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No.	KEGG PATHWAY	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Endocrine resistance 💬	[1] BCL2 💬	Venetoclax 💬	Venetoclax	[1] 28 💬 💬
2	Endocrine resistance 💬	[1] BRAF 💬	Dabrafenib 💬	Dabrafenib	[1] 34 💬 💬
3	Endocrine resistance 💬	[2] BRAF, RAF1 💬	Sorafenib 💬	Sorafenib	[2] 34, 86 💬 💬
4	Endocrine resistance 💬	[1] CDK4 💬	Abemaciclib 💬	Abemaciclib	[1] 34 💬 💬
5	Endocrine resistance 💬	[1] EGFR 💬	Cetuximab 💬	Cetuximab	[2] 51, 86 💬 💬
6	Endocrine resistance 💬	[1] EGFR 💬	Erlotinib 💬	Erlotinib	[1] 94 💬 💬
7	Endocrine resistance 💬	[1] EGFR 💬	Gefitinib 💬	Gefitinib	[1] 75 💬 💬
8	Endocrine resistance 💬	[1] EGFR 💬	Icotinib 💬	Icotinib	[1] 34 💬 💬
9	Endocrine resistance 💬	[2] EGFR, ERBB2 💬	Lapatinib 💬	Lapatinib	[3] 34, 74, 75 💬 💬
10	Endocrine resistance 💬	[2] EGFR, ERBB2 💬	Neratinib 💬	Neratinib	[1] 34 💬 💬
11	Endocrine resistance 💬	[2] EGFR, ERBB2 💬	Tesevatinib 💬	Tesevatinib	[1] 67 💬 💬
12	Endocrine resistance 💬	[1] ESR1 💬	Danazol 💬	Danazol	[5] 60, 63, 64, 65, 285 💬 💬
13	Endocrine resistance 💬	[1] ESR1 💬	Desogestrel 💬	Desogestrel	[1] 230 💬 💬
14	Endocrine resistance 💬	[1] ESR1 💬	Ethinyl estradiol 💬	Ethinylestradiol	[4] 13, 46, 49, 299 💬 💬
15	Endocrine resistance 💬	[2] ESR1, ESR2 💬	Clomifene 💬	Clomifene	[1] 74 💬 💬
16	Endocrine resistance 💬	[2] ESR1, ESR2 💬	Estetrol 💬	Estetrol	[1] 53 💬 💬
17	Endocrine resistance 💬	[2] ESR1, ESR2 💬	Estetrol 💬	Estetrol	[1] 53 💬 💬
18	Endocrine resistance 💬	[2] ESR1, ESR2 💬	Estradiol 💬	Estradiol	[7] 13, 46, 49, 65, 76, 226, 299 💬 💬
19	Endocrine resistance 💬	[2] ESR1, ESR2 💬	Estradiol valerate 💬	Estradiol valerate	[1] 65 💬 💬
20	Endocrine resistance 💬	[2] ESR1, ESR2 💬	Estriol 💬	Estriol	[2] 13, 227 💬 💬
21	Endocrine resistance 💬	[2] ESR1, ESR2 💬	Estriol tripropionate 💬	Estriol	[2] 13, 227 💬 💬
22	Endocrine resistance 💬	[2] ESR1, ESR2 💬	Fulvestrant 💬	Fulvestrant	[2] 49, 86 💬 💬
23	Endocrine resistance 💬	[2] ESR1, ESR2 💬	Mestranol 💬	Mestranol	[2] 46, 49 💬 💬
24	Endocrine resistance 💬	[2] ESR1, ESR2 💬	Prasterone 💬	Prasterone	[6] 49, 53, 83, 86, 96, 113 💬 💬
25	Endocrine resistance 💬	[2] ESR1, ESR2 💬	Raloxifene 💬	Raloxifene	[1] 46 💬 💬
26	Endocrine resistance 💬	[2] ESR1, ESR2 💬	Tamoxifen 💬	Tamoxifen	[3] 2 , 113, 227 💬 💬
27	Endocrine resistance 💬	[1] IGF1R 💬	Linsitinib 💬	Linsitinib	[1] 232 💬 💬
28	Endocrine resistance 💬	[1] IGF1R 💬	Mecasermin 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬 💬
29	Endocrine resistance 💬	[1] IGF1R 💬	Teprotumumab 💬	Teprotumumab	[1] 51 💬 💬
30	Endocrine resistance 💬	[2] MAP2K1, MAP2K2 💬	Binimetinib 💬	Binimetinib	[1] 34 💬 💬
31	Endocrine resistance 💬	[2] MAP2K1, MAP2K2 💬	Cobimetinib 💬	Cobimetinib	[1] 280 💬 💬
32	Endocrine resistance 💬	[2] MAP2K1, MAP2K2 💬	Mirdametinib 💬	Mirdametinib	[1] 34 💬 💬
33	Endocrine resistance 💬	[2] MAP2K1, MAP2K2 💬	Selumetinib 💬	Selumetinib	[1] 34 💬 💬
34	Endocrine resistance 💬	[2] MAP2K1, MAP2K2 💬	Trametinib 💬	Trametinib	[4] 2 , 34, 279, 280 💬 💬
35	Endocrine resistance 💬	[4] MAPK11, MAPK12, MAPK13, MAPK14 💬	Losmapimod 💬	Losmapimod	[2] 113, 222 💬 💬
36	Endocrine resistance 💬	[4] MAPK11, MAPK12, MAPK13, MAPK14 💬	Neflamapimod 💬	Neflamapimod	[1] 8 💬 💬
37	Endocrine resistance 💬	[1] MTOR 💬	Everolimus 💬	Everolimus	[9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 💬
38	Endocrine resistance 💬	[1] MTOR 💬	Sirolimus 💬	Sirolimus	[40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
39	Endocrine resistance 💬	[1] MTOR 💬	Temsirolimus 💬	Temsirolimus	[1] 13 💬 💬
40	Endocrine resistance 💬	[1] PIK3CA 💬	Alpelisib 💬	Alpelisib	[1] 138 💬 💬
41	Endocrine resistance 💬	[3] PIK3CA, PIK3CB, PIK3CD 💬	Leniolisib 💬	Leniolisib	[2] 53, 65 💬 💬
42	Endocrine resistance 💬	[1] PIK3CD 💬	Parsaclisib 💬	Parsaclisib	[3] 35, 53, 61 💬 💬
43	Endocrine resistance 💬	[1] SRC 💬	Bosutinib 💬	Bosutinib	[2] 2 , 67 💬 💬
44	Endocrine resistance 💬	[1] SRC 💬	Dasatinib 💬	Dasatinib	[2] 51, 85 💬 💬
45	Endocrine resistance 💬	[1] SRC 💬	Dasatinib 💬	Dasatinib	[2] 51, 85 💬 💬
46	Endocrine resistance 💬	[1] SRC 💬	Saracatinib 💬	Saracatinib	[3] 6 , 89, 272 💬 💬