Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 EGFR 12件: Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Shigellosis, Pathways in cancer, Proteoglycans in cancer, Prostate cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D01977 Gefitinib 1件: 75
2 EGFR 12件: Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Shigellosis, Pathways in cancer, Proteoglycans in cancer, Prostate cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D03455 Cetuximab 2件: 51, 86
3 EGFR 12件: Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Shigellosis, Pathways in cancer, Proteoglycans in cancer, Prostate cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D07907 Erlotinib 1件: 94
4 EGFR 12件: Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Shigellosis, Pathways in cancer, Proteoglycans in cancer, Prostate cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D08108 Lapatinib 3件: 34, 74, 75
5 EGFR 12件: Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Shigellosis, Pathways in cancer, Proteoglycans in cancer, Prostate cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D08950 Neratinib 1件: 34
6 EGFR 12件: Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Shigellosis, Pathways in cancer, Proteoglycans in cancer, Prostate cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D11251 Icotinib 1件: 34
7 EGFR 12件: Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Shigellosis, Pathways in cancer, Proteoglycans in cancer, Prostate cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D11772 Tesevatinib 1件: 67
8 FGFR1 10件: Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Thermogenesis, Regulation of actin cytoskeleton, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Proteoglycans in cancer, Prostate cancer D10481 Nintedanib 5件: 51, 85, 89, 227, 228
9 FGFR1 10件: Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Signaling pathways regulating pluripotency of stem cells, Thermogenesis, Regulation of actin cytoskeleton, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Proteoglycans in cancer, Prostate cancer D11589 Infigratinib 1件: 276
10 MMP13 2件: Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action D08859 Apratastat 1件: 46
11 SOST 2件: Wnt signaling pathway, Parathyroid hormone synthesis, secretion and action D10156 Romosozumab 1件: 274
12 PDE4A 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D00227 Aminophylline 1件: 63
13 PDE4A 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D00302 Dipyridamole 6件: 46, 49, 51, 66, 96, 224
14 PDE4A 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D00371 Theophylline 2件: 236, 299
15 PDE4A 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D00528 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
16 PDE4A 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D01385 Ibudilast 2件: 2, 13
17 PDE4A 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D01453 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
18 PDE4A 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D01783 Rolipram 2件: 8, 13
19 PDE4A 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D05744 Roflumilast 4件: 84, 97, 206, 299
20 PDE4A 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D06103 Theophylline 2件: 236, 299
21 PDE4A 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D07546 Bucladesine 1件: 246
22 PDE4A 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D07961 Flavoxate 1件: 226
23 PDE4A 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D08860 Apremilast 7件: 46, 50, 56, 97, 107, 162, 271
24 PDE4B 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D00227 Aminophylline 1件: 63
25 PDE4B 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D00371 Theophylline 2件: 236, 299
26 PDE4B 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D00528 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
27 PDE4B 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D01385 Ibudilast 2件: 2, 13
28 PDE4B 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D01453 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
29 PDE4B 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D01783 Rolipram 2件: 8, 13
30 PDE4B 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D05744 Roflumilast 4件: 84, 97, 206, 299
31 PDE4B 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D06103 Theophylline 2件: 236, 299
32 PDE4B 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D07546 Bucladesine 1件: 246
33 PDE4B 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D07961 Flavoxate 1件: 226
34 PDE4B 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D08860 Apremilast 7件: 46, 50, 56, 97, 107, 162, 271
35 PDE4C 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D00227 Aminophylline 1件: 63
36 PDE4C 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D00371 Theophylline 2件: 236, 299
37 PDE4C 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D00528 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
38 PDE4C 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D01385 Ibudilast 2件: 2, 13
39 PDE4C 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D01453 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
40 PDE4C 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D01783 Rolipram 2件: 8, 13
41 PDE4C 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D05744 Roflumilast 4件: 84, 97, 206, 299
42 PDE4C 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D06103 Theophylline 2件: 236, 299
43 PDE4C 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D07546 Bucladesine 1件: 246
44 PDE4C 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D07961 Flavoxate 1件: 226
45 PDE4C 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D08860 Apremilast 7件: 46, 50, 56, 97, 107, 162, 271
46 PDE4D 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D00227 Aminophylline 1件: 63
47 PDE4D 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D00371 Theophylline 2件: 236, 299
48 PDE4D 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D00528 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
49 PDE4D 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D01385 Ibudilast 2件: 2, 13
50 PDE4D 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D01453 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265
51 PDE4D 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D01783 Rolipram 2件: 8, 13
52 PDE4D 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D05744 Roflumilast 4件: 84, 97, 206, 299
53 PDE4D 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D06103 Theophylline 2件: 236, 299
54 PDE4D 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D07546 Bucladesine 1件: 246
55 PDE4D 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D07961 Flavoxate 1件: 226
56 PDE4D 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D08860 Apremilast 7件: 46, 50, 56, 97, 107, 162, 271
57 PDE4D 2件: Purine metabolism, Parathyroid hormone synthesis, secretion and action D12173 Zatolmilast 1件: 206
58 PRKCB 17件: Ras signaling pathway, Rap1 signaling pathway, Phosphatidylinositol signaling system, Sphingolipid signaling pathway, Vascular smooth muscle contraction, Wnt signaling pathway, VEGF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Parathyroid hormone synthesis, secretion and action, Salivary secretion, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Proteoglycans in cancer D11935 Enzastaurin 1件: 168
59 MAP2K1 27件: Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Yersinia infection, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D09666 Selumetinib 1件: 34
60 MAP2K1 27件: Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Yersinia infection, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D10175 Trametinib 4件: 2, 34, 279, 280
61 MAP2K1 27件: Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Yersinia infection, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D10405 Cobimetinib 1件: 280
62 MAP2K1 27件: Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Yersinia infection, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D10604 Binimetinib 1件: 34
63 MAP2K1 27件: Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Yersinia infection, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D11675 Mirdametinib 1件: 34
64 PTH1R 1件: Parathyroid hormone synthesis, secretion and action D05364 Parathyroid hormone 4件: 65, 70, 235, 326
65 PTH1R 1件: Parathyroid hormone synthesis, secretion and action D06078 Teriparatide 7件: 46, 65, 68, 70, 71, 235, 274
66 RAF1 24件: Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, T cell receptor signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Tuberculosis, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D08524 Sorafenib 2件: 34, 86
67 BCL2 13件: Platinum drug resistance, Sphingolipid signaling pathway, Protein processing in endoplasmic reticulum, PI3K-Akt signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Shigellosis, Salmonella infection, Toxoplasmosis, Tuberculosis, Pathways in cancer, Prostate cancer, Small cell lung cancer D10679 Venetoclax 1件: 28
68 RXRA 9件: PPAR signaling pathway, PI3K-Akt signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Small cell lung cancer D02754 Acitretin 1件: 37
69 RXRA 9件: PPAR signaling pathway, PI3K-Akt signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Small cell lung cancer D02815 Alitretinoin 1件: 49
70 RXRA 9件: PPAR signaling pathway, PI3K-Akt signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Small cell lung cancer D03106 Bexarotene 2件: 13, 75
71 RXRB 8件: PPAR signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Small cell lung cancer D02754 Acitretin 1件: 37
72 RXRB 8件: PPAR signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Small cell lung cancer D02815 Alitretinoin 1件: 49
73 RXRB 8件: PPAR signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Small cell lung cancer D03106 Bexarotene 2件: 13, 75
74 RXRG 8件: PPAR signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Small cell lung cancer D02754 Acitretin 1件: 37
75 RXRG 8件: PPAR signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Small cell lung cancer D02815 Alitretinoin 1件: 49
76 RXRG 8件: PPAR signaling pathway, Th17 cell differentiation, Thyroid hormone signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Transcriptional misregulation in cancer, Thyroid cancer, Small cell lung cancer D03106 Bexarotene 2件: 13, 75
77 BRAF 12件: Rap1 signaling pathway, Vascular smooth muscle contraction, Serotonergic synapse, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Parathyroid hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer D08524 Sorafenib 2件: 34, 86
78 BRAF 12件: Rap1 signaling pathway, Vascular smooth muscle contraction, Serotonergic synapse, Regulation of actin cytoskeleton, Progesterone-mediated oocyte maturation, Parathyroid hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Pathways in cancer, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer D10064 Dabrafenib 1件: 34
79 VDR 2件: Parathyroid hormone synthesis, secretion and action, Tuberculosis D00122 Calcifediol 2件: 113, 299
80 VDR 2件: Parathyroid hormone synthesis, secretion and action, Tuberculosis D00129 Calcitriol 9件: 18, 37, 46, 49, 66, 96, 158, 235, 326
81 VDR 2件: Parathyroid hormone synthesis, secretion and action, Tuberculosis D00187 Ergocalciferol 6件: 46, 49, 84, 96, 97, 299
82 VDR 2件: Parathyroid hormone synthesis, secretion and action, Tuberculosis D00188 Cholecalciferol 24件: 6, 13, 19, 20, 28, 34, 46, 49, 51, 53, 56, 60, 65, 84, 85, 96, 97, 98, 162, 202, 228, 271, 298, 299
83 VDR 2件: Parathyroid hormone synthesis, secretion and action, Tuberculosis D00299 Dihydrotachysterol 2件: 6, 85
84 VDR 2件: Parathyroid hormone synthesis, secretion and action, Tuberculosis D00930 Paricalcitol 5件: 19, 66, 218, 238, 298
85 VDR 2件: Parathyroid hormone synthesis, secretion and action, Tuberculosis D01125 Calcipotriol 2件: 36, 51
86 VDR 2件: Parathyroid hormone synthesis, secretion and action, Tuberculosis D01518 Alfacalcidol 8件: 41, 46, 49, 50, 96, 107, 235, 238
87 VDR 2件: Parathyroid hormone synthesis, secretion and action, Tuberculosis D07578 Eldecalcitol 1件: 46
88 FGF23 6件: Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Parathyroid hormone synthesis, secretion and action, Pathways in cancer D10913 Burosumab 1件: 238
89 CASR 1件: Parathyroid hormone synthesis, secretion and action D03504 Cinacalcet 1件: 238
90 TNFSF11 3件: Prolactin signaling pathway, Parathyroid hormone synthesis, secretion and action, Rheumatoid arthritis D03684 Denosumab 8件: 46, 50, 70, 93, 95, 96, 274, 299