Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 cGMP-PKG signaling pathway 💬
 [6] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C 💬 Methylergometrine 💬 Methylergometrine [1] 280 💬
2 cGMP-PKG signaling pathway 💬
 [9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 💬 Dipivefrin 💬 Dipivefrin [1]  6  💬
3 cGMP-PKG signaling pathway 💬
 [9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 💬 Droxidopa 💬 Droxidopa [5]  5 ,  6 , 17, 169, 170 💬
4 cGMP-PKG signaling pathway 💬
 [9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 💬 Ephedrine 💬 Ephedrine [1] 11 💬
5 cGMP-PKG signaling pathway 💬
 [9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 💬 Epinephrine 💬 Epinephrine [3] 46, 70, 96 💬
6 cGMP-PKG signaling pathway 💬
 [9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 💬 Noradrenaline 💬 Norepinephrine [2] 22, 296 💬
7 cGMP-PKG signaling pathway 💬
 [9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 💬 Pseudoephedrine 💬 Pseudoephedrine [1] 17 💬
8 cGMP-PKG signaling pathway 💬
 [1] ADRA2A 💬 Guanfacine 💬 Guanfacine [1] 193 💬
9 cGMP-PKG signaling pathway 💬
 [1] ADRA2A 💬 Pimozide 💬 Pimozide [1]  2  💬
10 cGMP-PKG signaling pathway 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 Apraclonidine 💬 Apraclonidine [1] 11 💬
11 cGMP-PKG signaling pathway 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 Brimonidine 💬 Brimonidine [2] 13, 90 💬
12 cGMP-PKG signaling pathway 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 Chlorpromazine 💬 Chlorpromazine [1] 254 💬
13 cGMP-PKG signaling pathway 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 Clonidine 💬 Clonidine [4]  6 , 65, 70, 78 💬
14 cGMP-PKG signaling pathway 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 Clozapine 💬 Clozapine [1]  6  💬
15 cGMP-PKG signaling pathway 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 Dexmedetomidine 💬 Dexmedetomidine [14]  2 ,  4 ,  6 , 21, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280 💬
16 cGMP-PKG signaling pathway 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 Guanabenz 💬 Guanabenz [2]  2 , 13 💬
17 cGMP-PKG signaling pathway 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 Rilmenidine 💬 Rilmenidine [1]  8  💬
18 cGMP-PKG signaling pathway 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 Tizanidine 💬 Tizanidine [1] 13 💬
19 cGMP-PKG signaling pathway 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 Yohimbine 💬 Yohimbine [1]  6  💬
20 Neuroactive ligand-receptor interaction 💬
 [6] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C 💬 Methylergometrine 💬 Methylergometrine [1] 280 💬
21 Neuroactive ligand-receptor interaction 💬
 [9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 💬 Dipivefrin 💬 Dipivefrin [1]  6  💬
22 Neuroactive ligand-receptor interaction 💬
 [9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 💬 Droxidopa 💬 Droxidopa [5]  5 ,  6 , 17, 169, 170 💬
23 Neuroactive ligand-receptor interaction 💬
 [9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 💬 Ephedrine 💬 Ephedrine [1] 11 💬
24 Neuroactive ligand-receptor interaction 💬
 [9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 💬 Epinephrine 💬 Epinephrine [3] 46, 70, 96 💬
25 Neuroactive ligand-receptor interaction 💬
 [9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 💬 Noradrenaline 💬 Norepinephrine [2] 22, 296 💬
26 Neuroactive ligand-receptor interaction 💬
 [9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 💬 Pseudoephedrine 💬 Pseudoephedrine [1] 17 💬
27 Neuroactive ligand-receptor interaction 💬
 [1] ADRA2A 💬 Guanfacine 💬 Guanfacine [1] 193 💬
28 Neuroactive ligand-receptor interaction 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 Apraclonidine 💬 Apraclonidine [1] 11 💬
29 Neuroactive ligand-receptor interaction 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 Brimonidine 💬 Brimonidine [2] 13, 90 💬
30 Neuroactive ligand-receptor interaction 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 Clonidine 💬 Clonidine [4]  6 , 65, 70, 78 💬
31 Neuroactive ligand-receptor interaction 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 Dexmedetomidine 💬 Dexmedetomidine [14]  2 ,  4 ,  6 , 21, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280 💬
32 Neuroactive ligand-receptor interaction 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 Guanabenz 💬 Guanabenz [2]  2 , 13 💬
33 Neuroactive ligand-receptor interaction 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 Rilmenidine 💬 Rilmenidine [1]  8  💬
34 Neuroactive ligand-receptor interaction 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 Tizanidine 💬 Tizanidine [1] 13 💬
35 Neuroactive ligand-receptor interaction 💬
 [3] ADRA2A, ADRA2B, ADRA2C 💬 Yohimbine 💬 Yohimbine [1]  6  💬
36 Neuroactive ligand-receptor interaction 💬
 [13] ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD2, HRH1, HTR2A, HTR2B, HTR2C 💬 Chlorpromazine 💬 Chlorpromazine [1] 254 💬
37 Neuroactive ligand-receptor interaction 💬
 [6] ADRA2A, ADRA2B, ADRA2C, DRD4, HTR2A, HTR2C 💬 Clozapine 💬 Clozapine [1]  6  💬
38 Neuroactive ligand-receptor interaction 💬
 [2] ADRA2A, DRD2 💬 Pimozide 💬 Pimozide [1]  2  💬

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