79. Homozygous familial hypercholesterolemia Disease details / Clinical trials / Drug dev / DR info


Clinical trials : 145 Drugs : 114 - (DrugBank : 26) / Drug target genes : 8 - Drug target pathways : 17

Drugs and their primary sponsors and trial info
(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[4’-   
   Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc
      2013   Phase 3   EUCTR2012-002434-37-GB   Australia;Canada;Czech Republic;Israel;Italy;Malaysia;Norway;South Africa;United Kingdom;United States;
      2013   -   EUCTR2012-002434-37-CZ   Australia;Canada;Czech Republic;Israel;Malaysia;Norway;South Africa;United Kingdom;United States;
      2012   -   EUCTR2012-002434-37-NO   Australia;Canada;Czech Republic;Israel;Malaysia;Norway;South Africa;United Kingdom;United States;
1,2-Dihexadecanoyl-sn-Glycero-3-Phospho-(1-raac-glycerol)   
   CERENIS THERAPEUTICS SA
      2012   -   EUCTR2011-003998-28-IT   Canada;Italy;Netherlands;United Kingdom;United States;
   Cerenis Therapeutics
      2012   Phase 2   EUCTR2011-003998-28-GB   Canada;Italy;Netherlands;United Kingdom;United States;
      2012   -   EUCTR2011-003998-28-NL   Canada;France;Italy;Netherlands;United Kingdom;United States;
AAV directed hLDLR gene therapy   
   Regenxbio Inc.
      2016   Phase 1/Phase 2   NCT02651675   Canada;Italy;Netherlands;United States;
AAV8.TBG.hLDLR   
   REGENXBIO Inc.
      2020   Phase 2   EUCTR2019-004496-39-NL   Canada;Italy;Netherlands;United States;
      2017   Phase 1;Phase 2   EUCTR2016-001446-25-IT   Canada;Italy;Netherlands;United States;
   University of Pennsylvania
      2017   Phase 1;Phase 2   EUCTR2016-001446-25-NL   Canada;Italy;Netherlands;United States;
AEGR-733   
   AEGERION PHARMACEUTICALS
      2011   -   EUCTR2010-023742-79-IT   Italy;
   Aegerion Pharmaceuticals
      2009   -   EUCTR2008-007058-36-IT   Italy;
   Aegerion Pharmaceuticals Inc.
      2016   Phase 3   EUCTR2014-003806-33-GR   Austria;Canada;Germany;Greece;Israel;Italy;Turkey;
   Aegerion Pharmaceuticals, Inc.
      2007   Phase 3   NCT00730236   Canada;Italy;South Africa;United States;
AK102   
   Akeso
      2019   Phase 2   NCT03933293   China;
AKCEA-ANGPTL3-LRX   
   Akcea Therapeutics
      2018   Phase 2   NCT03455777   Canada;
ALN-60212   
   The Medicines Company
      2017   Phase 2   EUCTR2016-003376-49-NL   Netherlands;South Africa;United States;
AMG 145   
   AMGEN INC.
      2016   Phase 3   EUCTR2015-002276-25-IT   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
   Amgen Europe B.V.
      2019   Phase 3   EUCTR2015-002276-25-SI   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Malaysia;Netherlands;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Swaziland;Switzerland;Taiwan;Turkey;Ukraine;United Kingdom;United States;
   Amgen Inc
      2019   Phase 3   EUCTR2015-002276-25-PT   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
      2019   Phase 3   EUCTR2015-002276-25-PL   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Malaysia;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2017   Phase 3   EUCTR2015-002276-25-NL   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
      2017   Phase 3   EUCTR2015-002276-25-ES   Australia;Austria;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Netherlands;New Zealand;South Africa;Spain;Turkey;
      2016   Phase 3   EUCTR2015-002276-25-HU   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom;
      2016   Phase 3   EUCTR2015-002276-25-GR   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom;
      2016   Phase 3   EUCTR2015-002276-25-DE   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom;
      2016   Phase 3   EUCTR2015-002276-25-CZ   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom;
      2016   Phase 3   EUCTR2015-002276-25-BE   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
      2016   Phase 3   EUCTR2015-002276-25-AT   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
      2013   Phase 2;Phase 3   EUCTR2011-005400-15-NL   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United Kingdom;United States;
      2013   Phase 2;Phase 3   EUCTR2011-005400-15-GB   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United Kingdom;United States;
      2013   Phase 2;Phase 3   EUCTR2011-005400-15-CZ   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Netherlands;New Zealand;South Africa;Spain;United Kingdom;United States;
      2013   Phase 2;Phase 3   EUCTR2011-005399-40-CZ   Belgium;Brazil;Canada;Czech Republic;France;Hong Kong;Italy;Lebanon;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United States;
      2013   Phase 2   EUCTR2011-005400-15-IT   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Malaysia;Netherlands;New Zealand;Norway;Poland;South Africa;Spain;Turkey;United Kingdom;United States;
      2013   Phase 2   EUCTR2011-005400-15-ES   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Malaysia;Netherlands;New Zealand;Norway;Poland;South Africa;Spain;Turkey;United Kingdom;United States;
      2013   -   EUCTR2011-005400-15-AT   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Malaysia;New Zealand;Norway;Poland;South Africa;Spain;Turkey;United Kingdom;United States;
      2013   -   EUCTR2011-005399-40-NL   Belgium;Brazil;Canada;Czech Republic;France;Hong Kong;Italy;Lebanon;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United States;
      2013   -   EUCTR2011-005399-40-IT   Austria;Belgium;Brazil;Canada;Czech Republic;France;Hong Kong;Italy;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United States;
      2013   -   EUCTR2011-005399-40-ES   Austria;Belgium;Brazil;Canada;Czech Republic;France;Hong Kong;Malaysia;New Zealand;South Africa;Spain;Turkey;United States;
      2012   Phase 2;Phase 3   EUCTR2011-005400-15-BE   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United Kingdom;United States;
      2012   Phase 2;Phase 3   EUCTR2011-005399-40-BE   Belgium;Brazil;Canada;Czech Republic;France;Hong Kong;Italy;Lebanon;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United States;
      2012   Phase 2   EUCTR2011-005400-15-GR   Belgium;Canada;Czech Republic;Greece;Italy;Netherlands;South Africa;Spain;United Kingdom;United States;
      -   Phase 3   EUCTR2015-002276-25-NO   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom;
      -   Phase 3   EUCTR2015-002276-25-GB   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Turkey;United Kingdom;
      -   -   EUCTR2011-005399-40-Outside-EU/EEA   Brazil;Canada;Hong Kong;Lebanon;Malaysia;New Zealand;South Africa;Turkey;United States;
AMG145   
   Amgen Inc
      2013   Phase 2;Phase 3   EUCTR2011-005400-15-NL   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United Kingdom;United States;
      2013   Phase 2;Phase 3   EUCTR2011-005400-15-GB   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United Kingdom;United States;
      2013   Phase 2;Phase 3   EUCTR2011-005400-15-CZ   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Netherlands;New Zealand;South Africa;Spain;United Kingdom;United States;
      2012   Phase 2;Phase 3   EUCTR2011-005400-15-BE   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Malaysia;Netherlands;New Zealand;South Africa;Spain;Turkey;United Kingdom;United States;
Alirocumab   
   REGENERON PHARMACEUTICALS, INC.
      2019   Phase 3   EUCTR2017-003170-13-IT   Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Japan;Netherlands;Norway;South Africa;Ukraine;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-001388-19-IT   Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
      2017   Phase 3   EUCTR2017-000351-95-IT   Austria;Canada;Czech Republic;Czechia;Denmark;France;Germany;Greece;Italy;South Africa;Turkey;Ukraine;United States;
   Regeneron Pharmaceuticals
      2017   Phase 3   NCT03156621   Austria;Canada;Czechia;France;Germany;Greece;Italy;Japan;South Africa;Taiwan;Turkey;Ukraine;United States;
Alirocumab SAR236553 (REGN727)   
   Sanofi
      2018   Phase 3   NCT03510715   Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
Anacetrapib   
   Merck Sharp & Dohme Corp.
      2013   Phase 3   NCT01841684   Canada;Germany;Israel;Italy;Norway;United Kingdom;United States;
Atorvastatin   
   Organon and Co
      2000   Phase 3   NCT03885921   -
      2000   Phase 3   NCT03884452   -
   Sanofi
      2018   Phase 3   NCT03510715   Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
CER-001   
   CERENIS THERAPEUTICS SA
      2012   -   EUCTR2011-003998-28-IT   Canada;Italy;Netherlands;United Kingdom;United States;
   Cerenis Therapeutics
      2012   Phase 2   EUCTR2011-003998-28-GB   Canada;Italy;Netherlands;United Kingdom;United States;
      2012   -   EUCTR2011-003998-28-NL   Canada;France;Italy;Netherlands;United Kingdom;United States;
   Cerenis Therapeutics, SA
      2011   Phase 2   NCT01412034   Canada;Italy;Netherlands;United Kingdom;United States;
Cholestyramine   
   Sanofi
      2018   Phase 3   NCT03510715   Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
Comparator: ezetimibe   
   Organon and Co
      2002   Phase 3   NCT00092833   United States;
Crestor Film-Coated Tablet   
   AstraZeneca AB
      2015   Phase 3   EUCTR2014-004746-99-DK   Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States;
      2015   Phase 3   EUCTR2014-004746-99-BE   Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States;
      -   Phase 3   EUCTR2014-004746-99-SE   Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States;
Crestor Tablets (calcium rosuvastatin) Film-Coated tablets   
   AstraZeneca AB
      2014   Phase 3   EUCTR2014-000972-24-BE   Australia;Belgium;Czech Republic;Denmark;Germany;Hong Kong;Israel;Netherlands;Norway;South Africa;Sweden;Taiwan;United Kingdom;United States;
      2014   -   EUCTR2014-000972-24-SE   Australia;Belgium;Czech Republic;Denmark;Germany;Hong Kong;Israel;Netherlands;Norway;South Africa;Sweden;Taiwan;United Kingdom;United States;
      2014   -   EUCTR2014-000972-24-NL   Australia;Belgium;Czech Republic;Denmark;Germany;Hong Kong;Israel;Netherlands;Norway;South Africa;Sweden;Taiwan;United Kingdom;United States;
      2014   -   EUCTR2014-000972-24-DK   Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States;
      2014   -   EUCTR2014-000972-24-DE   Australia;Belgium;Czech Republic;Denmark;Germany;Hong Kong;Israel;Netherlands;Norway;South Africa;Sweden;Taiwan;United Kingdom;United States;
DPPG   
   Cerenis Therapeutics
      2012   Phase 2   EUCTR2011-003998-28-GB   Canada;Italy;Netherlands;United Kingdom;United States;
Dextran sulfate adsorption   
   Laval University
      2013   -   NCT02286596   Canada;
Evinacumab   
   REGENERON PHARMACEUTICALS, INC.
      2018   Phase 3   EUCTR2017-001388-19-IT   Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
   Regeneron Pharmaceuticals
      2020   Phase 3   NCT04233918   Australia;Austria;Netherlands;Taiwan;Ukraine;United States;
      2018   Phase 3   NCT03409744   Australia;Austria;Canada;Czechia;France;Greece;Italy;Japan;Netherlands;Norway;South Africa;Ukraine;United States;
      2018   Phase 3   NCT03399786   Australia;Austria;Canada;Czechia;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Turkey;Ukraine;United States;
   Regeneron Pharmaceuticals, Inc.(ICCC: PAREXEL International)
      2018   -   JPRN-JapicCTI-184099   Japan, North America, Europe, Oceania, Africa;
Evinacumab (REGN1500)   
   REGENERON PHARMACEUTICALS, INC.
      2019   Phase 3   EUCTR2017-003170-13-IT   Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Japan;Netherlands;Norway;South Africa;Ukraine;United Kingdom;United States;
   Regeneron Pharmaceuticals Inc.
      2018   Phase 3   EUCTR2017-001388-19-GR   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Turkey;Ukraine;United States;
      2018   Phase 3   EUCTR2017-001388-19-DE   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
      2018   Phase 3   EUCTR2017-001388-19-AT   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
      -   Phase 3   EUCTR2017-001388-19-FR   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
      -   Phase 3   EUCTR2017-001388-19-CZ   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
   Regeneron Pharmaceuticals, Inc.
      2019   Phase 3   EUCTR2017-003170-13-GR   Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2017-003170-13-GB   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;Norway;South Africa;Turkey;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2017-003170-13-AT   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Ukraine;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-003170-13-NL   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Ukraine;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-003170-13-CZ   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Ukraine;United Kingdom;United States;
      -   Phase 3   EUCTR2017-003170-13-FR   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;Norway;South Africa;Turkey;Ukraine;United Kingdom;United States;
Evolocumab   
   Amgen
      2018   Phase 4   NCT03403374   India;
      2012   Phase 2/Phase 3   NCT01588496   Belgium;Canada;Czech Republic;Czechia;France;Hong Kong;Italy;Lebanon;Netherlands;New Zealand;South Africa;Spain;United States;
   Amgen Europe B.V.
      2019   Phase 3   EUCTR2015-002276-25-SI   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Malaysia;Netherlands;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Swaziland;Switzerland;Taiwan;Turkey;Ukraine;United Kingdom;United States;
   Amgen Inc
      2013   Phase 2;Phase 3   EUCTR2011-005400-15-CZ   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Netherlands;New Zealand;South Africa;Spain;United Kingdom;United States;
   Kanazawa University Hospital
      2016   -   JPRN-UMIN000022603   Japan;
   LIB Therapeutics LLC
      2019   Phase 3   NCT04034485   India;Israel;Norway;South Africa;Turkey;United States;
Evolocumab (AMG 145)   
   Amgen
      2016   Phase 3   NCT02624869   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czechia;Greece;Hungary;Italy;Malaysia;Netherlands;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;United States;
Ezetimibe   
   Akeso
      2019   Phase 2   NCT03933293   China;
   Organon and Co
      2006   -   NCT00704535   Philippines;
      2000   Phase 3   NCT03885921   -
      2000   Phase 3   NCT03884452   -
   Sanofi
      2018   Phase 3   NCT03510715   Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
Fenofibrate   
   Sanofi
      2018   Phase 3   NCT03510715   Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
Fluvastatin   
   Sanofi
      2018   Phase 3   NCT03510715   Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
Gemcabene   
   NeuroBo Pharmaceuticals Inc.
      2016   Phase 2   NCT02722408   Canada;Israel;United States;
Heparin-induced extracorporeal LDL precipitation   
   Laval University
      2013   -   NCT02286596   Canada;
IBI306   
   Innovent Biologics (Suzhou) Co. Ltd.
      2019   Phase 2/Phase 3   NCT04031742   China;
   Shenzhen People's Hospital
      2019   Phase 2/Phase 3   NCT04948008   China;
ISIS 301012   
   Kastle Therapeutics, LLC
      2006   Phase 2   NCT00280995   Netherlands;United States;
ISIS 301012 phosphorothioate oligonucleotide   
   Genzyme Europe B.V.
      2007   Phase 3   EUCTR2005-003449-15-GB   United Kingdom;
ISIS 703802   
   Ionis Pharmaceuticals, Inc.
      2016   Phase 1;Phase 2   EUCTR2015-004003-23-IT   Canada;Italy;Netherlands;
Implitapide   
   Medical Research Laboratories International
      2003   Phase 2   NCT00079846   Canada;Israel;Netherlands;Norway;United States;
Inclisiran   
   Novartis Pharmaceuticals
      2021   Phase 3   NCT04659863   Canada;France;Greece;Lebanon;Netherlands;Slovenia;Switzerland;Turkey;United States;
Inclisiran Sodium   
   Novartis Pharmaceuticals
      2019   Phase 3   NCT03814187   Canada;Czechia;Denmark;Germany;Hungary;Netherlands;Poland;South Africa;Spain;Sweden;Ukraine;United Kingdom;United States;
Inclisiran for injection   
   Novartis Pharmaceuticals
      2019   Phase 3   NCT03851705   Czechia;Hong Kong;Israel;Russian Federation;Serbia;South Africa;Taiwan;Turkey;Ukraine;
Inclisiran sodium   
   Novartis Pharma AG
      2021   Phase 3   EUCTR2020-002755-38-NL   Canada;France;Greece;Lebanon;Netherlands;Serbia;Slovenia;Switzerland;Turkey;United States;
      2021   Phase 3   EUCTR2020-002755-38-GR   Canada;France;Greece;Lebanon;Netherlands;Serbia;Slovenia;Switzerland;Turkey;United States;
      2020   Phase 3   EUCTR2020-002755-38-SI   Canada;France;Germany;Greece;Italy;Lebanon;Netherlands;Serbia;Slovenia;South Africa;Switzerland;Turkey;United States;
JS002   
   Shanghai Junshi Bioscience Co., Ltd.
      2020   Phase 2   NCT04515927   China;
KJX839   
   Novartis Pharma AG
      2021   Phase 3   EUCTR2020-002755-38-NL   Canada;France;Greece;Lebanon;Netherlands;Serbia;Slovenia;Switzerland;Turkey;United States;
      2021   Phase 3   EUCTR2020-002755-38-GR   Canada;France;Greece;Lebanon;Netherlands;Serbia;Slovenia;Switzerland;Turkey;United States;
      2020   Phase 3   EUCTR2020-002755-38-SI   Canada;France;Germany;Greece;Italy;Lebanon;Netherlands;Serbia;Slovenia;South Africa;Switzerland;Turkey;United States;
LIB003   
   LIB Therapeutics, LLC
      2021   Phase 3   EUCTR2020-004394-49-NO   Canada;France;Germany;India;Israel;New Zealand;Norway;South Africa;Spain;Turkey;United Kingdom;United States;
      2020   Phase 3   EUCTR2019-003611-62-NO   Israel;Norway;South Africa;Turkey;United States;
      -   Phase 3   EUCTR2020-004394-49-DE   Canada;France;Germany;India;Israel;New Zealand;Norway;South Africa;Spain;Turkey;United Kingdom;United States;
Lapaquistat acetate and current lipid-lowering treatment   
   Takeda
      2005   Phase 3   NCT00263081   Canada;France;Israel;Poland;United Kingdom;United States;
Lerodalcibep   
   LIB Therapeutics LLC
      2019   Phase 3   NCT04034485   India;Israel;Norway;South Africa;Turkey;United States;
   LIB Therapeutics, LLC
      2021   Phase 3   EUCTR2020-004394-49-NO   Canada;France;Germany;India;Israel;New Zealand;Norway;South Africa;Spain;Turkey;United Kingdom;United States;
      -   Phase 3   EUCTR2020-004394-49-DE   Canada;France;Germany;India;Israel;New Zealand;Norway;South Africa;Spain;Turkey;United Kingdom;United States;
Lojuxta 10 mg hard capsules   
   Amryt Pharmaceuticals DAC
      2020   Phase 3   EUCTR2019-002278-30-IT   Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;Turkey;
      2020   Phase 3   EUCTR2019-002278-30-DE   Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;Turkey;
Lojuxta 20 mg hard capsules   
   Amryt Pharmaceuticals DAC
      2020   Phase 3   EUCTR2019-002278-30-IT   Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;Turkey;
      2020   Phase 3   EUCTR2019-002278-30-DE   Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;Turkey;
Lojuxta 5 mg hard capsules   
   Amryt Pharmaceuticals DAC
      2020   Phase 3   EUCTR2019-002278-30-IT   Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;Turkey;
      2020   Phase 3   EUCTR2019-002278-30-DE   Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;Turkey;
Lomitapide   
   AEGERION PHARMACEUTICALS
      2011   -   EUCTR2010-023742-79-IT   Italy;
   Aegerion Pharmaceuticals, Inc.
      2016   Phase 3   NCT02765841   -
      2015   -   NCT02399852   -
      2014   Phase 3   NCT02173158   Japan;
      2009   Phase 3   NCT00943306   Canada;Italy;South Africa;United States;
      2003   Phase 2   NCT01556906   United States;
   Amryt Pharma
      2020   Phase 3   NCT04681170   Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;
      2014   -   NCT02135705   United States;
Lomitapide 2mg hard capsules   
   Amryt Pharmaceuticals DAC
      2020   Phase 3   EUCTR2019-002278-30-IT   Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;Turkey;
      2020   Phase 3   EUCTR2019-002278-30-DE   Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;Turkey;
Lovastatin   
   Sanofi
      2018   Phase 3   NCT03510715   Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
MBX-8025   
   CymaBay Therapeutics, Inc.
      2015   Phase 2   EUCTR2014-004856-68-NO   France;Netherlands;Norway;
      2015   Phase 2   EUCTR2014-004856-68-FR   France;Netherlands;Norway;
      2015   -   EUCTR2014-004856-68-NL   France;Netherlands;Norway;
MBX-8025 50 mg (Dose Escalation Period 1)   
   CymaBay Therapeutics, Inc.
      2015   Phase 2   NCT02472535   Canada;France;Netherlands;Norway;
MBX-8025 50 mg or 100 mg (Dose Escalation Period 2)   
   CymaBay Therapeutics, Inc.
      2015   Phase 2   NCT02472535   Canada;France;Netherlands;Norway;
MBX-8025 50 mg, 100 mg or 200 mg (Dose Escalation Period 3)   
   CymaBay Therapeutics, Inc.
      2015   Phase 2   NCT02472535   Canada;France;Netherlands;Norway;
MK-0859   
   Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc
      2013   Phase 3   EUCTR2012-002434-37-IT   Brazil;Canada;Czech Republic;Israel;Italy;Malaysia;Norway;South Africa;United Kingdom;United States;
      2013   Phase 3   EUCTR2012-002434-37-GB   Australia;Canada;Czech Republic;Israel;Italy;Malaysia;Norway;South Africa;United Kingdom;United States;
      2013   -   EUCTR2012-002434-37-CZ   Australia;Canada;Czech Republic;Israel;Malaysia;Norway;South Africa;United Kingdom;United States;
      2012   -   EUCTR2012-002434-37-NO   Australia;Canada;Czech Republic;Israel;Malaysia;Norway;South Africa;United Kingdom;United States;
Mipomersen   
   Kastle Therapeutics, LLC
      2007   Phase 3   NCT00607373   Brazil;Canada;Netherlands;Singapore;South Africa;Taiwan;United Kingdom;United States;
Nicotinic acid   
   Sanofi
      2018   Phase 3   NCT03510715   Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
Omega-3 fatty acids   
   Sanofi
      2018   Phase 3   NCT03510715   Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
PLACEBO   
   Regeneron Pharmaceuticals, Inc.(ICCC: PAREXEL International)
      2018   -   JPRN-JapicCTI-184099   Japan, North America, Europe, Oceania, Africa;
PRD7255830   
   Amryt Pharmaceuticals DAC
      2020   Phase 3   EUCTR2019-002278-30-IT   Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;Turkey;
PRD7255977   
   Amryt Pharmaceuticals DAC
      2020   Phase 3   EUCTR2019-002278-30-IT   Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;Turkey;
PRD7256003   
   Amryt Pharmaceuticals DAC
      2020   Phase 3   EUCTR2019-002278-30-IT   Germany;Israel;Italy;Saudi Arabia;Spain;Tunisia;Turkey;
Praluent   
   REGENERON PHARMACEUTICALS, INC.
      2019   Phase 3   EUCTR2017-003170-13-IT   Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Japan;Netherlands;Norway;South Africa;Ukraine;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-001388-19-IT   Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
      2017   Phase 3   EUCTR2017-000351-95-IT   Austria;Canada;Czech Republic;Czechia;Denmark;France;Germany;Greece;Italy;South Africa;Turkey;Ukraine;United States;
   Regeneron Pharmaceuticals Inc.
      2018   Phase 3   EUCTR2017-001388-19-GR   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Turkey;Ukraine;United States;
      2018   Phase 3   EUCTR2017-001388-19-DE   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
      2018   Phase 3   EUCTR2017-001388-19-AT   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
      -   Phase 3   EUCTR2017-001388-19-FR   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
      -   Phase 3   EUCTR2017-001388-19-CZ   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
   Regeneron Pharmaceuticals, Inc.
      2019   Phase 3   EUCTR2017-003170-13-GR   Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Ukraine;United Kingdom;United States;
      2019   Phase 3   EUCTR2017-003170-13-AT   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Ukraine;United Kingdom;United States;
      2018   Phase 3   EUCTR2017-003170-13-CZ   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;South Africa;Ukraine;United Kingdom;United States;
      2017   Phase 3   EUCTR2017-000351-95-GR   Austria;Canada;Czech Republic;France;Germany;Greece;Italy;South Africa;Turkey;Ukraine;United States;
      2017   Phase 3   EUCTR2017-000351-95-FR   Austria;Belgium;Bulgaria;Canada;Croatia;Czech Republic;Denmark;France;Germany;Greece;Israel;Italy;Netherlands;Poland;Portugal;Serbia;Slovenia;South Africa;Spain;Sweden;Tunisia;Turkey;Ukraine;United Kingdom;United States;
      2017   Phase 3   EUCTR2017-000351-95-DE   Austria;Canada;Czech Republic;France;Germany;Greece;Italy;South Africa;Turkey;Ukraine;United States;
      2017   Phase 3   EUCTR2017-000351-95-AT   Austria;Canada;Czech Republic;France;Germany;Greece;Italy;South Africa;Turkey;Ukraine;United States;
      -   Phase 3   EUCTR2017-003170-13-FR   Australia;Austria;Canada;Czech Republic;France;Germany;Greece;Italy;Japan;Netherlands;Norway;South Africa;Turkey;Ukraine;United Kingdom;United States;
      -   Phase 3   EUCTR2017-000351-95-CZ   Austria;Belgium;Bulgaria;Canada;Croatia;Czech Republic;Denmark;Germany;Greece;Israel;Italy;Netherlands;Poland;Portugal;Serbia;Slovenia;South Africa;Spain;Sweden;Tunisia;Turkey;Ukraine;United Kingdom;United States;
   Sanofi-Aventis Recherche & Développement
      2018   Phase 3   EUCTR2017-002297-39-DK   Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
Pravastatin   
   Sanofi
      2018   Phase 3   NCT03510715   Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
Prednisone   
   REGENXBIO Inc.
      2017   Phase 1;Phase 2   EUCTR2016-001446-25-IT   Canada;Italy;Netherlands;United States;
R727   
   REGENERON PHARMACEUTICALS, INC.
      2017   Phase 3   EUCTR2017-000351-95-IT   Austria;Canada;Czech Republic;Czechia;Denmark;France;Germany;Greece;Italy;South Africa;Turkey;Ukraine;United States;
REGN1500   
   REGENERON PHARMACEUTICALS, INC.
      2018   Phase 3   EUCTR2017-001388-19-IT   Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
   Regeneron Pharmaceuticals, Inc.
      2020   Phase 1;Phase 3   EUCTR2019-001931-30-NL   Australia;Austria;Belgium;Canada;France;Germany;Italy;Jordan;Lebanon;Netherlands;Norway;Taiwan;Ukraine;United States;
      2020   Phase 1;Phase 3   EUCTR2019-001931-30-AT   Australia;Austria;Belgium;Canada;France;Germany;Italy;Jordan;Lebanon;Netherlands;Norway;Taiwan;Ukraine;United States;
      2016   Phase 2   EUCTR2016-000411-32-NL   Canada;Netherlands;United States;
REGN1500 250 mg SC/15 mg/kg IV/450 mg SC   
   Regeneron Pharmaceuticals
      2015   Phase 2   NCT02265952   Canada;Netherlands;United States;
REGN7272   
   REGENERON PHARMACEUTICALS, INC.
      2018   Phase 3   EUCTR2017-001388-19-IT   Australia;Austria;Canada;Czech Republic;Czechia;France;Germany;Greece;Italy;Netherlands;South Africa;Turkey;Ukraine;United States;
Recombinant Human Apolipoprotein A-I   
   CERENIS THERAPEUTICS SA
      2012   -   EUCTR2011-003998-28-IT   Canada;Italy;Netherlands;United Kingdom;United States;
Recombinant Human Apolipoprotein A-I/Phospholipids Complex   
   Cerenis Therapeutics
      2012   Phase 2   EUCTR2011-003998-28-GB   Canada;Italy;Netherlands;United Kingdom;United States;
      2012   -   EUCTR2011-003998-28-NL   Canada;France;Italy;Netherlands;United Kingdom;United States;
Recombinant human apolipoprotein a1   
   Cerenis Therapeutics
      2012   Phase 2   EUCTR2011-003998-28-GB   Canada;Italy;Netherlands;United Kingdom;United States;
Repatha (evolocumab)   
   LIB Therapeutics, LLC
      2020   Phase 3   EUCTR2019-003611-62-NO   Israel;Norway;South Africa;Turkey;United States;
Repatha 140 mg Solution for Injection in Pre-filled Pen   
   Amgen Europe B.V.
      2019   Phase 3   EUCTR2015-002276-25-SI   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Malaysia;Netherlands;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Swaziland;Switzerland;Taiwan;Turkey;Ukraine;United Kingdom;United States;
   Amgen Inc
      2019   Phase 3   EUCTR2015-002276-25-PT   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
      2019   Phase 3   EUCTR2015-002276-25-PL   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Malaysia;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2017   Phase 3   EUCTR2015-002276-25-NL   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
      2017   Phase 3   EUCTR2015-002276-25-ES   Australia;Austria;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Netherlands;New Zealand;South Africa;Spain;Turkey;
      2016   Phase 3   EUCTR2015-002276-25-HU   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom;
      2016   Phase 3   EUCTR2015-002276-25-GR   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom;
      2016   Phase 3   EUCTR2015-002276-25-DE   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom;
      2016   Phase 3   EUCTR2015-002276-25-CZ   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom;
      2016   Phase 3   EUCTR2015-002276-25-BE   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
      2016   Phase 3   EUCTR2015-002276-25-AT   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
      -   Phase 3   EUCTR2015-002276-25-NO   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom;
      -   Phase 3   EUCTR2015-002276-25-GB   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Turkey;United Kingdom;
Repatha 140 mg solution for injection in pre-filled pen   
   Amgen Inc
      2013   Phase 2;Phase 3   EUCTR2011-005400-15-CZ   Australia;Austria;Belgium;Brazil;Canada;Czech Republic;France;Greece;Hong Kong;Israel;Italy;Japan;Lebanon;Netherlands;New Zealand;South Africa;Spain;United Kingdom;United States;
Repatha 140 mg soluzione per iniezione in penna preriempita.   
   AMGEN INC.
      2016   Phase 3   EUCTR2015-002276-25-IT   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
Repatha 420 mg solution for injection in cartridge   
   Amgen Europe B.V.
      2019   Phase 3   EUCTR2015-002276-25-SI   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Malaysia;Netherlands;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Swaziland;Switzerland;Taiwan;Turkey;Ukraine;United Kingdom;United States;
   Amgen Inc
      2019   Phase 3   EUCTR2015-002276-25-PT   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
      2019   Phase 3   EUCTR2015-002276-25-PL   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Malaysia;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Taiwan;Turkey;Ukraine;United Kingdom;United States;
      2017   Phase 3   EUCTR2015-002276-25-NL   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
      2016   Phase 3   EUCTR2015-002276-25-CZ   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom;
      2016   Phase 3   EUCTR2015-002276-25-BE   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
      2016   Phase 3   EUCTR2015-002276-25-AT   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
      -   Phase 3   EUCTR2015-002276-25-NO   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Slovenia;South Africa;Spain;Turkey;United Kingdom;
      -   Phase 3   EUCTR2015-002276-25-GB   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Turkey;United Kingdom;
Repatha 420 mg soluzione per iniezione in cartuccia   
   AMGEN INC.
      2016   Phase 3   EUCTR2015-002276-25-IT   Australia;Austria;Belgium;Brazil;Canada;Colombia;Czech Republic;Czechia;Germany;Greece;Hungary;Italy;Netherlands;New Zealand;Norway;Poland;Portugal;Russian Federation;Slovenia;South Africa;Spain;Switzerland;Turkey;United Kingdom;
Rosuvastatin   
   AstraZeneca
      2015   Phase 3   NCT02434497   Belgium;Canada;Denmark;Israel;Malaysia;Taiwan;
      2014   Phase 3   NCT02226198   Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States;
   Sanofi
      2018   Phase 3   NCT03510715   Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
Rosuvastatin calcium   
   AstraZeneca AB
      2015   Phase 3   EUCTR2014-004746-99-DK   Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States;
      2015   Phase 3   EUCTR2014-004746-99-BE   Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States;
      -   Phase 3   EUCTR2014-004746-99-SE   Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States;
SAR236553   
   Sanofi-Aventis Recherche & Développement
      2018   Phase 3   EUCTR2017-002297-39-SI   Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
      2018   Phase 3   EUCTR2017-002297-39-NO   Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
      2018   Phase 3   EUCTR2017-002297-39-NL   Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
      2018   Phase 3   EUCTR2017-002297-39-IT   Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
      2018   Phase 3   EUCTR2017-002297-39-FR   Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
      2018   Phase 3   EUCTR2017-002297-39-ES   Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
      2018   Phase 3   EUCTR2017-002297-39-DK   Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
      2018   Phase 3   EUCTR2017-002297-39-BG   Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
      2018   Phase 3   EUCTR2017-002297-39-AT   Argentina;Austria;Brazil;Bulgaria;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
SHR-1209   
   Jiangsu HengRui Medicine Co., Ltd.
      2020   Phase 2   NCT04455581   -
Sfingomielina   
   CERENIS THERAPEUTICS SA
      2012   -   EUCTR2011-003998-28-IT   Canada;Italy;Netherlands;United Kingdom;United States;
Simvastatin   
   Organon and Co
      2000   Phase 3   NCT03885921   -
      2000   Phase 3   NCT03884452   -
   Sanofi
      2018   Phase 3   NCT03510715   Austria;Brazil;Canada;Denmark;France;Italy;Mexico;Netherlands;Norway;Russian Federation;Slovenia;Spain;Taiwan;Turkey;United States;
Single intravenous (IV) dose of human Low Density Lipoprotein Receptor (LDLR) Gene Therapy   
   Regenxbio Inc.
      2019   -   NCT04080050   Canada;Italy;Netherlands;United States;
Sphingomyelin   
   Cerenis Therapeutics
      2012   Phase 2   EUCTR2011-003998-28-GB   Canada;Italy;Netherlands;United Kingdom;United States;
      2012   -   EUCTR2011-003998-28-NL   Canada;France;Italy;Netherlands;United Kingdom;United States;
Statins   
   Akeso
      2019   Phase 2   NCT03933293   China;
TAK-475   
   Takeda Europe R&D Centre Ltd
      2006   -   EUCTR2005-003626-26-GB   United Kingdom;
ZD4522   
   AstraZeneca AB
      2015   Phase 3   EUCTR2014-004746-99-DK   Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States;
      2015   Phase 3   EUCTR2014-004746-99-BE   Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States;
      2014   Phase 3   EUCTR2014-000972-24-BE   Australia;Belgium;Czech Republic;Denmark;Germany;Hong Kong;Israel;Netherlands;Norway;South Africa;Sweden;Taiwan;United Kingdom;United States;
      2014   -   EUCTR2014-000972-24-SE   Australia;Belgium;Czech Republic;Denmark;Germany;Hong Kong;Israel;Netherlands;Norway;South Africa;Sweden;Taiwan;United Kingdom;United States;
      2014   -   EUCTR2014-000972-24-NL   Australia;Belgium;Czech Republic;Denmark;Germany;Hong Kong;Israel;Netherlands;Norway;South Africa;Sweden;Taiwan;United Kingdom;United States;
      2014   -   EUCTR2014-000972-24-DK   Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States;
      2014   -   EUCTR2014-000972-24-DE   Australia;Belgium;Czech Republic;Denmark;Germany;Hong Kong;Israel;Netherlands;Norway;South Africa;Sweden;Taiwan;United Kingdom;United States;
      -   Phase 3   EUCTR2014-004746-99-SE   Belgium;Canada;Denmark;Germany;Israel;Lebanon;Malaysia;Netherlands;Sweden;Taiwan;United States;