Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY KEGG GENES KEGG DRUG DrugBank Disease ID
1 Lipid and atherosclerosis 💬
 [1] BCL2 💬 Venetoclax 💬 Venetoclax [1] 28 💬 💬
2 Lipid and atherosclerosis 💬
 [1] CASP9 💬 Rimiducid 💬 Rimiducid [6] 19, 60, 65, 284, 285, 326 💬 💬
3 Lipid and atherosclerosis 💬
 [4] CCL2, IL1B, IL6, TNF 💬 Pirfenidone 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬
4 Lipid and atherosclerosis 💬
 [1] CD40 💬 Bleselumab 💬 Bleselumab [1] 222 💬 💬
5 Lipid and atherosclerosis 💬
 [1] CD40 💬 Iscalimab 💬 Iscalimab [2] 49, 53 💬 💬
6 Lipid and atherosclerosis 💬
 [1] CD40 💬 Ravagalimab 💬 Ravagalimab [2] 53, 97 💬 💬
7 Lipid and atherosclerosis 💬
 [1] CD40LG 💬 Toralizumab 💬 Toralizumab [1] 63 💬 💬
8 Lipid and atherosclerosis 💬
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 Rontalizumab 💬 Rontalizumab [1] 49 💬 💬
9 Lipid and atherosclerosis 💬
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 Sifalimumab 💬 Sifalimumab [1] 49 💬 💬
10 Lipid and atherosclerosis 💬
 [2] IL12A, IL12B 💬 Ustekinumab 💬 Ustekinumab [16] 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬 💬
11 Lipid and atherosclerosis 💬
 [1] IL1B 💬 Canakinumab 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬
12 Lipid and atherosclerosis 💬
 [1] IL1B 💬 Gevokizumab 💬 Gevokizumab [4] 41, 50, 56, 269 💬 💬
13 Lipid and atherosclerosis 💬
 [1] IL1B 💬 Rilonacept 💬 Rilonacept [4] 51, 106, 107, 266 💬 💬
14 Lipid and atherosclerosis 💬
 [1] IL6 💬 Olokizumab 💬 Olokizumab [2] 46, 96 💬 💬
15 Lipid and atherosclerosis 💬
 [1] IL6 💬 Siltuximab 💬 Siltuximab [2] 28, 331 💬 💬
16 Lipid and atherosclerosis 💬
 [1] IL6 💬 Sirukumab 💬 Sirukumab [2] 41, 46 💬 💬
17 Lipid and atherosclerosis 💬
 [2] IL6, TNF 💬 Pomalidomide 💬 Pomalidomide [5] 28, 51, 85, 227, 331 💬 💬
18 Lipid and atherosclerosis 💬
 [1] JAK2 💬 Baricitinib 💬 Baricitinib [13]  2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬
19 Lipid and atherosclerosis 💬
 [1] JAK2 💬 Peficitinib 💬 Peficitinib [1] 46 💬 💬
20 Lipid and atherosclerosis 💬
 [1] JAK2 💬 Ruxolitinib 💬 Ruxolitinib [3] 60, 65, 228 💬 💬
21 Lipid and atherosclerosis 💬
 [1] JAK2 💬 Tofacitinib 💬 Tofacitinib [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬 💬
22 Lipid and atherosclerosis 💬
 [1] MAP3K5 💬 Selonsertib 💬 Selonsertib [1] 86 💬 💬
23 Lipid and atherosclerosis 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Losmapimod 💬 Losmapimod [2] 113, 222 💬 💬
24 Lipid and atherosclerosis 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 Neflamapimod 💬 Neflamapimod [1]  8  💬 💬
25 Lipid and atherosclerosis 💬
 [1] NFE2L2 💬 Omaveloxolone 💬 Omaveloxolone [1] 18 💬 💬
26 Lipid and atherosclerosis 💬
 [1] NFKB1 💬 Iguratimod 💬 Iguratimod [5] 46, 51, 53, 271, 300 💬 💬
27 Lipid and atherosclerosis 💬
 [1] PIK3CA 💬 Alpelisib 💬 Alpelisib [1] 138 💬 💬
28 Lipid and atherosclerosis 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 Leniolisib 💬 Leniolisib [2] 53, 65 💬 💬
29 Lipid and atherosclerosis 💬
 [1] PIK3CD 💬 Parsaclisib 💬 Parsaclisib [3] 35, 53, 61 💬 💬
30 Lipid and atherosclerosis 💬
 [1] PPARG 💬 Bocidelpar 💬 Bocidelpar [1] 113 💬 💬
31 Lipid and atherosclerosis 💬
 [1] PPARG 💬 Leriglitazone 💬 Leriglitazone [1] 20 💬 💬
32 Lipid and atherosclerosis 💬
 [1] PPARG 💬 Pioglitazone 💬 Pioglitazone [17]  2 ,  6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬 💬
33 Lipid and atherosclerosis 💬
 [1] PPARG 💬 Rosiglitazone 💬 Rosiglitazone [5] 46, 75, 97, 222, 265 💬 💬
34 Lipid and atherosclerosis 💬
 [1] PPARG 💬 Seladelpar 💬 Seladelpar [2] 93, 94 💬 💬
35 Lipid and atherosclerosis 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Cyclosporine 💬 Cyclosporine [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬
36 Lipid and atherosclerosis 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Pimecrolimus 💬 Pimecrolimus [1] 160 💬 💬
37 Lipid and atherosclerosis 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Tacrolimus 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬
38 Lipid and atherosclerosis 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Tacrolimus 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬
39 Lipid and atherosclerosis 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Voclosporin 💬 Voclosporin [2] 49, 222 💬 💬
40 Lipid and atherosclerosis 💬
 [1] RELA 💬 Edasalonexent 💬 Edasalonexent [1] 113 💬 💬
41 Lipid and atherosclerosis 💬
 [1] ROCK2 💬 Belumosudil 💬 Belumosudil [2] 51, 85 💬 💬
42 Lipid and atherosclerosis 💬
 [1] ROCK2 💬 Fasudil 💬 Fasudil [4]  2 ,  5 ,  7 , 51 💬 💬
43 Lipid and atherosclerosis 💬
 [3] RXRA, RXRB, RXRG 💬 Acitretin 💬 Acitretin [1] 37 💬 💬
44 Lipid and atherosclerosis 💬
 [3] RXRA, RXRB, RXRG 💬 Alitretinoin 💬 Alitretinoin [1] 49 💬 💬
45 Lipid and atherosclerosis 💬
 [3] RXRA, RXRB, RXRG 💬 Bexarotene 💬 Bexarotene [2] 13, 75 💬 💬
46 Lipid and atherosclerosis 💬
 [1] SRC 💬 Bosutinib 💬 Bosutinib [2]  2 , 67 💬 💬
47 Lipid and atherosclerosis 💬
 [1] SRC 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬 💬
48 Lipid and atherosclerosis 💬
 [1] SRC 💬 Dasatinib 💬 Dasatinib [2] 51, 85 💬 💬
49 Lipid and atherosclerosis 💬
 [1] SRC 💬 Saracatinib 💬 Saracatinib [3]  6 , 89, 272 💬 💬
50 Lipid and atherosclerosis 💬
 [1] TNF 💬 Adalimumab 💬 Adalimumab [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬 💬
51 Lipid and atherosclerosis 💬
 [1] TNF 💬 Certolizumab pegol 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬 💬
52 Lipid and atherosclerosis 💬
 [1] TNF 💬 Etanercept 💬 Etanercept [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬 💬
53 Lipid and atherosclerosis 💬
 [1] TNF 💬 Golimumab 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬 💬
54 Lipid and atherosclerosis 💬
 [1] TNF 💬 Infliximab 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬 💬
55 Lipid and atherosclerosis 💬
 [1] TNF 💬 Lenalidomide 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬 💬
56 Lipid and atherosclerosis 💬
 [1] TNF 💬 Ozoralizumab 💬 Ozoralizumab [1] 46 💬 💬
57 Lipid and atherosclerosis 💬
 [1] TNF 💬 Pegsunercept 💬 Pegsunercept [1] 46 💬 💬
58 Lipid and atherosclerosis 💬
 [1] TNF 💬 Thalidomide 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬