Tramadol ( DrugBank: Tramadol )

5 diseases

告示番号	疾患名（ページ内リンク）	臨床試験数
46	悪性関節リウマチ	3
70	広範脊柱管狭窄症	2
78	下垂体前葉機能低下症	1
226	間質性膀胱炎（ハンナ型）	1
271	強直性脊椎炎	2

46. 悪性関節リウマチ

臨床試験数 : 4,356 / 薬物数 : 2,567 - (DrugBank : 415) / 標的遺伝子数 : 192 - 標的パスウェイ数 : 228

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	JPRN-jRCTs041180071	13/10/2016	07/03/2019	T-ReX study	Tocilizumab treatment with Reducing and stopping methotreXate in patients with rheumatoid arthritis in stable low disease activity-state - T-ReX study	Rheumatoid arthritis	At week 0, the dosing frequency of MTX was decreased from weekly to biweekly without a change in dose, regardless of the initial dose. At week 12, MTX was discontinued if low disease activity was maintained. TCZ and csDMARDs other than MTX were continued at a stable dose and interval throughout the course of the study. Glucocorticoids were continued at a stable dose up to week 36, and allowed to taper after week 36. The use of oral analgesics (non-steroidal anti-inflammatory drugs, acetaminophen, pregabalin, and tramadol) was not prohibited during the study period. One or more of the following rescue treatments were performed if the CDAI score was >10 and at the discretion of the investigator and/or upon patient request: changing the dosing frequency back to weekly administration, restarting, or increasing doses of MTX; increasing doses of or adding csDMARDs other than MTX or glucocorticoids; and administering an intraarticular injection of corticosteroids, hyaluronic acid, or lidocaine.	Kojima Toshihisa	NULL	Complete	>= 20age old	Not applicable	Both	51	N/A	Japan
2	JPRN-UMIN000012364	2014/01/10	25/11/2013	Drug registry study to evaluate the effectiveness of tramadol / acetaminophen combination tablets as pain management for patient with rheumatoid arthritis.	Drug registry study to evaluate the effectiveness of tramadol / acetaminophen combination tablets as pain management for patient with rheumatoid arthritis. - Research for an appropriate use of tramadol / acetaminophen combination tablets for patient with rheumatoid arthritis.	rheumatoid arthritis	Tramadol / acetaminophen combination tablets will be administrated by 1 tablets / time/ qid and every 4 hours for pain relief. Step by step dose up administration schedule over 4weeks will be applied at beginning of treatment as bellows; Day1-Day7(1 tablet/day, after night meal) Day8-Day14(1 tabletX2 times /day, after morning and night meal) Day15-Day21(1 tabletX3 times /day, after morning, afternoon and night meal Day22-Day30(1 tabletX4 times /day, after morning, night meal and before bedtime) Once dose reached to 1 tabletX4 times /day, then treatment will be continue up to 24 weeks.	Osaka City University Medical School, Department of Orthopedic Surgery	NULL	Complete: follow-up complete	25years-old	75years-old	Male and Female	31	Not applicable	Japan
3	NCT00246168 (ClinicalTrials.gov)	January 2005	28/10/2005	ULTRACET (Tramadol Hydrochloride and Acetaminophen) for the Treatment of Rheumatoid Arthritis Pain.	ULTRACET (Tramadol Hydrochloride and Acetaminophen) add-on Therapy for the Treatment of the Pain of Rheumatoid Arthritis: A Randomized, Double-blind, Placebo-controlled Study	Arthritis, Rheumatoid	Drug: tramadol hydrochloride + acetaminophen	Janssen Korea, Ltd., Korea	NULL	Completed	18 Years	79 Years	Both	277	Phase 4	NULL

70. 広範脊柱管狭窄症

臨床試験数 : 95 / 薬物数 : 169 - (DrugBank : 61) / 標的遺伝子数 : 68 - 標的パスウェイ数 : 90

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04391855 (ClinicalTrials.gov)	May 10, 2020	13/5/2020	Wound Infiltration With Tramadol, Dexmedetomidine, or Magnesium Plus Ropivacaine for Pain Relief After Spine Surgery	Effect of Wound Infiltration With Tramadol, Dexmedetomidine, or Magnesium Sulfate as Adjuncts to the Local Anesthetic on Pain Relief After Spine Surgery	Analgesia;Pain, Postoperative;Spinal Stenosis;Spinal Disease	Drug: Tramadol with ropivacaine;Drug: Dexmedetomidine with ropivacaine;Drug: Magnesium with ropivacaine;Drug: Ropivacaine plus normal saline	Aristotle University Of Thessaloniki	NULL	Completed	18 Years	80 Years	All	72	Phase 4	Greece
2	NCT02416804 (ClinicalTrials.gov)	January 2015	10/4/2015	Postoperative Analgesia With Buprenorphine for Postoperative Pain Control and Quality of Life After Spinal Surgery	Postoperative Analgesia With Buprenorphine Transdermal System (BTDS) Versus Tramadol for Postoperative Pain Control and Quality of Life After Spinal Surgery	Spinal Stenosis;Pain, Postoperative	Drug: Buprenorphine;Drug: Tramadol	Seoul National University Hospital	NULL	Completed	20 Years	N/A	All	69	Phase 4	Korea, Republic of

78. 下垂体前葉機能低下症

臨床試験数 : 492 / 薬物数 : 341 - (DrugBank : 47) / 標的遺伝子数 : 45 - 標的パスウェイ数 : 100

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00497562 (ClinicalTrials.gov)	May 2004	5/7/2007	Growth Hormone as Add-on Treatment in Severe Fibromyalgia With Low IGF-1 Serum Levels (56 Characters)	Exploratory Study to Investigate the Efficacy and Safety of Recombinant Growth Hormone as Add-on Treatment in Patients With Severe Fibromialgia	Fibromyalgia;Growth Hormone Deficiency	Drug: sc recombinant growth hormone + amitriptyline, fluoxetine and tramadol (treated group);Drug: amitriptyline, fluoxetine and tramadol alone (control group)	Centro Medico Teknon	NULL	Completed	18 Years	N/A	Both		Phase 2	Spain

226. 間質性膀胱炎（ハンナ型）

臨床試験数 : 145 / 薬物数 : 156 - (DrugBank : 51) / 標的遺伝子数 : 64 - 標的パスウェイ数 : 146

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	JPRN-UMIN000009197	2014/07/01	01/11/2012	Safety and efficacy of tramadol in the treatment of refractory pain of interstitial cystitis: a double-blind, placebo-controlled, randomized prospective study	Safety and efficacy of tramadol in the treatment of refractory pain of interstitial cystitis: a double-blind, placebo-controlled, randomized prospective study - The effect of tramadol on interstitial cystitis	interstitial cystitis	oral administration of Tramadol after randomization oral administration of placebo after randomization	Departmen of Urology, The University of Tokyo Hospital	NULL	Complete: follow-up complete	20years-old	80years-old	Male and Female	90	Not applicable	Japan

271. 強直性脊椎炎

臨床試験数 : 574 / 薬物数 : 359 - (DrugBank : 68) / 標的遺伝子数 : 41 - 標的パスウェイ数 : 146

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00766402 (ClinicalTrials.gov)	October 2008	3/10/2008	An Efficacy and Safety Study of Tramadol/Acetaminophen Versus Diclofenac in the Treatment of Pain in Participants With Ankylosing Spondylitis Receiving Stable Treatment of Disease Modifying Anti-rheumatic Drugs (DMARDs)	A Study to Evaluate the Clinical Benefits of Tramadol/Acetaminophen (Ultracet®) vs. Diclofenac (Voltaren®) in the Treatment of Pain in Patients With Ankylosing Spondylitis Receiving Stable Treatment of Disease Modifying Anti-rheumatic Drugs (DMARDs)	Spondylitis, Ankylosing;Pain	Drug: Tramadol /acetaminophen;Drug: Diclofenac	Johnson & Johnson Taiwan Ltd	NULL	Terminated	18 Years	70 Years	Both	8	Phase 4	NULL
2	NCT00647517 (ClinicalTrials.gov)	March 2008	26/3/2008	Tramadol/Acetaminophen(Ultracet) AS add-on Therapy in the Treatment of Patients With Ankylosing Spondylitis	Chung Shan Medical University Hospital, Taiwan	Ankylosing Spondylitis	Drug: Ultracet	Chung Shan Medical University	NULL	Completed	18 Years	65 Years	Both	60	Phase 4	Taiwan

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