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No. 薬物名（臨床試験情報から抽出） DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target genes 		指定難病告示番号
1(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4’-----1件: 79
21,2-Dihexadecanoyl-sn-Glycero-3-Phospho-(1-raac-glycerol)1件: Glycerin1件: D00028 --1件: 79
3[AMG 145]1件: Evolocumab1件: D10557 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
4[Lomitapide 2mg hard capsules]1件: Lomitapide1件: D09637 1件: MTTP 💬1件: Fat digestion and absorption 💬1件: 79
5[NA]1件: Vedolizumab1件: D08083 2件: ITGA4,
ITGB7 💬		15件: Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Transcriptional misregulation in cancer, Yersinia infection 💬25件: 3, 6, 11, 13, 14, 28, 35, 41, 46, 49, 50, 53, 62, 63, 65, 75, 79, 96, 97, 98, 222, 229, 288, 294, 299
6[PRD7255830]1件: Lomitapide1件: D09637 1件: MTTP 💬1件: Fat digestion and absorption 💬1件: 79
7[PRD7255977]1件: Lomitapide1件: D09637 1件: MTTP 💬1件: Fat digestion and absorption 💬1件: 79
8[PRD7256003]1件: Lomitapide1件: D09637 1件: MTTP 💬1件: Fat digestion and absorption 💬1件: 79
9[R727]1件: Alirocumab1件: D10335 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
10[REGN1500]1件: Alirocumab1件: D10335 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
11[REGN7272]1件: Alirocumab1件: D10335 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
12AAV directed hLDLR gene therapy----1件: 79
13AAV8.TBG.hLDLR----1件: 79
14Acetate1件: Benazepril2件: D00620 ,
D07499 		1件: ACE 💬6件: Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬43件: 1, 2, 6, 10, 13, 35, 40, 46, 49, 51, 60, 64, 67, 70, 71, 73, 75, 76, 78, 79, 81, 83, 85, 86, 88, 90, 96, 97, 113, 145, 156, 162, 171, 206, 222, 224, 225, 227, 235, 265, 288, 298, 299
15AEGR-733----1件: 79
16AK1021件: Ezetimibe1件: D01966 1件: NPC1L1 💬1件: Fat digestion and absorption 💬1件: 79
17AKCEA-ANGPTL3-LRX----2件: 79, 265
18ALIROCUMAB1件: Alirocumab1件: D10335 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
19Alirocumab SAR236553 (REGN727)1件: Pravastatin2件: D00893 ,
D08410 		1件: HMGCR 💬4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬1件: 79
20ALN-602121件: Inclisiran1件: D11931 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
21ALN-PCSSC1件: Inclisiran1件: D11931 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
22AMG 1451件: Evolocumab1件: D10557 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
23AMG1451件: Evolocumab1件: D10557 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
24ANACETRAPIB1件: Anacetrapib1件: D08855 1件: CETP 💬1件: Cholesterol metabolism 💬1件: 79
25Atorvastatin1件: Simvastatin1件: D00434 1件: HMGCR 💬4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬18件: 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 299
26Calcium1件: Calcitriol1件: D00129 1件: VDR 💬5件: Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Mineral absorption, Parathyroid hormone synthesis, secretion and action, Tuberculosis 💬30件: 3, 6, 13, 15, 19, 46, 49, 51, 53, 56, 68, 75, 79, 84, 93, 94, 95, 96, 97, 186, 214, 215, 222, 224, 235, 256, 265, 274, 298, 299
27Calcium rosuvastatin1件: Rosuvastatin2件: D01915 ,
D08492 		1件: HMGCR 💬4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬1件: 79
28CER-001----1件: 79
29Cholestyramine1件: Cholestyramine---2件: 13, 79
30Comparator: ezetimibe1件: Ezetimibe1件: D01966 1件: NPC1L1 💬1件: Fat digestion and absorption 💬2件: 79, 260
31Crestor1件: Rosuvastatin2件: D01915 ,
D08492 		1件: HMGCR 💬4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬3件: 49, 79, 299
32Crestor Film-Coated Tablet1件: Rosuvastatin2件: D01915 ,
D08492 		1件: HMGCR 💬4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬1件: 79
33Crestor Tablets (calcium rosuvastatin) Film-Coated tablets1件: Rosuvastatin2件: D01915 ,
D08492 		1件: HMGCR 💬4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬1件: 79
34Current lipid-lowering treatment1件: Acetate---1件: 79
35Dextran1件: Heparin1件: D07510 1件: SERPINC1 💬1件: Complement and coagulation cascades 💬5件: 2, 62, 79, 96, 97
36Dextran sulfate adsorption1件: Heparin1件: D07510 1件: SERPINC1 💬1件: Complement and coagulation cascades 💬1件: 79
37DPPG1件: Glycerin1件: D00028 --1件: 79
38EVINACUMAB1件: Evinacumab1件: D11753 1件: ANGPTL3 💬1件: Cholesterol metabolism 💬1件: 79
39Evinacumab (REGN1500)1件: Alirocumab1件: D10335 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
40EVOLOCUMAB1件: Evolocumab1件: D10557 1件: PCSK9 💬1件: Cholesterol metabolism 💬2件: 79, 222
41Evolocumab (AMG 145)1件: Evolocumab1件: D10557 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
42Ezetimibe1件: Simvastatin1件: D00434 1件: HMGCR 💬4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬4件: 49, 79, 93, 260
43Fenofibrate1件: Fenofibrate1件: D00565 1件: PPARA 💬10件: Adipocytokine signaling pathway, Alcoholic liver disease, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy, Glucagon signaling pathway, Hepatitis C, Insulin resistance, Non-alcoholic fatty liver disease, PPAR signaling pathway, cAMP signaling pathway 💬5件: 8, 79, 93, 94, 265
44Fluvastatin1件: Valsartan1件: D00400 1件: AGTR1 💬16件: AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬3件: 79, 218, 222
45Gemcabene1件: Gemcabene---2件: 79, 265
46Glycerol1件: Phenylbutyric acid---5件: 6, 13, 79, 316, 317
47Heparin1件: Benazepril2件: D00620 ,
D07499 		1件: ACE 💬6件: Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬12件: 47, 60, 70, 79, 84, 107, 224, 226, 280, 299, 316, 317
48Heparin-induced extracorporeal LDL precipitation1件: Heparin1件: D07510 1件: SERPINC1 💬1件: Complement and coagulation cascades 💬1件: 79
49IBI306----1件: 79
50Implitapide1件: Implitapide---1件: 79
51Inclisiran1件: Inclisiran1件: D11931 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
52Inclisiran for injection1件: Inclisiran1件: D11931 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
53Inclisiran Sodium1件: Inclisiran1件: D11931 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
54ISIS 301012----1件: 79
55ISIS 301012 phosphorothioate oligonucleotide----1件: 79
56ISIS 703802----1件: 79
57JS002----1件: 79
58KJX8391件: Inclisiran1件: D11931 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
59Lapaquistat1件: Acetate---1件: 79
60Lapaquistat acetate and current lipid-lowering treatment1件: Acetate---1件: 79
61Lerodalcibep----1件: 79
62LIB0031件: Evolocumab1件: D10557 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
63Lojuxta1件: Lomitapide1件: D09637 1件: MTTP 💬1件: Fat digestion and absorption 💬1件: 79
64Lojuxta 10 mg hard capsules1件: Lomitapide1件: D09637 1件: MTTP 💬1件: Fat digestion and absorption 💬1件: 79
65Lojuxta 20 mg hard capsules1件: Lomitapide1件: D09637 1件: MTTP 💬1件: Fat digestion and absorption 💬1件: 79
66Lojuxta 5 mg hard capsules1件: Lomitapide1件: D09637 1件: MTTP 💬1件: Fat digestion and absorption 💬1件: 79
67LOMITAPIDE1件: Lomitapide1件: D09637 1件: MTTP 💬1件: Fat digestion and absorption 💬1件: 79
68Lomitapide 2mg hard capsules1件: Lomitapide1件: D09637 1件: MTTP 💬1件: Fat digestion and absorption 💬1件: 79
69Lovastatin1件: Lovastatin1件: D00359 1件: HMGCR 💬4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬11件: 6, 34, 46, 79, 156, 160, 195, 206, 263, 280, 310
70MBX-80251件: Seladelpar1件: D11256 1件: PPARG 💬11件: AMPK signaling pathway, Huntington disease, Lipid and atherosclerosis, Longevity regulating pathway, Non-alcoholic fatty liver disease, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer 💬3件: 79, 93, 94
71MBX-8025 50 mg (Dose Escalation Period 1)----1件: 79
72MBX-8025 50 mg or 100 mg (Dose Escalation Period 2)----1件: 79
73MBX-8025 50 mg, 100 mg or 200 mg (Dose Escalation Period 3)----1件: 79
74Mipomersen1件: Mipomersen---1件: 79
75MK-0859----1件: 79
76Nicotinic acid1件: Pravastatin2件: D00893 ,
D08410 		1件: HMGCR 💬4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬1件: 79
77Omega-31件: Rituximab1件: D02994 1件: MS4A1 💬1件: Hematopoietic cell lineage 💬7件: 13, 46, 49, 66, 79, 96, 299
78Omega-3 fatty acids1件: Lipoic acid2件: D00048 ,
D00086 		--2件: 13, 79
79Phospholipids1件: Glycerin1件: D00028 --1件: 79
80Placebo1件: Guselkumab1件: D10438 1件: IL23A 💬9件: C-type lectin receptor signaling pathway, Cytokine-cytokine receptor interaction, Inflammatory bowel disease, JAK-STAT signaling pathway, Pathways in cancer, Pertussis, Rheumatoid arthritis, Th17 cell differentiation, Tuberculosis 💬27件: 3, 5, 6, 13, 14, 37, 40, 46, 49, 50, 51, 53, 63, 66, 67, 79, 85, 86, 88, 96, 97, 140, 144, 149, 226, 271, 276
81Praluent1件: Alirocumab1件: D10335 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
82Pravastatin1件: Pravastatin2件: D00893 ,
D08410 		1件: HMGCR 💬4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬9件: 13, 46, 49, 67, 79, 96, 164, 265, 333
83Prednisone1件: Mesalazine1件: D00377 --48件: 2, 6, 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 95, 96, 97, 113, 127, 162, 164, 205, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331
84R7271件: Alirocumab1件: D10335 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
85Recombinant Human Apolipoprotein1件: Glycerin1件: D00028 --1件: 79
86Recombinant Human Apolipoprotein A-I1件: Glycerin1件: D00028 --1件: 79
87Recombinant Human Apolipoprotein A-I/Phospholipids Complex1件: Glycerin1件: D00028 --1件: 79
88Recombinant human apolipoprotein a11件: Glycerin1件: D00028 --1件: 79
89REGN15001件: Evinacumab1件: D11753 1件: ANGPTL3 💬1件: Cholesterol metabolism 💬1件: 79
90REGN1500 250 mg SC/15 mg/kg IV/450 mg SC----1件: 79
91Repatha1件: Evolocumab1件: D10557 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
92Repatha (evolocumab)1件: Evolocumab1件: D10557 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
93Repatha 140 mg Solution for Injection in Pre-filled Pen1件: Evolocumab1件: D10557 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
94Repatha 140 mg soluzione per iniezione in penna preriempita.1件: Evolocumab1件: D10557 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
95Repatha 420 mg solution for injection in cartridge1件: Evolocumab1件: D10557 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
96Repatha 420 mg soluzione per iniezione in cartuccia1件: Evolocumab1件: D10557 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
97Rosuvastatin1件: Rosuvastatin2件: D01915 ,
D08492 		1件: HMGCR 💬4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬11件: 6, 18, 46, 49, 51, 56, 79, 96, 97, 271, 299
98Rosuvastatin 20mg1件: Rosuvastatin2件: D01915 ,
D08492 		1件: HMGCR 💬4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬1件: 79
99ROSUVASTATIN CALCIUM1件: Rosuvastatin2件: D01915 ,
D08492 		1件: HMGCR 💬4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬4件: 49, 79, 97, 299
100SAR2365531件: Alirocumab1件: D10335 1件: PCSK9 💬1件: Cholesterol metabolism 💬1件: 79
101Sfingomielina1件: Glycerin1件: D00028 --1件: 79
102SHR-1209----1件: 79
103Simvastatin1件: Simvastatin1件: D00434 1件: HMGCR 💬4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬21件: 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310
104Single intravenous (IV) dose of human Low Density Lipoprotein Receptor (LDLR) Gene Therapy----1件: 79
105Sphingomyelin1件: Glycerin1件: D00028 --1件: 79
106Standard of Care----10件: 6, 13, 46, 49, 51, 63, 64, 79, 171, 271
107Statins1件: Angiotensin II2件: D00150 ,
D02014 		2件: AGTR1,
AGTR2 💬		16件: AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬2件: 46, 79
108Sulfate1件: Filgrastim1件: D03235 1件: CSF3R 💬5件: Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, JAK-STAT signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer 💬27件: 2, 3, 6, 11, 13, 26, 28, 34, 36, 46, 49, 53, 60, 64, 66, 79, 85, 86, 96, 111, 218, 222, 226, 265, 296, 297, 299
109TAK-4751件: TAK-475---1件: 79
110ZD45221件: Rosuvastatin2件: D01915 ,
D08492 		1件: HMGCR 💬4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬1件: 79