Target Gene/Pathway Pathway / Gene

  

Search results

No. KEGG PATHWAY KEGG GENES KEGG DRUG DrugBank Disease ID
1 Acute myeloid leukemia 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
2 Adipocytokine signaling pathway 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
3 Adrenergic signaling in cardiomyocytes 💬
 [1] ADRB2 💬 Clenbuterol 💬 Clenbuterol [5]  1 ,  2 ,  6 , 13, 256 💬 💬
4 Adrenergic signaling in cardiomyocytes 💬
 [1] ADRB2 💬 Albuterol 💬 Salbutamol [12]  3 , 11, 12, 13, 49, 85, 86, 89, 111, 113, 256, 299 💬 💬
5 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 Lidocaine 💬 Lidocaine [13]  6 , 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬 💬
6 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 Lidocaine hydrochloride monohydrate 💬 Lidocaine [13]  6 , 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬 💬
7 Alanine, aspartate and glutamate metabolism 💬
 [4] ABAT, ALDH5A1, GAD1, GAD2 💬 Valproic acid 💬 Valproic acid [14]  2 ,  3 ,  5 ,  6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬
8 Aldosterone synthesis and secretion 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 Valproic acid 💬 Valproic acid [14]  2 ,  3 ,  5 ,  6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬
9 Alzheimer disease 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
10 Alzheimer disease 💬
 [1] PSMB5 💬 Bortezomib 💬 Bortezomib [17] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 222, 228, 256, 283, 288, 331 💬 💬
11 Alzheimer disease 💬
 [1] PTGS2 💬 Acetaminophen 💬 Acetaminophen [15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 💬
12 AMPK signaling pathway 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
13 Amyotrophic lateral sclerosis 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
14 Amyotrophic lateral sclerosis 💬
 [1] PSMB5 💬 Bortezomib 💬 Bortezomib [17] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 222, 228, 256, 283, 288, 331 💬 💬
15 Antifolate resistance 💬
 [2] DHFR, DHFR2 💬 Methotrexate 💬 Methotrexate [38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬 💬
16 Apelin signaling pathway 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
17 Arachidonic acid metabolism 💬
 [2] PTGS1, PTGS2 💬 Acetaminophen 💬 Acetaminophen [15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 💬
18 Autophagy - animal 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
19 Autophagy - other 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
20 beta-Alanine metabolism 💬
 [3] ABAT, GAD1, GAD2 💬 Valproic acid 💬 Valproic acid [14]  2 ,  3 ,  5 ,  6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬
21 Biosynthesis of cofactors 💬
 [2] DHFR, DHFR2 💬 Methotrexate 💬 Methotrexate [38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬 💬
22 Breast cancer 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
23 Butanoate metabolism 💬
 [4] ABAT, ALDH5A1, GAD1, GAD2 💬 Valproic acid 💬 Valproic acid [14]  2 ,  3 ,  5 ,  6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬
24 C-type lectin receptor signaling pathway 💬
 [1] PTGS2 💬 Acetaminophen 💬 Acetaminophen [15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 💬
25 Calcium signaling pathway 💬
 [1] ADRB2 💬 Clenbuterol 💬 Clenbuterol [5]  1 ,  2 ,  6 , 13, 256 💬 💬
26 Calcium signaling pathway 💬
 [1] ADRB2 💬 Albuterol 💬 Salbutamol [12]  3 , 11, 12, 13, 49, 85, 86, 89, 111, 113, 256, 299 💬 💬
27 Calcium signaling pathway 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 Valproic acid 💬 Valproic acid [14]  2 ,  3 ,  5 ,  6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬
28 Calcium signaling pathway 💬
 [1] HRH1 💬 Diphenhydramine 💬 Diphenhydramine [8] 11, 13, 49, 51, 70, 86, 222, 256 💬 💬
29 cAMP signaling pathway 💬
 [1] ADRB2 💬 Clenbuterol 💬 Clenbuterol [5]  1 ,  2 ,  6 , 13, 256 💬 💬
30 cAMP signaling pathway 💬
 [1] ADRB2 💬 Albuterol 💬 Salbutamol [12]  3 , 11, 12, 13, 49, 85, 86, 89, 111, 113, 256, 299 💬 💬
31 Cellular senescence 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
32 Central carbon metabolism in cancer 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
33 cGMP-PKG signaling pathway 💬
 [1] ADRB2 💬 Clenbuterol 💬 Clenbuterol [5]  1 ,  2 ,  6 , 13, 256 💬 💬
34 cGMP-PKG signaling pathway 💬
 [1] ADRB2 💬 Albuterol 💬 Salbutamol [12]  3 , 11, 12, 13, 49, 85, 86, 89, 111, 113, 256, 299 💬 💬
35 Chemical carcinogenesis - DNA adducts 💬
 [1] PTGS2 💬 Acetaminophen 💬 Acetaminophen [15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 💬
36 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB2 💬 Clenbuterol 💬 Clenbuterol [5]  1 ,  2 ,  6 , 13, 256 💬 💬
37 Chemical carcinogenesis - receptor activation 💬
 [1] ADRB2 💬 Albuterol 💬 Salbutamol [12]  3 , 11, 12, 13, 49, 85, 86, 89, 111, 113, 256, 299 💬 💬
38 Chemical carcinogenesis - receptor activation 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
39 Choline metabolism in cancer 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
40 Circadian entrainment 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 Valproic acid 💬 Valproic acid [14]  2 ,  3 ,  5 ,  6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬
41 Colorectal cancer 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
42 Cortisol synthesis and secretion 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 Valproic acid 💬 Valproic acid [14]  2 ,  3 ,  5 ,  6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬
43 Cushing syndrome 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 Valproic acid 💬 Valproic acid [14]  2 ,  3 ,  5 ,  6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬
44 Cytokine-cytokine receptor interaction 💬
 [1] CSF3R 💬 Filgrastim 💬 Filgrastim [35]  2 ,  6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬 💬
45 Diabetic cardiomyopathy 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
46 Dopaminergic synapse 💬
 [1] SCN1A 💬 Lidocaine 💬 Lidocaine [13]  6 , 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬 💬
47 Dopaminergic synapse 💬
 [1] SCN1A 💬 Lidocaine hydrochloride monohydrate 💬 Lidocaine [13]  6 , 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬 💬
48 EGFR tyrosine kinase inhibitor resistance 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
49 Endocrine resistance 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
50 ErbB signaling pathway 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
51 Folate biosynthesis 💬
 [2] DHFR, DHFR2 💬 Methotrexate 💬 Methotrexate [38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬 💬
52 GABAergic synapse 💬
 [3] ABAT, GAD1, GAD2 💬 Valproic acid 💬 Valproic acid [14]  2 ,  3 ,  5 ,  6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬
53 Galactose metabolism 💬
 [1] GAA 💬 Alglucosidase alfa 💬 Alglucosidase alfa [1] 256 💬 💬
54 Galactose metabolism 💬
 [1] GAA 💬 Avalglucosidase alfa 💬 Avalglucosidase alfa [1] 256 💬 💬
55 Galactose metabolism 💬
 [1] GAA 💬 Cipaglucosidase alfa 💬 Cipaglucosidase alfa [1] 256 💬 💬
56 Galactose metabolism 💬
 [1] GAA 💬 Duvoglustat 💬 Duvoglustat [1] 256 💬 💬
57 Gastric cancer 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
58 Glioma 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
59 Glycosaminoglycan degradation 💬
 [1] IDUA 💬 Laronidase 💬 Laronidase [2] 19, 256 💬 💬
60 GnRH secretion 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 Valproic acid 💬 Valproic acid [14]  2 ,  3 ,  5 ,  6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬
61 Growth hormone synthesis, secretion and action 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
62 Hematopoietic cell lineage 💬
 [1] CSF3R 💬 Filgrastim 💬 Filgrastim [35]  2 ,  6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬 💬
63 Hematopoietic cell lineage 💬
 [1] MS4A1 💬 Rituximab 💬 Rituximab [48] 11, 13, 14, 19, 26, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331 💬 💬
64 Hepatocellular carcinoma 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
65 Herpes simplex virus 1 infection 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
66 HIF-1 signaling pathway 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
67 Human cytomegalovirus infection 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
68 Human cytomegalovirus infection 💬
 [1] PTGS2 💬 Acetaminophen 💬 Acetaminophen [15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 💬
69 Human immunodeficiency virus 1 infection 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
70 Human papillomavirus infection 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
71 Human papillomavirus infection 💬
 [1] PTGS2 💬 Acetaminophen 💬 Acetaminophen [15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 💬
72 Huntington disease 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
73 Huntington disease 💬
 [1] PSMB5 💬 Bortezomib 💬 Bortezomib [17] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 222, 228, 256, 283, 288, 331 💬 💬
74 IL-17 signaling pathway 💬
 [1] PTGS2 💬 Acetaminophen 💬 Acetaminophen [15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 💬
75 Inflammatory mediator regulation of TRP channels 💬
 [1] HRH1 💬 Diphenhydramine 💬 Diphenhydramine [8] 11, 13, 49, 51, 70, 86, 222, 256 💬 💬
76 Insulin resistance 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
77 Insulin signaling pathway 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
78 JAK-STAT signaling pathway 💬
 [1] CSF3R 💬 Filgrastim 💬 Filgrastim [35]  2 ,  6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬 💬
79 JAK-STAT signaling pathway 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
80 Kaposi sarcoma-associated herpesvirus infection 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
81 Kaposi sarcoma-associated herpesvirus infection 💬
 [1] PTGS2 💬 Acetaminophen 💬 Acetaminophen [15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 💬
82 Leishmaniasis 💬
 [1] PTGS2 💬 Acetaminophen 💬 Acetaminophen [15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 💬
83 Longevity regulating pathway 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
84 Longevity regulating pathway - multiple species 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
85 Lysosome 💬
 [1] GAA 💬 Alglucosidase alfa 💬 Alglucosidase alfa [1] 256 💬 💬
86 Lysosome 💬
 [1] GAA 💬 Avalglucosidase alfa 💬 Avalglucosidase alfa [1] 256 💬 💬
87 Lysosome 💬
 [1] GAA 💬 Cipaglucosidase alfa 💬 Cipaglucosidase alfa [1] 256 💬 💬
88 Lysosome 💬
 [1] GAA 💬 Duvoglustat 💬 Duvoglustat [1] 256 💬 💬
89 Lysosome 💬
 [1] IDUA 💬 Laronidase 💬 Laronidase [2] 19, 256 💬 💬
90 MAPK signaling pathway 💬
 [3] CACNA1G, CACNA1H, CACNA1I 💬 Valproic acid 💬 Valproic acid [14]  2 ,  3 ,  5 ,  6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬
91 Metabolic pathways 💬
 [4] ABAT, ALDH5A1, GAD1, GAD2 💬 Valproic acid 💬 Valproic acid [14]  2 ,  3 ,  5 ,  6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬
92 Metabolic pathways 💬
 [2] DHFR, DHFR2 💬 Methotrexate 💬 Methotrexate [38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬 💬
93 Metabolic pathways 💬
 [1] GAA 💬 Alglucosidase alfa 💬 Alglucosidase alfa [1] 256 💬 💬
94 Metabolic pathways 💬
 [1] GAA 💬 Avalglucosidase alfa 💬 Avalglucosidase alfa [1] 256 💬 💬
95 Metabolic pathways 💬
 [1] GAA 💬 Cipaglucosidase alfa 💬 Cipaglucosidase alfa [1] 256 💬 💬
96 Metabolic pathways 💬
 [1] GAA 💬 Duvoglustat 💬 Duvoglustat [1] 256 💬 💬
97 Metabolic pathways 💬
 [1] IDUA 💬 Laronidase 💬 Laronidase [2] 19, 256 💬 💬
98 Metabolic pathways 💬
 [2] PTGS1, PTGS2 💬 Acetaminophen 💬 Acetaminophen [15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 💬
99 Metabolic pathways 💬
 [1] UGCG 💬 Miglustat 💬 Miglustat [3] 19, 256, 299 💬 💬
100 MicroRNAs in cancer 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
101 MicroRNAs in cancer 💬
 [1] PTGS2 💬 Acetaminophen 💬 Acetaminophen [15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 💬
102 mTOR signaling pathway 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
103 Neuroactive ligand-receptor interaction 💬
 [1] ADRB2 💬 Clenbuterol 💬 Clenbuterol [5]  1 ,  2 ,  6 , 13, 256 💬 💬
104 Neuroactive ligand-receptor interaction 💬
 [1] ADRB2 💬 Albuterol 💬 Salbutamol [12]  3 , 11, 12, 13, 49, 85, 86, 89, 111, 113, 256, 299 💬 💬
105 Neuroactive ligand-receptor interaction 💬
 [1] HRH1 💬 Diphenhydramine 💬 Diphenhydramine [8] 11, 13, 49, 51, 70, 86, 222, 256 💬 💬
106 Neutrophil extracellular trap formation 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
107 NF-kappa B signaling pathway 💬
 [1] PTGS2 💬 Acetaminophen 💬 Acetaminophen [15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 💬
108 One carbon pool by folate 💬
 [2] DHFR, DHFR2 💬 Methotrexate 💬 Methotrexate [38] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331 💬 💬
109 Ovarian steroidogenesis 💬
 [1] PTGS2 💬 Acetaminophen 💬 Acetaminophen [15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 💬
110 Oxytocin signaling pathway 💬
 [1] PTGS2 💬 Acetaminophen 💬 Acetaminophen [15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 💬
111 Pancreatic cancer 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
112 Parkinson disease 💬
 [1] PSMB5 💬 Bortezomib 💬 Bortezomib [17] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 222, 228, 256, 283, 288, 331 💬 💬
113 Pathways in cancer 💬
 [1] CSF3R 💬 Filgrastim 💬 Filgrastim [35]  2 ,  6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬 💬
114 Pathways in cancer 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
115 Pathways in cancer 💬
 [1] PTGS2 💬 Acetaminophen 💬 Acetaminophen [15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 💬
116 Pathways of neurodegeneration - multiple diseases 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
117 Pathways of neurodegeneration - multiple diseases 💬
 [1] PSMB5 💬 Bortezomib 💬 Bortezomib [17] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 222, 228, 256, 283, 288, 331 💬 💬
118 Pathways of neurodegeneration - multiple diseases 💬
 [1] PTGS2 💬 Acetaminophen 💬 Acetaminophen [15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 💬
119 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
120 Phospholipase D signaling pathway 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
121 PI3K-Akt signaling pathway 💬
 [1] CSF3R 💬 Filgrastim 💬 Filgrastim [35]  2 ,  6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬 💬
122 PI3K-Akt signaling pathway 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
123 Platelet activation 💬
 [1] PTGS1 💬 Acetaminophen 💬 Acetaminophen [15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 💬
124 Prion disease 💬
 [1] PSMB5 💬 Bortezomib 💬 Bortezomib [17] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 222, 228, 256, 283, 288, 331 💬 💬
125 Propanoate metabolism 💬
 [1] ABAT 💬 Valproic acid 💬 Valproic acid [14]  2 ,  3 ,  5 ,  6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬
126 Prostate cancer 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
127 Proteasome 💬
 [1] PSMB5 💬 Bortezomib 💬 Bortezomib [17] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 222, 228, 256, 283, 288, 331 💬 💬
128 Proteoglycans in cancer 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
129 Regulation of lipolysis in adipocytes 💬
 [1] ADRB2 💬 Clenbuterol 💬 Clenbuterol [5]  1 ,  2 ,  6 , 13, 256 💬 💬
130 Regulation of lipolysis in adipocytes 💬
 [1] ADRB2 💬 Albuterol 💬 Salbutamol [12]  3 , 11, 12, 13, 49, 85, 86, 89, 111, 113, 256, 299 💬 💬
131 Regulation of lipolysis in adipocytes 💬
 [2] PTGS1, PTGS2 💬 Acetaminophen 💬 Acetaminophen [15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 💬
132 Renin secretion 💬
 [1] ADRB2 💬 Clenbuterol 💬 Clenbuterol [5]  1 ,  2 ,  6 , 13, 256 💬 💬
133 Renin secretion 💬
 [1] ADRB2 💬 Albuterol 💬 Salbutamol [12]  3 , 11, 12, 13, 49, 85, 86, 89, 111, 113, 256, 299 💬 💬
134 Retrograde endocannabinoid signaling 💬
 [1] PTGS2 💬 Acetaminophen 💬 Acetaminophen [15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 💬
135 Salivary secretion 💬
 [1] ADRB2 💬 Clenbuterol 💬 Clenbuterol [5]  1 ,  2 ,  6 , 13, 256 💬 💬
136 Salivary secretion 💬
 [1] ADRB2 💬 Albuterol 💬 Salbutamol [12]  3 , 11, 12, 13, 49, 85, 86, 89, 111, 113, 256, 299 💬 💬
137 Serotonergic synapse 💬
 [2] PTGS1, PTGS2 💬 Acetaminophen 💬 Acetaminophen [15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 💬
138 Shigellosis 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
139 Small cell lung cancer 💬
 [1] PTGS2 💬 Acetaminophen 💬 Acetaminophen [15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 💬
140 Sphingolipid metabolism 💬
 [1] UGCG 💬 Miglustat 💬 Miglustat [3] 19, 256, 299 💬 💬
141 Spinocerebellar ataxia 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
142 Spinocerebellar ataxia 💬
 [1] PSMB5 💬 Bortezomib 💬 Bortezomib [17] 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 222, 228, 256, 283, 288, 331 💬 💬
143 Starch and sucrose metabolism 💬
 [1] GAA 💬 Alglucosidase alfa 💬 Alglucosidase alfa [1] 256 💬 💬
144 Starch and sucrose metabolism 💬
 [1] GAA 💬 Avalglucosidase alfa 💬 Avalglucosidase alfa [1] 256 💬 💬
145 Starch and sucrose metabolism 💬
 [1] GAA 💬 Cipaglucosidase alfa 💬 Cipaglucosidase alfa [1] 256 💬 💬
146 Starch and sucrose metabolism 💬
 [1] GAA 💬 Duvoglustat 💬 Duvoglustat [1] 256 💬 💬
147 Taste transduction 💬
 [3] SCN2A, SCN3A, SCN9A 💬 Lidocaine 💬 Lidocaine [13]  6 , 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬 💬
148 Taste transduction 💬
 [3] SCN2A, SCN3A, SCN9A 💬 Lidocaine hydrochloride monohydrate 💬 Lidocaine [13]  6 , 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256 💬 💬
149 Taurine and hypotaurine metabolism 💬
 [2] GAD1, GAD2 💬 Valproic acid 💬 Valproic acid [14]  2 ,  3 ,  5 ,  6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬
150 Th17 cell differentiation 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
151 Thermogenesis 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
152 Thyroid hormone signaling pathway 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
153 TNF signaling pathway 💬
 [1] PTGS2 💬 Acetaminophen 💬 Acetaminophen [15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 💬
154 Type I diabetes mellitus 💬
 [2] GAD1, GAD2 💬 Valproic acid 💬 Valproic acid [14]  2 ,  3 ,  5 ,  6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬
155 Type II diabetes mellitus 💬
 [1] CACNA1G 💬 Valproic acid 💬 Valproic acid [14]  2 ,  3 ,  5 ,  6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬
156 Type II diabetes mellitus 💬
 [1] MTOR 💬 Sirolimus 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
157 Valine, leucine and isoleucine degradation 💬
 [1] ABAT 💬 Valproic acid 💬 Valproic acid [14]  2 ,  3 ,  5 ,  6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬
158 VEGF signaling pathway 💬
 [1] PTGS2 💬 Acetaminophen 💬 Acetaminophen [15]  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬 💬

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