Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Acute myeloid leukemia 💬
 [4] BRAF, FLT3, KIT, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
2 Alcoholism 💬
 [2] BRAF, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
3 Alzheimer disease 💬
 [2] BRAF, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
4 Apelin signaling pathway 💬
 [1] RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
5 Apoptosis 💬
 [1] RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
6 Autophagy - animal 💬
 [1] RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
7 Axon guidance 💬
 [1] RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
8 B cell receptor signaling pathway 💬
 [1] RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
9 Bladder cancer 💬
 [2] BRAF, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
10 Breast cancer 💬
 [4] BRAF, FLT4, KIT, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
11 C-type lectin receptor signaling pathway 💬
 [1] RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
12 cAMP signaling pathway 💬
 [2] BRAF, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
13 Cellular senescence 💬
 [1] RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
14 Central carbon metabolism in cancer 💬
 [5] FLT3, KIT, PDGFRB, RAF1, RET 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
15 cGMP-PKG signaling pathway 💬
 [1] RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
16 Chemical carcinogenesis - reactive oxygen species 💬
 [2] BRAF, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
17 Chemical carcinogenesis - receptor activation 💬
 [1] RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
18 Chemokine signaling pathway 💬
 [2] BRAF, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
19 Choline metabolism in cancer 💬
 [2] PDGFRB, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
20 Chronic myeloid leukemia 💬
 [2] BRAF, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
21 Colorectal cancer 💬
 [2] BRAF, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
22 EGFR tyrosine kinase inhibitor resistance 💬
 [4] BRAF, KDR, PDGFRB, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
23 Endocrine resistance 💬
 [2] BRAF, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
24 Endometrial cancer 💬
 [2] BRAF, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
25 ErbB signaling pathway 💬
 [2] BRAF, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
26 Estrogen signaling pathway 💬
 [1] RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
27 Fc epsilon RI signaling pathway 💬
 [1] RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
28 Fc gamma R-mediated phagocytosis 💬
 [1] RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
29 Focal adhesion 💬
 [5] BRAF, FLT4, KDR, PDGFRB, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
30 FoxO signaling pathway 💬
 [2] BRAF, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
31 Gap junction 💬
 [2] PDGFRB, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
32 Gastric cancer 💬
 [2] BRAF, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
33 Glioma 💬
 [3] BRAF, PDGFRB, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
34 GnRH secretion 💬
 [1] RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
35 GnRH signaling pathway 💬
 [1] RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
36 Growth hormone synthesis, secretion and action 💬
 [1] RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
37 Hepatitis B 💬
 [2] BRAF, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
38 Hepatitis C 💬
 [2] BRAF, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
39 Hepatocellular carcinoma 💬
 [2] BRAF, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
40 Human cytomegalovirus infection 💬
 [1] RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
41 Human immunodeficiency virus 1 infection 💬
 [1] RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
42 Human papillomavirus infection 💬
 [2] PDGFRB, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
43 Influenza A 💬
 [1] RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
44 Insulin signaling pathway 💬
 [2] BRAF, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
45 JAK-STAT signaling pathway 💬
 [2] PDGFRB, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
46 Kaposi sarcoma-associated herpesvirus infection 💬
 [1] RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
47 Long-term depression 💬
 [2] BRAF, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
48 Long-term potentiation 💬
 [2] BRAF, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
49 MAPK signaling pathway 💬
 [7] BRAF, FLT3, FLT4, KDR, KIT, PDGFRB, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
50 Melanogenesis 💬
 [2] KIT, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
51 Melanoma 💬
 [3] BRAF, PDGFRB, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
52 MicroRNAs in cancer 💬
 [2] PDGFRB, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
53 mTOR signaling pathway 💬
 [2] BRAF, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
54 Natural killer cell mediated cytotoxicity 💬
 [2] BRAF, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
55 Neurotrophin signaling pathway 💬
 [2] BRAF, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
56 Neutrophil extracellular trap formation 💬
 [1] RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
57 Non-small cell lung cancer 💬
 [3] BRAF, RAF1, RET 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
58 Oxytocin signaling pathway 💬
 [1] RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
59 Pancreatic cancer 💬
 [2] BRAF, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
60 Parathyroid hormone synthesis, secretion and action 💬
 [2] BRAF, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
61 Pathways in cancer 💬
 [7] BRAF, FLT3, FLT4, KIT, PDGFRB, RAF1, RET 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
62 Pathways of neurodegeneration - multiple diseases 💬
 [2] BRAF, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
63 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [1] RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
64 Phospholipase D signaling pathway 💬
 [3] KIT, PDGFRB, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
65 PI3K-Akt signaling pathway 💬
 [6] FLT3, FLT4, KDR, KIT, PDGFRB, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
66 Progesterone-mediated oocyte maturation 💬
 [2] BRAF, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
67 Prolactin signaling pathway 💬
 [1] RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
68 Prostate cancer 💬
 [3] BRAF, PDGFRB, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
69 Proteoglycans in cancer 💬
 [3] BRAF, KDR, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
70 Rap1 signaling pathway 💬
 [6] BRAF, FLT4, KDR, KIT, PDGFRB, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
71 Ras signaling pathway 💬
 [6] FLT3, FLT4, KDR, KIT, PDGFRB, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
72 Regulation of actin cytoskeleton 💬
 [3] BRAF, PDGFRB, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
73 Relaxin signaling pathway 💬
 [1] RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
74 Renal cell carcinoma 💬
 [2] BRAF, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
75 Salmonella infection 💬
 [1] RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
76 Serotonergic synapse 💬
 [2] BRAF, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
77 Signaling pathways regulating pluripotency of stem cells 💬
 [1] RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
78 Sphingolipid signaling pathway 💬
 [1] RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
79 T cell receptor signaling pathway 💬
 [1] RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
80 Thyroid hormone signaling pathway 💬
 [1] RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
81 Tuberculosis 💬
 [1] RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
82 Vascular smooth muscle contraction 💬
 [2] BRAF, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬
83 VEGF signaling pathway 💬
 [2] KDR, RAF1 💬 Sorafenib 💬 Sorafenib [2] 34, 86 💬

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