Target Gene/Pathway Pathway / Gene
Search results
No. | KEGG PATHWAY | KEGG GENES | KEGG DRUG | DrugBank | Disease ID |
---|---|---|---|---|---|
1 | Acute myeloid leukemia 💬 17 genes, 30 drugs (DrugBank) and 62 diseases |
PML [2] PML, RARA 💬 |
Tretinoin Tretinoin 💬 |
Tretinoin | 002 [6] 2 , 62, 63, 75, 94, 231 💬 💬 |
2 | Adherens junction 💬 9 genes, 19 drugs (DrugBank) and 23 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
3 | Adherens junction 💬 9 genes, 19 drugs (DrugBank) and 23 diseases |
EGFR [2] EGFR, ERBB2 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
4 | Adipocytokine signaling pathway 💬 16 genes, 31 drugs (DrugBank) and 95 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
5 | Adipocytokine signaling pathway 💬 16 genes, 31 drugs (DrugBank) and 95 diseases |
RXRA [3] RXRA, RXRB, RXRG 💬 |
Bexarotene Bexarotene 💬 |
Bexarotene | 013 [2] 13, 75 💬 💬 |
6 | Adrenergic signaling in cardiomyocytes 💬 27 genes, 80 drugs (DrugBank) and 71 diseases |
AGTR1 [1] AGTR1 💬 |
Valsartan Valsartan 💬 |
Valsartan | 057 [7] 57, 58, 66, 75, 218, 222, 224 💬 💬 |
7 | AGE-RAGE signaling pathway in diabetic complications 💬 26 genes, 45 drugs (DrugBank) and 83 diseases |
AGTR1 [1] AGTR1 💬 |
Valsartan Valsartan 💬 |
Valsartan | 057 [7] 57, 58, 66, 75, 218, 222, 224 💬 💬 |
8 | Alcoholic liver disease 💬 39 genes, 46 drugs (DrugBank) and 87 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
9 | Alcoholism 💬 28 genes, 75 drugs (DrugBank) and 53 diseases |
DRD2 [1] DRD2 💬 |
Cabergoline Cabergoline 💬 |
Cabergoline | 006 [3] 6 , 74, 75 💬 💬 |
10 | Alcoholism 💬 28 genes, 75 drugs (DrugBank) and 53 diseases |
HDAC1 [11] HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9 💬 |
Vorinostat Vorinostat 💬 |
Vorinostat | 075 [2] 75, 96 💬 💬 |
11 | Aldosterone synthesis and secretion 💬 20 genes, 38 drugs (DrugBank) and 62 diseases |
AGTR1 [1] AGTR1 💬 |
Valsartan Valsartan 💬 |
Valsartan | 057 [7] 57, 58, 66, 75, 218, 222, 224 💬 💬 |
12 | Aldosterone synthesis and secretion 💬 20 genes, 38 drugs (DrugBank) and 62 diseases |
CYP11A1 [1] CYP11A1 💬 |
Levoketoconazole Levoketoconazole 💬 |
Levoketoconazole | 075 [1] 75 💬 💬 |
13 | Aldosterone synthesis and secretion 💬 20 genes, 38 drugs (DrugBank) and 62 diseases |
CYP11B2 [1] CYP11B2 💬 |
Osilodrostat Osilodrostat 💬 |
Osilodrostat | 075 [1] 75 💬 💬 |
14 | Aldosterone synthesis and secretion 💬 20 genes, 38 drugs (DrugBank) and 62 diseases |
MC2R [1] MC2R 💬 |
Corticotropin Corticotropin 💬 |
Corticotropin | 002 [12] 2 , 13, 14, 46, 49, 50, 66, 75, 81, 84, 145, 222 💬 💬 |
15 | Aldosterone-regulated sodium reabsorption 💬 13 genes, 14 drugs (DrugBank) and 25 diseases |
NR3C2 [1] NR3C2 💬 |
Eplerenone Eplerenone 💬 |
Eplerenone | 075 [4] 75, 113, 210, 215 💬 💬 |
16 | Amphetamine addiction 💬 25 genes, 51 drugs (DrugBank) and 91 diseases |
HDAC1 [2] HDAC1, HDAC2 💬 |
Vorinostat Vorinostat 💬 |
Vorinostat | 075 [2] 75, 96 💬 💬 |
17 | AMPK signaling pathway 💬 16 genes, 49 drugs (DrugBank) and 93 diseases |
PPARG [1] PPARG 💬 |
Rosiglitazone Rosiglitazone 💬 |
Rosiglitazone | 046 [5] 46, 75, 97, 222, 265 💬 💬 |
18 | AMPK signaling pathway 💬 16 genes, 49 drugs (DrugBank) and 93 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
19 | Amyotrophic lateral sclerosis 💬 35 genes, 48 drugs (DrugBank) and 108 diseases |
HDAC6 [1] HDAC6 💬 |
Vorinostat Vorinostat 💬 |
Vorinostat | 075 [2] 75, 96 💬 💬 |
20 | Apelin signaling pathway 💬 12 genes, 30 drugs (DrugBank) and 72 diseases |
AGTR1 [1] AGTR1 💬 |
Valsartan Valsartan 💬 |
Valsartan | 057 [7] 57, 58, 66, 75, 218, 222, 224 💬 💬 |
21 | Apelin signaling pathway 💬 12 genes, 30 drugs (DrugBank) and 72 diseases |
HDAC4 [2] HDAC4, HDAC5 💬 |
Vorinostat Vorinostat 💬 |
Vorinostat | 075 [2] 75, 96 💬 💬 |
22 | Apelin signaling pathway 💬 12 genes, 30 drugs (DrugBank) and 72 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
23 | Autophagy - animal 💬 13 genes, 18 drugs (DrugBank) and 62 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
24 | Bile secretion 💬 11 genes, 29 drugs (DrugBank) and 60 diseases |
RXRA [1] RXRA 💬 |
Bexarotene Bexarotene 💬 |
Bexarotene | 013 [2] 13, 75 💬 💬 |
25 | Bladder cancer 💬 10 genes, 23 drugs (DrugBank) and 22 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
26 | Bladder cancer 💬 10 genes, 23 drugs (DrugBank) and 22 diseases |
EGFR [2] EGFR, ERBB2 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
27 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
28 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
EGFR [2] EGFR, ERBB2 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
29 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
PGR [1] PGR 💬 |
Mifepristone Mifepristone 💬 |
Mifepristone | 075 [1] 75 💬 💬 |
30 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
AGTR1 [1] AGTR1 💬 |
Valsartan Valsartan 💬 |
Valsartan | 057 [7] 57, 58, 66, 75, 218, 222, 224 💬 💬 |
31 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
32 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
EGFR [2] EGFR, ERBB2 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
33 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
CRHR1 [2] CRHR1, CRHR2 💬 |
Corticorelin Corticorelin 💬 |
Corticorelin | 075 [1] 75 💬 💬 |
34 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
CRHR1 [2] CRHR1, CRHR2 💬 |
Corticorelin ovine triflutate Corticorelin ovine triflutate 💬 |
Corticorelin ovine triflutate | 075 [1] 75 💬 💬 |
35 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
DRD2 [1] DRD2 💬 |
Cabergoline Cabergoline 💬 |
Cabergoline | 006 [3] 6 , 74, 75 💬 💬 |
36 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
GLP1R [1] GLP1R 💬 |
Liraglutide Liraglutide 💬 |
Liraglutide | 006 [3] 6 , 75, 193 💬 💬 |
37 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
MC2R [1] MC2R 💬 |
Corticotropin Corticotropin 💬 |
Corticotropin | 002 [12] 2 , 13, 14, 46, 49, 50, 66, 75, 81, 84, 145, 222 💬 💬 |
38 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
SSTR1 [3] SSTR1, SSTR2, SSTR5 💬 |
Pasireotide Pasireotide 💬 |
Pasireotide | 067 [3] 67, 74, 75 💬 💬 |
39 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
SSTR2 [1] SSTR2 💬 |
Octreotide Octreotide 💬 |
Octreotide | 067 [7] 67, 75, 84, 85, 89, 193, 227 💬 💬 |
40 | Cell cycle 💬 10 genes, 9 drugs (DrugBank) and 21 diseases |
HDAC1 [3] HDAC1, HDAC2, HDAC8 💬 |
Vorinostat Vorinostat 💬 |
Vorinostat | 075 [2] 75, 96 💬 💬 |
41 | Central carbon metabolism in cancer 💬 18 genes, 29 drugs (DrugBank) and 56 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
42 | Central carbon metabolism in cancer 💬 18 genes, 29 drugs (DrugBank) and 56 diseases |
EGFR [2] EGFR, ERBB2 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
43 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
AGTR1 [1] AGTR1 💬 |
Valsartan Valsartan 💬 |
Valsartan | 057 [7] 57, 58, 66, 75, 218, 222, 224 💬 💬 |
44 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
PDE5A [1] PDE5A 💬 |
Tadalafil Tadalafil 💬 |
Tadalafil | 006 [7] 6 , 51, 75, 84, 86, 113, 210 💬 💬 |
45 | Chemical carcinogenesis - reactive oxygen species 💬 25 genes, 37 drugs (DrugBank) and 42 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
46 | Chemical carcinogenesis - reactive oxygen species 💬 25 genes, 37 drugs (DrugBank) and 42 diseases |
EGFR [1] EGFR 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
47 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
48 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
EGFR [1] EGFR 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
49 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
PGR [1] PGR 💬 |
Mifepristone Mifepristone 💬 |
Mifepristone | 075 [1] 75 💬 💬 |
50 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
RXRA [3] RXRA, RXRB, RXRG 💬 |
Bexarotene Bexarotene 💬 |
Bexarotene | 013 [2] 13, 75 💬 💬 |
51 | Choline metabolism in cancer 💬 11 genes, 25 drugs (DrugBank) and 53 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
52 | Choline metabolism in cancer 💬 11 genes, 25 drugs (DrugBank) and 53 diseases |
EGFR [1] EGFR 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
53 | Chronic myeloid leukemia 💬 17 genes, 20 drugs (DrugBank) and 29 diseases |
HDAC1 [2] HDAC1, HDAC2 💬 |
Vorinostat Vorinostat 💬 |
Vorinostat | 075 [2] 75, 96 💬 💬 |
54 | Circadian rhythm 💬 2 genes, 1 drug (DrugBank) and 25 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
55 | Cocaine addiction 💬 15 genes, 63 drugs (DrugBank) and 52 diseases |
DRD2 [1] DRD2 💬 |
Cabergoline Cabergoline 💬 |
Cabergoline | 006 [3] 6 , 74, 75 💬 💬 |
56 | Colorectal cancer 💬 14 genes, 23 drugs (DrugBank) and 49 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
57 | Colorectal cancer 💬 14 genes, 23 drugs (DrugBank) and 49 diseases |
EGFR [1] EGFR 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
58 | Complement and coagulation cascades 💬 17 genes, 29 drugs (DrugBank) and 44 diseases |
F2 [1] F2 💬 |
Dabigatran Dabigatran 💬 |
Dabigatran | 051 [5] 51, 75, 85, 91, 124 💬 💬 |
59 | Complement and coagulation cascades 💬 17 genes, 29 drugs (DrugBank) and 44 diseases |
F2 [1] F2 💬 |
Dabigatran etexilate Dabigatran etexilate 💬 |
Dabigatran etexilate | 051 [2] 51, 75 💬 💬 |
60 | Complement and coagulation cascades 💬 17 genes, 29 drugs (DrugBank) and 44 diseases |
F8 [1] F8 💬 |
Desmopressin Desmopressin 💬 |
Desmopressin | 006 [6] 6 , 64, 72, 75, 225, 288 💬 💬 |
61 | Coronavirus disease - COVID-19 💬 51 genes, 94 drugs (DrugBank) and 91 diseases |
AGTR1 [1] AGTR1 💬 |
Valsartan Valsartan 💬 |
Valsartan | 057 [7] 57, 58, 66, 75, 218, 222, 224 💬 💬 |
62 | Coronavirus disease - COVID-19 💬 51 genes, 94 drugs (DrugBank) and 91 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
63 | Coronavirus disease - COVID-19 💬 51 genes, 94 drugs (DrugBank) and 91 diseases |
EGFR [1] EGFR 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
64 | Coronavirus disease - COVID-19 💬 51 genes, 94 drugs (DrugBank) and 91 diseases |
F2 [1] F2 💬 |
Dabigatran Dabigatran 💬 |
Dabigatran | 051 [5] 51, 75, 85, 91, 124 💬 💬 |
65 | Coronavirus disease - COVID-19 💬 51 genes, 94 drugs (DrugBank) and 91 diseases |
F2 [1] F2 💬 |
Dabigatran etexilate Dabigatran etexilate 💬 |
Dabigatran etexilate | 051 [2] 51, 75 💬 💬 |
66 | Cortisol synthesis and secretion 💬 15 genes, 33 drugs (DrugBank) and 61 diseases |
AGTR1 [1] AGTR1 💬 |
Valsartan Valsartan 💬 |
Valsartan | 057 [7] 57, 58, 66, 75, 218, 222, 224 💬 💬 |
67 | Cortisol synthesis and secretion 💬 15 genes, 33 drugs (DrugBank) and 61 diseases |
CYP11A1 [3] CYP11A1, CYP11B1, CYP17A1 💬 |
Levoketoconazole Levoketoconazole 💬 |
Levoketoconazole | 075 [1] 75 💬 💬 |
68 | Cortisol synthesis and secretion 💬 15 genes, 33 drugs (DrugBank) and 61 diseases |
CYP11B1 [1] CYP11B1 💬 |
Metyrapone Metyrapone 💬 |
Metyrapone | 075 [1] 75 💬 💬 |
69 | Cortisol synthesis and secretion 💬 15 genes, 33 drugs (DrugBank) and 61 diseases |
CYP17A1 [1] CYP17A1 💬 |
Ketoconazole Ketoconazole 💬 |
Ketoconazole | 008 [3] 8 , 13, 75 💬 💬 |
70 | Cortisol synthesis and secretion 💬 15 genes, 33 drugs (DrugBank) and 61 diseases |
MC2R [1] MC2R 💬 |
Corticotropin Corticotropin 💬 |
Corticotropin | 002 [12] 2 , 13, 14, 46, 49, 50, 66, 75, 81, 84, 145, 222 💬 💬 |
71 | Cushing syndrome 💬 24 genes, 50 drugs (DrugBank) and 66 diseases |
AGTR1 [1] AGTR1 💬 |
Valsartan Valsartan 💬 |
Valsartan | 057 [7] 57, 58, 66, 75, 218, 222, 224 💬 💬 |
72 | Cushing syndrome 💬 24 genes, 50 drugs (DrugBank) and 66 diseases |
CRHR1 [2] CRHR1, CRHR2 💬 |
Corticorelin Corticorelin 💬 |
Corticorelin | 075 [1] 75 💬 💬 |
73 | Cushing syndrome 💬 24 genes, 50 drugs (DrugBank) and 66 diseases |
CRHR1 [2] CRHR1, CRHR2 💬 |
Corticorelin ovine triflutate Corticorelin ovine triflutate 💬 |
Corticorelin ovine triflutate | 075 [1] 75 💬 💬 |
74 | Cushing syndrome 💬 24 genes, 50 drugs (DrugBank) and 66 diseases |
CYP11A1 [3] CYP11A1, CYP11B1, CYP17A1 💬 |
Levoketoconazole Levoketoconazole 💬 |
Levoketoconazole | 075 [1] 75 💬 💬 |
75 | Cushing syndrome 💬 24 genes, 50 drugs (DrugBank) and 66 diseases |
CYP11B1 [1] CYP11B1 💬 |
Metyrapone Metyrapone 💬 |
Metyrapone | 075 [1] 75 💬 💬 |
76 | Cushing syndrome 💬 24 genes, 50 drugs (DrugBank) and 66 diseases |
CYP17A1 [1] CYP17A1 💬 |
Ketoconazole Ketoconazole 💬 |
Ketoconazole | 008 [3] 8 , 13, 75 💬 💬 |
77 | Cushing syndrome 💬 24 genes, 50 drugs (DrugBank) and 66 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
78 | Cushing syndrome 💬 24 genes, 50 drugs (DrugBank) and 66 diseases |
EGFR [1] EGFR 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
79 | Cushing syndrome 💬 24 genes, 50 drugs (DrugBank) and 66 diseases |
MC2R [1] MC2R 💬 |
Corticotropin Corticotropin 💬 |
Corticotropin | 002 [12] 2 , 13, 14, 46, 49, 50, 66, 75, 81, 84, 145, 222 💬 💬 |
80 | Cytokine-cytokine receptor interaction 💬 81 genes, 114 drugs (DrugBank) and 92 diseases |
PRL [1] PRL 💬 |
Cabergoline Cabergoline 💬 |
Cabergoline | 006 [3] 6 , 74, 75 💬 💬 |
81 | Diabetic cardiomyopathy 💬 26 genes, 42 drugs (DrugBank) and 73 diseases |
AGTR1 [1] AGTR1 💬 |
Valsartan Valsartan 💬 |
Valsartan | 057 [7] 57, 58, 66, 75, 218, 222, 224 💬 💬 |
82 | Dopaminergic synapse 💬 31 genes, 99 drugs (DrugBank) and 101 diseases |
DRD2 [1] DRD2 💬 |
Cabergoline Cabergoline 💬 |
Cabergoline | 006 [3] 6 , 74, 75 💬 💬 |
83 | EGFR tyrosine kinase inhibitor resistance 💬 26 genes, 56 drugs (DrugBank) and 83 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
84 | EGFR tyrosine kinase inhibitor resistance 💬 26 genes, 56 drugs (DrugBank) and 83 diseases |
EGFR [2] EGFR, ERBB2 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
85 | Endocrine resistance 💬 20 genes, 43 drugs (DrugBank) and 62 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
86 | Endocrine resistance 💬 20 genes, 43 drugs (DrugBank) and 62 diseases |
EGFR [2] EGFR, ERBB2 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
87 | Endocytosis 💬 15 genes, 28 drugs (DrugBank) and 51 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
88 | Endocytosis 💬 15 genes, 28 drugs (DrugBank) and 51 diseases |
EGFR [1] EGFR 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
89 | Endocytosis 💬 15 genes, 28 drugs (DrugBank) and 51 diseases |
PML [1] PML 💬 |
Tretinoin Tretinoin 💬 |
Tretinoin | 002 [6] 2 , 62, 63, 75, 94, 231 💬 💬 |
90 | Endometrial cancer 💬 10 genes, 18 drugs (DrugBank) and 20 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
91 | Endometrial cancer 💬 10 genes, 18 drugs (DrugBank) and 20 diseases |
EGFR [2] EGFR, ERBB2 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
92 | Epithelial cell signaling in Helicobacter pylori infection 💬 12 genes, 17 drugs (DrugBank) and 21 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
93 | Epithelial cell signaling in Helicobacter pylori infection 💬 12 genes, 17 drugs (DrugBank) and 21 diseases |
EGFR [1] EGFR 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
94 | Epstein-Barr virus infection 💬 44 genes, 62 drugs (DrugBank) and 66 diseases |
HDAC1 [2] HDAC1, HDAC2 💬 |
Vorinostat Vorinostat 💬 |
Vorinostat | 075 [2] 75, 96 💬 💬 |
95 | ErbB signaling pathway 💬 14 genes, 26 drugs (DrugBank) and 53 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
96 | ErbB signaling pathway 💬 14 genes, 26 drugs (DrugBank) and 53 diseases |
EGFR [2] EGFR, ERBB2 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
97 | Estrogen signaling pathway 💬 19 genes, 74 drugs (DrugBank) and 64 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
98 | Estrogen signaling pathway 💬 19 genes, 74 drugs (DrugBank) and 64 diseases |
EGFR [1] EGFR 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
99 | Estrogen signaling pathway 💬 19 genes, 74 drugs (DrugBank) and 64 diseases |
PGR [1] PGR 💬 |
Mifepristone Mifepristone 💬 |
Mifepristone | 075 [1] 75 💬 💬 |
100 | Estrogen signaling pathway 💬 19 genes, 74 drugs (DrugBank) and 64 diseases |
RARA [1] RARA 💬 |
Tretinoin Tretinoin 💬 |
Tretinoin | 002 [6] 2 , 62, 63, 75, 94, 231 💬 💬 |
101 | Fluid shear stress and atherosclerosis 💬 29 genes, 48 drugs (DrugBank) and 86 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
102 | Focal adhesion 💬 27 genes, 43 drugs (DrugBank) and 44 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
103 | Focal adhesion 💬 27 genes, 43 drugs (DrugBank) and 44 diseases |
EGFR [2] EGFR, ERBB2 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
104 | FoxO signaling pathway 💬 24 genes, 40 drugs (DrugBank) and 54 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
105 | FoxO signaling pathway 💬 24 genes, 40 drugs (DrugBank) and 54 diseases |
EGFR [1] EGFR 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
106 | FoxO signaling pathway 💬 24 genes, 40 drugs (DrugBank) and 54 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
107 | GABAergic synapse 💬 29 genes, 38 drugs (DrugBank) and 55 diseases |
GABRA1 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
Alprazolam Alprazolam 💬 |
Alprazolam | 008 [2] 8 , 75 💬 💬 |
108 | GABAergic synapse 💬 29 genes, 38 drugs (DrugBank) and 55 diseases |
GABRA1 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
Propofol Propofol 💬 |
Propofol | 006 [9] 6 , 21, 22, 34, 46, 70, 75, 98, 296 💬 💬 |
109 | Gap junction 💬 26 genes, 87 drugs (DrugBank) and 77 diseases |
DRD2 [1] DRD2 💬 |
Cabergoline Cabergoline 💬 |
Cabergoline | 006 [3] 6 , 74, 75 💬 💬 |
110 | Gap junction 💬 26 genes, 87 drugs (DrugBank) and 77 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
111 | Gap junction 💬 26 genes, 87 drugs (DrugBank) and 77 diseases |
EGFR [1] EGFR 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
112 | Gastric acid secretion 💬 14 genes, 43 drugs (DrugBank) and 52 diseases |
SSTR2 [1] SSTR2 💬 |
Octreotide Octreotide 💬 |
Octreotide | 067 [7] 67, 75, 84, 85, 89, 193, 227 💬 💬 |
113 | Gastric acid secretion 💬 14 genes, 43 drugs (DrugBank) and 52 diseases |
SSTR2 [1] SSTR2 💬 |
Pasireotide Pasireotide 💬 |
Pasireotide | 067 [3] 67, 74, 75 💬 💬 |
114 | Gastric cancer 💬 21 genes, 34 drugs (DrugBank) and 57 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
115 | Gastric cancer 💬 21 genes, 34 drugs (DrugBank) and 57 diseases |
EGFR [2] EGFR, ERBB2 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
116 | Gastric cancer 💬 21 genes, 34 drugs (DrugBank) and 57 diseases |
RARB [1] RARB 💬 |
Tretinoin Tretinoin 💬 |
Tretinoin | 002 [6] 2 , 62, 63, 75, 94, 231 💬 💬 |
117 | Gastric cancer 💬 21 genes, 34 drugs (DrugBank) and 57 diseases |
RXRA [3] RXRA, RXRB, RXRG 💬 |
Bexarotene Bexarotene 💬 |
Bexarotene | 013 [2] 13, 75 💬 💬 |
118 | Glioma 💬 15 genes, 30 drugs (DrugBank) and 57 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
119 | Glioma 💬 15 genes, 30 drugs (DrugBank) and 57 diseases |
EGFR [1] EGFR 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
120 | Glucagon signaling pathway 💬 12 genes, 19 drugs (DrugBank) and 83 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
121 | GnRH signaling pathway 💬 16 genes, 36 drugs (DrugBank) and 37 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
122 | GnRH signaling pathway 💬 16 genes, 36 drugs (DrugBank) and 37 diseases |
EGFR [1] EGFR 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
123 | Growth hormone synthesis, secretion and action 💬 24 genes, 41 drugs (DrugBank) and 76 diseases |
SSTR1 [4] SSTR1, SSTR2, SSTR3, SSTR5 💬 |
Pasireotide Pasireotide 💬 |
Pasireotide | 067 [3] 67, 74, 75 💬 💬 |
124 | Growth hormone synthesis, secretion and action 💬 24 genes, 41 drugs (DrugBank) and 76 diseases |
SSTR2 [1] SSTR2 💬 |
Octreotide Octreotide 💬 |
Octreotide | 067 [7] 67, 75, 84, 85, 89, 193, 227 💬 💬 |
125 | Hepatitis C 💬 34 genes, 59 drugs (DrugBank) and 72 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
126 | Hepatitis C 💬 34 genes, 59 drugs (DrugBank) and 72 diseases |
EGFR [1] EGFR 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
127 | Hepatitis C 💬 34 genes, 59 drugs (DrugBank) and 72 diseases |
RXRA [1] RXRA 💬 |
Bexarotene Bexarotene 💬 |
Bexarotene | 013 [2] 13, 75 💬 💬 |
128 | Hepatocellular carcinoma 💬 21 genes, 31 drugs (DrugBank) and 57 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
129 | Hepatocellular carcinoma 💬 21 genes, 31 drugs (DrugBank) and 57 diseases |
EGFR [1] EGFR 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
130 | Herpes simplex virus 1 infection 💬 43 genes, 65 drugs (DrugBank) and 94 diseases |
PML [1] PML 💬 |
Tretinoin Tretinoin 💬 |
Tretinoin | 002 [6] 2 , 62, 63, 75, 94, 231 💬 💬 |
131 | HIF-1 signaling pathway 💬 23 genes, 48 drugs (DrugBank) and 76 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
132 | HIF-1 signaling pathway 💬 23 genes, 48 drugs (DrugBank) and 76 diseases |
EGFR [2] EGFR, ERBB2 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
133 | Human cytomegalovirus infection 💬 56 genes, 104 drugs (DrugBank) and 120 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
134 | Human cytomegalovirus infection 💬 56 genes, 104 drugs (DrugBank) and 120 diseases |
EGFR [1] EGFR 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
135 | Human papillomavirus infection 💬 40 genes, 91 drugs (DrugBank) and 105 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
136 | Human papillomavirus infection 💬 40 genes, 91 drugs (DrugBank) and 105 diseases |
EGFR [1] EGFR 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
137 | Human papillomavirus infection 💬 40 genes, 91 drugs (DrugBank) and 105 diseases |
HDAC1 [2] HDAC1, HDAC2 💬 |
Vorinostat Vorinostat 💬 |
Vorinostat | 075 [2] 75, 96 💬 💬 |
138 | Huntington disease 💬 24 genes, 33 drugs (DrugBank) and 82 diseases |
HDAC1 [2] HDAC1, HDAC2 💬 |
Vorinostat Vorinostat 💬 |
Vorinostat | 075 [2] 75, 96 💬 💬 |
139 | Huntington disease 💬 24 genes, 33 drugs (DrugBank) and 82 diseases |
PPARG [1] PPARG 💬 |
Rosiglitazone Rosiglitazone 💬 |
Rosiglitazone | 046 [5] 46, 75, 97, 222, 265 💬 💬 |
140 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
141 | Influenza A 💬 45 genes, 63 drugs (DrugBank) and 85 diseases |
PML [1] PML 💬 |
Tretinoin Tretinoin 💬 |
Tretinoin | 002 [6] 2 , 62, 63, 75, 94, 231 💬 💬 |
142 | Insulin resistance 💬 18 genes, 33 drugs (DrugBank) and 95 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
143 | Insulin secretion 💬 14 genes, 39 drugs (DrugBank) and 44 diseases |
GLP1R [1] GLP1R 💬 |
Liraglutide Liraglutide 💬 |
Liraglutide | 006 [3] 6 , 75, 193 💬 💬 |
144 | Insulin signaling pathway 💬 12 genes, 26 drugs (DrugBank) and 66 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
145 | JAK-STAT signaling pathway 💬 58 genes, 91 drugs (DrugBank) and 96 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
146 | JAK-STAT signaling pathway 💬 58 genes, 91 drugs (DrugBank) and 96 diseases |
EGFR [1] EGFR 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
147 | JAK-STAT signaling pathway 💬 58 genes, 91 drugs (DrugBank) and 96 diseases |
PRL [1] PRL 💬 |
Cabergoline Cabergoline 💬 |
Cabergoline | 006 [3] 6 , 74, 75 💬 💬 |
148 | Lipid and atherosclerosis 💬 46 genes, 56 drugs (DrugBank) and 93 diseases |
PPARG [1] PPARG 💬 |
Rosiglitazone Rosiglitazone 💬 |
Rosiglitazone | 046 [5] 46, 75, 97, 222, 265 💬 💬 |
149 | Lipid and atherosclerosis 💬 46 genes, 56 drugs (DrugBank) and 93 diseases |
RXRA [3] RXRA, RXRB, RXRG 💬 |
Bexarotene Bexarotene 💬 |
Bexarotene | 013 [2] 13, 75 💬 💬 |
150 | Long-term depression 💬 13 genes, 19 drugs (DrugBank) and 32 diseases |
CRHR1 [1] CRHR1 💬 |
Corticorelin Corticorelin 💬 |
Corticorelin | 075 [1] 75 💬 💬 |
151 | Long-term depression 💬 13 genes, 19 drugs (DrugBank) and 32 diseases |
CRHR1 [1] CRHR1 💬 |
Corticorelin ovine triflutate Corticorelin ovine triflutate 💬 |
Corticorelin ovine triflutate | 075 [1] 75 💬 💬 |
152 | Longevity regulating pathway 💬 11 genes, 20 drugs (DrugBank) and 68 diseases |
PPARG [1] PPARG 💬 |
Rosiglitazone Rosiglitazone 💬 |
Rosiglitazone | 046 [5] 46, 75, 97, 222, 265 💬 💬 |
153 | Longevity regulating pathway 💬 11 genes, 20 drugs (DrugBank) and 68 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
154 | Longevity regulating pathway - multiple species 💬 11 genes, 15 drugs (DrugBank) and 62 diseases |
HDAC1 [2] HDAC1, HDAC2 💬 |
Vorinostat Vorinostat 💬 |
Vorinostat | 075 [2] 75, 96 💬 💬 |
155 | Longevity regulating pathway - multiple species 💬 11 genes, 15 drugs (DrugBank) and 62 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
156 | MAPK signaling pathway 💬 61 genes, 85 drugs (DrugBank) and 110 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
157 | MAPK signaling pathway 💬 61 genes, 85 drugs (DrugBank) and 110 diseases |
EGFR [2] EGFR, ERBB2 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
158 | Melanoma 💬 16 genes, 29 drugs (DrugBank) and 35 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
159 | Melanoma 💬 16 genes, 29 drugs (DrugBank) and 35 diseases |
EGFR [1] EGFR 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
160 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
CYP11A1 [3] CYP11A1, CYP11B1, CYP17A1 💬 |
Levoketoconazole Levoketoconazole 💬 |
Levoketoconazole | 075 [1] 75 💬 💬 |
161 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
CYP11B1 [1] CYP11B1 💬 |
Metyrapone Metyrapone 💬 |
Metyrapone | 075 [1] 75 💬 💬 |
162 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
CYP11B2 [1] CYP11B2 💬 |
Osilodrostat Osilodrostat 💬 |
Osilodrostat | 075 [1] 75 💬 💬 |
163 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
CYP17A1 [1] CYP17A1 💬 |
Ketoconazole Ketoconazole 💬 |
Ketoconazole | 008 [3] 8 , 13, 75 💬 💬 |
164 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
PDE5A [1] PDE5A 💬 |
Tadalafil Tadalafil 💬 |
Tadalafil | 006 [7] 6 , 51, 75, 84, 86, 113, 210 💬 💬 |
165 | MicroRNAs in cancer 💬 31 genes, 65 drugs (DrugBank) and 85 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
166 | MicroRNAs in cancer 💬 31 genes, 65 drugs (DrugBank) and 85 diseases |
EGFR [2] EGFR, ERBB2 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
167 | MicroRNAs in cancer 💬 31 genes, 65 drugs (DrugBank) and 85 diseases |
HDAC1 [4] HDAC1, HDAC2, HDAC4, HDAC5 💬 |
Vorinostat Vorinostat 💬 |
Vorinostat | 075 [2] 75, 96 💬 💬 |
168 | Morphine addiction 💬 41 genes, 65 drugs (DrugBank) and 73 diseases |
GABRA1 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
Alprazolam Alprazolam 💬 |
Alprazolam | 008 [2] 8 , 75 💬 💬 |
169 | Morphine addiction 💬 41 genes, 65 drugs (DrugBank) and 73 diseases |
GABRA1 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
Propofol Propofol 💬 |
Propofol | 006 [9] 6 , 21, 22, 34, 46, 70, 75, 98, 296 💬 💬 |
170 | mTOR signaling pathway 💬 14 genes, 32 drugs (DrugBank) and 91 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
171 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
AGTR1 [1] AGTR1 💬 |
Valsartan Valsartan 💬 |
Valsartan | 057 [7] 57, 58, 66, 75, 218, 222, 224 💬 💬 |
172 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
AVPR2 [1] AVPR2 💬 |
Desmopressin Desmopressin 💬 |
Desmopressin | 006 [6] 6 , 64, 72, 75, 225, 288 💬 💬 |
173 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
CRHR1 [2] CRHR1, CRHR2 💬 |
Corticorelin Corticorelin 💬 |
Corticorelin | 075 [1] 75 💬 💬 |
174 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
CRHR1 [2] CRHR1, CRHR2 💬 |
Corticorelin ovine triflutate Corticorelin ovine triflutate 💬 |
Corticorelin ovine triflutate | 075 [1] 75 💬 💬 |
175 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
DRD2 [2] DRD2, PRL 💬 |
Cabergoline Cabergoline 💬 |
Cabergoline | 006 [3] 6 , 74, 75 💬 💬 |
176 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
F2 [1] F2 💬 |
Dabigatran Dabigatran 💬 |
Dabigatran | 051 [5] 51, 75, 85, 91, 124 💬 💬 |
177 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
F2 [1] F2 💬 |
Dabigatran etexilate Dabigatran etexilate 💬 |
Dabigatran etexilate | 051 [2] 51, 75 💬 💬 |
178 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
GABRA1 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
Alprazolam Alprazolam 💬 |
Alprazolam | 008 [2] 8 , 75 💬 💬 |
179 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
GABRA1 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
Propofol Propofol 💬 |
Propofol | 006 [9] 6 , 21, 22, 34, 46, 70, 75, 98, 296 💬 💬 |
180 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
GLP1R [1] GLP1R 💬 |
Liraglutide Liraglutide 💬 |
Liraglutide | 006 [3] 6 , 75, 193 💬 💬 |
181 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
MC2R [1] MC2R 💬 |
Corticotropin Corticotropin 💬 |
Corticotropin | 002 [12] 2 , 13, 14, 46, 49, 50, 66, 75, 81, 84, 145, 222 💬 💬 |
182 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
NR3C1 [1] NR3C1 💬 |
Hydrocortisone Hydrocortisone 💬 |
Hydrocortisone | 006 [10] 6 , 41, 46, 53, 75, 78, 81, 83, 97, 299 💬 💬 |
183 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
NR3C1 [1] NR3C1 💬 |
Mifepristone Mifepristone 💬 |
Mifepristone | 075 [1] 75 💬 💬 |
184 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
NR3C1 [1] NR3C1 💬 |
Prednisolone Prednisolone 💬 |
Prednisolone | 003 [42] 3 , 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬 💬 |
185 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
NR3C1 [1] NR3C1 💬 |
Relacorilant Relacorilant 💬 |
Relacorilant | 075 [1] 75 💬 💬 |
186 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
SSTR1 [4] SSTR1, SSTR2, SSTR3, SSTR5 💬 |
Pasireotide Pasireotide 💬 |
Pasireotide | 067 [3] 67, 74, 75 💬 💬 |
187 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
SSTR2 [1] SSTR2 💬 |
Octreotide Octreotide 💬 |
Octreotide | 067 [7] 67, 75, 84, 85, 89, 193, 227 💬 💬 |
188 | Neutrophil extracellular trap formation 💬 35 genes, 36 drugs (DrugBank) and 61 diseases |
HDAC1 [11] HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9 💬 |
Vorinostat Vorinostat 💬 |
Vorinostat | 075 [2] 75, 96 💬 💬 |
189 | Nicotine addiction 💬 30 genes, 30 drugs (DrugBank) and 44 diseases |
GABRA1 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
Alprazolam Alprazolam 💬 |
Alprazolam | 008 [2] 8 , 75 💬 💬 |
190 | Nicotine addiction 💬 30 genes, 30 drugs (DrugBank) and 44 diseases |
GABRA1 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
Propofol Propofol 💬 |
Propofol | 006 [9] 6 , 21, 22, 34, 46, 70, 75, 98, 296 💬 💬 |
191 | Non-alcoholic fatty liver disease 💬 23 genes, 47 drugs (DrugBank) and 86 diseases |
PPARG [1] PPARG 💬 |
Rosiglitazone Rosiglitazone 💬 |
Rosiglitazone | 046 [5] 46, 75, 97, 222, 265 💬 💬 |
192 | Non-alcoholic fatty liver disease 💬 23 genes, 47 drugs (DrugBank) and 86 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
193 | Non-alcoholic fatty liver disease 💬 23 genes, 47 drugs (DrugBank) and 86 diseases |
RXRA [1] RXRA 💬 |
Bexarotene Bexarotene 💬 |
Bexarotene | 013 [2] 13, 75 💬 💬 |
194 | Non-small cell lung cancer 💬 21 genes, 33 drugs (DrugBank) and 45 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
195 | Non-small cell lung cancer 💬 21 genes, 33 drugs (DrugBank) and 45 diseases |
EGFR [2] EGFR, ERBB2 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
196 | Non-small cell lung cancer 💬 21 genes, 33 drugs (DrugBank) and 45 diseases |
RARB [1] RARB 💬 |
Tretinoin Tretinoin 💬 |
Tretinoin | 002 [6] 2 , 62, 63, 75, 94, 231 💬 💬 |
197 | Non-small cell lung cancer 💬 21 genes, 33 drugs (DrugBank) and 45 diseases |
RXRA [3] RXRA, RXRB, RXRG 💬 |
Bexarotene Bexarotene 💬 |
Bexarotene | 013 [2] 13, 75 💬 💬 |
198 | Notch signaling pathway 💬 7 genes, 3 drugs (DrugBank) and 4 diseases |
HDAC1 [2] HDAC1, HDAC2 💬 |
Vorinostat Vorinostat 💬 |
Vorinostat | 075 [2] 75, 96 💬 💬 |
199 | Oocyte meiosis 💬 14 genes, 41 drugs (DrugBank) and 77 diseases |
PGR [1] PGR 💬 |
Mifepristone Mifepristone 💬 |
Mifepristone | 075 [1] 75 💬 💬 |
200 | Osteoclast differentiation 💬 36 genes, 71 drugs (DrugBank) and 93 diseases |
PPARG [1] PPARG 💬 |
Rosiglitazone Rosiglitazone 💬 |
Rosiglitazone | 046 [5] 46, 75, 97, 222, 265 💬 💬 |
201 | Ovarian steroidogenesis 💬 7 genes, 36 drugs (DrugBank) and 52 diseases |
CYP11A1 [2] CYP11A1, CYP17A1 💬 |
Levoketoconazole Levoketoconazole 💬 |
Levoketoconazole | 075 [1] 75 💬 💬 |
202 | Ovarian steroidogenesis 💬 7 genes, 36 drugs (DrugBank) and 52 diseases |
CYP17A1 [1] CYP17A1 💬 |
Ketoconazole Ketoconazole 💬 |
Ketoconazole | 008 [3] 8 , 13, 75 💬 💬 |
203 | Oxytocin signaling pathway 💬 34 genes, 73 drugs (DrugBank) and 108 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
204 | Oxytocin signaling pathway 💬 34 genes, 73 drugs (DrugBank) and 108 diseases |
EGFR [1] EGFR 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
205 | Oxytocin signaling pathway 💬 34 genes, 73 drugs (DrugBank) and 108 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
206 | Pancreatic cancer 💬 19 genes, 36 drugs (DrugBank) and 67 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
207 | Pancreatic cancer 💬 19 genes, 36 drugs (DrugBank) and 67 diseases |
EGFR [2] EGFR, ERBB2 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
208 | Parathyroid hormone synthesis, secretion and action 💬 21 genes, 48 drugs (DrugBank) and 65 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
209 | Parathyroid hormone synthesis, secretion and action 💬 21 genes, 48 drugs (DrugBank) and 65 diseases |
EGFR [1] EGFR 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
210 | Parathyroid hormone synthesis, secretion and action 💬 21 genes, 48 drugs (DrugBank) and 65 diseases |
RXRA [3] RXRA, RXRB, RXRG 💬 |
Bexarotene Bexarotene 💬 |
Bexarotene | 013 [2] 13, 75 💬 💬 |
211 | Parkinson disease 💬 24 genes, 73 drugs (DrugBank) and 66 diseases |
DRD2 [1] DRD2 💬 |
Cabergoline Cabergoline 💬 |
Cabergoline | 006 [3] 6 , 74, 75 💬 💬 |
212 | Pathogenic Escherichia coli infection 💬 26 genes, 39 drugs (DrugBank) and 74 diseases |
F2 [1] F2 💬 |
Dabigatran Dabigatran 💬 |
Dabigatran | 051 [5] 51, 75, 85, 91, 124 💬 💬 |
213 | Pathogenic Escherichia coli infection 💬 26 genes, 39 drugs (DrugBank) and 74 diseases |
F2 [1] F2 💬 |
Dabigatran etexilate Dabigatran etexilate 💬 |
Dabigatran etexilate | 051 [2] 51, 75 💬 💬 |
214 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
AGTR1 [1] AGTR1 💬 |
Valsartan Valsartan 💬 |
Valsartan | 057 [7] 57, 58, 66, 75, 218, 222, 224 💬 💬 |
215 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
216 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
EGFR [2] EGFR, ERBB2 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
217 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
F2 [1] F2 💬 |
Dabigatran Dabigatran 💬 |
Dabigatran | 051 [5] 51, 75, 85, 91, 124 💬 💬 |
218 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
F2 [1] F2 💬 |
Dabigatran etexilate Dabigatran etexilate 💬 |
Dabigatran etexilate | 051 [2] 51, 75 💬 💬 |
219 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
HDAC1 [2] HDAC1, HDAC2 💬 |
Vorinostat Vorinostat 💬 |
Vorinostat | 075 [2] 75, 96 💬 💬 |
220 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
PML [3] PML, RARA, RARB 💬 |
Tretinoin Tretinoin 💬 |
Tretinoin | 002 [6] 2 , 62, 63, 75, 94, 231 💬 💬 |
221 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
PPARG [1] PPARG 💬 |
Rosiglitazone Rosiglitazone 💬 |
Rosiglitazone | 046 [5] 46, 75, 97, 222, 265 💬 💬 |
222 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
RXRA [3] RXRA, RXRB, RXRG 💬 |
Bexarotene Bexarotene 💬 |
Bexarotene | 013 [2] 13, 75 💬 💬 |
223 | PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 34 genes, 51 drugs (DrugBank) and 92 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
224 | PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 34 genes, 51 drugs (DrugBank) and 92 diseases |
EGFR [1] EGFR 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
225 | Phospholipase D signaling pathway 💬 23 genes, 51 drugs (DrugBank) and 76 diseases |
AGTR1 [1] AGTR1 💬 |
Valsartan Valsartan 💬 |
Valsartan | 057 [7] 57, 58, 66, 75, 218, 222, 224 💬 💬 |
226 | Phospholipase D signaling pathway 💬 23 genes, 51 drugs (DrugBank) and 76 diseases |
AVPR2 [1] AVPR2 💬 |
Desmopressin Desmopressin 💬 |
Desmopressin | 006 [6] 6 , 64, 72, 75, 225, 288 💬 💬 |
227 | Phospholipase D signaling pathway 💬 23 genes, 51 drugs (DrugBank) and 76 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
228 | Phospholipase D signaling pathway 💬 23 genes, 51 drugs (DrugBank) and 76 diseases |
EGFR [1] EGFR 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
229 | Phospholipase D signaling pathway 💬 23 genes, 51 drugs (DrugBank) and 76 diseases |
F2 [1] F2 💬 |
Dabigatran Dabigatran 💬 |
Dabigatran | 051 [5] 51, 75, 85, 91, 124 💬 💬 |
230 | Phospholipase D signaling pathway 💬 23 genes, 51 drugs (DrugBank) and 76 diseases |
F2 [1] F2 💬 |
Dabigatran etexilate Dabigatran etexilate 💬 |
Dabigatran etexilate | 051 [2] 51, 75 💬 💬 |
231 | PI3K-Akt signaling pathway 💬 76 genes, 112 drugs (DrugBank) and 112 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
232 | PI3K-Akt signaling pathway 💬 76 genes, 112 drugs (DrugBank) and 112 diseases |
EGFR [2] EGFR, ERBB2 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
233 | PI3K-Akt signaling pathway 💬 76 genes, 112 drugs (DrugBank) and 112 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
234 | PI3K-Akt signaling pathway 💬 76 genes, 112 drugs (DrugBank) and 112 diseases |
PRL [1] PRL 💬 |
Cabergoline Cabergoline 💬 |
Cabergoline | 006 [3] 6 , 74, 75 💬 💬 |
235 | PI3K-Akt signaling pathway 💬 76 genes, 112 drugs (DrugBank) and 112 diseases |
RXRA [1] RXRA 💬 |
Bexarotene Bexarotene 💬 |
Bexarotene | 013 [2] 13, 75 💬 💬 |
236 | Platelet activation 💬 22 genes, 51 drugs (DrugBank) and 56 diseases |
F2 [1] F2 💬 |
Dabigatran Dabigatran 💬 |
Dabigatran | 051 [5] 51, 75, 85, 91, 124 💬 💬 |
237 | Platelet activation 💬 22 genes, 51 drugs (DrugBank) and 56 diseases |
F2 [1] F2 💬 |
Dabigatran etexilate Dabigatran etexilate 💬 |
Dabigatran etexilate | 051 [2] 51, 75 💬 💬 |
238 | Platinum drug resistance 💬 9 genes, 15 drugs (DrugBank) and 23 diseases |
ERBB2 [1] ERBB2 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
239 | PPAR signaling pathway 💬 10 genes, 14 drugs (DrugBank) and 32 diseases |
PPARG [1] PPARG 💬 |
Rosiglitazone Rosiglitazone 💬 |
Rosiglitazone | 046 [5] 46, 75, 97, 222, 265 💬 💬 |
240 | PPAR signaling pathway 💬 10 genes, 14 drugs (DrugBank) and 32 diseases |
RXRA [3] RXRA, RXRB, RXRG 💬 |
Bexarotene Bexarotene 💬 |
Bexarotene | 013 [2] 13, 75 💬 💬 |
241 | Progesterone-mediated oocyte maturation 💬 14 genes, 38 drugs (DrugBank) and 42 diseases |
PGR [1] PGR 💬 |
Mifepristone Mifepristone 💬 |
Mifepristone | 075 [1] 75 💬 💬 |
242 | Prolactin signaling pathway 💬 19 genes, 39 drugs (DrugBank) and 54 diseases |
CYP17A1 [1] CYP17A1 💬 |
Ketoconazole Ketoconazole 💬 |
Ketoconazole | 008 [3] 8 , 13, 75 💬 💬 |
243 | Prolactin signaling pathway 💬 19 genes, 39 drugs (DrugBank) and 54 diseases |
CYP17A1 [1] CYP17A1 💬 |
Levoketoconazole Levoketoconazole 💬 |
Levoketoconazole | 075 [1] 75 💬 💬 |
244 | Prolactin signaling pathway 💬 19 genes, 39 drugs (DrugBank) and 54 diseases |
PRL [1] PRL 💬 |
Cabergoline Cabergoline 💬 |
Cabergoline | 006 [3] 6 , 74, 75 💬 💬 |
245 | Prostate cancer 💬 22 genes, 51 drugs (DrugBank) and 80 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
246 | Prostate cancer 💬 22 genes, 51 drugs (DrugBank) and 80 diseases |
EGFR [2] EGFR, ERBB2 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
247 | Protein digestion and absorption 💬 7 genes, 7 drugs (DrugBank) and 13 diseases |
DPP4 [1] DPP4 💬 |
Sitagliptin Sitagliptin 💬 |
Sitagliptin | 006 [4] 6 , 75, 233, 299 💬 💬 |
248 | Proteoglycans in cancer 💬 30 genes, 68 drugs (DrugBank) and 96 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
249 | Proteoglycans in cancer 💬 30 genes, 68 drugs (DrugBank) and 96 diseases |
EGFR [2] EGFR, ERBB2 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
250 | Purine metabolism 💬 29 genes, 35 drugs (DrugBank) and 73 diseases |
PDE5A [1] PDE5A 💬 |
Tadalafil Tadalafil 💬 |
Tadalafil | 006 [7] 6 , 51, 75, 84, 86, 113, 210 💬 💬 |
251 | Rap1 signaling pathway 💬 42 genes, 101 drugs (DrugBank) and 85 diseases |
DRD2 [1] DRD2 💬 |
Cabergoline Cabergoline 💬 |
Cabergoline | 006 [3] 6 , 74, 75 💬 💬 |
252 | Rap1 signaling pathway 💬 42 genes, 101 drugs (DrugBank) and 85 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
253 | Rap1 signaling pathway 💬 42 genes, 101 drugs (DrugBank) and 85 diseases |
EGFR [1] EGFR 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
254 | Ras signaling pathway 💬 35 genes, 53 drugs (DrugBank) and 62 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
255 | Ras signaling pathway 💬 35 genes, 53 drugs (DrugBank) and 62 diseases |
EGFR [1] EGFR 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
256 | Regulation of actin cytoskeleton 💬 28 genes, 60 drugs (DrugBank) and 63 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
257 | Regulation of actin cytoskeleton 💬 28 genes, 60 drugs (DrugBank) and 63 diseases |
EGFR [1] EGFR 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
258 | Regulation of actin cytoskeleton 💬 28 genes, 60 drugs (DrugBank) and 63 diseases |
F2 [1] F2 💬 |
Dabigatran Dabigatran 💬 |
Dabigatran | 051 [5] 51, 75, 85, 91, 124 💬 💬 |
259 | Regulation of actin cytoskeleton 💬 28 genes, 60 drugs (DrugBank) and 63 diseases |
F2 [1] F2 💬 |
Dabigatran etexilate Dabigatran etexilate 💬 |
Dabigatran etexilate | 051 [2] 51, 75 💬 💬 |
260 | Relaxin signaling pathway 💬 19 genes, 30 drugs (DrugBank) and 38 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
261 | Relaxin signaling pathway 💬 19 genes, 30 drugs (DrugBank) and 38 diseases |
EGFR [1] EGFR 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
262 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
AGTR1 [1] AGTR1 💬 |
Valsartan Valsartan 💬 |
Valsartan | 057 [7] 57, 58, 66, 75, 218, 222, 224 💬 💬 |
263 | Renin-angiotensin system 💬 6 genes, 21 drugs (DrugBank) and 31 diseases |
AGTR1 [1] AGTR1 💬 |
Valsartan Valsartan 💬 |
Valsartan | 057 [7] 57, 58, 66, 75, 218, 222, 224 💬 💬 |
264 | Retrograde endocannabinoid signaling 💬 34 genes, 62 drugs (DrugBank) and 67 diseases |
GABRA1 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
Alprazolam Alprazolam 💬 |
Alprazolam | 008 [2] 8 , 75 💬 💬 |
265 | Retrograde endocannabinoid signaling 💬 34 genes, 62 drugs (DrugBank) and 67 diseases |
GABRA1 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
Propofol Propofol 💬 |
Propofol | 006 [9] 6 , 21, 22, 34, 46, 70, 75, 98, 296 💬 💬 |
266 | Serotonergic synapse 💬 38 genes, 112 drugs (DrugBank) and 79 diseases |
GABRB1 [3] GABRB1, GABRB2, GABRB3 💬 |
Alprazolam Alprazolam 💬 |
Alprazolam | 008 [2] 8 , 75 💬 💬 |
267 | Serotonergic synapse 💬 38 genes, 112 drugs (DrugBank) and 79 diseases |
GABRB1 [3] GABRB1, GABRB2, GABRB3 💬 |
Propofol Propofol 💬 |
Propofol | 006 [9] 6 , 21, 22, 34, 46, 70, 75, 98, 296 💬 💬 |
268 | Shigellosis 💬 23 genes, 41 drugs (DrugBank) and 86 diseases |
EGFR [1] EGFR 💬 |
Gefitinib Gefitinib 💬 |
Gefitinib | 075 [1] 75 💬 💬 |
269 | Shigellosis 💬 23 genes, 41 drugs (DrugBank) and 86 diseases |
EGFR [1] EGFR 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
270 | Small cell lung cancer 💬 14 genes, 39 drugs (DrugBank) and 59 diseases |
RARB [1] RARB 💬 |
Tretinoin Tretinoin 💬 |
Tretinoin | 002 [6] 2 , 62, 63, 75, 94, 231 💬 💬 |
271 | Small cell lung cancer 💬 14 genes, 39 drugs (DrugBank) and 59 diseases |
RXRA [3] RXRA, RXRB, RXRG 💬 |
Bexarotene Bexarotene 💬 |
Bexarotene | 013 [2] 13, 75 💬 💬 |
272 | Steroid hormone biosynthesis 💬 8 genes, 11 drugs (DrugBank) and 14 diseases |
CYP11A1 [3] CYP11A1, CYP11B1, CYP17A1 💬 |
Levoketoconazole Levoketoconazole 💬 |
Levoketoconazole | 075 [1] 75 💬 💬 |
273 | Steroid hormone biosynthesis 💬 8 genes, 11 drugs (DrugBank) and 14 diseases |
CYP11B1 [1] CYP11B1 💬 |
Metyrapone Metyrapone 💬 |
Metyrapone | 075 [1] 75 💬 💬 |
274 | Steroid hormone biosynthesis 💬 8 genes, 11 drugs (DrugBank) and 14 diseases |
CYP11B2 [1] CYP11B2 💬 |
Osilodrostat Osilodrostat 💬 |
Osilodrostat | 075 [1] 75 💬 💬 |
275 | Steroid hormone biosynthesis 💬 8 genes, 11 drugs (DrugBank) and 14 diseases |
CYP17A1 [1] CYP17A1 💬 |
Ketoconazole Ketoconazole 💬 |
Ketoconazole | 008 [3] 8 , 13, 75 💬 💬 |
276 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
GABRA1 [6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬 |
Alprazolam Alprazolam 💬 |
Alprazolam | 008 [2] 8 , 75 💬 💬 |
277 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
GABRA1 [6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬 |
Propofol Propofol 💬 |
Propofol | 006 [9] 6 , 21, 22, 34, 46, 70, 75, 98, 296 💬 💬 |
278 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
RARA [1] RARA 💬 |
Tretinoin Tretinoin 💬 |
Tretinoin | 002 [6] 2 , 62, 63, 75, 94, 231 💬 💬 |
279 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
RXRA [3] RXRA, RXRB, RXRG 💬 |
Bexarotene Bexarotene 💬 |
Bexarotene | 013 [2] 13, 75 💬 💬 |
280 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
PPARG [1] PPARG 💬 |
Rosiglitazone Rosiglitazone 💬 |
Rosiglitazone | 046 [5] 46, 75, 97, 222, 265 💬 💬 |
281 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
282 | Thyroid cancer 💬 8 genes, 16 drugs (DrugBank) and 28 diseases |
PPARG [1] PPARG 💬 |
Rosiglitazone Rosiglitazone 💬 |
Rosiglitazone | 046 [5] 46, 75, 97, 222, 265 💬 💬 |
283 | Thyroid cancer 💬 8 genes, 16 drugs (DrugBank) and 28 diseases |
RXRA [3] RXRA, RXRB, RXRG 💬 |
Bexarotene Bexarotene 💬 |
Bexarotene | 013 [2] 13, 75 💬 💬 |
284 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
HDAC1 [3] HDAC1, HDAC2, HDAC3 💬 |
Vorinostat Vorinostat 💬 |
Vorinostat | 075 [2] 75, 96 💬 💬 |
285 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
RXRA [3] RXRA, RXRB, RXRG 💬 |
Bexarotene Bexarotene 💬 |
Bexarotene | 013 [2] 13, 75 💬 💬 |
286 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
ERBB2 [1] ERBB2 💬 |
Lapatinib Lapatinib 💬 |
Lapatinib | 034 [3] 34, 74, 75 💬 💬 |
287 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
288 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
HDAC1 [2] HDAC1, HDAC2 💬 |
Vorinostat Vorinostat 💬 |
Vorinostat | 075 [2] 75, 96 💬 💬 |
289 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
PML [2] PML, RARA 💬 |
Tretinoin Tretinoin 💬 |
Tretinoin | 002 [6] 2 , 62, 63, 75, 94, 231 💬 💬 |
290 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
PPARG [1] PPARG 💬 |
Rosiglitazone Rosiglitazone 💬 |
Rosiglitazone | 046 [5] 46, 75, 97, 222, 265 💬 💬 |
291 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
RXRA [3] RXRA, RXRB, RXRG 💬 |
Bexarotene Bexarotene 💬 |
Bexarotene | 013 [2] 13, 75 💬 💬 |
292 | Ubiquitin mediated proteolysis 💬 2 genes, 2 drugs (DrugBank) and 11 diseases |
PML [1] PML 💬 |
Tretinoin Tretinoin 💬 |
Tretinoin | 002 [6] 2 , 62, 63, 75, 94, 231 💬 💬 |
293 | Vascular smooth muscle contraction 💬 31 genes, 77 drugs (DrugBank) and 68 diseases |
AGTR1 [1] AGTR1 💬 |
Valsartan Valsartan 💬 |
Valsartan | 057 [7] 57, 58, 66, 75, 218, 222, 224 💬 💬 |
294 | Vasopressin-regulated water reabsorption 💬 1 gene, 6 drugs (DrugBank) and 10 diseases |
AVPR2 [1] AVPR2 💬 |
Desmopressin Desmopressin 💬 |
Desmopressin | 006 [6] 6 , 64, 72, 75, 225, 288 💬 💬 |
295 | Viral carcinogenesis 💬 25 genes, 23 drugs (DrugBank) and 40 diseases |
HDAC1 [11] HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9 💬 |
Vorinostat Vorinostat 💬 |
Vorinostat | 075 [2] 75, 96 💬 💬 |