Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. DrugBank 薬物名（臨床試験情報から抽出） KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
1 Acetaminophen
(Synonym: TopCare Pain Relief Rapid Release)		4件: Acetaminophen; Paracetamol; Tylenol; Ultracet1件: D00217 2件: PTGS1,
PTGS2 💬		23件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬15件: 3, 6, 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337
2 Acetazolamide
(Synonym: Acetazolamide Extended-release)		1件: Acetazolamide1件: D00218 13件: CA1,
CA12,
CA13,
CA14,
CA2,
CA3,
CA4,
CA5A,
CA5B,
CA6,
CA7,
CA8,
CA9 💬		7件: Bile secretion, Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Nitrogen metabolism, Pancreatic secretion, Proximal tubule bicarbonate reclamation 💬8件: 13, 86, 90, 115, 154, 155, 225, 230
3 Acetylsalicylic acid
(Synonym: Aspirin Coated for Delayed Release Extra Strength)		2件: ACETYLSALICYLIC ACID; Aspirin1件: D00109 2件: PTGS1,
PTGS2 💬		23件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬14件: 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251
4 Alfuzosin
(Synonym: Alfuzosin Hydrochloride extended release)		1件: Alfuzosin1件: D07124 1件: ADRA1A 💬7件: AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬1件: 13
5 alpha-Tocopherol acetate
(Synonym: Icaps Time Release)		3件: Tocopherol acetate; TOCOPHERYL ACETATE; Vitamin E---2件: 49, 206
6 Alprazolam
(Synonym: Alprazolam Extended Release)		1件: Alprazolam1件: D00225 16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬2件: 8, 75
7 Amoxicillin
(Synonym: Amoxicillin Extended-Release)		4件: Amoxicilina; Amoxicillin; Amoxycillin; Augmentin2件: D00229 ,
D07452 		--9件: 6, 19, 46, 63, 84, 96, 97, 222, 299
8 Ascorbic acid
(Synonym: Vitamin C Timed Release Tab 1000mg)		4件: Acidum ascorbicum; ASCORBIC ACID; Iron; Vitamin C1件: D00018 --8件: 10, 97, 192, 206, 210, 211, 212, 298
9 Beta carotene
(Synonym: Complete Multivitamins and Minerals Tablets Timed Release)		3件: Beta carotene; Beta-Carotene; BETACAROTENE1件: D03101 --2件: 13, 96
10 Biotin
(Synonym: Time Release B 100 Compound - Tablet)		4件: BIOTIN; Biotina; D-BIOTIN; Vitamin B71件: D00029 --5件: 2, 8, 10, 13, 20
11 Bisacodyl
(Synonym: Delayed Release Laxative Bisacodyl)		1件: Bisacodyl1件: D00245 --1件: 13
12 Bupropion
(Synonym: Contrave Extended-Release)		2件: Bupropion; Bupropion Hydrochloride1件: D07591 2件: SLC6A2,
SLC6A3 💬		7件: Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Synaptic vesicle cycle 💬5件: 8, 18, 21, 96, 171
13 Calcium
(Synonym: Timed Release Vita-vim Srt)		2件: Calcio; Calcium---27件: 6, 13, 19, 46, 49, 51, 53, 56, 68, 75, 79, 84, 93, 94, 95, 96, 97, 156, 214, 215, 222, 224, 235, 265, 274, 298, 299
14 Calcium carbonate
(Synonym: Swiss One Timed Release Tab)		3件: Calcio carbonato; Calcium; Calcium carbonate2件: D00932 ,
D10802 		--9件: 13, 19, 46, 53, 75, 96, 235, 274, 299
15 Chlorpheniramine
(Synonym: Hydrocodone Polistirex and Chlorpheniramine Polistirex extended-release)		1件: Clorfenamina1件: D07398 1件: HRH1 💬3件: Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬1件: 14
16 Choline
(Synonym: Timed Release B Complex 100 Srt)		1件: Choline1件: D07690 --4件: 93, 171, 193, 299
17 Chromium
(Synonym: Complete Multivitamins and Minerals Tablets Timed Release)		1件: Chromium---1件: 46
18 Clarithromycin
(Synonym: Clarithromycin extended release)		1件: Clarithromycin1件: D00276 --8件: 6, 63, 84, 96, 97, 222, 228, 299
19 Clavulanic acid
(Synonym: Amoxicillin and Clavulanate Potassium Extended Release)		4件: AMOXICILLIN; Augmentin; Clavulanate; CLAVULANIC ACID1件: D07711 --1件: 299
20 Clonidine
(Synonym: Clonidine hydrochloride extended-release)		4件: Clonidin; Clonidina; Clonidine; Clonidine hydrochloride1件: D00281 3件: ADRA2A,
ADRA2B,
ADRA2C 💬		2件: Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬4件: 6, 65, 70, 78
21 Copper
(Synonym: Complete Multivitamins and Minerals Tablets Timed Release)		2件: Copper; Nicotinamide---4件: 2, 169, 170, 171
22 Cyanocobalamin
(Synonym: Timed Release B-complex 100)		2件: Cianocobalamina; Vitamin B124件: D00166 ,
D03615 ,
D03616 ,
D03617 		--5件: 6, 13, 201, 229, 299
23 Cysteamine
(Synonym: PROCYSBI Delayed-release)		8件: 2-aminoethanethiol; Beta-Mercaptoethylamine; CYSTADROPS; CYSTAGON; CYSTEAMINE; Mercaptamina; Mercaptamine; PROCYSBI1件: D03634 --4件: 8, 19, 21, 299
24 Darifenacin
(Synonym: Darifenacin Hydrobromide Extended-Release)		2件: Darifenacin; Emselex1件: D03654 1件: CHRM3 💬11件: Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction 💬2件: 6, 13
25 Dexlansoprazole
(Synonym: Dexlansoprazole delayed release)		1件: Dexlansoprazole1件: D08903 2件: ATP4A,
ATP4B 💬		4件: Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬1件: 98
26 Dextromethorphan
(Synonym: Mucus DM Extended-Release)		4件: Dextromethorphan; DEXTROMETHORPHAN HYDROBROMIDE; Dextrometorfano; Nuedexta1件: D03742 6件: GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D,
SIGMAR1 💬		20件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
27 Diclofenac
(Synonym: Diclofenac Sodium and Misoprostol Delayed-Release)		3件: Diclofenac; Diclofenac Sodium; Diclofenac SR1件: D07816 2件: PTGS1,
PTGS2 💬		23件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬5件: 13, 34, 46, 78, 271
28 Diltiazem
(Synonym: Diltiazem Hydrochloride Extended-Release)		2件: Diltiazem; Diltiazem Hydrochloride1件: D07845 4件: CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬		37件: Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬3件: 51, 58, 86
29 Dimethyl fumarate
(Synonym: Sandoz Dimethyl Fumarate Delayed-release Capsules)		3件: Dimethyl fumarate; Dimethylfumarat; TECFIDERA1件: D03846 1件: KEAP1 💬6件: Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Parkinson disease, Pathways in cancer, Ubiquitin mediated proteolysis 💬5件: 13, 49, 51, 86, 296
30 Diphenhydramine
(Synonym: Rapid Release Pain Relief PM)		2件: Diphenhydramine; Diphenhydramine hydrochloride1件: D00300 1件: HRH1 💬3件: Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬8件: 11, 13, 49, 51, 70, 86, 222, 256
31 Dipyridamole
(Synonym: Asprin and Extended-release Dipyridamole)		1件: Dipyridamole1件: D00302 2件: PDE4A,
PDE5A 💬		6件: Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway, cGMP-PKG signaling pathway 💬6件: 46, 49, 51, 66, 96, 224
32 Donepezil
(Synonym: Memantine and Donepezil Hydrochlorides Extended-release)		3件: ARICEPT; Donepezil; Donepezil Hydrochloride1件: D07869 1件: ACHE 💬2件: Cholinergic synapse, Glycerophospholipid metabolism 💬9件: 5, 6, 13, 46, 78, 124, 127, 156, 206
33 Doxycycline
(Synonym: Doxycycline Hyclate Delayed Release)		4件: Doxycyclin; Doxycycline; DOXYCYCLINE HYCLATE; Doxycycline Tablets2件: D00307 ,
D07876 		--17件: 13, 23, 28, 34, 46, 84, 85, 89, 96, 97, 158, 161, 162, 167, 227, 280, 299
34 Duloxetine
(Synonym: Duloxetine Hydrochloride Delayed Release)		3件: Cymbalta; DULOXETINE; Duloxetine hydrochloride1件: D07880 2件: SLC6A2,
SLC6A4 💬		2件: Serotonergic synapse, Synaptic vesicle cycle 💬2件: 6, 13
35 Ergocalciferol
(Synonym: Timed Release Vita-vim Srt)		3件: Ergocalciferol; Vitamin D; Vitamin D21件: D00187 1件: VDR 💬5件: Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Mineral absorption, Parathyroid hormone synthesis, secretion and action, Tuberculosis 💬6件: 46, 49, 84, 96, 97, 299
36 Erythromycin
(Synonym: Eryc Delayed-release Capsules)		1件: Erythromycin1件: D00140 --5件: 6, 36, 164, 228, 291
37 Ferrous sulfate anhydrous
(Synonym: Iron Cap 50mg Time Release)		0件: ---1件: 46
38 Folic acid
(Synonym: Timed Release B-complex 100)		5件: Acide folique; Folate; Folic Acid; Multivitamin; Nicotinamide1件: D00070 --6件: 6, 41, 46, 49, 84, 296
39 Guanfacine
(Synonym: Guanfacine Extended-Release)		1件: Guanfacine1件: D08031 1件: ADRA2A 💬2件: Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬1件: 193
40 Hydromorphone
(Synonym: Hydromorph Contin-controlled Release Cap - 30mg)		1件: Hydromorphone1件: D08047 1件: OPRM1 💬3件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬1件: 70
41 Ibuprofen
(Synonym: IBUPROFEN Immediate Release)		2件: Ibuprofen; IBUPROFEN 200MG1件: D00126 2件: PTGS1,
PTGS2 💬		23件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬7件: 13, 46, 65, 107, 113, 271, 299
42 Indomethacin
(Synonym: Indomethacin extended-release)		2件: INDOMETACIN; Indomethacin1件: D00141 2件: PTGS1,
PTGS2 💬		23件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬3件: 225, 271, 298
43 Inositol
(Synonym: Timed Release B Complex 100 Srt)		1件: Inositol1件: D08079 --2件: 96, 97
44 Iodine
(Synonym: Swiss One Timed Release Tab)		2件: Iodine; Iodo1件: D00108 --2件: 28, 46
45 Iron
(Synonym: Complete Multivitamins and Minerals Tablets Timed Release)		1件: Iron---6件: 18, 96, 97, 238, 254, 284
46 Ketoprofen
(Synonym: Oruvail Extended Release)		1件: Ketoprofen1件: D00132 2件: PTGS1,
PTGS2 💬		23件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬1件: 46
47 Lamotrigine
(Synonym: Lamotrigine Extended Release)		2件: Lamictal; LAMOTRIGINE1件: D00354 (Name: LAMOTRIGINE EXTENDED RELEASE)5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬5件: 13, 34, 38, 114, 144
48 Lansoprazole
(Synonym: Equate Lansoprazole Delayed Release)		1件: LANSOPRAZOLE1件: D00355 2件: ATP4A,
ATP4B 💬		4件: Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬7件: 63, 71, 85, 98, 166, 222, 299
49 Levetiracetam
(Synonym: Levetiracetam Extended Release)		2件: KEPPRA; Levetiracetam1件: D00709 (Name: LEVETIRACETAM EXTENDED RELEASE)1件: SV2A 💬1件: ECM-receptor interaction 💬5件: 2, 4, 6, 13, 307
50 Lidocaine
(Synonym: Lidovix Delayed Release)		4件: Aloe; Lidocaine; Lignocaine; Xylocaine2件: D00358 ,
D08127 		5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬13件: 6, 13, 22, 34, 46, 51, 70, 84, 86, 107, 168, 226, 256
51 Loratadine
(Synonym: KIRKLAND SIGNATURE ALLERCLEAR D 24 HR Extended Release)		2件: Loratadina; LORATADINE1件: D00364 1件: HRH1 💬3件: Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬4件: 13, 46, 89, 98
52 Magnesium
(Synonym: Timed Release Vita-vim Srt)		1件: Magnesium---19件: 6, 11, 13, 46, 51, 63, 64, 70, 93, 97, 111, 166, 225, 235, 284, 291, 296, 297, 298
53 Magnesium gluconate
(Synonym: Swiss One Timed Release Tab)		2件: Magnesium; Magnesium gluconate1件: D04835 --2件: 296, 297
54 Manganese citrate
(Synonym: Release)		1件: Release---12件: 6, 8, 13, 46, 65, 78, 81, 96, 97, 206, 226, 299
55 Melatonin
(Synonym: Melatonin Rapid Release Gelcaps 5 mg)		2件: Circadin; Melatonin1件: D08170 2件: MTNR1A,
MTNR1B 💬		2件: Circadian entrainment, Neuroactive ligand-receptor interaction 💬12件: 6, 8, 13, 37, 46, 49, 72, 78, 90, 97, 145, 202
56 Memantine
(Synonym: Memantine and Donepezil Hydrochlorides Extended-release)		3件: EBIXA; Memantine; MEMANTINE HYDROCHLORIDE1件: D08174 5件: GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		20件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬8件: 2, 6, 8, 13, 49, 127, 205, 206
57 Mesalazine
(Synonym: Pentasa Extended-release Tablets 250mg)		10件: 5-AminoSalicylic Acid; 5-ASA; ASACOL; Mesalamine; MESALAZINA; MESALAZINE; Mesalazinum; MEZAVANT; Pentasa; Salofalk1件: D00377 --5件: 46, 96, 97, 98, 164
58 Metformin
(Synonym: Metformin Hydrochloride Extended-Release)		5件: Metformin; Metformin HCl; Metformin hydrochloride; Metformina; Metformine1件: D04966 2件: PRKAA1,
PRKAA2 💬		20件: AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬25件: 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301
59 Methylphenidate
(Synonym: Methylphenidate Hydrochloride Extended-Release)		3件: Methylphenidate; METHYLPHENIDATE HYDROCHLORIDE; Ritalin1件: D04999 2件: SLC6A2,
SLC6A3 💬		7件: Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Synaptic vesicle cycle 💬7件: 6, 13, 34, 84, 113, 179, 206
60 Metoprolol
(Synonym: Metoprolol Succinate Extended-release)		2件: Metoprolol; METOPROLOL SUCCINATE1件: D02358 1件: ADRB1 💬11件: Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬6件: 17, 57, 58, 113, 193, 226
61 Minocycline
(Synonym: Minolira Extended Release)		3件: MINOCYCLINE; MINOCYCLINE HYDROCHLORIDE; Minomycin1件: D05045 --14件: 2, 6, 8, 13, 46, 84, 85, 90, 94, 162, 201, 206, 280, 299
62 Misoprostol
(Synonym: Diclofenac Sodium and Misoprostol Delayed-Release)		1件: Misoprostol1件: D00419 3件: PTGER2,
PTGER3,
PTGER4 💬		9件: Calcium signaling pathway, Human cytomegalovirus infection, Human papillomavirus infection, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Pathways in cancer, Regulation of lipolysis in adipocytes, Renin secretion, cAMP signaling pathway 💬3件: 46, 70, 271
63 Morphine
(Synonym: Oramorph SR Sustained Release)		2件: Morphine; MORPHINE SULFATE1件: D08233 1件: OPRM1 💬3件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬5件: 36, 46, 70, 85, 86
64 Naltrexone
(Synonym: Contrave Extended-Release)		2件: Naltrexone; NALTREXONE HYDROCHLORIDE1件: D05113 3件: OPRD1,
OPRK1,
OPRM1 💬		5件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬13件: 6, 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226
65 Naproxen
(Synonym: Naproxen Delayed-release)		5件: Naprosyn; Naproxen; Naproxen oral suspension; NAPROXEN SODIUM; Propanoic acid1件: D00118 2件: PTGS1,
PTGS2 💬		23件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬4件: 13, 46, 107, 271
66 Nevirapine
(Synonym: Nevirapine Extended Release)		1件: Nevirapine1件: D00435 --1件: 265
67 Niacin
(Synonym: Niodan 500 Mg Time Release Tablets)		2件: Niacin; Nicotinic acid1件: D00049 --3件: 6, 78, 79
68 Nicotinamide
(Synonym: Timed Release B Complex 100 Srt)		3件: Multivitamin; Niacinamide; Nicotinamide1件: D00036 --10件: 2, 5, 6, 18, 49, 67, 97, 107, 162, 191
69 Nifedipine
(Synonym: Mylan-nifedipine Extended Release)		1件: Nifedipine1件: D00437 4件: CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬		37件: Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬2件: 50, 81
70 Omeprazole
(Synonym: Equaline Omeprazole Delayed Release)		4件: Losec; Omeprazol; Omeprazole; OMEPRAZOLE MAGNESIUM1件: D00455 2件: ATP4A,
ATP4B 💬		4件: Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬14件: 6, 8, 21, 46, 51, 85, 96, 97, 225, 271, 282, 294, 298, 299
71 Oxybutynin
(Synonym: Oxybutynin ChlorideExtended Release Extended Release)		1件: Oxybutynin1件: D00465 5件: CHRM1,
CHRM2,
CHRM3,
CHRM4,
CHRM5 💬		13件: Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction, cAMP signaling pathway 💬3件: 6, 13, 53
72 Oxycodone
(Synonym: Oxycodone HCl Controlled-Release)		2件: Oxycodone; OXYCODONE HYDROCHLORIDE1件: D05312 3件: OPRD1,
OPRK1,
OPRM1 💬		5件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬5件: 6, 13, 70, 226, 298
73 Oxymorphone
(Synonym: Oxymorphone Hydrochloride Extended-Release)		1件: Opana1件: D08323 1件: OPRM1 💬3件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬1件: 70
74 Pantoprazole
(Synonym: Protonix Delayed-Release)		1件: PANTOPRAZOLE1件: D05353 2件: ATP4A,
ATP4B 💬		4件: Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬2件: 13, 65
75 Paroxetine
(Synonym: PAROXETINE HYDROCHLORIDE Controlled-Release)		1件: Paroxetine1件: D02362 1件: SLC6A4 💬2件: Serotonergic synapse, Synaptic vesicle cycle 💬4件: 6, 13, 46, 85
76 Phenylephrine
(Synonym: Tylenol Cold Rapid Release)		1件: Phenylephrine1件: D08365 3件: ADRA1A,
ADRA1B,
ADRA1D 💬		7件: AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬1件: 22
77 Potassium
(Synonym: Complete Multivitamins and Minerals Tablets Timed Release)		1件: Potassium1件: D08403 --13件: 36, 46, 66, 67, 88, 93, 94, 98, 115, 167, 179, 215, 235
78 Pramipexole
(Synonym: Pramipexole Dihydrochloride Extended-Release)		7件: Mirapex; Mirapex ER; Mirapexin; Pramipexol; Pramipexole; PRAMIPEXOLE DIHYDROCHLORIDE; SIFROL1件: D05575 3件: DRD2,
DRD3,
DRD4 💬		8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬3件: 2, 6, 20
79 Pregabalin
(Synonym: Pregabalin Extended Release)		2件: Lyrica; Pregabalin1件: D02716 (Name: PREGABALIN EXTENDED RELEASE)4件: CACNA2D1,
CACNA2D2,
CACNA2D3,
CACNA2D4 💬		7件: Adrenergic signaling in cardiomyocytes, Arrhythmogenic right ventricular cardiomyopathy, Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy, MAPK signaling pathway, Oxytocin signaling pathway 💬5件: 13, 36, 46, 70, 298
80 Pseudoephedrine
(Synonym: Guaifenesin and pseudoephedrine hydrochloride Extended Release)		1件: Pseudoephedrine1件: D08449 9件: ADRA1A,
ADRA1B,
ADRA1D,
ADRA2A,
ADRA2B,
ADRA2C,
ADRB1,
ADRB2,
ADRB3 💬		14件: AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Thermogenesis, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬1件: 17
81 Pyridoxine
(Synonym: B Plus C 300mg Timed Release)		2件: Pyridoxine; Vitamin B61件: D08454 --5件: 6, 93, 145, 206, 320
82 Quetiapine
(Synonym: Quetiapine Fumarate Extended Release)		2件: Quetiapine; Seroquel1件: D08456 2件: DRD2,
HTR2A 💬		11件: Alcoholism, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Serotonergic synapse, cAMP signaling pathway 💬2件: 6, 13
83 Rabeprazole
(Synonym: Rabeprazole Sodium Delayed-release)		1件: Rabeprazole1件: D08463 2件: ATP4A,
ATP4B 💬		4件: Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬2件: 2, 51
84 Ranitidine
(Synonym: Ranitidine Immediate release)		1件: Ranitidine1件: D00422 1件: HRH2 💬3件: Calcium signaling pathway, Gastric acid secretion, Neuroactive ligand-receptor interaction 💬2件: 13, 65
85 Riboflavin
(Synonym: Complete Multivitamins and Minerals Tablets Timed Release)		2件: RIBOFLAVIN; Vitamin B21件: D00050 --7件: 38, 46, 96, 97, 162, 168, 265
86 Salicylic acid
(Synonym: Smart Release Mandelic 8 PERCENT)		2件: 2-Hydroxybenzoic acid; Salicylic acid1件: D00097 --1件: 97
87 Selenium
(Synonym: Complete Multivitamins and Minerals Tablets Timed Release)		1件: Selenium---4件: 13, 96, 278, 298
88 Sodium fluoride
(Synonym: Flor-Opal Sustained-Release Fluoride)		1件: Sodium fluoride1件: D00943 --1件: 51
89 Somatostatin
(Synonym: Synthetic growth hormone release-inhibiting hormone)		1件: Somatostatin1件: D07431 5件: SSTR1,
SSTR2,
SSTR3,
SSTR4,
SSTR5 💬		4件: Gastric acid secretion, Growth hormone synthesis, secretion and action, Neuroactive ligand-receptor interaction, cAMP signaling pathway 💬2件: 67, 78
90 Sulfasalazine
(Synonym: Sulfasalazine Delayed-Release)		3件: Salazosulfapyridine; Salicylazosulfapyridine; Sulfasalazine1件: D00448 --6件: 46, 86, 94, 107, 270, 271
91 Theophylline
(Synonym: Theophylline Extended Release)		1件: Theophylline2件: D00371 ,
D06103 		18件: ADORA1,
ADORA2B,
PDE10A,
PDE11A,
PDE1A,
PDE1B,
PDE1C,
PDE2A,
PDE3A,
PDE3B,
PDE4A,
PDE4B,
PDE4C,
PDE4D,
PDE7A,
PDE7B,
PDE8A,
PDE8B 💬		23件: Alcoholism, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Cortisol synthesis and secretion, Cushing syndrome, Glucagon signaling pathway, Insulin signaling pathway, Metabolic pathways, Morphine addiction, Neuroactive ligand-receptor interaction, Olfactory transduction, Parathyroid hormone synthesis, secretion and action, Progesterone-mediated oocyte maturation, Purine metabolism, Rap1 signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Sphingolipid signaling pathway, Taste transduction, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬2件: 236, 299
92 Thiamine
(Synonym: B Plus C 300mg Timed Release)		2件: Thiamine; Vitamin B11件: D08580 --4件: 8, 93, 145, 265
93 Tolterodine
(Synonym: Tolterodine Tartrate Extended Release)		1件: Tolterodine1件: D00646 1件: CHRM3 💬11件: Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction 💬2件: 17, 53
94 Tramadol
(Synonym: Tramadol Hydrochloride Extended-Release)		2件: Tramadol; Ultracet1件: D08623 1件: OPRM1 💬3件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬5件: 46, 70, 78, 226, 271
95 Valproic acid
(Synonym: Divalproex Sodium Delayed-Release)		3件: Valproate; VALPROATE SODIUM; Valproic Acid1件: D00399 7件: ABAT,
ALDH5A1,
CACNA1G,
CACNA1H,
CACNA1I,
GAD1,
GAD2 💬		17件: Alanine, aspartate and glutamate metabolism, Aldosterone synthesis and secretion, Butanoate metabolism, Calcium signaling pathway, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, GABAergic synapse, GnRH secretion, MAPK signaling pathway, Metabolic pathways, Propanoate metabolism, Taurine and hypotaurine metabolism, Type I diabetes mellitus, Type II diabetes mellitus, Valine, leucine and isoleucine degradation, beta-Alanine metabolism 💬14件: 2, 3, 5, 6, 13, 26, 65, 85, 90, 102, 127, 222, 233, 256
96 Venlafaxine
(Synonym: Venlafaxine Hydrochloride Extended-release Capsules)		2件: Venlafaxine; Venlafaxine Hydrochloride1件: D08670 2件: SLC6A2,
SLC6A4 💬		2件: Serotonergic synapse, Synaptic vesicle cycle 💬3件: 6, 13, 46
97 Vitamin A
(Synonym: Timed Release Vita-vim Srt)		1件: Vitamin A1件: D06543 2件: RARA,
RARB 💬		8件: Acute myeloid leukemia, Estrogen signaling pathway, Gastric cancer, Non-small cell lung cancer, Pathways in cancer, Small cell lung cancer, Th17 cell differentiation, Transcriptional misregulation in cancer 💬3件: 13, 53, 90
98 Vitamin D
(Synonym: Swiss One Timed Release Tab)		3件: Calciferol; Cod liver oil; Vitamin D---20件: 13, 19, 41, 43, 44, 46, 49, 50, 68, 93, 95, 96, 97, 179, 222, 228, 235, 274, 298, 299
99 Vitamin E
(Synonym: Swiss One Timed Release Tab)		2件: Alpha-tocopherol; Vitamin E1件: D02331 --12件: 2, 6, 13, 20, 46, 49, 90, 96, 97, 206, 299, 317
100 Zinc
(Synonym: Icaps Time Release)		3件: Nicotinamide; Wilzin; Zinc---4件: 2, 113, 171, 299
101 Zinc gluconate
(Synonym: Swiss One Timed Release Tab)		1件: ZINC GLUCONATE1件: D02390 --1件: 171
102 Zolpidem
(Synonym: Zolpidem Tartrate Extended-Release)		2件: Zolpidem; Zolpidem Tartrate1件: D08690 16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬3件: 5, 6, 46