Gene

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KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related

Platelet activation 💬

[1] BTK 💬

Acalabrutinib 💬

Acalabrutinib

[2] 46, 61 💬

Platelet activation 💬

[1] BTK 💬

Branebrutinib 💬

Branebrutinib

[3] 46, 49, 53 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
53	Sjogren syndrome;Sjögren syndrome;Syndrome Sjogren's;SS;Autoimmune exocrinopathy;

Platelet activation 💬

[1] BTK 💬

Evobrutinib 💬

Evobrutinib

[3] 13, 46, 49 💬

Platelet activation 💬

[1] BTK 💬

Fenebrutinib 💬

Fenebrutinib

[1] 13 💬

Platelet activation 💬

[1] BTK 💬

Ibrutinib 💬

Ibrutinib

[3] 28, 60, 61 💬

Platelet activation 💬

[1] BTK 💬

Orelabrutinib 💬

Orelabrutinib

[4] 13, 49, 61, 63 💬

Platelet activation 💬

[1] BTK 💬

Remibrutinib 💬

Remibrutinib

[2] 13, 53 💬

Platelet activation 💬

[1] BTK 💬

Zanubrutinib 💬

Zanubrutinib

[5] 13, 63, 222, 300, 331 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
63	Idiopathic thrombocytopenic purpura;Primary immune thrombocytopenia;
222	Primary nephrotic syndrome;
300	IgG4-related disease;
331	Idiopathic multicentric castleman disease;iMCD;Castleman disease;

Platelet activation 💬

[1] F2 💬

Dabigatran 💬

Dabigatran

[5] 51, 75, 85, 91, 124 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
75	Cushing disease;Cushing;
85	Idiopathic interstitial pneumonia;IIPs;
91	Budd-Chiari syndrome;BCS;
124	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy;CADASIL;Autosomal dominant cerebral artery disease with subcortical infarct and leukoencephalopathy;Autosomal dominant cerebral artery disease;

Platelet activation 💬

[1] F2 💬

Dabigatran etexilate 💬

Dabigatran etexilate

[2] 51, 75 💬

Platelet activation 💬

[1] F2 💬

Thrombomodulin alfa 💬

Thrombomodulin Alfa

[1] 85 💬

Platelet activation 💬

[2] FYN, SRC 💬

Dasatinib 💬

Dasatinib

[2] 51, 85 💬

Platelet activation 💬

[2] FYN, SRC 💬

Dasatinib 💬

Dasatinib

[2] 51, 85 💬

Platelet activation 💬

[3] GUCY1A1, GUCY1A2, GUCY1B1 💬

Amyl nitrite 💬

Amyl Nitrite

[1] 58 💬

Platelet activation 💬

[3] GUCY1A1, GUCY1A2, GUCY1B1 💬

Riociguat 💬

Riociguat

[6] 51, 84, 86, 88, 225, 299 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
84	Sarcoidosis;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
299	Cystic fibrosis;

Platelet activation 💬

[4] MAPK11, MAPK12, MAPK13, MAPK14 💬

Losmapimod 💬

Losmapimod

[2] 113, 222 💬

Platelet activation 💬

[4] MAPK11, MAPK12, MAPK13, MAPK14 💬

Neflamapimod 💬

Neflamapimod

[1] 8 💬

Platelet activation 💬

[1] P2RY12 💬

Clopidogrel 💬

Clopidogrel

[3] 49, 51, 86 💬

Platelet activation 💬

[1] P2RY12 💬

Clopidogrel hydrochloride 💬

Clopidogrel

[3] 49, 51, 86 💬

Platelet activation 💬

[1] P2RY12 💬

Clopidogrel besilate 💬

Clopidogrel

[3] 49, 51, 86 💬

Platelet activation 💬

[1] P2RY12 💬

Ticagrelor 💬

Ticagrelor

[3] 36, 46, 85 💬

Platelet activation 💬

[1] PIK3CA 💬

Alpelisib 💬

Alpelisib

[1] 138 💬

Platelet activation 💬

[3] PIK3CA, PIK3CB, PIK3CD 💬

Name	Full Name
PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
PIK3CB	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

Leniolisib 💬

Leniolisib

[2] 53, 65 💬

Platelet activation 💬

[1] PIK3CD 💬

Parsaclisib 💬

Parsaclisib

[3] 35, 53, 61 💬

Platelet activation 💬

[1] PTGIR 💬

Beraprost 💬

Beraprost

[1] 86 💬

Platelet activation 💬

[1] PTGIR 💬

Epoprostenol 💬

Epoprostenol

[1] 86 💬

Platelet activation 💬

[1] PTGIR 💬

Ibudilast 💬

Ibudilast

[2] 2 , 13 💬

Platelet activation 💬

[1] PTGIR 💬

Iloprost 💬

Iloprost

[4] 51, 84, 85, 86 💬

Platelet activation 💬

[1] PTGIR 💬

Ralinepag 💬

Ralinepag

[1] 86 💬

Platelet activation 💬

[1] PTGIR 💬

Selexipag 💬

Selexipag

[5] 51, 70, 84, 86, 88 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
70	Spinal stenosis;Extensive spinal canal stenosis;
84	Sarcoidosis;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;

Platelet activation 💬

[1] PTGIR 💬

Treprostinil 💬

Treprostinil

[6] 51, 84, 85, 86, 88, 210 💬

Disease ID	Name
51	Scleroderma;Systemic sclerosis;SSc;
84	Sarcoidosis;
85	Idiopathic interstitial pneumonia;IIPs;
86	Pulmonary arterial hypertension;PAH;
88	Chronic thromboembolic pulmonary hypertension;CTEPH;Idiopathic chronic pulmonary thromboembolism;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;

Platelet activation 💬

[1] PTGS1 💬

Aceclofenac 💬

Aceclofenac

[1] 46 💬

Platelet activation 💬

[1] PTGS1 💬

Acetaminophen 💬

Acetaminophen

[15] 3 , 6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬

Disease ID	Name
3	Spinal muscular atrophy;Myelopathic muscular atrophy;
6	Parkinson disease;Disease Parkinson's;
11	Myasthenia gravis;MG;
13	Multiple sclerosis/Neuromyelitis optica;
34	Neurofibromatosis;
35	Pemphigus;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
70	Spinal stenosis;Extensive spinal canal stenosis;
86	Pulmonary arterial hypertension;PAH;
222	Primary nephrotic syndrome;
256	Muscle glycogenosis;Muscular glycogenosis;Muscle glycogen storage disease;Muscular glycogen storage disease;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
337	Homocystinuria;

Platelet activation 💬

[1] PTGS1 💬

Aspirin 💬

Acetylsalicylic acid

[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
22	Moyamoya disease;Occlusive disease in circle of Willis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
51	Scleroderma;Systemic sclerosis;SSc;
58	Hypertrophic cardiomyopathy;HCM;
64	Thrombotic thrombocytopenic purpura;TTP;
86	Pulmonary arterial hypertension;PAH;
97	Ulcerative colitis;
113	Muscular dystrophy;
158	Tuberous sclerosis;Tuberous sclerosis complex;
210	Single Ventricle;SV;Single ventricle heart defect;Univentricular heart;UVH;Single ventricular circulation syndrome;
231	Alpha-1-antitrypsin deficiency;AATD;
251	Urea cycle disorder;

Platelet activation 💬

[1] PTGS1 💬

Diclofenac 💬

Diclofenac

[5] 13, 34, 46, 78, 271 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
34	Neurofibromatosis;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
78	Hypopituitarism;Anterior pituitary hypothyroidism;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

Platelet activation 💬

[1] PTGS1 💬

Flurbiprofen 💬

Flurbiprofen

[3] 13, 21, 46 💬

Platelet activation 💬

[1] PTGS1 💬

Ibuprofen 💬

Ibuprofen

[7] 13, 46, 65, 107, 113, 271, 299 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
65	Primary immunodeficiency;
107	Juvenile idiopathic arthritis;JIA;
113	Muscular dystrophy;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
299	Cystic fibrosis;

Platelet activation 💬

[1] PTGS1 💬

Indomethacin 💬

Indomethacin

[3] 225, 271, 298 💬

Disease ID	Name
225	Congenital nephrogenic diabetes insipidus;Hereditary nephrogenic diabetes insipidus;Nephrogenic diabetes insipidus;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;
298	Hereditary pancreatitis;Chronic pancreatitis;

Platelet activation 💬

[1] PTGS1 💬

Ketoprofen 💬

Ketoprofen

[1] 46 💬

Platelet activation 💬

[1] PTGS1 💬

Ketorolac 💬

Ketorolac

[2] 70, 226 💬

Platelet activation 💬

[1] PTGS1 💬

Loxoprofen 💬

Loxoprofen

[2] 46, 271 💬

Platelet activation 💬

[1] PTGS1 💬

Naproxen 💬

Naproxen

[4] 13, 46, 107, 271 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica;
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
107	Juvenile idiopathic arthritis;JIA;
271	Ankylosing spondylitis;Spondylarthritis ankylopoietica;

Platelet activation 💬

[1] PTGS1 💬

Salsalate 💬

Salsalate

[1] 5 💬

Platelet activation 💬

[1] PTGS1 💬

Sulindac 💬

Sulindac

[1] 206 💬

Platelet activation 💬

[1] PTGS1 💬

Tolfenamic acid 💬

Tolfenamic acid

[1] 5 💬

Platelet activation 💬

[2] ROCK1, ROCK2 💬

Fasudil 💬

Fasudil

[4] 2 , 5 , 7 , 51 💬

Platelet activation 💬

[1] ROCK2 💬

Belumosudil 💬

Belumosudil

[2] 51, 85 💬

Platelet activation 💬

[1] SRC 💬

Bosutinib 💬

Bosutinib

[2] 2 , 67 💬

Platelet activation 💬

[1] SRC 💬

Saracatinib 💬

Saracatinib

[3] 6 , 89, 272 💬

Platelet activation 💬

[1] SYK 💬

Fostamatinib 💬

Fostamatinib

[4] 46, 49, 61, 66 💬

Disease ID	Name
46	Malignant rheumatoid arthritis;MRA;Rheumatoid vasculitis;RV;Rheumatoid arthritis;RA;
49	Systemic lupus erythematosus;SLE;
61	Autoimmune hemolytic anemia;AIHA;
66	IgA nephropathy;IgA nephritis;Berger disease;IgA-IgG nephropathy;