Gene

Disease ID	Name
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
19	Lysosomal storage disease;Lysosomal disease;
41	Giant cell arteritis;Temporal arteritis;
44	Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
55	Relapsing polychondritis;
60	Aplastic anemia;
65	Primary immunodeficiency;
84	Sarcoidosis;
93	Primary biliary cholangitis;Primary biliary cirrhosis;PBC;
95	Autoimmune hepatitis;
96	Crohn disease;Terminal ileitis;
97	Ulcerative colitis;
107	Juvenile idiopathic arthritis;JIA;
160	Congenital ichthyosis;
164	Oculocutaneous albinism;
222	Primary nephrotic syndrome;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
284	Diamond-Blackfan anemia;
285	Fanconi anemia;
300	IgG4-related disease;

Intestinal immune network for IgA production 💬

[2] CD80, CD86 💬

Belatacept 💬

Belatacept

[1] 46 💬

Intestinal immune network for IgA production 💬

[1] CXCR4 💬

Plerixafor 💬

Plerixafor

[5] 19, 20, 65, 285, 299 💬

Intestinal immune network for IgA production 💬

[2] IL10, IL6 💬

Pirfenidone 💬

Pirfenidone

[11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
50	Dermatomyositis;Polymyositis;
51	Scleroderma;Systemic sclerosis;SSc;
58	Hypertrophic cardiomyopathy;HCM;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
164	Oculocutaneous albinism;
222	Primary nephrotic syndrome;
228	Bronchiolitis obliterans;Obliterating bronchiolitis;

Intestinal immune network for IgA production 💬

[1] IL4 💬

Binetrakin 💬

Binetrakin

[1] 46 💬

Intestinal immune network for IgA production 💬

[1] IL5 💬

Mepolizumab 💬

Mepolizumab

[4] 44, 45, 98, 162 💬

Disease ID	Name
44	Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis;
45	Eosinophilic granulomatosis with Polyangiitis;EGPA;Eosinophilic multiple vasculitis granulomatous disease;Allergic granulomatous angiitis;AGA;Churg-Strauss syndrome;CSS;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;
162	Pemphigoid;

Intestinal immune network for IgA production 💬

[1] IL5 💬

Reslizumab 💬

Reslizumab

[2] 44, 98 💬

Disease ID	Name
44	Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis;
98	Eosinophilic gastrointestinal disease;Eosinophilic gastroenteritis;Eosinophilic esophagitis;Eosinophilic colitis;Eosinophilic gastro-intestinal disorder;EGID;

Intestinal immune network for IgA production 💬

[1] IL6 💬

Olokizumab 💬

Olokizumab

[2] 46, 96 💬

Intestinal immune network for IgA production 💬

[1] IL6 💬

Pomalidomide 💬

Pomalidomide

[5] 28, 51, 85, 227, 331 💬

Disease ID	Name
28	Systemic amyloidosis;AL amyloidosis;
51	Scleroderma;Systemic sclerosis;SSc;
85	Idiopathic interstitial pneumonia;IIPs;
227	Osler disease;Hereditary hemorrhagic telangiectasia;Osler-Weber-Rendu disease;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

Intestinal immune network for IgA production 💬

[1] IL6 💬

Siltuximab 💬

Siltuximab

[2] 28, 331 💬

Intestinal immune network for IgA production 💬

[1] IL6 💬

Sirukumab 💬

Sirukumab

[2] 41, 46 💬

Intestinal immune network for IgA production 💬

[1] ITGA4 💬

Firategrast 💬

Firategrast

[1] 13 💬

Intestinal immune network for IgA production 💬

[1] ITGA4 💬

Natalizumab 💬

Natalizumab

[6] 13, 15, 25, 46, 63, 96 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
15	Inclusion body myositis;
25	Progressive multifocal leukoencephalopathy;PML;Leukoencephalopathy, progressive multifocal;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
96	Crohn disease;Terminal ileitis;

Intestinal immune network for IgA production 💬

[2] ITGA4, ITGB7 💬

Abrilumab 💬

Abrilumab

[2] 96, 97 💬

Intestinal immune network for IgA production 💬

[2] ITGA4, ITGB7 💬

Vedolizumab 💬

Vedolizumab

[3] 94, 96, 97 💬

Intestinal immune network for IgA production 💬

[1] ITGB7 💬

Etrolizumab 💬

Etrolizumab

[2] 96, 97 💬

Intestinal immune network for IgA production 💬

[1] TGFB1 💬

Fresolimumab 💬

Fresolimumab

[3] 51, 85, 222 💬

Intestinal immune network for IgA production 💬

[1] TNFRSF13C 💬

Ianalumab 💬

Ianalumab

[7] 35, 46, 49, 53, 61, 63, 95 💬

Disease ID	Name
35	Pemphigus;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
61	Autoimmune hemolytic anemia;AIHA;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
95	Autoimmune hepatitis;

Intestinal immune network for IgA production 💬

[1] TNFRSF17 💬

Belantamab mafodotin 💬

Belantamab mafodotin

[1] 28 💬

Intestinal immune network for IgA production 💬

[2] TNFSF13, TNFSF13B 💬

Atacicept 💬

Atacicept

[4] 13, 46, 49, 66 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;

Intestinal immune network for IgA production 💬

[1] TNFSF13B 💬

Belimumab 💬

Belimumab

[13] 11, 13, 43, 44, 46, 49, 51, 53, 63, 66, 222, 296, 300 💬

Disease ID	Name
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
43	Microscopic polyangiitis;MPA;
44	Wegener granulomatosis;Multiple vasculitis granulomatous disease;Granulomatosis with polyangiitis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;
222	Primary nephrotic syndrome;
296	Biliary atresia;
300	IgG4-related disease;

Intestinal immune network for IgA production 💬

[1] TNFSF13B 💬

Tabalumab 💬

Tabalumab

[2] 46, 49 💬

Intestinal immune network for IgA production 💬

[1] TNFSF13B 💬

Tibulizumab 💬

Tibulizumab

[1] 53 💬