Target Gene/Pathway Pathway / Gene
Search results
No. | KEGG PATHWAY | KEGG GENES | KEGG DRUG | DrugBank | Disease ID |
---|---|---|---|---|---|
1 | Acute myeloid leukemia 💬 17 genes, 30 drugs (DrugBank) and 62 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
2 | Adipocytokine signaling pathway 💬 16 genes, 31 drugs (DrugBank) and 95 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
3 | Adipocytokine signaling pathway 💬 16 genes, 31 drugs (DrugBank) and 95 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
4 | Adrenergic signaling in cardiomyocytes 💬 27 genes, 80 drugs (DrugBank) and 71 diseases |
ADRA1A [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬 |
Carvedilol Carvedilol 💬 |
Carvedilol | 057 [4] 57, 86, 113, 210 💬 💬 |
5 | Adrenergic signaling in cardiomyocytes 💬 27 genes, 80 drugs (DrugBank) and 71 diseases |
ADRB1 [1] ADRB1 💬 |
Bisoprolol Bisoprolol 💬 |
Bisoprolol | 058 [4] 58, 67, 86, 113 💬 💬 |
6 | Adrenergic signaling in cardiomyocytes 💬 27 genes, 80 drugs (DrugBank) and 71 diseases |
ADRB1 [1] ADRB1 💬 |
Metoprolol Metoprolol 💬 |
Metoprolol | 017 [6] 17, 57, 58, 113, 193, 226 💬 💬 |
7 | Adrenergic signaling in cardiomyocytes 💬 27 genes, 80 drugs (DrugBank) and 71 diseases |
ADRB1 [1] ADRB1 💬 |
Nebivolol Nebivolol 💬 |
Nebivolol | 017 [4] 17, 85, 113, 167 💬 💬 |
8 | Adrenergic signaling in cardiomyocytes 💬 27 genes, 80 drugs (DrugBank) and 71 diseases |
ADRB2 [1] ADRB2 💬 |
Albuterol Albuterol 💬 |
Salbutamol | 003 [12] 3 , 11, 12, 13, 49, 85, 86, 89, 111, 113, 256, 299 💬 💬 |
9 | Adrenergic signaling in cardiomyocytes 💬 27 genes, 80 drugs (DrugBank) and 71 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
10 | Adrenergic signaling in cardiomyocytes 💬 27 genes, 80 drugs (DrugBank) and 71 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
11 | Adrenergic signaling in cardiomyocytes 💬 27 genes, 80 drugs (DrugBank) and 71 diseases |
SCN5A [1] SCN5A 💬 |
Mexiletine Mexiletine 💬 |
Mexiletine | 001 [5] 1 , 2 , 10, 113, 114 💬 💬 |
12 | African trypanosomiasis 💬 9 genes, 22 drugs (DrugBank) and 59 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
13 | AGE-RAGE signaling pathway in diabetic complications 💬 26 genes, 45 drugs (DrugBank) and 83 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
14 | AGE-RAGE signaling pathway in diabetic complications 💬 26 genes, 45 drugs (DrugBank) and 83 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
15 | AGE-RAGE signaling pathway in diabetic complications 💬 26 genes, 45 drugs (DrugBank) and 83 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
16 | AGE-RAGE signaling pathway in diabetic complications 💬 26 genes, 45 drugs (DrugBank) and 83 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
17 | Alcoholic liver disease 💬 39 genes, 46 drugs (DrugBank) and 87 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
18 | Alcoholic liver disease 💬 39 genes, 46 drugs (DrugBank) and 87 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
19 | Alcoholic liver disease 💬 39 genes, 46 drugs (DrugBank) and 87 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
20 | Alcoholic liver disease 💬 39 genes, 46 drugs (DrugBank) and 87 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
21 | Alcoholism 💬 28 genes, 75 drugs (DrugBank) and 53 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
22 | Alcoholism 💬 28 genes, 75 drugs (DrugBank) and 53 diseases |
SLC6A3 [1] SLC6A3 💬 |
Methylphenidate Methylphenidate 💬 |
Methylphenidate | 006 [7] 6 , 13, 34, 84, 113, 179, 206 💬 💬 |
23 | Aldosterone synthesis and secretion 💬 20 genes, 38 drugs (DrugBank) and 62 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
24 | Aldosterone synthesis and secretion 💬 20 genes, 38 drugs (DrugBank) and 62 diseases |
MC2R [1] MC2R 💬 |
Cosyntropin Cosyntropin 💬 |
Tetracosactide | 078 [5] 78, 83, 113, 145, 222 💬 💬 |
25 | Aldosterone-regulated sodium reabsorption 💬 13 genes, 14 drugs (DrugBank) and 25 diseases |
NR3C2 [1] NR3C2 💬 |
Eplerenone Eplerenone 💬 |
Eplerenone | 075 [4] 75, 113, 210, 215 💬 💬 |
26 | Aldosterone-regulated sodium reabsorption 💬 13 genes, 14 drugs (DrugBank) and 25 diseases |
NR3C2 [1] NR3C2 💬 |
Spironolactone Spironolactone 💬 |
Spironolactone | 046 [8] 46, 58, 67, 86, 113, 210, 218, 225 💬 💬 |
27 | Alzheimer disease 💬 55 genes, 116 drugs (DrugBank) and 122 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
28 | Alzheimer disease 💬 55 genes, 116 drugs (DrugBank) and 122 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
29 | Alzheimer disease 💬 55 genes, 116 drugs (DrugBank) and 122 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
30 | Alzheimer disease 💬 55 genes, 116 drugs (DrugBank) and 122 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
31 | Alzheimer disease 💬 55 genes, 116 drugs (DrugBank) and 122 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
32 | Alzheimer disease 💬 55 genes, 116 drugs (DrugBank) and 122 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
33 | Alzheimer disease 💬 55 genes, 116 drugs (DrugBank) and 122 diseases |
PTGS2 [1] PTGS2 💬 |
Ibuprofen Ibuprofen 💬 |
Ibuprofen | 013 [7] 13, 46, 65, 107, 113, 271, 299 💬 💬 |
34 | Alzheimer disease 💬 55 genes, 116 drugs (DrugBank) and 122 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
35 | Amoebiasis 💬 19 genes, 29 drugs (DrugBank) and 63 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
36 | Amoebiasis 💬 19 genes, 29 drugs (DrugBank) and 63 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
37 | Amphetamine addiction 💬 25 genes, 51 drugs (DrugBank) and 91 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
38 | Amphetamine addiction 💬 25 genes, 51 drugs (DrugBank) and 91 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
39 | Amphetamine addiction 💬 25 genes, 51 drugs (DrugBank) and 91 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
40 | Amphetamine addiction 💬 25 genes, 51 drugs (DrugBank) and 91 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
41 | Amphetamine addiction 💬 25 genes, 51 drugs (DrugBank) and 91 diseases |
SLC6A3 [1] SLC6A3 💬 |
Methylphenidate Methylphenidate 💬 |
Methylphenidate | 006 [7] 6 , 13, 34, 84, 113, 179, 206 💬 💬 |
42 | AMPK signaling pathway 💬 16 genes, 49 drugs (DrugBank) and 93 diseases |
ADRA1A [1] ADRA1A 💬 |
Carvedilol Carvedilol 💬 |
Carvedilol | 057 [4] 57, 86, 113, 210 💬 💬 |
43 | AMPK signaling pathway 💬 16 genes, 49 drugs (DrugBank) and 93 diseases |
PPARG [1] PPARG 💬 |
Bocidelpar Bocidelpar 💬 |
Bocidelpar | 113 [1] 113 💬 💬 |
44 | AMPK signaling pathway 💬 16 genes, 49 drugs (DrugBank) and 93 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
45 | Amyotrophic lateral sclerosis 💬 35 genes, 48 drugs (DrugBank) and 108 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
46 | Amyotrophic lateral sclerosis 💬 35 genes, 48 drugs (DrugBank) and 108 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
47 | Amyotrophic lateral sclerosis 💬 35 genes, 48 drugs (DrugBank) and 108 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
48 | Amyotrophic lateral sclerosis 💬 35 genes, 48 drugs (DrugBank) and 108 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
49 | Amyotrophic lateral sclerosis 💬 35 genes, 48 drugs (DrugBank) and 108 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
50 | Antifolate resistance 💬 8 genes, 21 drugs (DrugBank) and 66 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
51 | Antifolate resistance 💬 8 genes, 21 drugs (DrugBank) and 66 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
52 | Apelin signaling pathway 💬 12 genes, 30 drugs (DrugBank) and 72 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
53 | Apelin signaling pathway 💬 12 genes, 30 drugs (DrugBank) and 72 diseases |
CCN2 [1] CCN2 💬 |
Pamrevlumab Pamrevlumab 💬 |
Pamrevlumab | 085 [2] 85, 113 💬 💬 |
54 | Apelin signaling pathway 💬 12 genes, 30 drugs (DrugBank) and 72 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
55 | Apoptosis 💬 16 genes, 28 drugs (DrugBank) and 59 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
56 | Arachidonic acid metabolism 💬 4 genes, 26 drugs (DrugBank) and 43 diseases |
ALOX5 [1] ALOX5 💬 |
Oxatomide Oxatomide 💬 |
Oxatomide | 113 [1] 113 💬 💬 |
57 | Arachidonic acid metabolism 💬 4 genes, 26 drugs (DrugBank) and 43 diseases |
PTGS1 [2] PTGS1, PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
58 | Arachidonic acid metabolism 💬 4 genes, 26 drugs (DrugBank) and 43 diseases |
PTGS1 [2] PTGS1, PTGS2 💬 |
Ibuprofen Ibuprofen 💬 |
Ibuprofen | 013 [7] 13, 46, 65, 107, 113, 271, 299 💬 💬 |
59 | Arrhythmogenic right ventricular cardiomyopathy 💬 11 genes, 24 drugs (DrugBank) and 28 diseases |
DMD [1] DMD 💬 |
Casimersen Casimersen 💬 |
Casimersen | 113 [1] 113 💬 💬 |
60 | Arrhythmogenic right ventricular cardiomyopathy 💬 11 genes, 24 drugs (DrugBank) and 28 diseases |
DMD [1] DMD 💬 |
Drisapersen Drisapersen 💬 |
Drisapersen | 113 [1] 113 💬 💬 |
61 | Arrhythmogenic right ventricular cardiomyopathy 💬 11 genes, 24 drugs (DrugBank) and 28 diseases |
DMD [1] DMD 💬 |
Eteplirsen Eteplirsen 💬 |
Eteplirsen | 113 [1] 113 💬 💬 |
62 | Arrhythmogenic right ventricular cardiomyopathy 💬 11 genes, 24 drugs (DrugBank) and 28 diseases |
DMD [1] DMD 💬 |
Golodirsen Golodirsen 💬 |
Golodirsen | 113 [1] 113 💬 💬 |
63 | Arrhythmogenic right ventricular cardiomyopathy 💬 11 genes, 24 drugs (DrugBank) and 28 diseases |
DMD [1] DMD 💬 |
Viltolarsen Viltolarsen 💬 |
Viltolarsen | 113 [1] 113 💬 💬 |
64 | Autophagy - animal 💬 13 genes, 18 drugs (DrugBank) and 62 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
65 | Axon guidance 💬 20 genes, 21 drugs (DrugBank) and 70 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
66 | Axon guidance 💬 20 genes, 21 drugs (DrugBank) and 70 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
67 | Axon guidance 💬 20 genes, 21 drugs (DrugBank) and 70 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
68 | B cell receptor signaling pathway 💬 19 genes, 29 drugs (DrugBank) and 68 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
69 | B cell receptor signaling pathway 💬 19 genes, 29 drugs (DrugBank) and 68 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
70 | B cell receptor signaling pathway 💬 19 genes, 29 drugs (DrugBank) and 68 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
71 | B cell receptor signaling pathway 💬 19 genes, 29 drugs (DrugBank) and 68 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
72 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
ESR1 [2] ESR1, ESR2 💬 |
Prasterone Prasterone 💬 |
Prasterone | 049 [6] 49, 53, 83, 86, 96, 113 💬 💬 |
73 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
ESR1 [2] ESR1, ESR2 💬 |
Tamoxifen Tamoxifen 💬 |
Tamoxifen | 002 [3] 2 , 113, 227 💬 💬 |
74 | C-type lectin receptor signaling pathway 💬 26 genes, 64 drugs (DrugBank) and 99 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
75 | C-type lectin receptor signaling pathway 💬 26 genes, 64 drugs (DrugBank) and 99 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
76 | C-type lectin receptor signaling pathway 💬 26 genes, 64 drugs (DrugBank) and 99 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
77 | C-type lectin receptor signaling pathway 💬 26 genes, 64 drugs (DrugBank) and 99 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
78 | C-type lectin receptor signaling pathway 💬 26 genes, 64 drugs (DrugBank) and 99 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
79 | C-type lectin receptor signaling pathway 💬 26 genes, 64 drugs (DrugBank) and 99 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
80 | C-type lectin receptor signaling pathway 💬 26 genes, 64 drugs (DrugBank) and 99 diseases |
PTGS2 [1] PTGS2 💬 |
Ibuprofen Ibuprofen 💬 |
Ibuprofen | 013 [7] 13, 46, 65, 107, 113, 271, 299 💬 💬 |
81 | C-type lectin receptor signaling pathway 💬 26 genes, 64 drugs (DrugBank) and 99 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
82 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
ADRA1A [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬 |
Carvedilol Carvedilol 💬 |
Carvedilol | 057 [4] 57, 86, 113, 210 💬 💬 |
83 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
ADRB1 [1] ADRB1 💬 |
Bisoprolol Bisoprolol 💬 |
Bisoprolol | 058 [4] 58, 67, 86, 113 💬 💬 |
84 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
ADRB1 [1] ADRB1 💬 |
Metoprolol Metoprolol 💬 |
Metoprolol | 017 [6] 17, 57, 58, 113, 193, 226 💬 💬 |
85 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
ADRB1 [1] ADRB1 💬 |
Nebivolol Nebivolol 💬 |
Nebivolol | 017 [4] 17, 85, 113, 167 💬 💬 |
86 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
ADRB2 [1] ADRB2 💬 |
Albuterol Albuterol 💬 |
Salbutamol | 003 [12] 3 , 11, 12, 13, 49, 85, 86, 89, 111, 113, 256, 299 💬 💬 |
87 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
88 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
GRIN1 [4] GRIN1, GRIN2A, GRIN2C, GRIN2D 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
89 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
90 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
91 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
92 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
TBXA2R [1] TBXA2R 💬 |
Ifetroban Ifetroban 💬 |
Ifetroban | 085 [2] 85, 113 💬 💬 |
93 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
ADRB1 [1] ADRB1 💬 |
Bisoprolol Bisoprolol 💬 |
Bisoprolol | 058 [4] 58, 67, 86, 113 💬 💬 |
94 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
ADRB1 [1] ADRB1 💬 |
Metoprolol Metoprolol 💬 |
Metoprolol | 017 [6] 17, 57, 58, 113, 193, 226 💬 💬 |
95 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
ADRB1 [1] ADRB1 💬 |
Nebivolol Nebivolol 💬 |
Nebivolol | 017 [4] 17, 85, 113, 167 💬 💬 |
96 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
ADRB1 [2] ADRB1, ADRB2 💬 |
Carvedilol Carvedilol 💬 |
Carvedilol | 057 [4] 57, 86, 113, 210 💬 💬 |
97 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
ADRB2 [1] ADRB2 💬 |
Albuterol Albuterol 💬 |
Salbutamol | 003 [12] 3 , 11, 12, 13, 49, 85, 86, 89, 111, 113, 256, 299 💬 💬 |
98 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
99 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
MC2R [1] MC2R 💬 |
Cosyntropin Cosyntropin 💬 |
Tetracosactide | 078 [5] 78, 83, 113, 145, 222 💬 💬 |
100 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
101 | Cellular senescence 💬 26 genes, 40 drugs (DrugBank) and 92 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
102 | Cellular senescence 💬 26 genes, 40 drugs (DrugBank) and 92 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
103 | Cellular senescence 💬 26 genes, 40 drugs (DrugBank) and 92 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
104 | Cellular senescence 💬 26 genes, 40 drugs (DrugBank) and 92 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
105 | Cellular senescence 💬 26 genes, 40 drugs (DrugBank) and 92 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
106 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
ADRA1A [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬 |
Carvedilol Carvedilol 💬 |
Carvedilol | 057 [4] 57, 86, 113, 210 💬 💬 |
107 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
ADRA2A [3] ADRA2A, ADRA2B, ADRA2C 💬 |
Dexmedetomidine Dexmedetomidine 💬 |
Dexmedetomidine | 002 [14] 2 , 4 , 6 , 21, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280 💬 💬 |
108 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
ADRB1 [1] ADRB1 💬 |
Bisoprolol Bisoprolol 💬 |
Bisoprolol | 058 [4] 58, 67, 86, 113 💬 💬 |
109 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
ADRB1 [1] ADRB1 💬 |
Metoprolol Metoprolol 💬 |
Metoprolol | 017 [6] 17, 57, 58, 113, 193, 226 💬 💬 |
110 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
ADRB1 [1] ADRB1 💬 |
Nebivolol Nebivolol 💬 |
Nebivolol | 017 [4] 17, 85, 113, 167 💬 💬 |
111 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
ADRB2 [1] ADRB2 💬 |
Albuterol Albuterol 💬 |
Salbutamol | 003 [12] 3 , 11, 12, 13, 49, 85, 86, 89, 111, 113, 256, 299 💬 💬 |
112 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
113 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
PDE5A [1] PDE5A 💬 |
Sildenafil Sildenafil 💬 |
Sildenafil | 006 [17] 6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬 💬 |
114 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
PDE5A [1] PDE5A 💬 |
Tadalafil Tadalafil 💬 |
Tadalafil | 006 [7] 6 , 51, 75, 84, 86, 113, 210 💬 💬 |
115 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
116 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
117 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
118 | Chagas disease 💬 28 genes, 44 drugs (DrugBank) and 77 diseases |
ACE [1] ACE 💬 |
Enalapril Enalapril 💬 |
Enalapril | 019 [6] 19, 46, 66, 113, 210, 222 💬 💬 |
119 | Chagas disease 💬 28 genes, 44 drugs (DrugBank) and 77 diseases |
ACE [1] ACE 💬 |
Lisinopril Lisinopril 💬 |
Lisinopril | 019 [7] 19, 46, 49, 66, 67, 113, 222 💬 💬 |
120 | Chagas disease 💬 28 genes, 44 drugs (DrugBank) and 77 diseases |
ACE [1] ACE 💬 |
Lisinopril Lisinopril 💬 |
Lisinopril | 019 [7] 19, 46, 49, 66, 67, 113, 222 💬 💬 |
121 | Chagas disease 💬 28 genes, 44 drugs (DrugBank) and 77 diseases |
ACE [1] ACE 💬 |
Perindopril Perindopril 💬 |
Perindopril | 058 [4] 58, 113, 167, 222 💬 💬 |
122 | Chagas disease 💬 28 genes, 44 drugs (DrugBank) and 77 diseases |
ACE [1] ACE 💬 |
Ramipril Ramipril 💬 |
Ramipril | 046 [7] 46, 49, 66, 67, 113, 218, 257 💬 💬 |
123 | Chagas disease 💬 28 genes, 44 drugs (DrugBank) and 77 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
124 | Chagas disease 💬 28 genes, 44 drugs (DrugBank) and 77 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
125 | Chagas disease 💬 28 genes, 44 drugs (DrugBank) and 77 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
126 | Chemical carcinogenesis - DNA adducts 💬 1 gene, 24 drugs (DrugBank) and 40 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
127 | Chemical carcinogenesis - DNA adducts 💬 1 gene, 24 drugs (DrugBank) and 40 diseases |
PTGS2 [1] PTGS2 💬 |
Ibuprofen Ibuprofen 💬 |
Ibuprofen | 013 [7] 13, 46, 65, 107, 113, 271, 299 💬 💬 |
128 | Chemical carcinogenesis - reactive oxygen species 💬 25 genes, 37 drugs (DrugBank) and 42 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
129 | Chemical carcinogenesis - reactive oxygen species 💬 25 genes, 37 drugs (DrugBank) and 42 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
130 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
ADRB1 [1] ADRB1 💬 |
Bisoprolol Bisoprolol 💬 |
Bisoprolol | 058 [4] 58, 67, 86, 113 💬 💬 |
131 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
ADRB1 [1] ADRB1 💬 |
Metoprolol Metoprolol 💬 |
Metoprolol | 017 [6] 17, 57, 58, 113, 193, 226 💬 💬 |
132 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
ADRB1 [1] ADRB1 💬 |
Nebivolol Nebivolol 💬 |
Nebivolol | 017 [4] 17, 85, 113, 167 💬 💬 |
133 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
ADRB1 [2] ADRB1, ADRB2 💬 |
Carvedilol Carvedilol 💬 |
Carvedilol | 057 [4] 57, 86, 113, 210 💬 💬 |
134 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
ADRB2 [1] ADRB2 💬 |
Albuterol Albuterol 💬 |
Salbutamol | 003 [12] 3 , 11, 12, 13, 49, 85, 86, 89, 111, 113, 256, 299 💬 💬 |
135 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
AR [1] AR 💬 |
Testosterone Testosterone 💬 |
Testosterone | 001 [8] 1 , 2 , 3 , 13, 60, 76, 78, 113 💬 💬 |
136 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
AR [1] AR 💬 |
Testosterone decanoate Testosterone decanoate 💬 |
Testosterone decanoate | 113 [1] 113 💬 💬 |
137 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
AR [1] AR 💬 |
Testosterone enanthate Testosterone enanthate 💬 |
Testosterone enanthate | 113 [1] 113 💬 💬 |
138 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
AR [1] AR 💬 |
Testosterone phenylpropionate Testosterone phenylpropionate 💬 |
Testosterone phenylpropionate | 113 [1] 113 💬 💬 |
139 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
AR [1] AR 💬 |
Testosterone propionate Testosterone propionate 💬 |
Testosterone propionate | 113 [1] 113 💬 💬 |
140 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
AR [3] AR, ESR1, ESR2 💬 |
Prasterone Prasterone 💬 |
Prasterone | 049 [6] 49, 53, 83, 86, 96, 113 💬 💬 |
141 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
ESR1 [2] ESR1, ESR2 💬 |
Tamoxifen Tamoxifen 💬 |
Tamoxifen | 002 [3] 2 , 113, 227 💬 💬 |
142 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
143 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
VDR [1] VDR 💬 |
Calcifediol Calcifediol 💬 |
Calcifediol | 113 [2] 113, 299 💬 💬 |
144 | Chemokine signaling pathway 💬 22 genes, 29 drugs (DrugBank) and 51 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
145 | Chronic myeloid leukemia 💬 17 genes, 20 drugs (DrugBank) and 29 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
146 | Circadian entrainment 💬 22 genes, 32 drugs (DrugBank) and 55 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
147 | Circadian rhythm 💬 2 genes, 1 drug (DrugBank) and 25 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
148 | Cocaine addiction 💬 15 genes, 63 drugs (DrugBank) and 52 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
149 | Cocaine addiction 💬 15 genes, 63 drugs (DrugBank) and 52 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
150 | Cocaine addiction 💬 15 genes, 63 drugs (DrugBank) and 52 diseases |
SLC6A3 [1] SLC6A3 💬 |
Methylphenidate Methylphenidate 💬 |
Methylphenidate | 006 [7] 6 , 13, 34, 84, 113, 179, 206 💬 💬 |
151 | Collecting duct acid secretion 💬 3 genes, 11 drugs (DrugBank) and 35 diseases |
ATP4A [2] ATP4A, ATP4B 💬 |
Esomeprazole Esomeprazole 💬 |
Esomeprazole | 013 [8] 13, 46, 86, 98, 107, 113, 298, 299 💬 💬 |
152 | Coronavirus disease - COVID-19 💬 51 genes, 94 drugs (DrugBank) and 91 diseases |
ACE [1] ACE 💬 |
Enalapril Enalapril 💬 |
Enalapril | 019 [6] 19, 46, 66, 113, 210, 222 💬 💬 |
153 | Coronavirus disease - COVID-19 💬 51 genes, 94 drugs (DrugBank) and 91 diseases |
ACE [1] ACE 💬 |
Lisinopril Lisinopril 💬 |
Lisinopril | 019 [7] 19, 46, 49, 66, 67, 113, 222 💬 💬 |
154 | Coronavirus disease - COVID-19 💬 51 genes, 94 drugs (DrugBank) and 91 diseases |
ACE [1] ACE 💬 |
Lisinopril Lisinopril 💬 |
Lisinopril | 019 [7] 19, 46, 49, 66, 67, 113, 222 💬 💬 |
155 | Coronavirus disease - COVID-19 💬 51 genes, 94 drugs (DrugBank) and 91 diseases |
ACE [1] ACE 💬 |
Perindopril Perindopril 💬 |
Perindopril | 058 [4] 58, 113, 167, 222 💬 💬 |
156 | Coronavirus disease - COVID-19 💬 51 genes, 94 drugs (DrugBank) and 91 diseases |
ACE [1] ACE 💬 |
Ramipril Ramipril 💬 |
Ramipril | 046 [7] 46, 49, 66, 67, 113, 218, 257 💬 💬 |
157 | Coronavirus disease - COVID-19 💬 51 genes, 94 drugs (DrugBank) and 91 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
158 | Coronavirus disease - COVID-19 💬 51 genes, 94 drugs (DrugBank) and 91 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
159 | Coronavirus disease - COVID-19 💬 51 genes, 94 drugs (DrugBank) and 91 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
160 | Coronavirus disease - COVID-19 💬 51 genes, 94 drugs (DrugBank) and 91 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
161 | Cortisol synthesis and secretion 💬 15 genes, 33 drugs (DrugBank) and 61 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
162 | Cortisol synthesis and secretion 💬 15 genes, 33 drugs (DrugBank) and 61 diseases |
MC2R [1] MC2R 💬 |
Cosyntropin Cosyntropin 💬 |
Tetracosactide | 078 [5] 78, 83, 113, 145, 222 💬 💬 |
163 | Cushing syndrome 💬 24 genes, 50 drugs (DrugBank) and 66 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
164 | Cushing syndrome 💬 24 genes, 50 drugs (DrugBank) and 66 diseases |
MC2R [1] MC2R 💬 |
Cosyntropin Cosyntropin 💬 |
Tetracosactide | 078 [5] 78, 83, 113, 145, 222 💬 💬 |
165 | Cytokine-cytokine receptor interaction 💬 81 genes, 114 drugs (DrugBank) and 92 diseases |
CSF3R [1] CSF3R 💬 |
Filgrastim Filgrastim 💬 |
Filgrastim | 002 [35] 2 , 6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬 💬 |
166 | Cytokine-cytokine receptor interaction 💬 81 genes, 114 drugs (DrugBank) and 92 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
167 | Cytokine-cytokine receptor interaction 💬 81 genes, 114 drugs (DrugBank) and 92 diseases |
MSTN [1] MSTN 💬 |
Domagrozumab Domagrozumab 💬 |
Domagrozumab | 113 [1] 113 💬 💬 |
168 | Cytokine-cytokine receptor interaction 💬 81 genes, 114 drugs (DrugBank) and 92 diseases |
MSTN [1] MSTN 💬 |
Stamulumab Stamulumab 💬 |
Stamulumab | 113 [1] 113 💬 💬 |
169 | Cytosolic DNA-sensing pathway 💬 17 genes, 12 drugs (DrugBank) and 28 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
170 | Cytosolic DNA-sensing pathway 💬 17 genes, 12 drugs (DrugBank) and 28 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
171 | Diabetic cardiomyopathy 💬 26 genes, 42 drugs (DrugBank) and 73 diseases |
ACE [1] ACE 💬 |
Enalapril Enalapril 💬 |
Enalapril | 019 [6] 19, 46, 66, 113, 210, 222 💬 💬 |
172 | Diabetic cardiomyopathy 💬 26 genes, 42 drugs (DrugBank) and 73 diseases |
ACE [1] ACE 💬 |
Lisinopril Lisinopril 💬 |
Lisinopril | 019 [7] 19, 46, 49, 66, 67, 113, 222 💬 💬 |
173 | Diabetic cardiomyopathy 💬 26 genes, 42 drugs (DrugBank) and 73 diseases |
ACE [1] ACE 💬 |
Lisinopril Lisinopril 💬 |
Lisinopril | 019 [7] 19, 46, 49, 66, 67, 113, 222 💬 💬 |
174 | Diabetic cardiomyopathy 💬 26 genes, 42 drugs (DrugBank) and 73 diseases |
ACE [1] ACE 💬 |
Perindopril Perindopril 💬 |
Perindopril | 058 [4] 58, 113, 167, 222 💬 💬 |
175 | Diabetic cardiomyopathy 💬 26 genes, 42 drugs (DrugBank) and 73 diseases |
ACE [1] ACE 💬 |
Ramipril Ramipril 💬 |
Ramipril | 046 [7] 46, 49, 66, 67, 113, 218, 257 💬 💬 |
176 | Diabetic cardiomyopathy 💬 26 genes, 42 drugs (DrugBank) and 73 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
177 | Diabetic cardiomyopathy 💬 26 genes, 42 drugs (DrugBank) and 73 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
178 | Diabetic cardiomyopathy 💬 26 genes, 42 drugs (DrugBank) and 73 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
179 | Dilated cardiomyopathy 💬 17 genes, 55 drugs (DrugBank) and 83 diseases |
ADRB1 [1] ADRB1 💬 |
Bisoprolol Bisoprolol 💬 |
Bisoprolol | 058 [4] 58, 67, 86, 113 💬 💬 |
180 | Dilated cardiomyopathy 💬 17 genes, 55 drugs (DrugBank) and 83 diseases |
ADRB1 [1] ADRB1 💬 |
Carvedilol Carvedilol 💬 |
Carvedilol | 057 [4] 57, 86, 113, 210 💬 💬 |
181 | Dilated cardiomyopathy 💬 17 genes, 55 drugs (DrugBank) and 83 diseases |
ADRB1 [1] ADRB1 💬 |
Metoprolol Metoprolol 💬 |
Metoprolol | 017 [6] 17, 57, 58, 113, 193, 226 💬 💬 |
182 | Dilated cardiomyopathy 💬 17 genes, 55 drugs (DrugBank) and 83 diseases |
ADRB1 [1] ADRB1 💬 |
Nebivolol Nebivolol 💬 |
Nebivolol | 017 [4] 17, 85, 113, 167 💬 💬 |
183 | Dilated cardiomyopathy 💬 17 genes, 55 drugs (DrugBank) and 83 diseases |
DMD [1] DMD 💬 |
Casimersen Casimersen 💬 |
Casimersen | 113 [1] 113 💬 💬 |
184 | Dilated cardiomyopathy 💬 17 genes, 55 drugs (DrugBank) and 83 diseases |
DMD [1] DMD 💬 |
Drisapersen Drisapersen 💬 |
Drisapersen | 113 [1] 113 💬 💬 |
185 | Dilated cardiomyopathy 💬 17 genes, 55 drugs (DrugBank) and 83 diseases |
DMD [1] DMD 💬 |
Eteplirsen Eteplirsen 💬 |
Eteplirsen | 113 [1] 113 💬 💬 |
186 | Dilated cardiomyopathy 💬 17 genes, 55 drugs (DrugBank) and 83 diseases |
DMD [1] DMD 💬 |
Golodirsen Golodirsen 💬 |
Golodirsen | 113 [1] 113 💬 💬 |
187 | Dilated cardiomyopathy 💬 17 genes, 55 drugs (DrugBank) and 83 diseases |
DMD [1] DMD 💬 |
Viltolarsen Viltolarsen 💬 |
Viltolarsen | 113 [1] 113 💬 💬 |
188 | Dopaminergic synapse 💬 31 genes, 99 drugs (DrugBank) and 101 diseases |
GRIN2A [2] GRIN2A, GRIN2B 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
189 | Dopaminergic synapse 💬 31 genes, 99 drugs (DrugBank) and 101 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
190 | Dopaminergic synapse 💬 31 genes, 99 drugs (DrugBank) and 101 diseases |
PPP3CA [3] PPP3CA, PPP3CB, PPP3CC 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
191 | Dopaminergic synapse 💬 31 genes, 99 drugs (DrugBank) and 101 diseases |
PPP3CA [3] PPP3CA, PPP3CB, PPP3CC 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
192 | Dopaminergic synapse 💬 31 genes, 99 drugs (DrugBank) and 101 diseases |
PPP3CA [3] PPP3CA, PPP3CB, PPP3CC 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
193 | Dopaminergic synapse 💬 31 genes, 99 drugs (DrugBank) and 101 diseases |
SCN1A [1] SCN1A 💬 |
Mexiletine Mexiletine 💬 |
Mexiletine | 001 [5] 1 , 2 , 10, 113, 114 💬 💬 |
194 | Dopaminergic synapse 💬 31 genes, 99 drugs (DrugBank) and 101 diseases |
SLC6A3 [1] SLC6A3 💬 |
Methylphenidate Methylphenidate 💬 |
Methylphenidate | 006 [7] 6 , 13, 34, 84, 113, 179, 206 💬 💬 |
195 | Endocrine and other factor-regulated calcium reabsorption 💬 8 genes, 27 drugs (DrugBank) and 55 diseases |
ESR1 [1] ESR1 💬 |
Prasterone Prasterone 💬 |
Prasterone | 049 [6] 49, 53, 83, 86, 96, 113 💬 💬 |
196 | Endocrine and other factor-regulated calcium reabsorption 💬 8 genes, 27 drugs (DrugBank) and 55 diseases |
ESR1 [1] ESR1 💬 |
Tamoxifen Tamoxifen 💬 |
Tamoxifen | 002 [3] 2 , 113, 227 💬 💬 |
197 | Endocrine and other factor-regulated calcium reabsorption 💬 8 genes, 27 drugs (DrugBank) and 55 diseases |
VDR [1] VDR 💬 |
Calcifediol Calcifediol 💬 |
Calcifediol | 113 [2] 113, 299 💬 💬 |
198 | Endocrine resistance 💬 20 genes, 43 drugs (DrugBank) and 62 diseases |
ESR1 [2] ESR1, ESR2 💬 |
Prasterone Prasterone 💬 |
Prasterone | 049 [6] 49, 53, 83, 86, 96, 113 💬 💬 |
199 | Endocrine resistance 💬 20 genes, 43 drugs (DrugBank) and 62 diseases |
ESR1 [2] ESR1, ESR2 💬 |
Tamoxifen Tamoxifen 💬 |
Tamoxifen | 002 [3] 2 , 113, 227 💬 💬 |
200 | Endocrine resistance 💬 20 genes, 43 drugs (DrugBank) and 62 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
201 | Epithelial cell signaling in Helicobacter pylori infection 💬 12 genes, 17 drugs (DrugBank) and 21 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
202 | Epithelial cell signaling in Helicobacter pylori infection 💬 12 genes, 17 drugs (DrugBank) and 21 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
203 | Epstein-Barr virus infection 💬 44 genes, 62 drugs (DrugBank) and 66 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
204 | Epstein-Barr virus infection 💬 44 genes, 62 drugs (DrugBank) and 66 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
205 | Estrogen signaling pathway 💬 19 genes, 74 drugs (DrugBank) and 64 diseases |
ESR1 [2] ESR1, ESR2 💬 |
Prasterone Prasterone 💬 |
Prasterone | 049 [6] 49, 53, 83, 86, 96, 113 💬 💬 |
206 | Estrogen signaling pathway 💬 19 genes, 74 drugs (DrugBank) and 64 diseases |
ESR1 [2] ESR1, ESR2 💬 |
Tamoxifen Tamoxifen 💬 |
Tamoxifen | 002 [3] 2 , 113, 227 💬 💬 |
207 | Fc epsilon RI signaling pathway 💬 20 genes, 42 drugs (DrugBank) and 62 diseases |
ALOX5 [1] ALOX5 💬 |
Oxatomide Oxatomide 💬 |
Oxatomide | 113 [1] 113 💬 💬 |
208 | Fc epsilon RI signaling pathway 💬 20 genes, 42 drugs (DrugBank) and 62 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
209 | Fluid shear stress and atherosclerosis 💬 29 genes, 48 drugs (DrugBank) and 86 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
210 | Fluid shear stress and atherosclerosis 💬 29 genes, 48 drugs (DrugBank) and 86 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
211 | Fluid shear stress and atherosclerosis 💬 29 genes, 48 drugs (DrugBank) and 86 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
212 | Fluid shear stress and atherosclerosis 💬 29 genes, 48 drugs (DrugBank) and 86 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
213 | FoxO signaling pathway 💬 24 genes, 40 drugs (DrugBank) and 54 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
214 | FoxO signaling pathway 💬 24 genes, 40 drugs (DrugBank) and 54 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
215 | Gap junction 💬 26 genes, 87 drugs (DrugBank) and 77 diseases |
ADRB1 [1] ADRB1 💬 |
Bisoprolol Bisoprolol 💬 |
Bisoprolol | 058 [4] 58, 67, 86, 113 💬 💬 |
216 | Gap junction 💬 26 genes, 87 drugs (DrugBank) and 77 diseases |
ADRB1 [1] ADRB1 💬 |
Carvedilol Carvedilol 💬 |
Carvedilol | 057 [4] 57, 86, 113, 210 💬 💬 |
217 | Gap junction 💬 26 genes, 87 drugs (DrugBank) and 77 diseases |
ADRB1 [1] ADRB1 💬 |
Metoprolol Metoprolol 💬 |
Metoprolol | 017 [6] 17, 57, 58, 113, 193, 226 💬 💬 |
218 | Gap junction 💬 26 genes, 87 drugs (DrugBank) and 77 diseases |
ADRB1 [1] ADRB1 💬 |
Nebivolol Nebivolol 💬 |
Nebivolol | 017 [4] 17, 85, 113, 167 💬 💬 |
219 | Gastric acid secretion 💬 14 genes, 43 drugs (DrugBank) and 52 diseases |
ATP4A [2] ATP4A, ATP4B 💬 |
Esomeprazole Esomeprazole 💬 |
Esomeprazole | 013 [8] 13, 46, 86, 98, 107, 113, 298, 299 💬 💬 |
220 | Glucagon signaling pathway 💬 12 genes, 19 drugs (DrugBank) and 83 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
221 | Glucagon signaling pathway 💬 12 genes, 19 drugs (DrugBank) and 83 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
222 | Glucagon signaling pathway 💬 12 genes, 19 drugs (DrugBank) and 83 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
223 | Glucagon signaling pathway 💬 12 genes, 19 drugs (DrugBank) and 83 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
224 | Glutamatergic synapse 💬 23 genes, 27 drugs (DrugBank) and 83 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
225 | Glutamatergic synapse 💬 23 genes, 27 drugs (DrugBank) and 83 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
226 | Glutamatergic synapse 💬 23 genes, 27 drugs (DrugBank) and 83 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
227 | Glutamatergic synapse 💬 23 genes, 27 drugs (DrugBank) and 83 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
228 | GnRH secretion 💬 20 genes, 42 drugs (DrugBank) and 54 diseases |
ESR2 [1] ESR2 💬 |
Prasterone Prasterone 💬 |
Prasterone | 049 [6] 49, 53, 83, 86, 96, 113 💬 💬 |
229 | GnRH secretion 💬 20 genes, 42 drugs (DrugBank) and 54 diseases |
ESR2 [1] ESR2 💬 |
Tamoxifen Tamoxifen 💬 |
Tamoxifen | 002 [3] 2 , 113, 227 💬 💬 |
230 | GnRH signaling pathway 💬 16 genes, 36 drugs (DrugBank) and 37 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
231 | Graft-versus-host disease 💬 7 genes, 22 drugs (DrugBank) and 60 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
232 | Growth hormone synthesis, secretion and action 💬 24 genes, 41 drugs (DrugBank) and 76 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
233 | Hematopoietic cell lineage 💬 32 genes, 70 drugs (DrugBank) and 90 diseases |
CSF3R [1] CSF3R 💬 |
Filgrastim Filgrastim 💬 |
Filgrastim | 002 [35] 2 , 6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬 💬 |
234 | Hematopoietic cell lineage 💬 32 genes, 70 drugs (DrugBank) and 90 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
235 | Hepatitis B 💬 41 genes, 54 drugs (DrugBank) and 73 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
236 | Hepatitis B 💬 41 genes, 54 drugs (DrugBank) and 73 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
237 | Hepatitis C 💬 34 genes, 59 drugs (DrugBank) and 72 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
238 | Herpes simplex virus 1 infection 💬 43 genes, 65 drugs (DrugBank) and 94 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
239 | Herpes simplex virus 1 infection 💬 43 genes, 65 drugs (DrugBank) and 94 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
240 | HIF-1 signaling pathway 💬 23 genes, 48 drugs (DrugBank) and 76 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
241 | Hippo signaling pathway 💬 5 genes, 3 drugs (DrugBank) and 6 diseases |
CCN2 [1] CCN2 💬 |
Pamrevlumab Pamrevlumab 💬 |
Pamrevlumab | 085 [2] 85, 113 💬 💬 |
242 | Human cytomegalovirus infection 💬 56 genes, 104 drugs (DrugBank) and 120 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
243 | Human cytomegalovirus infection 💬 56 genes, 104 drugs (DrugBank) and 120 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
244 | Human cytomegalovirus infection 💬 56 genes, 104 drugs (DrugBank) and 120 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
245 | Human cytomegalovirus infection 💬 56 genes, 104 drugs (DrugBank) and 120 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
246 | Human cytomegalovirus infection 💬 56 genes, 104 drugs (DrugBank) and 120 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
247 | Human cytomegalovirus infection 💬 56 genes, 104 drugs (DrugBank) and 120 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
248 | Human cytomegalovirus infection 💬 56 genes, 104 drugs (DrugBank) and 120 diseases |
PTGS2 [1] PTGS2 💬 |
Ibuprofen Ibuprofen 💬 |
Ibuprofen | 013 [7] 13, 46, 65, 107, 113, 271, 299 💬 💬 |
249 | Human cytomegalovirus infection 💬 56 genes, 104 drugs (DrugBank) and 120 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
250 | Human immunodeficiency virus 1 infection 💬 41 genes, 43 drugs (DrugBank) and 89 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
251 | Human immunodeficiency virus 1 infection 💬 41 genes, 43 drugs (DrugBank) and 89 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
252 | Human immunodeficiency virus 1 infection 💬 41 genes, 43 drugs (DrugBank) and 89 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
253 | Human immunodeficiency virus 1 infection 💬 41 genes, 43 drugs (DrugBank) and 89 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
254 | Human immunodeficiency virus 1 infection 💬 41 genes, 43 drugs (DrugBank) and 89 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
255 | Human papillomavirus infection 💬 40 genes, 91 drugs (DrugBank) and 105 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
256 | Human papillomavirus infection 💬 40 genes, 91 drugs (DrugBank) and 105 diseases |
PTGS2 [1] PTGS2 💬 |
Ibuprofen Ibuprofen 💬 |
Ibuprofen | 013 [7] 13, 46, 65, 107, 113, 271, 299 💬 💬 |
257 | Human papillomavirus infection 💬 40 genes, 91 drugs (DrugBank) and 105 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
258 | Human T-cell leukemia virus 1 infection 💬 37 genes, 59 drugs (DrugBank) and 84 diseases |
FDPS [1] FDPS 💬 |
Risedronic acid Risedronic acid 💬 |
Risedronic acid | 046 [9] 46, 50, 66, 93, 95, 96, 107, 113, 274 💬 💬 |
259 | Human T-cell leukemia virus 1 infection 💬 37 genes, 59 drugs (DrugBank) and 84 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
260 | Human T-cell leukemia virus 1 infection 💬 37 genes, 59 drugs (DrugBank) and 84 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
261 | Human T-cell leukemia virus 1 infection 💬 37 genes, 59 drugs (DrugBank) and 84 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
262 | Human T-cell leukemia virus 1 infection 💬 37 genes, 59 drugs (DrugBank) and 84 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
263 | Huntington disease 💬 24 genes, 33 drugs (DrugBank) and 82 diseases |
GRIN1 [2] GRIN1, GRIN2B 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
264 | Huntington disease 💬 24 genes, 33 drugs (DrugBank) and 82 diseases |
PPARG [1] PPARG 💬 |
Bocidelpar Bocidelpar 💬 |
Bocidelpar | 113 [1] 113 💬 💬 |
265 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
ACE [1] ACE 💬 |
Enalapril Enalapril 💬 |
Enalapril | 019 [6] 19, 46, 66, 113, 210, 222 💬 💬 |
266 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
ACE [1] ACE 💬 |
Lisinopril Lisinopril 💬 |
Lisinopril | 019 [7] 19, 46, 49, 66, 67, 113, 222 💬 💬 |
267 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
ACE [1] ACE 💬 |
Lisinopril Lisinopril 💬 |
Lisinopril | 019 [7] 19, 46, 49, 66, 67, 113, 222 💬 💬 |
268 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
ACE [1] ACE 💬 |
Perindopril Perindopril 💬 |
Perindopril | 058 [4] 58, 113, 167, 222 💬 💬 |
269 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
ACE [1] ACE 💬 |
Ramipril Ramipril 💬 |
Ramipril | 046 [7] 46, 49, 66, 67, 113, 218, 257 💬 💬 |
270 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
DMD [1] DMD 💬 |
Casimersen Casimersen 💬 |
Casimersen | 113 [1] 113 💬 💬 |
271 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
DMD [1] DMD 💬 |
Drisapersen Drisapersen 💬 |
Drisapersen | 113 [1] 113 💬 💬 |
272 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
DMD [1] DMD 💬 |
Eteplirsen Eteplirsen 💬 |
Eteplirsen | 113 [1] 113 💬 💬 |
273 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
DMD [1] DMD 💬 |
Golodirsen Golodirsen 💬 |
Golodirsen | 113 [1] 113 💬 💬 |
274 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
DMD [1] DMD 💬 |
Viltolarsen Viltolarsen 💬 |
Viltolarsen | 113 [1] 113 💬 💬 |
275 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
276 | IL-17 signaling pathway 💬 20 genes, 60 drugs (DrugBank) and 83 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
277 | IL-17 signaling pathway 💬 20 genes, 60 drugs (DrugBank) and 83 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
278 | IL-17 signaling pathway 💬 20 genes, 60 drugs (DrugBank) and 83 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
279 | IL-17 signaling pathway 💬 20 genes, 60 drugs (DrugBank) and 83 diseases |
PTGS2 [1] PTGS2 💬 |
Ibuprofen Ibuprofen 💬 |
Ibuprofen | 013 [7] 13, 46, 65, 107, 113, 271, 299 💬 💬 |
280 | IL-17 signaling pathway 💬 20 genes, 60 drugs (DrugBank) and 83 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
281 | Inflammatory bowel disease 💬 24 genes, 43 drugs (DrugBank) and 64 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
282 | Inflammatory bowel disease 💬 24 genes, 43 drugs (DrugBank) and 64 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
283 | Inflammatory mediator regulation of TRP channels 💬 23 genes, 43 drugs (DrugBank) and 59 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
284 | Inflammatory mediator regulation of TRP channels 💬 23 genes, 43 drugs (DrugBank) and 59 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
285 | Influenza A 💬 45 genes, 63 drugs (DrugBank) and 85 diseases |
FDPS [1] FDPS 💬 |
Risedronic acid Risedronic acid 💬 |
Risedronic acid | 046 [9] 46, 50, 66, 93, 95, 96, 107, 113, 274 💬 💬 |
286 | Influenza A 💬 45 genes, 63 drugs (DrugBank) and 85 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
287 | Influenza A 💬 45 genes, 63 drugs (DrugBank) and 85 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
288 | Insulin resistance 💬 18 genes, 33 drugs (DrugBank) and 95 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
289 | Insulin resistance 💬 18 genes, 33 drugs (DrugBank) and 95 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
290 | Insulin secretion 💬 14 genes, 39 drugs (DrugBank) and 44 diseases |
SNAP25 [1] SNAP25 💬 |
Botulinum toxin type A Botulinum toxin type A 💬 |
Botulinum toxin type A | 002 [14] 2 , 5 , 6 , 7 , 13, 15, 17, 36, 47, 51, 70, 113, 149, 226 💬 💬 |
291 | Insulin signaling pathway 💬 12 genes, 26 drugs (DrugBank) and 66 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
292 | JAK-STAT signaling pathway 💬 58 genes, 91 drugs (DrugBank) and 96 diseases |
CSF3R [1] CSF3R 💬 |
Filgrastim Filgrastim 💬 |
Filgrastim | 002 [35] 2 , 6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬 💬 |
293 | Kaposi sarcoma-associated herpesvirus infection 💬 50 genes, 84 drugs (DrugBank) and 108 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
294 | Kaposi sarcoma-associated herpesvirus infection 💬 50 genes, 84 drugs (DrugBank) and 108 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
295 | Kaposi sarcoma-associated herpesvirus infection 💬 50 genes, 84 drugs (DrugBank) and 108 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
296 | Kaposi sarcoma-associated herpesvirus infection 💬 50 genes, 84 drugs (DrugBank) and 108 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
297 | Kaposi sarcoma-associated herpesvirus infection 💬 50 genes, 84 drugs (DrugBank) and 108 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
298 | Kaposi sarcoma-associated herpesvirus infection 💬 50 genes, 84 drugs (DrugBank) and 108 diseases |
PTGS2 [1] PTGS2 💬 |
Ibuprofen Ibuprofen 💬 |
Ibuprofen | 013 [7] 13, 46, 65, 107, 113, 271, 299 💬 💬 |
299 | Kaposi sarcoma-associated herpesvirus infection 💬 50 genes, 84 drugs (DrugBank) and 108 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
300 | Legionellosis 💬 9 genes, 22 drugs (DrugBank) and 61 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
301 | Legionellosis 💬 9 genes, 22 drugs (DrugBank) and 61 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
302 | Leishmaniasis 💬 25 genes, 63 drugs (DrugBank) and 93 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
303 | Leishmaniasis 💬 25 genes, 63 drugs (DrugBank) and 93 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
304 | Leishmaniasis 💬 25 genes, 63 drugs (DrugBank) and 93 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
305 | Leishmaniasis 💬 25 genes, 63 drugs (DrugBank) and 93 diseases |
PTGS2 [1] PTGS2 💬 |
Ibuprofen Ibuprofen 💬 |
Ibuprofen | 013 [7] 13, 46, 65, 107, 113, 271, 299 💬 💬 |
306 | Leishmaniasis 💬 25 genes, 63 drugs (DrugBank) and 93 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
307 | Leukocyte transendothelial migration 💬 13 genes, 14 drugs (DrugBank) and 30 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
308 | Lipid and atherosclerosis 💬 46 genes, 56 drugs (DrugBank) and 93 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
309 | Lipid and atherosclerosis 💬 46 genes, 56 drugs (DrugBank) and 93 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
310 | Lipid and atherosclerosis 💬 46 genes, 56 drugs (DrugBank) and 93 diseases |
PPARG [1] PPARG 💬 |
Bocidelpar Bocidelpar 💬 |
Bocidelpar | 113 [1] 113 💬 💬 |
311 | Lipid and atherosclerosis 💬 46 genes, 56 drugs (DrugBank) and 93 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
312 | Lipid and atherosclerosis 💬 46 genes, 56 drugs (DrugBank) and 93 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
313 | Lipid and atherosclerosis 💬 46 genes, 56 drugs (DrugBank) and 93 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
314 | Lipid and atherosclerosis 💬 46 genes, 56 drugs (DrugBank) and 93 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
315 | Long-term potentiation 💬 18 genes, 33 drugs (DrugBank) and 86 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
316 | Long-term potentiation 💬 18 genes, 33 drugs (DrugBank) and 86 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
317 | Long-term potentiation 💬 18 genes, 33 drugs (DrugBank) and 86 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
318 | Long-term potentiation 💬 18 genes, 33 drugs (DrugBank) and 86 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
319 | Longevity regulating pathway 💬 11 genes, 20 drugs (DrugBank) and 68 diseases |
PPARG [1] PPARG 💬 |
Bocidelpar Bocidelpar 💬 |
Bocidelpar | 113 [1] 113 💬 💬 |
320 | Longevity regulating pathway 💬 11 genes, 20 drugs (DrugBank) and 68 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
321 | Longevity regulating pathway 💬 11 genes, 20 drugs (DrugBank) and 68 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
322 | Longevity regulating pathway - multiple species 💬 11 genes, 15 drugs (DrugBank) and 62 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
323 | Malaria 💬 15 genes, 28 drugs (DrugBank) and 61 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
324 | MAPK signaling pathway 💬 61 genes, 85 drugs (DrugBank) and 110 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
325 | MAPK signaling pathway 💬 61 genes, 85 drugs (DrugBank) and 110 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
326 | MAPK signaling pathway 💬 61 genes, 85 drugs (DrugBank) and 110 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
327 | MAPK signaling pathway 💬 61 genes, 85 drugs (DrugBank) and 110 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
328 | MAPK signaling pathway 💬 61 genes, 85 drugs (DrugBank) and 110 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
329 | MAPK signaling pathway 💬 61 genes, 85 drugs (DrugBank) and 110 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
330 | Measles 💬 40 genes, 44 drugs (DrugBank) and 52 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
331 | Measles 💬 40 genes, 44 drugs (DrugBank) and 52 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
332 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
ALOX5 [1] ALOX5 💬 |
Oxatomide Oxatomide 💬 |
Oxatomide | 113 [1] 113 💬 💬 |
333 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
ATP4A [2] ATP4A, ATP4B 💬 |
Esomeprazole Esomeprazole 💬 |
Esomeprazole | 013 [8] 13, 46, 86, 98, 107, 113, 298, 299 💬 💬 |
334 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
FDPS [1] FDPS 💬 |
Risedronic acid Risedronic acid 💬 |
Risedronic acid | 046 [9] 46, 50, 66, 93, 95, 96, 107, 113, 274 💬 💬 |
335 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
PDE5A [1] PDE5A 💬 |
Sildenafil Sildenafil 💬 |
Sildenafil | 006 [17] 6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬 💬 |
336 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
PDE5A [1] PDE5A 💬 |
Tadalafil Tadalafil 💬 |
Tadalafil | 006 [7] 6 , 51, 75, 84, 86, 113, 210 💬 💬 |
337 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
PTGS1 [2] PTGS1, PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
338 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
PTGS1 [2] PTGS1, PTGS2 💬 |
Ibuprofen Ibuprofen 💬 |
Ibuprofen | 013 [7] 13, 46, 65, 107, 113, 271, 299 💬 💬 |
339 | MicroRNAs in cancer 💬 31 genes, 65 drugs (DrugBank) and 85 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
340 | MicroRNAs in cancer 💬 31 genes, 65 drugs (DrugBank) and 85 diseases |
PTGS2 [1] PTGS2 💬 |
Ibuprofen Ibuprofen 💬 |
Ibuprofen | 013 [7] 13, 46, 65, 107, 113, 271, 299 💬 💬 |
341 | Mineral absorption 💬 8 genes, 13 drugs (DrugBank) and 41 diseases |
VDR [1] VDR 💬 |
Calcifediol Calcifediol 💬 |
Calcifediol | 113 [2] 113, 299 💬 💬 |
342 | Mitophagy - animal 💬 2 genes, 4 drugs (DrugBank) and 8 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
343 | mTOR signaling pathway 💬 14 genes, 32 drugs (DrugBank) and 91 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
344 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
345 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
346 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
347 | Necroptosis 💬 28 genes, 39 drugs (DrugBank) and 68 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
348 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
ADRA1A [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬 |
Carvedilol Carvedilol 💬 |
Carvedilol | 057 [4] 57, 86, 113, 210 💬 💬 |
349 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
ADRA2A [3] ADRA2A, ADRA2B, ADRA2C 💬 |
Dexmedetomidine Dexmedetomidine 💬 |
Dexmedetomidine | 002 [14] 2 , 4 , 6 , 21, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280 💬 💬 |
350 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
ADRB1 [1] ADRB1 💬 |
Bisoprolol Bisoprolol 💬 |
Bisoprolol | 058 [4] 58, 67, 86, 113 💬 💬 |
351 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
ADRB1 [1] ADRB1 💬 |
Metoprolol Metoprolol 💬 |
Metoprolol | 017 [6] 17, 57, 58, 113, 193, 226 💬 💬 |
352 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
ADRB1 [1] ADRB1 💬 |
Nebivolol Nebivolol 💬 |
Nebivolol | 017 [4] 17, 85, 113, 167 💬 💬 |
353 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
ADRB2 [1] ADRB2 💬 |
Albuterol Albuterol 💬 |
Salbutamol | 003 [12] 3 , 11, 12, 13, 49, 85, 86, 89, 111, 113, 256, 299 💬 💬 |
354 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
355 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
356 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
HRH3 [1] HRH3 💬 |
Pitolisant Pitolisant 💬 |
Pitolisant | 006 [3] 6 , 113, 193 💬 💬 |
357 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
MC2R [1] MC2R 💬 |
Cosyntropin Cosyntropin 💬 |
Tetracosactide | 078 [5] 78, 83, 113, 145, 222 💬 💬 |
358 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
NR3C1 [1] NR3C1 💬 |
Deflazacort Deflazacort 💬 |
Deflazacort | 030 [2] 30, 113 💬 💬 |
359 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
NR3C1 [1] NR3C1 💬 |
Prednisolone Prednisolone 💬 |
Prednisolone | 003 [42] 3 , 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬 💬 |
360 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
NR3C1 [1] NR3C1 💬 |
Prednisone Prednisone 💬 |
Prednisone | 002 [45] 2 , 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 95, 96, 97, 113, 162, 164, 205, 222, 224, 228, 283, 284, 288, 299, 300, 307, 331 💬 💬 |
361 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
NR3C1 [1] NR3C1 💬 |
Vamorolone Vamorolone 💬 |
Vamorolone | 097 [2] 97, 113 💬 💬 |
362 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
TBXA2R [1] TBXA2R 💬 |
Ifetroban Ifetroban 💬 |
Ifetroban | 085 [2] 85, 113 💬 💬 |
363 | Neurotrophin signaling pathway 💬 21 genes, 26 drugs (DrugBank) and 32 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
364 | Neurotrophin signaling pathway 💬 21 genes, 26 drugs (DrugBank) and 32 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
365 | Neutrophil extracellular trap formation 💬 35 genes, 36 drugs (DrugBank) and 61 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
366 | Neutrophil extracellular trap formation 💬 35 genes, 36 drugs (DrugBank) and 61 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
367 | NF-kappa B signaling pathway 💬 20 genes, 67 drugs (DrugBank) and 87 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
368 | NF-kappa B signaling pathway 💬 20 genes, 67 drugs (DrugBank) and 87 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
369 | NF-kappa B signaling pathway 💬 20 genes, 67 drugs (DrugBank) and 87 diseases |
PTGS2 [1] PTGS2 💬 |
Ibuprofen Ibuprofen 💬 |
Ibuprofen | 013 [7] 13, 46, 65, 107, 113, 271, 299 💬 💬 |
370 | NF-kappa B signaling pathway 💬 20 genes, 67 drugs (DrugBank) and 87 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
371 | Nicotine addiction 💬 30 genes, 30 drugs (DrugBank) and 44 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
372 | NOD-like receptor signaling pathway 💬 30 genes, 42 drugs (DrugBank) and 65 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
373 | NOD-like receptor signaling pathway 💬 30 genes, 42 drugs (DrugBank) and 65 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
374 | NOD-like receptor signaling pathway 💬 30 genes, 42 drugs (DrugBank) and 65 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
375 | Non-alcoholic fatty liver disease 💬 23 genes, 47 drugs (DrugBank) and 86 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
376 | Non-alcoholic fatty liver disease 💬 23 genes, 47 drugs (DrugBank) and 86 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
377 | Non-alcoholic fatty liver disease 💬 23 genes, 47 drugs (DrugBank) and 86 diseases |
PPARG [1] PPARG 💬 |
Bocidelpar Bocidelpar 💬 |
Bocidelpar | 113 [1] 113 💬 💬 |
378 | Non-alcoholic fatty liver disease 💬 23 genes, 47 drugs (DrugBank) and 86 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
379 | Non-alcoholic fatty liver disease 💬 23 genes, 47 drugs (DrugBank) and 86 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
380 | Oocyte meiosis 💬 14 genes, 41 drugs (DrugBank) and 77 diseases |
AR [1] AR 💬 |
Prasterone Prasterone 💬 |
Prasterone | 049 [6] 49, 53, 83, 86, 96, 113 💬 💬 |
381 | Oocyte meiosis 💬 14 genes, 41 drugs (DrugBank) and 77 diseases |
AR [1] AR 💬 |
Testosterone Testosterone 💬 |
Testosterone | 001 [8] 1 , 2 , 3 , 13, 60, 76, 78, 113 💬 💬 |
382 | Oocyte meiosis 💬 14 genes, 41 drugs (DrugBank) and 77 diseases |
AR [1] AR 💬 |
Testosterone decanoate Testosterone decanoate 💬 |
Testosterone decanoate | 113 [1] 113 💬 💬 |
383 | Oocyte meiosis 💬 14 genes, 41 drugs (DrugBank) and 77 diseases |
AR [1] AR 💬 |
Testosterone enanthate Testosterone enanthate 💬 |
Testosterone enanthate | 113 [1] 113 💬 💬 |
384 | Oocyte meiosis 💬 14 genes, 41 drugs (DrugBank) and 77 diseases |
AR [1] AR 💬 |
Testosterone phenylpropionate Testosterone phenylpropionate 💬 |
Testosterone phenylpropionate | 113 [1] 113 💬 💬 |
385 | Oocyte meiosis 💬 14 genes, 41 drugs (DrugBank) and 77 diseases |
AR [1] AR 💬 |
Testosterone propionate Testosterone propionate 💬 |
Testosterone propionate | 113 [1] 113 💬 💬 |
386 | Oocyte meiosis 💬 14 genes, 41 drugs (DrugBank) and 77 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
387 | Oocyte meiosis 💬 14 genes, 41 drugs (DrugBank) and 77 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
388 | Oocyte meiosis 💬 14 genes, 41 drugs (DrugBank) and 77 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
389 | Oocyte meiosis 💬 14 genes, 41 drugs (DrugBank) and 77 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
390 | Osteoclast differentiation 💬 36 genes, 71 drugs (DrugBank) and 93 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
391 | Osteoclast differentiation 💬 36 genes, 71 drugs (DrugBank) and 93 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
392 | Osteoclast differentiation 💬 36 genes, 71 drugs (DrugBank) and 93 diseases |
PPARG [1] PPARG 💬 |
Bocidelpar Bocidelpar 💬 |
Bocidelpar | 113 [1] 113 💬 💬 |
393 | Osteoclast differentiation 💬 36 genes, 71 drugs (DrugBank) and 93 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
394 | Osteoclast differentiation 💬 36 genes, 71 drugs (DrugBank) and 93 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
395 | Osteoclast differentiation 💬 36 genes, 71 drugs (DrugBank) and 93 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
396 | Osteoclast differentiation 💬 36 genes, 71 drugs (DrugBank) and 93 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
397 | Ovarian steroidogenesis 💬 7 genes, 36 drugs (DrugBank) and 52 diseases |
ALOX5 [1] ALOX5 💬 |
Oxatomide Oxatomide 💬 |
Oxatomide | 113 [1] 113 💬 💬 |
398 | Ovarian steroidogenesis 💬 7 genes, 36 drugs (DrugBank) and 52 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
399 | Ovarian steroidogenesis 💬 7 genes, 36 drugs (DrugBank) and 52 diseases |
PTGS2 [1] PTGS2 💬 |
Ibuprofen Ibuprofen 💬 |
Ibuprofen | 013 [7] 13, 46, 65, 107, 113, 271, 299 💬 💬 |
400 | Oxidative phosphorylation 💬 2 genes, 7 drugs (DrugBank) and 25 diseases |
ATP4A [2] ATP4A, ATP4B 💬 |
Esomeprazole Esomeprazole 💬 |
Esomeprazole | 013 [8] 13, 46, 86, 98, 107, 113, 298, 299 💬 💬 |
401 | Oxytocin signaling pathway 💬 34 genes, 73 drugs (DrugBank) and 108 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
402 | Oxytocin signaling pathway 💬 34 genes, 73 drugs (DrugBank) and 108 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
403 | Oxytocin signaling pathway 💬 34 genes, 73 drugs (DrugBank) and 108 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
404 | Oxytocin signaling pathway 💬 34 genes, 73 drugs (DrugBank) and 108 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
405 | Oxytocin signaling pathway 💬 34 genes, 73 drugs (DrugBank) and 108 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
406 | Oxytocin signaling pathway 💬 34 genes, 73 drugs (DrugBank) and 108 diseases |
PTGS2 [1] PTGS2 💬 |
Ibuprofen Ibuprofen 💬 |
Ibuprofen | 013 [7] 13, 46, 65, 107, 113, 271, 299 💬 💬 |
407 | Pancreatic cancer 💬 19 genes, 36 drugs (DrugBank) and 67 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
408 | Parathyroid hormone synthesis, secretion and action 💬 21 genes, 48 drugs (DrugBank) and 65 diseases |
VDR [1] VDR 💬 |
Calcifediol Calcifediol 💬 |
Calcifediol | 113 [2] 113, 299 💬 💬 |
409 | Parkinson disease 💬 24 genes, 73 drugs (DrugBank) and 66 diseases |
SLC6A3 [1] SLC6A3 💬 |
Methylphenidate Methylphenidate 💬 |
Methylphenidate | 006 [7] 6 , 13, 34, 84, 113, 179, 206 💬 💬 |
410 | Pathogenic Escherichia coli infection 💬 26 genes, 39 drugs (DrugBank) and 74 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
411 | Pathogenic Escherichia coli infection 💬 26 genes, 39 drugs (DrugBank) and 74 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
412 | Pathogenic Escherichia coli infection 💬 26 genes, 39 drugs (DrugBank) and 74 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
413 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
414 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
AR [1] AR 💬 |
Testosterone Testosterone 💬 |
Testosterone | 001 [8] 1 , 2 , 3 , 13, 60, 76, 78, 113 💬 💬 |
415 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
AR [1] AR 💬 |
Testosterone decanoate Testosterone decanoate 💬 |
Testosterone decanoate | 113 [1] 113 💬 💬 |
416 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
AR [1] AR 💬 |
Testosterone enanthate Testosterone enanthate 💬 |
Testosterone enanthate | 113 [1] 113 💬 💬 |
417 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
AR [1] AR 💬 |
Testosterone phenylpropionate Testosterone phenylpropionate 💬 |
Testosterone phenylpropionate | 113 [1] 113 💬 💬 |
418 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
AR [1] AR 💬 |
Testosterone propionate Testosterone propionate 💬 |
Testosterone propionate | 113 [1] 113 💬 💬 |
419 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
AR [3] AR, ESR1, ESR2 💬 |
Prasterone Prasterone 💬 |
Prasterone | 049 [6] 49, 53, 83, 86, 96, 113 💬 💬 |
420 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
CSF3R [1] CSF3R 💬 |
Filgrastim Filgrastim 💬 |
Filgrastim | 002 [35] 2 , 6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬 💬 |
421 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
ESR1 [2] ESR1, ESR2 💬 |
Tamoxifen Tamoxifen 💬 |
Tamoxifen | 002 [3] 2 , 113, 227 💬 💬 |
422 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
PPARG [1] PPARG 💬 |
Bocidelpar Bocidelpar 💬 |
Bocidelpar | 113 [1] 113 💬 💬 |
423 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
424 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
PTGS2 [1] PTGS2 💬 |
Ibuprofen Ibuprofen 💬 |
Ibuprofen | 013 [7] 13, 46, 65, 107, 113, 271, 299 💬 💬 |
425 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
426 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
427 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
428 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
429 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
430 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
431 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
432 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
433 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
PTGS2 [1] PTGS2 💬 |
Ibuprofen Ibuprofen 💬 |
Ibuprofen | 013 [7] 13, 46, 65, 107, 113, 271, 299 💬 💬 |
434 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
435 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
SLC6A3 [1] SLC6A3 💬 |
Methylphenidate Methylphenidate 💬 |
Methylphenidate | 006 [7] 6 , 13, 34, 84, 113, 179, 206 💬 💬 |
436 | PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 34 genes, 51 drugs (DrugBank) and 92 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
437 | PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 34 genes, 51 drugs (DrugBank) and 92 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
438 | PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 34 genes, 51 drugs (DrugBank) and 92 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
439 | PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 34 genes, 51 drugs (DrugBank) and 92 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
440 | PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 34 genes, 51 drugs (DrugBank) and 92 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
441 | Pertussis 💬 18 genes, 38 drugs (DrugBank) and 66 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
442 | Pertussis 💬 18 genes, 38 drugs (DrugBank) and 66 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
443 | Pertussis 💬 18 genes, 38 drugs (DrugBank) and 66 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
444 | Phospholipase D signaling pathway 💬 23 genes, 51 drugs (DrugBank) and 76 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
445 | PI3K-Akt signaling pathway 💬 76 genes, 112 drugs (DrugBank) and 112 diseases |
CSF3R [1] CSF3R 💬 |
Filgrastim Filgrastim 💬 |
Filgrastim | 002 [35] 2 , 6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬 💬 |
446 | PI3K-Akt signaling pathway 💬 76 genes, 112 drugs (DrugBank) and 112 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
447 | PI3K-Akt signaling pathway 💬 76 genes, 112 drugs (DrugBank) and 112 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
448 | Platelet activation 💬 22 genes, 51 drugs (DrugBank) and 56 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
449 | Platelet activation 💬 22 genes, 51 drugs (DrugBank) and 56 diseases |
PTGS1 [1] PTGS1 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
450 | Platelet activation 💬 22 genes, 51 drugs (DrugBank) and 56 diseases |
PTGS1 [1] PTGS1 💬 |
Ibuprofen Ibuprofen 💬 |
Ibuprofen | 013 [7] 13, 46, 65, 107, 113, 271, 299 💬 💬 |
451 | Platelet activation 💬 22 genes, 51 drugs (DrugBank) and 56 diseases |
TBXA2R [1] TBXA2R 💬 |
Ifetroban Ifetroban 💬 |
Ifetroban | 085 [2] 85, 113 💬 💬 |
452 | PPAR signaling pathway 💬 10 genes, 14 drugs (DrugBank) and 32 diseases |
PPARG [1] PPARG 💬 |
Bocidelpar Bocidelpar 💬 |
Bocidelpar | 113 [1] 113 💬 💬 |
453 | Prion disease 💬 41 genes, 66 drugs (DrugBank) and 107 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
454 | Prion disease 💬 41 genes, 66 drugs (DrugBank) and 107 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
455 | Prion disease 💬 41 genes, 66 drugs (DrugBank) and 107 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
456 | Prion disease 💬 41 genes, 66 drugs (DrugBank) and 107 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
457 | Prion disease 💬 41 genes, 66 drugs (DrugBank) and 107 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
458 | Prion disease 💬 41 genes, 66 drugs (DrugBank) and 107 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
459 | Progesterone-mediated oocyte maturation 💬 14 genes, 38 drugs (DrugBank) and 42 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
460 | Prolactin signaling pathway 💬 19 genes, 39 drugs (DrugBank) and 54 diseases |
ESR1 [2] ESR1, ESR2 💬 |
Prasterone Prasterone 💬 |
Prasterone | 049 [6] 49, 53, 83, 86, 96, 113 💬 💬 |
461 | Prolactin signaling pathway 💬 19 genes, 39 drugs (DrugBank) and 54 diseases |
ESR1 [2] ESR1, ESR2 💬 |
Tamoxifen Tamoxifen 💬 |
Tamoxifen | 002 [3] 2 , 113, 227 💬 💬 |
462 | Prolactin signaling pathway 💬 19 genes, 39 drugs (DrugBank) and 54 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
463 | Prolactin signaling pathway 💬 19 genes, 39 drugs (DrugBank) and 54 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
464 | Prostate cancer 💬 22 genes, 51 drugs (DrugBank) and 80 diseases |
AR [1] AR 💬 |
Prasterone Prasterone 💬 |
Prasterone | 049 [6] 49, 53, 83, 86, 96, 113 💬 💬 |
465 | Prostate cancer 💬 22 genes, 51 drugs (DrugBank) and 80 diseases |
AR [1] AR 💬 |
Testosterone Testosterone 💬 |
Testosterone | 001 [8] 1 , 2 , 3 , 13, 60, 76, 78, 113 💬 💬 |
466 | Prostate cancer 💬 22 genes, 51 drugs (DrugBank) and 80 diseases |
AR [1] AR 💬 |
Testosterone decanoate Testosterone decanoate 💬 |
Testosterone decanoate | 113 [1] 113 💬 💬 |
467 | Prostate cancer 💬 22 genes, 51 drugs (DrugBank) and 80 diseases |
AR [1] AR 💬 |
Testosterone enanthate Testosterone enanthate 💬 |
Testosterone enanthate | 113 [1] 113 💬 💬 |
468 | Prostate cancer 💬 22 genes, 51 drugs (DrugBank) and 80 diseases |
AR [1] AR 💬 |
Testosterone phenylpropionate Testosterone phenylpropionate 💬 |
Testosterone phenylpropionate | 113 [1] 113 💬 💬 |
469 | Prostate cancer 💬 22 genes, 51 drugs (DrugBank) and 80 diseases |
AR [1] AR 💬 |
Testosterone propionate Testosterone propionate 💬 |
Testosterone propionate | 113 [1] 113 💬 💬 |
470 | Prostate cancer 💬 22 genes, 51 drugs (DrugBank) and 80 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
471 | Proteoglycans in cancer 💬 30 genes, 68 drugs (DrugBank) and 96 diseases |
ESR1 [1] ESR1 💬 |
Prasterone Prasterone 💬 |
Prasterone | 049 [6] 49, 53, 83, 86, 96, 113 💬 💬 |
472 | Proteoglycans in cancer 💬 30 genes, 68 drugs (DrugBank) and 96 diseases |
ESR1 [1] ESR1 💬 |
Tamoxifen Tamoxifen 💬 |
Tamoxifen | 002 [3] 2 , 113, 227 💬 💬 |
473 | Proteoglycans in cancer 💬 30 genes, 68 drugs (DrugBank) and 96 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
474 | Purine metabolism 💬 29 genes, 35 drugs (DrugBank) and 73 diseases |
PDE5A [1] PDE5A 💬 |
Sildenafil Sildenafil 💬 |
Sildenafil | 006 [17] 6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬 💬 |
475 | Purine metabolism 💬 29 genes, 35 drugs (DrugBank) and 73 diseases |
PDE5A [1] PDE5A 💬 |
Tadalafil Tadalafil 💬 |
Tadalafil | 006 [7] 6 , 51, 75, 84, 86, 113, 210 💬 💬 |
476 | Rap1 signaling pathway 💬 42 genes, 101 drugs (DrugBank) and 85 diseases |
GRIN1 [3] GRIN1, GRIN2A, GRIN2B 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
477 | Rap1 signaling pathway 💬 42 genes, 101 drugs (DrugBank) and 85 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
478 | Ras signaling pathway 💬 35 genes, 53 drugs (DrugBank) and 62 diseases |
GRIN1 [3] GRIN1, GRIN2A, GRIN2B 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
479 | Ras signaling pathway 💬 35 genes, 53 drugs (DrugBank) and 62 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
480 | Regulation of lipolysis in adipocytes 💬 13 genes, 71 drugs (DrugBank) and 69 diseases |
ADRB1 [1] ADRB1 💬 |
Bisoprolol Bisoprolol 💬 |
Bisoprolol | 058 [4] 58, 67, 86, 113 💬 💬 |
481 | Regulation of lipolysis in adipocytes 💬 13 genes, 71 drugs (DrugBank) and 69 diseases |
ADRB1 [1] ADRB1 💬 |
Metoprolol Metoprolol 💬 |
Metoprolol | 017 [6] 17, 57, 58, 113, 193, 226 💬 💬 |
482 | Regulation of lipolysis in adipocytes 💬 13 genes, 71 drugs (DrugBank) and 69 diseases |
ADRB1 [1] ADRB1 💬 |
Nebivolol Nebivolol 💬 |
Nebivolol | 017 [4] 17, 85, 113, 167 💬 💬 |
483 | Regulation of lipolysis in adipocytes 💬 13 genes, 71 drugs (DrugBank) and 69 diseases |
ADRB1 [2] ADRB1, ADRB2 💬 |
Carvedilol Carvedilol 💬 |
Carvedilol | 057 [4] 57, 86, 113, 210 💬 💬 |
484 | Regulation of lipolysis in adipocytes 💬 13 genes, 71 drugs (DrugBank) and 69 diseases |
ADRB2 [1] ADRB2 💬 |
Albuterol Albuterol 💬 |
Salbutamol | 003 [12] 3 , 11, 12, 13, 49, 85, 86, 89, 111, 113, 256, 299 💬 💬 |
485 | Regulation of lipolysis in adipocytes 💬 13 genes, 71 drugs (DrugBank) and 69 diseases |
PTGS1 [2] PTGS1, PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
486 | Regulation of lipolysis in adipocytes 💬 13 genes, 71 drugs (DrugBank) and 69 diseases |
PTGS1 [2] PTGS1, PTGS2 💬 |
Ibuprofen Ibuprofen 💬 |
Ibuprofen | 013 [7] 13, 46, 65, 107, 113, 271, 299 💬 💬 |
487 | Relaxin signaling pathway 💬 19 genes, 30 drugs (DrugBank) and 38 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
488 | Relaxin signaling pathway 💬 19 genes, 30 drugs (DrugBank) and 38 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
489 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
ACE [1] ACE 💬 |
Enalapril Enalapril 💬 |
Enalapril | 019 [6] 19, 46, 66, 113, 210, 222 💬 💬 |
490 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
ACE [1] ACE 💬 |
Lisinopril Lisinopril 💬 |
Lisinopril | 019 [7] 19, 46, 49, 66, 67, 113, 222 💬 💬 |
491 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
ACE [1] ACE 💬 |
Lisinopril Lisinopril 💬 |
Lisinopril | 019 [7] 19, 46, 49, 66, 67, 113, 222 💬 💬 |
492 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
ACE [1] ACE 💬 |
Perindopril Perindopril 💬 |
Perindopril | 058 [4] 58, 113, 167, 222 💬 💬 |
493 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
ACE [1] ACE 💬 |
Ramipril Ramipril 💬 |
Ramipril | 046 [7] 46, 49, 66, 67, 113, 218, 257 💬 💬 |
494 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
ADRB1 [1] ADRB1 💬 |
Bisoprolol Bisoprolol 💬 |
Bisoprolol | 058 [4] 58, 67, 86, 113 💬 💬 |
495 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
ADRB1 [1] ADRB1 💬 |
Metoprolol Metoprolol 💬 |
Metoprolol | 017 [6] 17, 57, 58, 113, 193, 226 💬 💬 |
496 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
ADRB1 [1] ADRB1 💬 |
Nebivolol Nebivolol 💬 |
Nebivolol | 017 [4] 17, 85, 113, 167 💬 💬 |
497 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
ADRB1 [2] ADRB1, ADRB2 💬 |
Carvedilol Carvedilol 💬 |
Carvedilol | 057 [4] 57, 86, 113, 210 💬 💬 |
498 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
ADRB2 [1] ADRB2 💬 |
Albuterol Albuterol 💬 |
Salbutamol | 003 [12] 3 , 11, 12, 13, 49, 85, 86, 89, 111, 113, 256, 299 💬 💬 |
499 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
500 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
501 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
502 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
503 | Renin-angiotensin system 💬 6 genes, 21 drugs (DrugBank) and 31 diseases |
ACE [1] ACE 💬 |
Enalapril Enalapril 💬 |
Enalapril | 019 [6] 19, 46, 66, 113, 210, 222 💬 💬 |
504 | Renin-angiotensin system 💬 6 genes, 21 drugs (DrugBank) and 31 diseases |
ACE [1] ACE 💬 |
Lisinopril Lisinopril 💬 |
Lisinopril | 019 [7] 19, 46, 49, 66, 67, 113, 222 💬 💬 |
505 | Renin-angiotensin system 💬 6 genes, 21 drugs (DrugBank) and 31 diseases |
ACE [1] ACE 💬 |
Lisinopril Lisinopril 💬 |
Lisinopril | 019 [7] 19, 46, 49, 66, 67, 113, 222 💬 💬 |
506 | Renin-angiotensin system 💬 6 genes, 21 drugs (DrugBank) and 31 diseases |
ACE [1] ACE 💬 |
Perindopril Perindopril 💬 |
Perindopril | 058 [4] 58, 113, 167, 222 💬 💬 |
507 | Renin-angiotensin system 💬 6 genes, 21 drugs (DrugBank) and 31 diseases |
ACE [1] ACE 💬 |
Ramipril Ramipril 💬 |
Ramipril | 046 [7] 46, 49, 66, 67, 113, 218, 257 💬 💬 |
508 | Renin-angiotensin system 💬 6 genes, 21 drugs (DrugBank) and 31 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
509 | Retrograde endocannabinoid signaling 💬 34 genes, 62 drugs (DrugBank) and 67 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
510 | Retrograde endocannabinoid signaling 💬 34 genes, 62 drugs (DrugBank) and 67 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
511 | Retrograde endocannabinoid signaling 💬 34 genes, 62 drugs (DrugBank) and 67 diseases |
PTGS2 [1] PTGS2 💬 |
Ibuprofen Ibuprofen 💬 |
Ibuprofen | 013 [7] 13, 46, 65, 107, 113, 271, 299 💬 💬 |
512 | Rheumatoid arthritis 💬 22 genes, 49 drugs (DrugBank) and 74 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
513 | RIG-I-like receptor signaling pathway 💬 22 genes, 18 drugs (DrugBank) and 55 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
514 | RIG-I-like receptor signaling pathway 💬 22 genes, 18 drugs (DrugBank) and 55 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
515 | Salivary secretion 💬 19 genes, 61 drugs (DrugBank) and 56 diseases |
ADRA1A [5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬 |
Carvedilol Carvedilol 💬 |
Carvedilol | 057 [4] 57, 86, 113, 210 💬 💬 |
516 | Salivary secretion 💬 19 genes, 61 drugs (DrugBank) and 56 diseases |
ADRB1 [1] ADRB1 💬 |
Bisoprolol Bisoprolol 💬 |
Bisoprolol | 058 [4] 58, 67, 86, 113 💬 💬 |
517 | Salivary secretion 💬 19 genes, 61 drugs (DrugBank) and 56 diseases |
ADRB1 [1] ADRB1 💬 |
Metoprolol Metoprolol 💬 |
Metoprolol | 017 [6] 17, 57, 58, 113, 193, 226 💬 💬 |
518 | Salivary secretion 💬 19 genes, 61 drugs (DrugBank) and 56 diseases |
ADRB1 [1] ADRB1 💬 |
Nebivolol Nebivolol 💬 |
Nebivolol | 017 [4] 17, 85, 113, 167 💬 💬 |
519 | Salivary secretion 💬 19 genes, 61 drugs (DrugBank) and 56 diseases |
ADRB2 [1] ADRB2 💬 |
Albuterol Albuterol 💬 |
Salbutamol | 003 [12] 3 , 11, 12, 13, 49, 85, 86, 89, 111, 113, 256, 299 💬 💬 |
520 | Salmonella infection 💬 27 genes, 40 drugs (DrugBank) and 66 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
521 | Salmonella infection 💬 27 genes, 40 drugs (DrugBank) and 66 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
522 | Salmonella infection 💬 27 genes, 40 drugs (DrugBank) and 66 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
523 | Serotonergic synapse 💬 38 genes, 112 drugs (DrugBank) and 79 diseases |
ALOX5 [1] ALOX5 💬 |
Oxatomide Oxatomide 💬 |
Oxatomide | 113 [1] 113 💬 💬 |
524 | Serotonergic synapse 💬 38 genes, 112 drugs (DrugBank) and 79 diseases |
PTGS1 [2] PTGS1, PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
525 | Serotonergic synapse 💬 38 genes, 112 drugs (DrugBank) and 79 diseases |
PTGS1 [2] PTGS1, PTGS2 💬 |
Ibuprofen Ibuprofen 💬 |
Ibuprofen | 013 [7] 13, 46, 65, 107, 113, 271, 299 💬 💬 |
526 | Shigellosis 💬 23 genes, 41 drugs (DrugBank) and 86 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
527 | Shigellosis 💬 23 genes, 41 drugs (DrugBank) and 86 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
528 | Shigellosis 💬 23 genes, 41 drugs (DrugBank) and 86 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
529 | Signaling pathways regulating pluripotency of stem cells 💬 19 genes, 28 drugs (DrugBank) and 48 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
530 | Small cell lung cancer 💬 14 genes, 39 drugs (DrugBank) and 59 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
531 | Small cell lung cancer 💬 14 genes, 39 drugs (DrugBank) and 59 diseases |
PTGS2 [1] PTGS2 💬 |
Ibuprofen Ibuprofen 💬 |
Ibuprofen | 013 [7] 13, 46, 65, 107, 113, 271, 299 💬 💬 |
532 | Small cell lung cancer 💬 14 genes, 39 drugs (DrugBank) and 59 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
533 | Sphingolipid signaling pathway 💬 30 genes, 52 drugs (DrugBank) and 73 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
534 | Sphingolipid signaling pathway 💬 30 genes, 52 drugs (DrugBank) and 73 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
535 | Spinocerebellar ataxia 💬 17 genes, 25 drugs (DrugBank) and 70 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
536 | Synaptic vesicle cycle 💬 7 genes, 30 drugs (DrugBank) and 40 diseases |
SLC6A2 [2] SLC6A2, SLC6A3 💬 |
Methylphenidate Methylphenidate 💬 |
Methylphenidate | 006 [7] 6 , 13, 34, 84, 113, 179, 206 💬 💬 |
537 | Synaptic vesicle cycle 💬 7 genes, 30 drugs (DrugBank) and 40 diseases |
SNAP25 [1] SNAP25 💬 |
Botulinum toxin type A Botulinum toxin type A 💬 |
Botulinum toxin type A | 002 [14] 2 , 5 , 6 , 7 , 13, 15, 17, 36, 47, 51, 70, 113, 149, 226 💬 💬 |
538 | Systemic lupus erythematosus 💬 14 genes, 38 drugs (DrugBank) and 78 diseases |
GRIN2A [2] GRIN2A, GRIN2B 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
539 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
540 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
541 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
542 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
543 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
544 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
SCN2A [3] SCN2A, SCN3A, SCN9A 💬 |
Mexiletine Mexiletine 💬 |
Mexiletine | 001 [5] 1 , 2 , 10, 113, 114 💬 💬 |
545 | Terpenoid backbone biosynthesis 💬 4 genes, 12 drugs (DrugBank) and 53 diseases |
FDPS [1] FDPS 💬 |
Risedronic acid Risedronic acid 💬 |
Risedronic acid | 046 [9] 46, 50, 66, 93, 95, 96, 107, 113, 274 💬 💬 |
546 | Terpenoid backbone biosynthesis 💬 4 genes, 12 drugs (DrugBank) and 53 diseases |
FNTA [2] FNTA, FNTB 💬 |
Lonafarnib Lonafarnib 💬 |
Lonafarnib | 113 [2] 113, 333 💬 💬 |
547 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
548 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
549 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
550 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
551 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
552 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
553 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
554 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
555 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
556 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
557 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
558 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
559 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
PPARG [1] PPARG 💬 |
Bocidelpar Bocidelpar 💬 |
Bocidelpar | 113 [1] 113 💬 💬 |
560 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
561 | Thyroid cancer 💬 8 genes, 16 drugs (DrugBank) and 28 diseases |
PPARG [1] PPARG 💬 |
Bocidelpar Bocidelpar 💬 |
Bocidelpar | 113 [1] 113 💬 💬 |
562 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
ESR1 [1] ESR1 💬 |
Prasterone Prasterone 💬 |
Prasterone | 049 [6] 49, 53, 83, 86, 96, 113 💬 💬 |
563 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
ESR1 [1] ESR1 💬 |
Tamoxifen Tamoxifen 💬 |
Tamoxifen | 002 [3] 2 , 113, 227 💬 💬 |
564 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
565 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
566 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
567 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
568 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
PTGS2 [1] PTGS2 💬 |
Ibuprofen Ibuprofen 💬 |
Ibuprofen | 013 [7] 13, 46, 65, 107, 113, 271, 299 💬 💬 |
569 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
570 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
571 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
572 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
573 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
ALOX5 [1] ALOX5 💬 |
Oxatomide Oxatomide 💬 |
Oxatomide | 113 [1] 113 💬 💬 |
574 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
575 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
576 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
PPARG [1] PPARG 💬 |
Bocidelpar Bocidelpar 💬 |
Bocidelpar | 113 [1] 113 💬 💬 |
577 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
578 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
579 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
580 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
581 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
582 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
583 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
584 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
VDR [1] VDR 💬 |
Calcifediol Calcifediol 💬 |
Calcifediol | 113 [2] 113, 299 💬 💬 |
585 | Type I diabetes mellitus 💬 11 genes, 22 drugs (DrugBank) and 68 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
586 | Vascular smooth muscle contraction 💬 31 genes, 77 drugs (DrugBank) and 68 diseases |
ADRA1A [3] ADRA1A, ADRA1B, ADRA1D 💬 |
Carvedilol Carvedilol 💬 |
Carvedilol | 057 [4] 57, 86, 113, 210 💬 💬 |
587 | Vascular smooth muscle contraction 💬 31 genes, 77 drugs (DrugBank) and 68 diseases |
AGTR1 [1] AGTR1 💬 |
Losartan Losartan 💬 |
Losartan | 017 [17] 17, 19, 36, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬 💬 |
588 | VEGF signaling pathway 💬 21 genes, 53 drugs (DrugBank) and 90 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
589 | VEGF signaling pathway 💬 21 genes, 53 drugs (DrugBank) and 90 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
590 | VEGF signaling pathway 💬 21 genes, 53 drugs (DrugBank) and 90 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
591 | VEGF signaling pathway 💬 21 genes, 53 drugs (DrugBank) and 90 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
592 | VEGF signaling pathway 💬 21 genes, 53 drugs (DrugBank) and 90 diseases |
PTGS2 [1] PTGS2 💬 |
Aspirin Aspirin 💬 |
Acetylsalicylic acid | 013 [14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬 💬 |
593 | VEGF signaling pathway 💬 21 genes, 53 drugs (DrugBank) and 90 diseases |
PTGS2 [1] PTGS2 💬 |
Ibuprofen Ibuprofen 💬 |
Ibuprofen | 013 [7] 13, 46, 65, 107, 113, 271, 299 💬 💬 |
594 | Viral carcinogenesis 💬 25 genes, 23 drugs (DrugBank) and 40 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |
595 | Viral myocarditis 💬 10 genes, 19 drugs (DrugBank) and 46 diseases |
DMD [1] DMD 💬 |
Casimersen Casimersen 💬 |
Casimersen | 113 [1] 113 💬 💬 |
596 | Viral myocarditis 💬 10 genes, 19 drugs (DrugBank) and 46 diseases |
DMD [1] DMD 💬 |
Drisapersen Drisapersen 💬 |
Drisapersen | 113 [1] 113 💬 💬 |
597 | Viral myocarditis 💬 10 genes, 19 drugs (DrugBank) and 46 diseases |
DMD [1] DMD 💬 |
Eteplirsen Eteplirsen 💬 |
Eteplirsen | 113 [1] 113 💬 💬 |
598 | Viral myocarditis 💬 10 genes, 19 drugs (DrugBank) and 46 diseases |
DMD [1] DMD 💬 |
Golodirsen Golodirsen 💬 |
Golodirsen | 113 [1] 113 💬 💬 |
599 | Viral myocarditis 💬 10 genes, 19 drugs (DrugBank) and 46 diseases |
DMD [1] DMD 💬 |
Viltolarsen Viltolarsen 💬 |
Viltolarsen | 113 [1] 113 💬 💬 |
600 | Wnt signaling pathway 💬 9 genes, 9 drugs (DrugBank) and 61 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Cyclosporine Cyclosporine 💬 |
Cyclosporine | 011 [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬 💬 |
601 | Wnt signaling pathway 💬 9 genes, 9 drugs (DrugBank) and 61 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
602 | Wnt signaling pathway 💬 9 genes, 9 drugs (DrugBank) and 61 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
603 | Yersinia infection 💬 22 genes, 39 drugs (DrugBank) and 69 diseases |
IL1B [1] IL1B 💬 |
Canakinumab Canakinumab 💬 |
Canakinumab | 046 [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬 💬 |
604 | Yersinia infection 💬 22 genes, 39 drugs (DrugBank) and 69 diseases |
MAPK11 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 |
Losmapimod Losmapimod 💬 |
Losmapimod | 113 [2] 113, 222 💬 💬 |
605 | Yersinia infection 💬 22 genes, 39 drugs (DrugBank) and 69 diseases |
RELA [1] RELA 💬 |
Edasalonexent Edasalonexent 💬 |
Edasalonexent | 113 [1] 113 💬 💬 |