬

Fingolimod 💬

Fingolimod

[3] 13, 14, 156 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
14	Chronic inflammatory demyelinating polyneuropathy;Chronic inflammatory demyelinating poly (radiculo) neuropathy;CIDP;Multifocal motor neuropathy;
156	Rett syndrome;

Sphingolipid signaling pathway 💬

[1] S1PR1 💬

Ponesimod 💬

Ponesimod

[1] 13 💬

Sphingolipid signaling pathway 💬

[5] S1PR1, S1PR2, S1PR3, S1PR4, S1PR5 💬

Name	Full Name
S1PR1	sphingosine-1-phosphate receptor 1
S1PR2	sphingosine-1-phosphate receptor 2
S1PR3	sphingosine-1-phosphate receptor 3
S1PR4	sphingosine-1-phosphate receptor 4
S1PR5	sphingosine-1-phosphate receptor 5

Amiselimod 💬

Amiselimod

[1] 97 💬

Sphingolipid signaling pathway 💬

[5] S1PR1, S1PR2, S1PR3, S1PR4, S1PR5 💬

Name	Full Name
S1PR1	sphingosine-1-phosphate receptor 1
S1PR2	sphingosine-1-phosphate receptor 2
S1PR3	sphingosine-1-phosphate receptor 3
S1PR4	sphingosine-1-phosphate receptor 4
S1PR5	sphingosine-1-phosphate receptor 5

Etrasimod 💬

Etrasimod

[3] 96, 97, 98 💬

Disease ID	Name
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;

Sphingolipid signaling pathway 💬

[5] S1PR1, S1PR2, S1PR3, S1PR4, S1PR5 💬

Name	Full Name
S1PR1	sphingosine-1-phosphate receptor 1
S1PR2	sphingosine-1-phosphate receptor 2
S1PR3	sphingosine-1-phosphate receptor 3
S1PR4	sphingosine-1-phosphate receptor 4
S1PR5	sphingosine-1-phosphate receptor 5

Ozanimod 💬

Ozanimod

[3] 13, 96, 97 💬

Sphingolipid signaling pathway 💬

[2] S1PR1, S1PR5 💬

Siponimod 💬

Siponimod

[2] 13, 50 💬

Sphingolipid signaling pathway 💬

[1] SMPD1 💬

Olipudase alfa 💬

Olipudase alfa

[1] 19 💬

Sphingolipid signaling pathway 💬

[1] TNF 💬

Adalimumab 💬

Name

Other Names

Adalimumab

Adalimumab (USAN/INN)
Adalimumab (genetical recombination) (JAN)
Adalimumab (genetical recombination) [Adalimumab biosimilar 1] (JAN)
Adalimumab (genetical recombination) [Adalimumab biosimilar 2] (JAN)
Adalimumab (genetical recombination) [Adalimumab biosimilar 3] (JAN)
Adalimumab-adaz
Adalimumab-adbm
Adalimumab-afzb
Adalimumab-atto
Adalimumab-bwwd
Adalimumab-fkjp
Humira (TN)
Abrilada (TN)
Amjevita (TN)
Cyltezo (TN)
Hadlima (TN)
Hyrimoz (TN)

Adalimumab

[17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬

Disease ID	Name
19	Lysosomal storage disease;Lysosomal disease;
37	Generalised pustular psoriasis;Pustular psoriasis;
40	Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome;
41	Giant cell arteritis;Temporal arteritis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
56	Behcet disease;Behçet disease;BD;
84	Sarcoidosis;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
107	Juvenile idiopathic arthritis;JIA;
160	Congenital ichthyosis;
164	Oculocutaneous albinism;
222	Primary nephrotic syndrome;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
269	Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome;
270	Chronic recurrent multifocal osteomyelitis;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

Sphingolipid signaling pathway 💬

[1] TNF 💬

Certolizumab pegol 💬

Certolizumab pegol

[8] 37, 46, 49, 96, 97, 107, 226, 271 💬

Disease ID	Name
37	Generalised pustular psoriasis;Pustular psoriasis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
107	Juvenile idiopathic arthritis;JIA;
226	Interstitial cystitis with Hunners ulcer;Interstitial cystitis;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

Sphingolipid signaling pathway 💬

[1] TNF 💬

Etanercept 💬

Name	Other Names
Etanercept	Etanercept (USAN/INN) Etanercept (genetical recombination) (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 1] (JAN) Etanercept (genetical recombination) [Etanercept biosimilar 2] (JAN) Enbrel (TN)

Etanercept

[16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬

Disease ID	Name
15	Inclusion body myositis;
28	Systemic amyloidosis;AL amyloidosis;
35	Pemphigus;
38	Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome;
39	Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
50	Dermatomyositis;Polymyositis;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
56	Behcet disease;Behçet disease;BD;
60	Aplastic anemia;
85	Idiopathic interstitial pneumonia;IIPs;
107	Juvenile idiopathic arthritis;JIA;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;
270	Chronic recurrent multifocal osteomyelitis;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
285	Fanconi anemia;

Sphingolipid signaling pathway 💬

[1] TNF 💬

Golimumab 💬

Golimumab

[8] 46, 56, 84, 96, 97, 107, 270, 271 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
56	Behcet disease;Behçet disease;BD;
84	Sarcoidosis;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
107	Juvenile idiopathic arthritis;JIA;
270	Chronic recurrent multifocal osteomyelitis;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

Sphingolipid signaling pathway 💬

[1] TNF 💬

Infliximab 💬

Name	Other Names
Infliximab	Infliximab (USAN/INN) Infliximab (genetical recombination) (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 1] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 2] (JAN) Infliximab (genetical recombination) [Infliximab biosimilar 3] (JAN) Infliximab-dyyb Infliximab-abda Infliximab-axxq Remicade (TN) Inflectra (TN) Renflexis (TN) Avsola (TN)

Infliximab

[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬

Disease ID	Name
35	Pemphigus;
37	Generalised pustular psoriasis;Pustular psoriasis;
38	Stevens-Johnson syndrome;SJS;Mucocutaneous ocular syndrome;
39	Toxic epidermal necrolysis;Toxic epidermal necrosis;TEN;
40	Takayasu arteritis;Aortitis syndrome;Pulseless disease;Aortitis syndrome;
41	Giant cell arteritis;Temporal arteritis;
42	Polyarteritis nodosa;PAN;
43	Microscopic polyangiitis;MPA;
45	Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
55	Relapsing polychondritis;
56	Behcet disease;Behçet disease;BD;
65	Primary immunodeficiency;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
95	Autoimmune hepatitis;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
107	Juvenile idiopathic arthritis;JIA;
162	Pemphigoid;
164	Oculocutaneous albinism;
269	Pyogenic arthritis;Pyoderma gangrenosum;Acne syndrome;PAPA syndrome;
270	Chronic recurrent multifocal osteomyelitis;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

Sphingolipid signaling pathway 💬

[1] TNF 💬

Lenalidomide 💬

Lenalidomide

[8] 16, 26, 28, 34, 49, 284, 300, 331 💬

Disease ID	Name
16	Crow-Fukase syndrome;POEMS syndrome;
26	HTLV-1-associated myelopathy;Tropical spastic paraparesis;HTLV-1;HTLV-I-associated myelopathy;HAM;
28	Systemic amyloidosis;AL amyloidosis;
34	Neurofibromatosis;
49	Systemic lupus erythematosus;SLE;
284	Diamond-Blackfan anemia;
300	IgG4-related disease;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

Sphingolipid signaling pathway 💬

[1] TNF 💬

Ozoralizumab 💬

Ozoralizumab

[1] 46 💬

Sphingolipid signaling pathway 💬

[1] TNF 💬

Pegsunercept 💬

Pegsunercept

[1] 46 💬

Sphingolipid signaling pathway 💬

[1] TNF 💬

Pirfenidone 💬

Pirfenidone

[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
58	Hypertrophic cardiomyopathy;HCM;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
164	Oculocutaneous albinism;
222	Primary nephrotic syndrome;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;

Sphingolipid signaling pathway 💬

[1] TNF 💬

Pomalidomide 💬

Pomalidomide

[5] 28, 51, 85, 227, 331 💬

Disease ID	Name
28	Systemic amyloidosis;AL amyloidosis;
51	Scleroderma;Systemic sclerosis;SSc;
85	Idiopathic interstitial pneumonia;IIPs;
227	Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

Sphingolipid signaling pathway 💬

[1] TNF 💬

Thalidomide 💬

Thalidomide

[20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis;ALS;
16	Crow-Fukase syndrome;POEMS syndrome;
20	Adrenoleukodystrophy;ALD;
28	Systemic amyloidosis;AL amyloidosis;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
56	Behcet disease;Behçet disease;BD;
65	Primary immunodeficiency;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
94	Primary sclerosing cholangitis;PSC;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
227	Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
280	Huge arteriovenous malformation with cervicofacial or limb lesion;Huge arteriovenous malformation;Arteriovenous malformation;
298	Hereditary pancreatitis;Chronic pancreatitis;
300	IgG4-related disease;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;