KEGG DRUG

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No.	KEGG DRUG	DrugBank	薬物名（臨床試験情報から抽出）	KEGG GENES	KEGG PATHWAY	指定難病告示番号
1	Fomepizole	1件: Fomepizole	1件: 4-Methylpyrazole;	3件: ADH1A, ADH1B, ADH1C 💬	9件: Alcoholic liver disease, Drug metabolism - cytochrome P450, Fatty acid degradation, Glycolysis / Gluconeogenesis, Metabolic pathways, Metabolism of xenobiotics by cytochrome P450, Pyruvate metabolism, Retinol metabolism, Tyrosine metabolism 💬	1件: 301
2	Interferon gamma-1b	1件: Interferon gamma-1b	2件: ACTIMMUNE; Interferon gamma-1b;	2件: IFNGR1, IFNGR2 💬	18件: Chagas disease, Cytokine-cytokine receptor interaction, HIF-1 signaling pathway, Herpes simplex virus 1 infection, Inflammatory bowel disease, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Natural killer cell mediated cytotoxicity, Necroptosis, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways in cancer, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis 💬	7件: 18, 65, 85, 228, 299, 301, 326
3	Metformin	1件: Metformin	5件: Metformin; Metformin HCl; Metformin hydrochloride; Metformina; Metformine;	2件: PRKAA1, PRKAA2 💬	20件: AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬	25件: 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301
4	Ranibizumab	1件: Ranibizumab	3件: Lucentis; Ranibizumab; RhuFab V2;	1件: VEGFA 💬	24件: AGE-RAGE signaling pathway in diabetic complications, Bladder cancer, Calcium signaling pathway, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, EGFR tyrosine kinase inhibitor resistance, Fluid shear stress and atherosclerosis, Focal adhesion, HIF-1 signaling pathway, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, MAPK signaling pathway, MicroRNAs in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Relaxin signaling pathway, Renal cell carcinoma, Rheumatoid arthritis, VEGF signaling pathway 💬	4件: 34, 166, 227, 301
5	Icosapent	1件: Icosapent	2件: Eicosapentaenoic acid; Icosapent;	-	-	11件: 8, 46, 48, 49, 96, 97, 113, 296, 297, 301, 338
6	Sildenafil	1件: Sildenafil	6件: Mysildecard; REVATIO; Sildenafil; SILDENAFIL CITRATE; SILDENAFILO; VIAGRA;	1件: PDE5A 💬	3件: Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	17件: 6, 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301
7	Emixustat	1件: Emixustat	1件: Emixustat;	-	-	1件: 301