266. 家族性地中海熱 Familial mediterranean fever Clinical trials / Disease details


臨床試験数 : 28 薬物数 : 24 - (DrugBank : 6) / 標的遺伝子数 : 14 - 標的パスウェイ数 : 59

  
13 trials found
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PhaseCountries
1NCT05190991
(ClinicalTrials.gov)
October 5, 20213/11/2021Safety and Efficacy of RPH-104 Used to Prevent Recurrent Fever Attacks in Adult Patients With Colchicine Resistant or Colchicine Intolerant Familial Mediterranean FeverAn International Multicenter Open-label Clinical Study of the Safety and Efficacy of RPH-104 for Prevention of Recurring Attacks in Adult Subjects With Familial Mediterranean Fever With Resistance to or Intolerance of ColchicineFamilial Mediterranean Fever;FMFBiological: RPH-104R-Pharm International, LLCAtlant Clinical LLC;Center for Pharmaceutical Analytics LLC;Unimed Laboratories CJSC;Data Management 365 LLCRecruiting18 Years80 YearsAll60Phase 2Armenia;Georgia;Russian Federation
2JPRN-UMIN000032557
2018/09/0130/05/2018An open-label continuation trial of tocilizumab for familial Mediterranean fever with colchicine ineffective or intoleranceAn open-label continuation trial of tocilizumab for familial Mediterranean fever with colchicine ineffective or intolerance - An open-label continuation trial of tocilizumab for familial Mediterranean fever familial Mediterranean feverTocilizumabDepartment of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical SciencesNULLComplete: follow-up continuing12years-oldNot applicableMale and Female24Not selectedJapan
3JPRN-UMIN000028010
2018/03/0107/07/2017Randomized, double-blind, parallel group comparison trial of Tocilizumab for colchicine-resistant familial Mediterranean feverRandomized, double-blind, parallel group comparison trial of Tocilizumab for colchicine-resistant familial Mediterranean fever - Clinical trial of Tocilizumab for colchicine-resistant familial Mediterranean fever familial Mediterranean feverTocilizumab
Placebo
Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical SciencesNULLComplete: follow-up complete12years-oldNot applicableMale and Female24Not selectedJapan
4NCT03210610
(ClinicalTrials.gov)
October 19, 201729/6/2017Colchicine Levels in the Serum of FMF (Familial Mediterranean Fever) PatientsMeasurement of Colchicine Levels in the Serum of FMF PatientsFMF;Colchicine Resistance;Colchicine ToxicityDiagnostic Test: colchicine level measurementSheba Medical CenterNULLUnknown status18 YearsN/AAll80Israel
5NCT02175589
(ClinicalTrials.gov)
June 201424/6/2014Controlled Ceasing of Colchicine Therapy in Familial Mediterranean Fever (FMF) Patients With Single MEFV (Mediterranean Fever) Gene MutationControlled Ceasing of Colchicine Therapy in Familial Mediterranean Fever (FMF) Patients With Single MEFV (Mediterranean Fever) Gene MutationFamilial Mediterranean FeverOther: Colchicine CessationRambam Health Care CampusSchneider Children's HospitalEnrolling by invitation2 Years18 YearsBoth80Phase 2Israel
6NCT02021084
(ClinicalTrials.gov)
December 201329/10/2013The Effect of Probiotics on Response to Therapy and on Adverse Effect in Patients Treated With Colchicine for Familial Mediterranean Fever.Familial Mediterranean Fever (FMF )Dietary Supplement: probiotic;Dietary Supplement: PlaceboRambam Health Care CampusNULLWithdrawn5 Years18 YearsBoth0N/ANULL
7NCT01705756
(ClinicalTrials.gov)
November 201227/9/2012Kineret (Anakinra), in Adult Patients With Colchicine-Resistant Familial Mediterranean FeverA Randomized Placebo-Controlled Study of the Efficacy and Safety of Kineret (Anakinra), in Adult Patients With Colchicine-Resistant Familial Mediterranean FeverFamilial Mediterranean FeverDrug: KineretSheba Medical CenterNULLCompleted18 Years65 YearsAll25Phase 3Israel
8NCT02602028
(ClinicalTrials.gov)
April 20115/11/2015The Comparison of the Efficacy of Once and Twice Daily Colchicine Dosage in Pediatric Patients With FMFThe Comparison of the Efficacy of Once and Twice Daily Colchicine Dosage in Pediatric Patients With Familial Mediterranean Fever: A Randomized TrialFamilial Mediterranean FeverDrug: colchicineGulhane Military Medical AcademyNULLCompleted5 Years16 YearsBoth79Phase 4Turkey
9NCT01148797
(ClinicalTrials.gov)
December 201021/6/2010Evaluate the Safety and Efficacy of Canakinumab in Pediatric Patients With Colchicine Intolerant or Colchicine Resistant Familial Mediterranean Fever (FMF)A 6 Month Phase 2, Multi-Center, Open-label, Single Arm Study to Evaluate the Safety and Efficacy of Treatment With Canakinumab in Pediatric Patients With Colchicine Intolerant or Colchicine Resistant Familial Mediterranean FeverColchicine Resistant/Intolerant Familial Mediterranean FeverDrug: CanakinumabNovartis PharmaceuticalsNULLCompleted4 Years20 YearsBoth15Phase 2Israel
10NCT01075906
(ClinicalTrials.gov)
August 201024/2/2010Pharmacokinetics Study of Colchicine in Familial Mediterranean Fever (FMF) PatientsAn Open-label, Parallel-group, Multiple-Dose, Pharmacokinetic and Safety Study of Colchicine Pediatric Formulation in Pediatric and Adult Patients With FMFFamilial Mediterranean FeverDrug: colchicine sprinkle capsulesMutual Pharmaceutical Company, Inc.NULLCompleted2 Years65 YearsBoth75Phase 1United States;Armenia;Israel;Turkey
11NCT01088880
(ClinicalTrials.gov)
April 201016/3/2010Efficacy and Safety of Canakinumab in Patients With Colchicine Resistant Familial Mediterranean FeverAn Open-label, Exploratory Study to Establish the Safety and Efficacy of 3 Months Treatment With Canakinumab in Patients With Colchicine Resistant Familial Mediterranean FeverFamilial Mediterranean FeverDrug: CanakinumabNovartis PharmaceuticalsNULLCompleted12 Years75 YearsBoth10Phase 2Turkey
12EUCTR2015-003522-13-Outside-EU/EEA
(EUCTR)
14/04/2016Evaluate the Safety and Efficacy of Canakinumab in Pediatric Patients With Colchicine Intolerant or Colchicine Resistant Familial Mediterranean Fever (FMF)A 6 Month Phase 2, Multi-Center, Open-label, Single Arm Study to Evaluate the Safety and Efficacy of Treatment With Canakinumab in Pediatric Patients With Colchicine Intolerant or Colchicine Resistant Familial Mediterranean Fever Colchicine Resistant/Intolerant Familial Mediterranean Fever
MedDRA version: 19.0;Level: PT;Classification code 10016207;Term: Familial mediterranean fever;System Organ Class: 10010331 - Congenital, familial and genetic disorders;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
Trade Name: Ilaris
Product Name: canakinumab
Product Code: ACZ885
INN or Proposed INN: CANAKINUMAB
Novartis PharmaceuticalsNULLNAFemale: yes
Male: yes
15Phase 2Israel
13EUCTR2015-003527-57-Outside-EU/EEA
(EUCTR)
14/04/2016Efficacy and Safety of Canakinumab in Patients With Colchicine Resistant Familial Mediterranean FeverAn Open-label, Exploratory Study to Establish the Safety and Efficacy of 3 Months Treatment With Canakinumab in Patients With Colchicine Resistant Familial Mediterranean Fever Familial Mediterranean Fever
MedDRA version: 19.0;Level: PT;Classification code 10016207;Term: Familial mediterranean fever;System Organ Class: 10010331 - Congenital, familial and genetic disorders;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
Trade Name: Ilaris
Product Name: canakinumab
Product Code: ACZ885
INN or Proposed INN: CANAKINUMAB
Novartis PharmaceuticalsNULLNAFemale: yes
Male: yes
9Turkey